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The map label for this gene is mdh [H]

Identifier: 124027209

GI number: 124027209

Start: 303512

End: 304663

Strand: Reverse

Name: mdh [H]

Synonym: Hbut_0312

Alternate gene names: 124027209

Gene position: 304663-303512 (Counterclockwise)

Preceding gene: 124027217

Following gene: 124027208

Centisome position: 18.27

GC content: 56.25

Gene sequence:

>1152_bases
TTGCACCCCAAGTTCTACGAGAAGGAGAAGCCTGTACCCCCAGAGGAGTATGTGCGTGTTGACCACGAGAGCCTCCGCAG
CTGGGTCTCAAAGGTCTTCCAGGCCCTAGGGCTACGCAGGGACTACGCCGACATCGTGGCTGACAACCTGGTGGCAGCAG
ACCTTATGGGCATCAGCAGCCACGGCGTACAGAGGATCCGGAGGTATGTTGGCGGGATAAAGGTTGGCTCAATAAACGTA
AACCCGGACATAAGGATAGTACGGGATATGGGTGCGGCAGTCCTCCTCGATGGCGACAATGGACCAGGCCAGGTGGTAGG
CACCAAGGCCATGAACATTGCTATCGAGAGGGCCAAAAGGTATGGTGTTGGTGTTGTGGGTGTCAGAAGGAGCCACCACT
ACGGCATAGCCGGCTACTATGCCCTCATGGCAGTTGAACATGGCATGATAGGGGTGTCACTCACAAACGCTAGGTCCCTC
GTAGCATACGTAGGCACACTCTCCAAGTATCTGGGCACAAACCCGATAGCAGTAGCTGCGCCCCGGAGGAACCCGCCACC
ATTCCTCTTTGACGCCGCTACGAGCACAGTGCCAGTGGGGAAGGTAGAGATCTACGCTAAGACCGGGAGGTCCGTGCCTC
ATGGCTGGGCTGTCAGCCTGGAGGACGGCAGGGAGCTGACCGGTGACGCAGCACCAATCCTTGAGGCGATAAGGAAAGGT
AGGGCAGCACTACTACCCCTCGGAGGCCTAGCAGAGGAAACGGGCGGCCACAAGGGGAGCGGCCTGGCACTAATAGTAGA
GCTGCTGGCGGGCGTACTAACTGGCGCAGCCTGGGCAATACATGTCCGAAACACCACCGACCCGCAGCCAGCCAATGTGG
GCCACTTCTTCATGTCGATAAACATCGAGGCATTCATGTCACTCGAAGAATTCTACGACAGGTTCGAGAAGATGATAGAG
GAGATCAAGAGTCTGCCCAAGCACCCACAAGCGGACAGAATATGGATACCCGGCGAGAAAGCCTGGCTAACAATGGAGAC
TAGGAAGAAGATCGGGATACCACTACACCGCAACGTCTTCAACGACCTAAAGAAGCTCTCAGAGGAGCTTGGATTAGACT
TCACAGTAAAGGTCCTAAAGGAGACGGCCTAG

Upstream 100 bases:

>100_bases
TAGAGTCTCCGTCATATGTTTGGCTCCCGGCTGAGGCACTAGCAACTGGTGTCACAAGGCTTTAACCCCGGATACATTTG
GGCTTAGTGTGGTGGGCTTT

Downstream 100 bases:

>100_bases
AGAAGTTAATCAACCTCCTTCCGGTTGCAGCACGTGGCGGACGCAGCTAGTAAGGCTAACTCATTTCACAACAGCCGCTG
TGTGAGGAGTAGCGCATCTC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MHPKFYEKEKPVPPEEYVRVDHESLRSWVSKVFQALGLRRDYADIVADNLVAADLMGISSHGVQRIRRYVGGIKVGSINV
NPDIRIVRDMGAAVLLDGDNGPGQVVGTKAMNIAIERAKRYGVGVVGVRRSHHYGIAGYYALMAVEHGMIGVSLTNARSL
VAYVGTLSKYLGTNPIAVAAPRRNPPPFLFDAATSTVPVGKVEIYAKTGRSVPHGWAVSLEDGRELTGDAAPILEAIRKG
RAALLPLGGLAEETGGHKGSGLALIVELLAGVLTGAAWAIHVRNTTDPQPANVGHFFMSINIEAFMSLEEFYDRFEKMIE
EIKSLPKHPQADRIWIPGEKAWLTMETRKKIGIPLHRNVFNDLKKLSEELGLDFTVKVLKETA

Sequences:

>Translated_383_residues
MHPKFYEKEKPVPPEEYVRVDHESLRSWVSKVFQALGLRRDYADIVADNLVAADLMGISSHGVQRIRRYVGGIKVGSINV
NPDIRIVRDMGAAVLLDGDNGPGQVVGTKAMNIAIERAKRYGVGVVGVRRSHHYGIAGYYALMAVEHGMIGVSLTNARSL
VAYVGTLSKYLGTNPIAVAAPRRNPPPFLFDAATSTVPVGKVEIYAKTGRSVPHGWAVSLEDGRELTGDAAPILEAIRKG
RAALLPLGGLAEETGGHKGSGLALIVELLAGVLTGAAWAIHVRNTTDPQPANVGHFFMSINIEAFMSLEEFYDRFEKMIE
EIKSLPKHPQADRIWIPGEKAWLTMETRKKIGIPLHRNVFNDLKKLSEELGLDFTVKVLKETA
>Mature_383_residues
MHPKFYEKEKPVPPEEYVRVDHESLRSWVSKVFQALGLRRDYADIVADNLVAADLMGISSHGVQRIRRYVGGIKVGSINV
NPDIRIVRDMGAAVLLDGDNGPGQVVGTKAMNIAIERAKRYGVGVVGVRRSHHYGIAGYYALMAVEHGMIGVSLTNARSL
VAYVGTLSKYLGTNPIAVAAPRRNPPPFLFDAATSTVPVGKVEIYAKTGRSVPHGWAVSLEDGRELTGDAAPILEAIRKG
RAALLPLGGLAEETGGHKGSGLALIVELLAGVLTGAAWAIHVRNTTDPQPANVGHFFMSINIEAFMSLEEFYDRFEKMIE
EIKSLPKHPQADRIWIPGEKAWLTMETRKKIGIPLHRNVFNDLKKLSEELGLDFTVKVLKETA

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=357, Percent_Identity=32.2128851540616, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786727, Length=348, Percent_Identity=30.4597701149425, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790000, Length=350, Percent_Identity=24.2857142857143, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17507179, Length=364, Percent_Identity=32.4175824175824, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17536633, Length=380, Percent_Identity=32.3684210526316, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45553211, Length=349, Percent_Identity=33.2378223495702, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24667912, Length=349, Percent_Identity=33.2378223495702, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24667904, Length=318, Percent_Identity=34.2767295597484, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24667908, Length=349, Percent_Identity=33.2378223495702, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24648360, Length=371, Percent_Identity=30.4582210242588, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24658010, Length=348, Percent_Identity=25, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 41856; Mature: 41856

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPKFYEKEKPVPPEEYVRVDHESLRSWVSKVFQALGLRRDYADIVADNLVAADLMGISS
CCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
HGVQRIRRYVGGIKVGSINVNPDIRIVRDMGAAVLLDGDNGPGQVVGTKAMNIAIERAKR
HHHHHHHHHHCCEEEEEEECCCCEEEEECCCCEEEEECCCCCCCEEEHHHHHHHHHHHHH
YGVGVVGVRRSHHYGIAGYYALMAVEHGMIGVSLTNARSLVAYVGTLSKYLGTNPIAVAA
CCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEC
PRRNPPPFLFDAATSTVPVGKVEIYAKTGRSVPHGWAVSLEDGRELTGDAAPILEAIRKG
CCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCC
RAALLPLGGLAEETGGHKGSGLALIVELLAGVLTGAAWAIHVRNTTDPQPANVGHFFMSI
CEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEE
NIEAFMSLEEFYDRFEKMIEEIKSLPKHPQADRIWIPGEKAWLTMETRKKIGIPLHRNVF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEHHHHCCCCHHHHHH
NDLKKLSEELGLDFTVKVLKETA
HHHHHHHHHHCCCEEEHHHHHCC
>Mature Secondary Structure
MHPKFYEKEKPVPPEEYVRVDHESLRSWVSKVFQALGLRRDYADIVADNLVAADLMGISS
CCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
HGVQRIRRYVGGIKVGSINVNPDIRIVRDMGAAVLLDGDNGPGQVVGTKAMNIAIERAKR
HHHHHHHHHHCCEEEEEEECCCCEEEEECCCCEEEEECCCCCCCEEEHHHHHHHHHHHHH
YGVGVVGVRRSHHYGIAGYYALMAVEHGMIGVSLTNARSLVAYVGTLSKYLGTNPIAVAA
CCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEC
PRRNPPPFLFDAATSTVPVGKVEIYAKTGRSVPHGWAVSLEDGRELTGDAAPILEAIRKG
CCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCC
RAALLPLGGLAEETGGHKGSGLALIVELLAGVLTGAAWAIHVRNTTDPQPANVGHFFMSI
CEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEE
NIEAFMSLEEFYDRFEKMIEEIKSLPKHPQADRIWIPGEKAWLTMETRKKIGIPLHRNVF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEHHHHCCCCHHHHHH
NDLKKLSEELGLDFTVKVLKETA
HHHHHHHHHHCCCEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]