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The map label for this gene is 124027123

Identifier: 124027123

GI number: 124027123

Start: 212695

End: 214287

Strand: Reverse

Name: 124027123

Synonym: Hbut_0226

Alternate gene names: NA

Gene position: 214287-212695 (Counterclockwise)

Preceding gene: 124027124

Following gene: 124027122

Centisome position: 12.85

GC content: 51.98

Gene sequence:

>1593_bases
GTGACTGTCCGAACGAGGGAATACTGGGCGACAAGGATAGGCCTCATCCTAGCAATGGCAGGTAATGCTATCGGCCTAGG
CAACTTCCTAAGATTCCCTGGCAAGGCTGCCGCCTACGGTGGCGGCGCCTACCTCATACCATACTTCATAGCCCTTGTAC
TCCTAGGCATCCCACTAATGTTCGTAGAGTGGACCCTCGGCCGGCACGGCGGCCTACATGGCCATGGCTACCTAACCCCA
ATGCTCTACATAGTCTCAAGGAATAGGCTCACAAAGAAGAATGCAGCAGCGTTTGCAATCATAGGTGGCACCATAGCATT
CCTAACTGGCGTAATGATCACGGGCTACTACACCAATATCATAGGCTGGATGGGCTACTATGCAACGGCAGCAATTAGCG
GCAAGTTTGCCGAGCTGACAGACGCCACCAAGGCCAAAACGTTCTTCATAGACTTCCTAACGGATCCAGCTAGAAATGTG
CCGGCGTGGTTCATCTCCCTACTAGTAATTACACTAATTGTATCCAGGAGGGTCAGACGCGGCATTGAGATTGCAGCAAA
GATAATGATGCCAATACTGTTTATTGAGGCTGTAATCCTAGCAACGGTCTCGCTAACCCTTGGCGCTCCTGTAAAGCCGG
AATGGTCCACGCTTAAGGGCTTTGAGTGGCTCTGGACCCCGAACTTTGAGAAGCTAAAGGACCCTGCAACATTCATTGAG
GGTGCTGGCCAGATCTTCTTCACGCTAAGCATCGGTATCGGTGGCATCATACCAAACTACGCTAGCTATCTGCGCAGGGA
GGACGATCTACCACTATCAGCCCTAACTACCACCTCCCTCAACGAGTTCGCCGAGGTAGTACTCGGAGGCAGCATCGTGA
TACCATTACTGTACGCGTTTGGAGGCCCAAGCATCATACAGGACATCGCTGCAGGCAAGCTCTCAATATTCCTTGCGTCA
ATGGTTGCCCTGCCACCACTATTCAACCACCTAGGAGGCCTTGGTGCCCTGGCAGGCTTCCTCTGGTACTCGCTGCTATG
GTTTGCCGGTATAACAAGCGCCATTGCGATAGTTAACGTTCTAACTTCGATGTTCGAGGAGGATTACGGCATCGCGAGAA
GGTATAGTGCATGGATAGCCTTCATGATGGTATTCATAACCGGCGTATTCGTAAACATTGAGGGCGCCATGAAGACTGAC
CAGCTGACGGACTACCTCGATCTCGTAGACTTCTACGCCGGTAGCCTGCTGCTGCTAGTGGTAGCACTATTCGAGGTCGT
AGCTGCCCTGTGGCTGTGGGGCATTGAGGAGAGCTACAGGGAGCTGCATAATGGTGCCTACATTACCGTGCCGAAGTGGT
ACTGGAAGTACGTTGTCGGCATTATCACACCAATCTACCTGATAATAATGCTGGCATGGTTCCTGGCAACAGGTACCGAA
TCCGCTGCCGCCAAGCCAGAGAACATCTTCGGCTGGATAGGCGTTGCGATGATGGTGATAATGTTCCTAATAGGCCTAGC
TCTCAACTATAAGGCCCTCTATAAGAGGTATGGTGAGGAAATTAGGAGGGGGGTGAGTCCACGTGAAGGCTAG

Upstream 100 bases:

>100_bases
CGGGCCAGCTAATATTGCAAGACAGGTTTCCACAATTTGCTACTCGCCGGGTAAGATTTTTTTCAGCTATGGCTCCCACA
CTATTAACGGTGATAGACTA

Downstream 100 bases:

>100_bases
CGCGCTAGGCCTTCGTAGCATTTGGCTGGGGCGTAGTATTCCTACTAATAACCCTCGTAGCATATAAGTGGATGACTGTT
AGGCGCCAACGGTAAGTGCT

Product: SNF family Na(+)/neurotransmitter symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MTVRTREYWATRIGLILAMAGNAIGLGNFLRFPGKAAAYGGGAYLIPYFIALVLLGIPLMFVEWTLGRHGGLHGHGYLTP
MLYIVSRNRLTKKNAAAFAIIGGTIAFLTGVMITGYYTNIIGWMGYYATAAISGKFAELTDATKAKTFFIDFLTDPARNV
PAWFISLLVITLIVSRRVRRGIEIAAKIMMPILFIEAVILATVSLTLGAPVKPEWSTLKGFEWLWTPNFEKLKDPATFIE
GAGQIFFTLSIGIGGIIPNYASYLRREDDLPLSALTTTSLNEFAEVVLGGSIVIPLLYAFGGPSIIQDIAAGKLSIFLAS
MVALPPLFNHLGGLGALAGFLWYSLLWFAGITSAIAIVNVLTSMFEEDYGIARRYSAWIAFMMVFITGVFVNIEGAMKTD
QLTDYLDLVDFYAGSLLLLVVALFEVVAALWLWGIEESYRELHNGAYITVPKWYWKYVVGIITPIYLIIMLAWFLATGTE
SAAAKPENIFGWIGVAMMVIMFLIGLALNYKALYKRYGEEIRRGVSPREG

Sequences:

>Translated_530_residues
MTVRTREYWATRIGLILAMAGNAIGLGNFLRFPGKAAAYGGGAYLIPYFIALVLLGIPLMFVEWTLGRHGGLHGHGYLTP
MLYIVSRNRLTKKNAAAFAIIGGTIAFLTGVMITGYYTNIIGWMGYYATAAISGKFAELTDATKAKTFFIDFLTDPARNV
PAWFISLLVITLIVSRRVRRGIEIAAKIMMPILFIEAVILATVSLTLGAPVKPEWSTLKGFEWLWTPNFEKLKDPATFIE
GAGQIFFTLSIGIGGIIPNYASYLRREDDLPLSALTTTSLNEFAEVVLGGSIVIPLLYAFGGPSIIQDIAAGKLSIFLAS
MVALPPLFNHLGGLGALAGFLWYSLLWFAGITSAIAIVNVLTSMFEEDYGIARRYSAWIAFMMVFITGVFVNIEGAMKTD
QLTDYLDLVDFYAGSLLLLVVALFEVVAALWLWGIEESYRELHNGAYITVPKWYWKYVVGIITPIYLIIMLAWFLATGTE
SAAAKPENIFGWIGVAMMVIMFLIGLALNYKALYKRYGEEIRRGVSPREG
>Mature_529_residues
TVRTREYWATRIGLILAMAGNAIGLGNFLRFPGKAAAYGGGAYLIPYFIALVLLGIPLMFVEWTLGRHGGLHGHGYLTPM
LYIVSRNRLTKKNAAAFAIIGGTIAFLTGVMITGYYTNIIGWMGYYATAAISGKFAELTDATKAKTFFIDFLTDPARNVP
AWFISLLVITLIVSRRVRRGIEIAAKIMMPILFIEAVILATVSLTLGAPVKPEWSTLKGFEWLWTPNFEKLKDPATFIEG
AGQIFFTLSIGIGGIIPNYASYLRREDDLPLSALTTTSLNEFAEVVLGGSIVIPLLYAFGGPSIIQDIAAGKLSIFLASM
VALPPLFNHLGGLGALAGFLWYSLLWFAGITSAIAIVNVLTSMFEEDYGIARRYSAWIAFMMVFITGVFVNIEGAMKTDQ
LTDYLDLVDFYAGSLLLLVVALFEVVAALWLWGIEESYRELHNGAYITVPKWYWKYVVGIITPIYLIIMLAWFLATGTES
AAAKPENIFGWIGVAMMVIMFLIGLALNYKALYKRYGEEIRRGVSPREG

Specific function: Putative sodium-dependent transporter [H]

COG id: COG0733

COG function: function code R; Na+-dependent transporters of the SNF family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family [H]

Homologues:

Organism=Homo sapiens, GI4507043, Length=514, Percent_Identity=24.7081712062257, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI188528618, Length=504, Percent_Identity=25.1984126984127, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI58219014, Length=317, Percent_Identity=26.4984227129338, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI51468073, Length=308, Percent_Identity=26.2987012987013, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI33354281, Length=317, Percent_Identity=25.8675078864353, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI289191351, Length=516, Percent_Identity=21.8992248062016, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4557046, Length=516, Percent_Identity=21.8992248062016, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI289191377, Length=516, Percent_Identity=21.8992248062016, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI194018524, Length=312, Percent_Identity=27.5641025641026, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4507041, Length=586, Percent_Identity=22.1843003412969, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI134304856, Length=486, Percent_Identity=24.4855967078189, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI21361693, Length=132, Percent_Identity=34.8484848484849, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI92859670, Length=65, Percent_Identity=47.6923076923077, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17555248, Length=355, Percent_Identity=25.0704225352113, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17554804, Length=505, Percent_Identity=25.1485148514851, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71995588, Length=522, Percent_Identity=22.0306513409962, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24762620, Length=517, Percent_Identity=23.7911025145068, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI19921936, Length=509, Percent_Identity=22.7897838899804, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI221329674, Length=544, Percent_Identity=24.6323529411765, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24639514, Length=543, Percent_Identity=24.4935543278085, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24639516, Length=563, Percent_Identity=24.1563055062167, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551088, Length=500, Percent_Identity=21.8, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24652942, Length=499, Percent_Identity=21.8436873747495, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921352, Length=521, Percent_Identity=21.4971209213052, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24584353, Length=521, Percent_Identity=21.4971209213052, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281365034, Length=530, Percent_Identity=20.7547169811321, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136952, Length=486, Percent_Identity=23.0452674897119, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24655079, Length=539, Percent_Identity=22.4489795918367, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24582567, Length=488, Percent_Identity=23.7704918032787, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281364394, Length=488, Percent_Identity=22.5409836065574, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574704, Length=488, Percent_Identity=22.5409836065574, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136950, Length=488, Percent_Identity=22.5409836065574, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574702, Length=488, Percent_Identity=22.5409836065574, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24639853, Length=579, Percent_Identity=23.1433506044905, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281363702, Length=562, Percent_Identity=22.4199288256228, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24661428, Length=315, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550877, Length=212, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551183, Length=212, Percent_Identity=28.3018867924528, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24654186, Length=318, Percent_Identity=23.2704402515723, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000175 [H]

Pfam domain/function: PF00209 SNF [H]

EC number: NA

Molecular weight: Translated: 58391; Mature: 58260

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50267 NA_NEUROTRAN_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TVRTREYWATRIGLILAMAGNAIGLGNFLRFPGKAAAYGGGAYLIPYFIALVLLGIPLM
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVEWTLGRHGGLHGHGYLTPMLYIVSRNRLTKKNAAAFAIIGGTIAFLTGVMITGYYTNI
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
IGWMGYYATAAISGKFAELTDATKAKTFFIDFLTDPARNVPAWFISLLVITLIVSRRVRR
HHHHHHHHHHHHCCCHHHHHCCHHHHHEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GIEIAAKIMMPILFIEAVILATVSLTLGAPVKPEWSTLKGFEWLWTPNFEKLKDPATFIE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEECCCHHHHCCHHHHHH
GAGQIFFTLSIGIGGIIPNYASYLRREDDLPLSALTTTSLNEFAEVVLGGSIVIPLLYAF
CCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GGPSIIQDIAAGKLSIFLASMVALPPLFNHLGGLGALAGFLWYSLLWFAGITSAIAIVNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTSMFEEDYGIARRYSAWIAFMMVFITGVFVNIEGAMKTDQLTDYLDLVDFYAGSLLLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
VALFEVVAALWLWGIEESYRELHNGAYITVPKWYWKYVVGIITPIYLIIMLAWFLATGTE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAAAKPENIFGWIGVAMMVIMFLIGLALNYKALYKRYGEEIRRGVSPREG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]