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The map label for this gene is hmuU [H]

Identifier: 124027069

GI number: 124027069

Start: 156155

End: 157123

Strand: Direct

Name: hmuU [H]

Synonym: Hbut_0172

Alternate gene names: 124027069

Gene position: 156155-157123 (Clockwise)

Preceding gene: 124027068

Following gene: 124027070

Centisome position: 9.37

GC content: 59.65

Gene sequence:

>969_bases
TTGGCGAGTTTTTTACCACTCACGATAACCTTGCTGCTCTTCCCACTCCTTATCCTCGCGAGCCTTGCGGTGGGGCCCGC
GGGGCTGGTAAACCCTCTGGATCCGGGAAGCCAGCTCATAGCAAGGCTCCGGCTCATGCGCACCCTTCTAGCAGTAGGTG
TCGGCACTGCCCTGGGTCTCTCCGGGACACTAGTCCAGTACAGCGTGGCCAACCCCCTGGCGAGCCCGAGCATACTTGGA
GTCTCAGCTGGCGCCCTTGCTGCAGCCTCGGCGGCCTACATCGTGTATCGTGGGTCTCCCCCGCCAGCTGCACCGTTGGC
AGCGGCTGTAATGGGTGGGCTAGCTGCGTATGCGTTGACGCTAGCTATAGCTTCGAGGGCGGGGCTCACGAGAGTCTCCA
TGGTGCTCGCCGGTATAGCGGTCTCGAGCAGCCTCGCTGGCATAGCCAGTATGCTCGTAATATACATCAATGCACGGTAC
CATGTGGCATCAGCGCTGTTGCTAATGGGAAGTTTTGCCTATGCGGTCGAGGAGAAAGTGTTAGTAGCAGCTGTAGCTGC
GCTAGTAGCAGCGGCTACAGCGCTAATCCTGGCAAACCCTCTCGACGCTCTCTCATACGGCGACGAGACAGCACTAAGCC
TAGGCTACAGCCCAGCCAAGATAAGGCTCGCAGCTACAGCAGCCGCGGTAGCAGCTACAGCAGCCACGGTCTACGCCGCC
GGGCTCATAGGCTTCGCCGACCTCGTAGCAGCCAACATAGCCAGGAGCATTGCTGGAAGCCATCCCTCAAGATCGGCGCC
AGCCTCGGCGCTGATAGGTGCAGAGATAGCACTAGCAGCAGACATAGCAGGAAGGCTAGCAGCAACAACCATAAGGCTCG
GCGAGATCCCAGCAGGCCTCCTCACAAGCACTGTTGGCGGATTATTCCTTGCCTTCCTCGTAGCGAGAAAGGCGGGACAG
GGATGGTGA

Upstream 100 bases:

>100_bases
CTGCTAGCATCGATACTACATCCAGACGCTGTGGAACCCCCGAGCAAGCTGGCAGGCTACATAACTTGCATAGGCGCTGG
GGGCTGAGGTGGCCACGTCC

Downstream 100 bases:

>100_bases
GACATGCAGCACGTCCTAGAGGCTGAGAACGTCACAGTAGAGTTCAACGGTAGAATAGTACTCCGGGACATAAACCTGAA
GCTCGAGTCAGGTAAGCTCA

Product: ABC transporter

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MASFLPLTITLLLFPLLILASLAVGPAGLVNPLDPGSQLIARLRLMRTLLAVGVGTALGLSGTLVQYSVANPLASPSILG
VSAGALAAASAAYIVYRGSPPPAAPLAAAVMGGLAAYALTLAIASRAGLTRVSMVLAGIAVSSSLAGIASMLVIYINARY
HVASALLLMGSFAYAVEEKVLVAAVAALVAAATALILANPLDALSYGDETALSLGYSPAKIRLAATAAAVAATAATVYAA
GLIGFADLVAANIARSIAGSHPSRSAPASALIGAEIALAADIAGRLAATTIRLGEIPAGLLTSTVGGLFLAFLVARKAGQ
GW

Sequences:

>Translated_322_residues
MASFLPLTITLLLFPLLILASLAVGPAGLVNPLDPGSQLIARLRLMRTLLAVGVGTALGLSGTLVQYSVANPLASPSILG
VSAGALAAASAAYIVYRGSPPPAAPLAAAVMGGLAAYALTLAIASRAGLTRVSMVLAGIAVSSSLAGIASMLVIYINARY
HVASALLLMGSFAYAVEEKVLVAAVAALVAAATALILANPLDALSYGDETALSLGYSPAKIRLAATAAAVAATAATVYAA
GLIGFADLVAANIARSIAGSHPSRSAPASALIGAEIALAADIAGRLAATTIRLGEIPAGLLTSTVGGLFLAFLVARKAGQ
GW
>Mature_321_residues
ASFLPLTITLLLFPLLILASLAVGPAGLVNPLDPGSQLIARLRLMRTLLAVGVGTALGLSGTLVQYSVANPLASPSILGV
SAGALAAASAAYIVYRGSPPPAAPLAAAVMGGLAAYALTLAIASRAGLTRVSMVLAGIAVSSSLAGIASMLVIYINARYH
VASALLLMGSFAYAVEEKVLVAAVAALVAAATALILANPLDALSYGDETALSLGYSPAKIRLAATAAAVAATAATVYAAG
LIGFADLVAANIARSIAGSHPSRSAPASALIGAEIALAADIAGRLAATTIRLGEIPAGLLTSTVGGLFLAFLVARKAGQG
W

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=274, Percent_Identity=35.036496350365, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790741, Length=286, Percent_Identity=32.8671328671329, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786804, Length=287, Percent_Identity=29.616724738676, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786805, Length=264, Percent_Identity=31.0606060606061, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786347, Length=282, Percent_Identity=27.3049645390071, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788004, Length=302, Percent_Identity=29.8013245033113, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 31733; Mature: 31602

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFLPLTITLLLFPLLILASLAVGPAGLVNPLDPGSQLIARLRLMRTLLAVGVGTALGL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
SGTLVQYSVANPLASPSILGVSAGALAAASAAYIVYRGSPPPAAPLAAAVMGGLAAYALT
CCHHEEEECCCCCCCCCEECCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
LAIASRAGLTRVSMVLAGIAVSSSLAGIASMLVIYINARYHVASALLLMGSFAYAVEEKV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LVAAVAALVAAATALILANPLDALSYGDETALSLGYSPAKIRLAATAAAVAATAATVYAA
HHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCHHEEHHHHHHHHHHHHHHHHHH
GLIGFADLVAANIARSIAGSHPSRSAPASALIGAEIALAADIAGRLAATTIRLGEIPAGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHH
LTSTVGGLFLAFLVARKAGQGW
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ASFLPLTITLLLFPLLILASLAVGPAGLVNPLDPGSQLIARLRLMRTLLAVGVGTALGL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
SGTLVQYSVANPLASPSILGVSAGALAAASAAYIVYRGSPPPAAPLAAAVMGGLAAYALT
CCHHEEEECCCCCCCCCEECCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
LAIASRAGLTRVSMVLAGIAVSSSLAGIASMLVIYINARYHVASALLLMGSFAYAVEEKV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LVAAVAALVAAATALILANPLDALSYGDETALSLGYSPAKIRLAATAAAVAATAATVYAA
HHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCHHEEHHHHHHHHHHHHHHHHHH
GLIGFADLVAANIARSIAGSHPSRSAPASALIGAEIALAADIAGRLAATTIRLGEIPAGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHH
LTSTVGGLFLAFLVARKAGQGW
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]