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The map label for this gene is nudF [H]

Identifier: 124027066

GI number: 124027066

Start: 153652

End: 154182

Strand: Reverse

Name: nudF [H]

Synonym: Hbut_0169

Alternate gene names: 124027066

Gene position: 154182-153652 (Counterclockwise)

Preceding gene: 124027074

Following gene: 124027063

Centisome position: 9.25

GC content: 55.93

Gene sequence:

>531_bases
GTGGCAGCTGAAAGACGTGTTGAAGAGCTTTGCCGGGGGCGTAGACTCGTTCTCGCCCGGATATACGACGTCGTGAAAGG
CAGTGTTAAGGCCTTCGACGCACTGCTCCACCCTGGCGCGGTAGCTGTAGTAGCTGAGGAGAATGGAAGGATACTGCTCG
AGAAGCAGTACCGGCCTGTTGTTGGCGAGTGGCTCTACGAGATACCCGCTGGCACCCTTGAACCTGGGGAGGAGCCCGAG
GAGACGGCTAGGAGAGAGCTTGTAGAGGAGACTGGCTACGAGCCCGGCTGGCTAAAGAGGCTTGTAGAGTTCTATACGAG
TCCAGGTGTCTCAACAGAGAAGCTCGTAGTATTTGCTGCAGGGGATCTCCGGTGGAGGGGGCAGAAACTCGAGGAGGACG
AGCTCATAGAGGTTGAGTGGGTGAAACTCGAGGAAGCTCTTGAAATGATACGTGGTGGCGTCATAAGGGATGCCAAGTCG
ATTATAGGGATACTGTACTACCATGCAGGCCGGGTTATGGGCTGGCTTTAG

Upstream 100 bases:

>100_bases
AGACACCACACCCTTCCACACTCCCCAATCCGGAAGCAGGGTATCCCCACCCTAGTTAATTACCGCCCTTACAGCTTGTG
TACAAGCGTGGTGCTTCACT

Downstream 100 bases:

>100_bases
CGGTTTAAACCCCTGAGCACCCAGCCACGGCCAGCTGCGTAATAGACCATACCCTCGTCTCTCAGTATGCGGAATAGCAC
TCTATACTTTCCAAGCTTCA

Product: ADP-ribose pyrophosphatase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MAAERRVEELCRGRRLVLARIYDVVKGSVKAFDALLHPGAVAVVAEENGRILLEKQYRPVVGEWLYEIPAGTLEPGEEPE
ETARRELVEETGYEPGWLKRLVEFYTSPGVSTEKLVVFAAGDLRWRGQKLEEDELIEVEWVKLEEALEMIRGGVIRDAKS
IIGILYYHAGRVMGWL

Sequences:

>Translated_176_residues
MAAERRVEELCRGRRLVLARIYDVVKGSVKAFDALLHPGAVAVVAEENGRILLEKQYRPVVGEWLYEIPAGTLEPGEEPE
ETARRELVEETGYEPGWLKRLVEFYTSPGVSTEKLVVFAAGDLRWRGQKLEEDELIEVEWVKLEEALEMIRGGVIRDAKS
IIGILYYHAGRVMGWL
>Mature_175_residues
AAERRVEELCRGRRLVLARIYDVVKGSVKAFDALLHPGAVAVVAEENGRILLEKQYRPVVGEWLYEIPAGTLEPGEEPEE
TARRELVEETGYEPGWLKRLVEFYTSPGVSTEKLVVFAAGDLRWRGQKLEEDELIEVEWVKLEEALEMIRGGVIRDAKSI
IGILYYHAGRVMGWL

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788810, Length=134, Percent_Identity=38.0597014925373, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 19995; Mature: 19864

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAERRVEELCRGRRLVLARIYDVVKGSVKAFDALLHPGAVAVVAEENGRILLEKQYRPV
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCH
VGEWLYEIPAGTLEPGEEPEETARRELVEETGYEPGWLKRLVEFYTSPGVSTEKLVVFAA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEEC
GDLRWRGQKLEEDELIEVEWVKLEEALEMIRGGVIRDAKSIIGILYYHAGRVMGWL
CCCEECCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAERRVEELCRGRRLVLARIYDVVKGSVKAFDALLHPGAVAVVAEENGRILLEKQYRPV
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCH
VGEWLYEIPAGTLEPGEEPEETARRELVEETGYEPGWLKRLVEFYTSPGVSTEKLVVFAA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEEC
GDLRWRGQKLEEDELIEVEWVKLEEALEMIRGGVIRDAKSIIGILYYHAGRVMGWL
CCCEECCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]