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The map label for this gene is frdB [H]

Identifier: 124027054

GI number: 124027054

Start: 142016

End: 142939

Strand: Direct

Name: frdB [H]

Synonym: Hbut_0157

Alternate gene names: 124027054

Gene position: 142016-142939 (Clockwise)

Preceding gene: 124027053

Following gene: 124027057

Centisome position: 8.52

GC content: 55.63

Gene sequence:

>924_bases
ATGGCCGAGAGGCTCGGCTCGATACCCGAGCCACCGAAGGAGGTAATCTTTCGGATTAAACGCTACGATCCCGAGACAGG
GAGAAGCTGGTGGCAAGAGTACAGGGTGCAGACATACCGAGGCATGACGGTGCTTGACGCCCTGATATGGATTAAGGAGC
GTCTGGACCCGACGCTGTCGATGAGGTATAGCTGCCGCCAGGGCGTCTGTGGGAGCTGTGGAATGCTGATAAATGGTACC
CCGAGGCTCGCTTGTCAGACACAAGTGGGGGCAATAGCCACCAATGAGAAGCCAGTGGTTACCGTGGAGCCGTTGCCAAA
CTTTCCGGTGGTACGTGACCTCGTAACAGACTTTACAAGGTTCTTCGAGAAGCATAGAGCCATAATGCCCTACATCATAA
GGCGGAACCCCAGGGAGGTTGACGAAGCCAAATACGAGTTTCTGATGAGCCCCGAGGAGCACATGGAAATATACCAGTAC
AGCCTATGTATAATGTGTGGCCTATGCTATGCAGCCTGCCCAGTAGCAGCCTCCGACCCCGAGTACCTTGGGCCGCAAGC
GCTAACCCAGGCCTATAGGTTCATAGTAGATGTCCGCGATGAAGGTGCAGAGAAGAGGATAGCAGTAGTAGATACAGAGC
ACGGCTGCCACCGCTGCCACTTTGCGGCCTCATGCAGCGCGGTCTGCCCCAAGGACGTGGATCCAGCGGCGGCGATACAG
AGGCTGAGGAGAATAGTCTTCCTAGACAAGCTAGGCCTCTGGAGGAAGAGGAAGACATCAAAGGTTGCGGGTCCATTGGA
GAAGCCGCTAAGACAAGTAAAGGCTGAGTACCCCAAGCACAACCTGCTAGAAGGCGTAGACCCCGAGCAACAGGCGAGGG
AGCCGGTAAACATAGACCTCCACGAGGAGTGGCTCAGAGAGTGA

Upstream 100 bases:

>100_bases
ATAGGCTTCACCATATACGGGCTCAACACGATAATAACTCATCTCCAGGGCTAGCCCGTGAAGGCCATGCGGCAGGCTAT
AATGTGGGGGTGAACGATGT

Downstream 100 bases:

>100_bases
GTGGCACATCAAAAAAGGGTTGTGTTGGCAAGCCTAATCCTGCTTTTTCACACCCCTCTTTTAGTCTGGAAGACATCGCC
GCTTATATCCTGCTAAGTAT

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MAERLGSIPEPPKEVIFRIKRYDPETGRSWWQEYRVQTYRGMTVLDALIWIKERLDPTLSMRYSCRQGVCGSCGMLINGT
PRLACQTQVGAIATNEKPVVTVEPLPNFPVVRDLVTDFTRFFEKHRAIMPYIIRRNPREVDEAKYEFLMSPEEHMEIYQY
SLCIMCGLCYAACPVAASDPEYLGPQALTQAYRFIVDVRDEGAEKRIAVVDTEHGCHRCHFAASCSAVCPKDVDPAAAIQ
RLRRIVFLDKLGLWRKRKTSKVAGPLEKPLRQVKAEYPKHNLLEGVDPEQQAREPVNIDLHEEWLRE

Sequences:

>Translated_307_residues
MAERLGSIPEPPKEVIFRIKRYDPETGRSWWQEYRVQTYRGMTVLDALIWIKERLDPTLSMRYSCRQGVCGSCGMLINGT
PRLACQTQVGAIATNEKPVVTVEPLPNFPVVRDLVTDFTRFFEKHRAIMPYIIRRNPREVDEAKYEFLMSPEEHMEIYQY
SLCIMCGLCYAACPVAASDPEYLGPQALTQAYRFIVDVRDEGAEKRIAVVDTEHGCHRCHFAASCSAVCPKDVDPAAAIQ
RLRRIVFLDKLGLWRKRKTSKVAGPLEKPLRQVKAEYPKHNLLEGVDPEQQAREPVNIDLHEEWLRE
>Mature_306_residues
AERLGSIPEPPKEVIFRIKRYDPETGRSWWQEYRVQTYRGMTVLDALIWIKERLDPTLSMRYSCRQGVCGSCGMLINGTP
RLACQTQVGAIATNEKPVVTVEPLPNFPVVRDLVTDFTRFFEKHRAIMPYIIRRNPREVDEAKYEFLMSPEEHMEIYQYS
LCIMCGLCYAACPVAASDPEYLGPQALTQAYRFIVDVRDEGAEKRIAVVDTEHGCHRCHFAASCSAVCPKDVDPAAAIQR
LRRIVFLDKLGLWRKRKTSKVAGPLEKPLRQVKAEYPKHNLLEGVDPEQQAREPVNIDLHEEWLRE

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=239, Percent_Identity=38.0753138075314, Blast_Score=169, Evalue=3e-42,
Organism=Escherichia coli, GI1790596, Length=230, Percent_Identity=44.3478260869565, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1786943, Length=237, Percent_Identity=37.1308016877637, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17533915, Length=235, Percent_Identity=34.468085106383, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322987, Length=238, Percent_Identity=36.1344537815126, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17137106, Length=241, Percent_Identity=38.5892116182573, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24643156, Length=255, Percent_Identity=39.2156862745098, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 35296; Mature: 35165

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERLGSIPEPPKEVIFRIKRYDPETGRSWWQEYRVQTYRGMTVLDALIWIKERLDPTLS
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHH
MRYSCRQGVCGSCGMLINGTPRLACQTQVGAIATNEKPVVTVEPLPNFPVVRDLVTDFTR
HHHHHHCCCCCCCCEEECCCCCEEEECCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHH
FFEKHRAIMPYIIRRNPREVDEAKYEFLMSPEEHMEIYQYSLCIMCGLCYAACPVAASDP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EYLGPQALTQAYRFIVDVRDEGAEKRIAVVDTEHGCHRCHFAASCSAVCPKDVDPAAAIQ
CCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHH
RLRRIVFLDKLGLWRKRKTSKVAGPLEKPLRQVKAEYPKHNLLEGVDPEQQAREPVNIDL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCCCCCC
HEEWLRE
HHHHHCC
>Mature Secondary Structure 
AERLGSIPEPPKEVIFRIKRYDPETGRSWWQEYRVQTYRGMTVLDALIWIKERLDPTLS
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHH
MRYSCRQGVCGSCGMLINGTPRLACQTQVGAIATNEKPVVTVEPLPNFPVVRDLVTDFTR
HHHHHHCCCCCCCCEEECCCCCEEEECCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHH
FFEKHRAIMPYIIRRNPREVDEAKYEFLMSPEEHMEIYQYSLCIMCGLCYAACPVAASDP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EYLGPQALTQAYRFIVDVRDEGAEKRIAVVDTEHGCHRCHFAASCSAVCPKDVDPAAAIQ
CCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHH
RLRRIVFLDKLGLWRKRKTSKVAGPLEKPLRQVKAEYPKHNLLEGVDPEQQAREPVNIDL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCCCCCC
HEEWLRE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]