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The map label for this gene is sdhA [H]

Identifier: 124027051

GI number: 124027051

Start: 139283

End: 141040

Strand: Direct

Name: sdhA [H]

Synonym: Hbut_0154

Alternate gene names: 124027051

Gene position: 139283-141040 (Clockwise)

Preceding gene: 124027049

Following gene: 124027052

Centisome position: 8.35

GC content: 52.45

Gene sequence:

>1758_bases
ATGGTGGATATGTTCTACTATGACGTAGTGATAGTTGGCTCTGGATTAGCGGGTCTGCGCGCTGCACTAGAGATCAAGCG
CACCTACGGCGACAAGATTAGCGTTGCGCTGATAAGCAAGGTTCAGCTCATGAGGAGCCACAGTGTCGCAGCCCAGGGTG
GTACAGCGGCAGTACTCTACCCGGAGGAGGGAGACAGCTTTGCCCTACACGCCTGGGATACGATTAAGGGTAGTGACTTC
CTTGCCGACCAGGATGCGGTCTGGCTGTTTGTAAAGCTAATGCCCGAGGAAATAAGACTGCTTGAGCGCTGGGGGCTCCC
CTGGAGCAGAAGGCCCGACGGTAGAATAGCACAGAGGCCCTTCGGAGGGCACAGCTTTCCCCGAGCCACATATGCAGCTG
ACAAGACTGGCTTCTACGAGATGCAGACCCTCTATAGCAGGCTAGTTGGCTATGACAACTGGGATCGCTATGACGAGGTC
TTTGTTACAAGCATTATAATCGAGGATGGAGTATTCAAGGGTGTTACAGCCATTGATATGAGGAGTGGCGAGTTTCTAGT
CTTCCGGGCTAGGGCAGGCATAATTGCTACGGGTGGTGCTGGCAGAATATACAAGTTCACCACTTACGCCCACACGGTAA
CAGGCGACGGCCAAGCAATGGCGCTACGTGCTGGTATACCACTCAAAGACATGGAGTTCATCCAGTTCCATCCCACGGGC
CTAGTCCCCTCGGGTATACTAATCACGGAGGGTGCACGCGGCGAGGGAGGCTATCTCATAAACAAGAACGGCGAAAGGTT
CATGAAGCGTTATGCTCCTCAGAGGATGGAGCTAGCACCACGTGATGTCGTGTCGAGAGCAATTATGACTGAGATACGTG
AGGGTAGAGGGTTCCGCGATCCGGTAAGCGGGCTCGAGTACGTGCTGCTTGACCTGCGCCATCTCGGCGAGGAGAAGATA
AATGAAAGGCTCCCCGGTATACGCGAGATAGCAATCAAGCATGCAGGCATAGACCCTGTCACGGAGCCCATACCGGTGAG
ACCTGCAGCCCACTACTCGATGGGCGGCATTCACACCGACAAGTACTATCGCGTCTTAACCGTGGATGGTAAGTGGGTTA
AGGGTCTCTGGGCTGCGGGTGAGGTTGCATCAGCAAGTATTCATGGCGCTAACAGATTGGGTGCCAACAGCACAGCAGAG
TGTCTCACAAGCGGTCGTATAGCTGGCAGGCAAGCAGCTCAGTATGTGATCAAGACCAAGGAGATGGGTATGCCCGACCC
GAAGCCCAGCGAGTCCAGCATAGCCAAGGAGGAGAAGAGGATATTCGATATGCTATTGAAGCATGAATCCGGCTCTGCAA
CAGTATACGAAATTAGGGCGAAGCTCCGCGAGACAATGGACAAGTATGTCTACGTATTCCGCGATGAAGAGGGGTTAAAG
AAGGCACTGAAGATAATACTAGAGCTACGCGAGGCCATGAAAAAGGTGTATCCGAGCGATAAGAGCAGGATATACAACAC
AGACATGATAACAGTTCTCGAGACCCAAAACATGCTCGATGTAGCCTACTCAGTAGCCTATGGAGCTCTACTACGTACAG
AGAGTCGCGGAGCCCACTACAGAATAGACTATCCGAAGAGAGACGATGAGAACTGGCTAAAACACACCCTAACATACCTA
ACAGCAGACGACAAAATAGAAGTAACCTACACACCGGTAACAATCACAACGTGGAAGCCGATAGAGCGCAAGTACTAG

Upstream 100 bases:

>100_bases
ATTTGTTTGTGGAATGTATTCATCAATACACTTAATGTGTCCGCTCCTTGCAGACTCACTGAGTGGAGGCTACAGGGGCT
TAACGGGAGGCGCGTAACAC

Downstream 100 bases:

>100_bases
TACACCCCTATCTTGTTTCCCGTGCTTAGCGTGTCAATCTCAGATCATGGGGGATGTATGGCTTGGCCGGGGAGAAGAGG
AAACGTGTACTCCTCGAGAA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MVDMFYYDVVIVGSGLAGLRAALEIKRTYGDKISVALISKVQLMRSHSVAAQGGTAAVLYPEEGDSFALHAWDTIKGSDF
LADQDAVWLFVKLMPEEIRLLERWGLPWSRRPDGRIAQRPFGGHSFPRATYAADKTGFYEMQTLYSRLVGYDNWDRYDEV
FVTSIIIEDGVFKGVTAIDMRSGEFLVFRARAGIIATGGAGRIYKFTTYAHTVTGDGQAMALRAGIPLKDMEFIQFHPTG
LVPSGILITEGARGEGGYLINKNGERFMKRYAPQRMELAPRDVVSRAIMTEIREGRGFRDPVSGLEYVLLDLRHLGEEKI
NERLPGIREIAIKHAGIDPVTEPIPVRPAAHYSMGGIHTDKYYRVLTVDGKWVKGLWAAGEVASASIHGANRLGANSTAE
CLTSGRIAGRQAAQYVIKTKEMGMPDPKPSESSIAKEEKRIFDMLLKHESGSATVYEIRAKLRETMDKYVYVFRDEEGLK
KALKIILELREAMKKVYPSDKSRIYNTDMITVLETQNMLDVAYSVAYGALLRTESRGAHYRIDYPKRDDENWLKHTLTYL
TADDKIEVTYTPVTITTWKPIERKY

Sequences:

>Translated_585_residues
MVDMFYYDVVIVGSGLAGLRAALEIKRTYGDKISVALISKVQLMRSHSVAAQGGTAAVLYPEEGDSFALHAWDTIKGSDF
LADQDAVWLFVKLMPEEIRLLERWGLPWSRRPDGRIAQRPFGGHSFPRATYAADKTGFYEMQTLYSRLVGYDNWDRYDEV
FVTSIIIEDGVFKGVTAIDMRSGEFLVFRARAGIIATGGAGRIYKFTTYAHTVTGDGQAMALRAGIPLKDMEFIQFHPTG
LVPSGILITEGARGEGGYLINKNGERFMKRYAPQRMELAPRDVVSRAIMTEIREGRGFRDPVSGLEYVLLDLRHLGEEKI
NERLPGIREIAIKHAGIDPVTEPIPVRPAAHYSMGGIHTDKYYRVLTVDGKWVKGLWAAGEVASASIHGANRLGANSTAE
CLTSGRIAGRQAAQYVIKTKEMGMPDPKPSESSIAKEEKRIFDMLLKHESGSATVYEIRAKLRETMDKYVYVFRDEEGLK
KALKIILELREAMKKVYPSDKSRIYNTDMITVLETQNMLDVAYSVAYGALLRTESRGAHYRIDYPKRDDENWLKHTLTYL
TADDKIEVTYTPVTITTWKPIERKY
>Mature_585_residues
MVDMFYYDVVIVGSGLAGLRAALEIKRTYGDKISVALISKVQLMRSHSVAAQGGTAAVLYPEEGDSFALHAWDTIKGSDF
LADQDAVWLFVKLMPEEIRLLERWGLPWSRRPDGRIAQRPFGGHSFPRATYAADKTGFYEMQTLYSRLVGYDNWDRYDEV
FVTSIIIEDGVFKGVTAIDMRSGEFLVFRARAGIIATGGAGRIYKFTTYAHTVTGDGQAMALRAGIPLKDMEFIQFHPTG
LVPSGILITEGARGEGGYLINKNGERFMKRYAPQRMELAPRDVVSRAIMTEIREGRGFRDPVSGLEYVLLDLRHLGEEKI
NERLPGIREIAIKHAGIDPVTEPIPVRPAAHYSMGGIHTDKYYRVLTVDGKWVKGLWAAGEVASASIHGANRLGANSTAE
CLTSGRIAGRQAAQYVIKTKEMGMPDPKPSESSIAKEEKRIFDMLLKHESGSATVYEIRAKLRETMDKYVYVFRDEEGLK
KALKIILELREAMKKVYPSDKSRIYNTDMITVLETQNMLDVAYSVAYGALLRTESRGAHYRIDYPKRDDENWLKHTLTYL
TADDKIEVTYTPVTITTWKPIERKY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=41.9298245614035, Blast_Score=412, Evalue=1e-115,
Organism=Escherichia coli, GI1790597, Length=564, Percent_Identity=45.3900709219858, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786942, Length=598, Percent_Identity=43.8127090301003, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1788928, Length=553, Percent_Identity=33.4538878842676, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17550100, Length=584, Percent_Identity=40.5821917808219, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17505833, Length=587, Percent_Identity=41.0562180579216, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71986328, Length=384, Percent_Identity=30.7291666666667, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=45.4873646209386, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322701, Length=538, Percent_Identity=45.5390334572491, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6320788, Length=484, Percent_Identity=27.8925619834711, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322511, Length=479, Percent_Identity=25.0521920668058, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137288, Length=579, Percent_Identity=43.0051813471503, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655642, Length=579, Percent_Identity=43.0051813471503, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655647, Length=579, Percent_Identity=43.0051813471503, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24663005, Length=577, Percent_Identity=39.5147313691508, Blast_Score=396, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65788; Mature: 65788

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDMFYYDVVIVGSGLAGLRAALEIKRTYGDKISVALISKVQLMRSHSVAAQGGTAAVLY
CCEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCCCEEEEEE
PEEGDSFALHAWDTIKGSDFLADQDAVWLFVKLMPEEIRLLERWGLPWSRRPDGRIAQRP
CCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCC
FGGHSFPRATYAADKTGFYEMQTLYSRLVGYDNWDRYDEVFVTSIIIEDGVFKGVTAIDM
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHEEHEEECCCCCCCEEEEEE
RSGEFLVFRARAGIIATGGAGRIYKFTTYAHTVTGDGQAMALRAGIPLKDMEFIQFHPTG
CCCCEEEEEECCCEEEECCCCCEEEEEEEEEEEECCCCEEEEECCCCCCCCCEEEECCCC
LVPSGILITEGARGEGGYLINKNGERFMKRYAPQRMELAPRDVVSRAIMTEIREGRGFRD
CCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHCCCCCC
PVSGLEYVLLDLRHLGEEKINERLPGIREIAIKHAGIDPVTEPIPVRPAAHYSMGGIHTD
HHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECC
KYYRVLTVDGKWVKGLWAAGEVASASIHGANRLGANSTAECLTSGRIAGRQAAQYVIKTK
CEEEEEEECCCCEEEEECCCCHHHCEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHH
EMGMPDPKPSESSIAKEEKRIFDMLLKHESGSATVYEIRAKLRETMDKYVYVFRDEEGLK
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCHHHH
KALKIILELREAMKKVYPSDKSRIYNTDMITVLETQNMLDVAYSVAYGALLRTESRGAHY
HHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHEECCCCCEE
RIDYPKRDDENWLKHTLTYLTADDKIEVTYTPVTITTWKPIERKY
EECCCCCCCHHHHHHHHHEEECCCEEEEEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MVDMFYYDVVIVGSGLAGLRAALEIKRTYGDKISVALISKVQLMRSHSVAAQGGTAAVLY
CCEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCCCEEEEEE
PEEGDSFALHAWDTIKGSDFLADQDAVWLFVKLMPEEIRLLERWGLPWSRRPDGRIAQRP
CCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCC
FGGHSFPRATYAADKTGFYEMQTLYSRLVGYDNWDRYDEVFVTSIIIEDGVFKGVTAIDM
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHEEHEEECCCCCCCEEEEEE
RSGEFLVFRARAGIIATGGAGRIYKFTTYAHTVTGDGQAMALRAGIPLKDMEFIQFHPTG
CCCCEEEEEECCCEEEECCCCCEEEEEEEEEEEECCCCEEEEECCCCCCCCCEEEECCCC
LVPSGILITEGARGEGGYLINKNGERFMKRYAPQRMELAPRDVVSRAIMTEIREGRGFRD
CCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHCCCCCC
PVSGLEYVLLDLRHLGEEKINERLPGIREIAIKHAGIDPVTEPIPVRPAAHYSMGGIHTD
HHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECC
KYYRVLTVDGKWVKGLWAAGEVASASIHGANRLGANSTAECLTSGRIAGRQAAQYVIKTK
CEEEEEEECCCCEEEEECCCCHHHCEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHH
EMGMPDPKPSESSIAKEEKRIFDMLLKHESGSATVYEIRAKLRETMDKYVYVFRDEEGLK
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCHHHH
KALKIILELREAMKKVYPSDKSRIYNTDMITVLETQNMLDVAYSVAYGALLRTESRGAHY
HHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHEECCCCCEE
RIDYPKRDDENWLKHTLTYLTADDKIEVTYTPVTITTWKPIERKY
EECCCCCCCHHHHHHHHHEEECCCEEEEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7037404; 7610040; 9278503; 2668268; 1856194; 10535936; 10373108; 11850430 [H]