BacMap

Definition	Hyperthermus butylicus DSM 5456 chromosome, complete genome.
Accession	NC_008818
Length	1,667,163

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The map label for this gene is natA [H]

Identifier: 124027004

GI number: 124027004

Start: 93665

End: 94408

Strand: Direct

Name: natA [H]

Synonym: Hbut_0104

Alternate gene names: 124027004

Gene position: 93665-94408 (Clockwise)

Preceding gene: 124027003

Following gene: 124027005

Centisome position: 5.62

GC content: 52.15

Gene sequence:

>744_bases
TTGGAGACCGCTGTACGGGCTGAAAACCTTCACAAGGTCTACCCAGGTGGAGTTCACGCGCTAAGAGGCCTCTCCTTCAC
GGTATTCGATGGCGAAATATACGGGCTAGTTGGGCCTAACGGCTCGGGGAAGACAACTACACTACGCATACTTGCCACGC
TTTTACGTCCAACCTCGGGGAAAGTGCTAATCTACAACATAGACGTACTCTCGGAGCCAGCGAAGGTGAGAAGCCTCATA
GCATACCTCCCAGAGGATGCAGGAGTTTACCGAAGGCTAAAAGGTATCGAGATTATAGAACTCTTTGCGAAGACCCGGTT
CAAGAGTAGCCGCGACCGTGAAGCCTTCATAGACGAGGCTGCTCGGCTCTCTGGGCTTAGCTGGGAGGAACTTGAGAGGC
CTGCTGGAGGCTATAGTAAGGGCATGAAGCGTCGTCTCTTGCTCGCAATAACTCTTGCATTAAGGCCTCGACTACTGATA
CTTGACGAGCCTACATCTGGTCTCGACGTGATGCAGAGTATGCGCATGAGGAGGATGATACTACGCTACAACCGAGAACA
CAACATCACAGTATTACTGAGCAGCCATAACATGCTTGAGGTTGAGTTTCTCTGCAACCGCGTGGGCATAATTTACGGCG
GCAGGCTACTCGCCGAGGGCTCTCCAAGGGAGCTGAAGGAGAAGTTCTCGGCAGAGAACCTCGAGCAAGTATTCGAGAAG
ATTACGGGAGGTGTTAACGCATGA

Upstream 100 bases:

>100_bases
TGCGATCACATGACATAATACTCTCTGCAATCTCTTCGGTAAGCATATTTAGGTACTTTCACAGCTCTCCTTGAAGGCCT
ATCTGAAGAGGCTGTTGAGT

Downstream 100 bases:

>100_bases
TCGGCGTGCTTGCTGTTAAGGAGATAAAAAGTATTCTGAGGGATAGAGCGTTTATAGCCAGCCTAATAATAGCCCCTATG
CTAATAATTATGCTCGGCCA

Product: ABC-type uncharacterized transporter

Products: NA

Alternate protein names: Na(+) ABC transporter [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
METAVRAENLHKVYPGGVHALRGLSFTVFDGEIYGLVGPNGSGKTTTLRILATLLRPTSGKVLIYNIDVLSEPAKVRSLI
AYLPEDAGVYRRLKGIEIIELFAKTRFKSSRDREAFIDEAARLSGLSWEELERPAGGYSKGMKRRLLLAITLALRPRLLI
LDEPTSGLDVMQSMRMRRMILRYNREHNITVLLSSHNMLEVEFLCNRVGIIYGGRLLAEGSPRELKEKFSAENLEQVFEK
ITGGVNA

Sequences:

>Translated_247_residues
METAVRAENLHKVYPGGVHALRGLSFTVFDGEIYGLVGPNGSGKTTTLRILATLLRPTSGKVLIYNIDVLSEPAKVRSLI
AYLPEDAGVYRRLKGIEIIELFAKTRFKSSRDREAFIDEAARLSGLSWEELERPAGGYSKGMKRRLLLAITLALRPRLLI
LDEPTSGLDVMQSMRMRRMILRYNREHNITVLLSSHNMLEVEFLCNRVGIIYGGRLLAEGSPRELKEKFSAENLEQVFEK
ITGGVNA
>Mature_247_residues
METAVRAENLHKVYPGGVHALRGLSFTVFDGEIYGLVGPNGSGKTTTLRILATLLRPTSGKVLIYNIDVLSEPAKVRSLI
AYLPEDAGVYRRLKGIEIIELFAKTRFKSSRDREAFIDEAARLSGLSWEELERPAGGYSKGMKRRLLLAITLALRPRLLI
LDEPTSGLDVMQSMRMRRMILRYNREHNITVLLSSHNMLEVEFLCNRVGIIYGGRLLAEGSPRELKEKFSAENLEQVFEK
ITGGVNA

Specific function: Involved in ATP-dependent electrogenic sodium extrusion [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI150417984, Length=225, Percent_Identity=36.8888888888889, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI45446740, Length=235, Percent_Identity=35.3191489361702, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI47078218, Length=235, Percent_Identity=35.3191489361702, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI21536376, Length=229, Percent_Identity=32.7510917030568, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI105990541, Length=226, Percent_Identity=34.070796460177, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI27436953, Length=253, Percent_Identity=31.2252964426877, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI6005701, Length=218, Percent_Identity=31.1926605504587, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI116734710, Length=234, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI27477115, Length=216, Percent_Identity=31.4814814814815, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI153792144, Length=223, Percent_Identity=29.1479820627803, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI27262624, Length=238, Percent_Identity=30.2521008403361, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI27262626, Length=238, Percent_Identity=30.2521008403361, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI31657092, Length=217, Percent_Identity=32.7188940092166, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI27881501, Length=212, Percent_Identity=31.6037735849057, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI30795238, Length=212, Percent_Identity=31.6037735849057, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI9665248, Length=235, Percent_Identity=27.2340425531915, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI9955963, Length=176, Percent_Identity=30.6818181818182, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786319, Length=238, Percent_Identity=34.0336134453782, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87081782, Length=247, Percent_Identity=32.7935222672065, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI48994943, Length=237, Percent_Identity=31.2236286919831, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1789593, Length=236, Percent_Identity=33.0508474576271, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787712, Length=225, Percent_Identity=27.5555555555556, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI87081791, Length=228, Percent_Identity=28.9473684210526, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787758, Length=214, Percent_Identity=28.9719626168224, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786345, Length=228, Percent_Identity=30.7017543859649, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789864, Length=234, Percent_Identity=26.0683760683761, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI145693107, Length=220, Percent_Identity=33.1818181818182, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787759, Length=233, Percent_Identity=30.9012875536481, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1789032, Length=222, Percent_Identity=30.6306306306306, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786398, Length=230, Percent_Identity=30, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787370, Length=212, Percent_Identity=27.3584905660377, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI48994883, Length=226, Percent_Identity=29.2035398230088, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082267, Length=229, Percent_Identity=29.2576419213974, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788761, Length=245, Percent_Identity=27.3469387755102, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788506, Length=209, Percent_Identity=30.1435406698565, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI87081709, Length=221, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786698, Length=187, Percent_Identity=32.0855614973262, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789962, Length=212, Percent_Identity=28.3018867924528, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790739, Length=247, Percent_Identity=29.1497975708502, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1786803, Length=223, Percent_Identity=25.1121076233184, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790162, Length=260, Percent_Identity=25, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1787029, Length=249, Percent_Identity=25.7028112449799, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790467, Length=226, Percent_Identity=26.9911504424779, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI48994997, Length=229, Percent_Identity=29.6943231441048, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787547, Length=234, Percent_Identity=26.4957264957265, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1790525, Length=263, Percent_Identity=27.7566539923954, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786253, Length=212, Percent_Identity=28.3018867924528, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788225, Length=251, Percent_Identity=27.4900398406374, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787164, Length=196, Percent_Identity=31.6326530612245, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789672, Length=225, Percent_Identity=25.3333333333333, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786703, Length=227, Percent_Identity=30.3964757709251, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787500, Length=215, Percent_Identity=29.3023255813954, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790190, Length=207, Percent_Identity=27.0531400966184, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788450, Length=232, Percent_Identity=26.2931034482759, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787792, Length=208, Percent_Identity=27.8846153846154, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082268, Length=220, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788165, Length=219, Percent_Identity=29.6803652968037, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI87081834, Length=231, Percent_Identity=29.4372294372294, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789991, Length=235, Percent_Identity=29.3617021276596, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789873, Length=213, Percent_Identity=28.169014084507, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788210, Length=208, Percent_Identity=27.4038461538462, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787041, Length=206, Percent_Identity=29.126213592233, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786563, Length=215, Percent_Identity=24.6511627906977, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI87082064, Length=180, Percent_Identity=32.2222222222222, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789891, Length=209, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=208, Percent_Identity=35.5769230769231, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71983523, Length=224, Percent_Identity=34.375, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71983516, Length=224, Percent_Identity=34.375, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71983510, Length=224, Percent_Identity=34.375, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17565586, Length=230, Percent_Identity=30.4347826086957, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17510237, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193202878, Length=198, Percent_Identity=28.2828282828283, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17541710, Length=231, Percent_Identity=26.4069264069264, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532730, Length=180, Percent_Identity=31.1111111111111, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71992285, Length=177, Percent_Identity=27.683615819209, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17511077, Length=220, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=241, Percent_Identity=24.896265560166, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319856, Length=224, Percent_Identity=27.6785714285714, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324498, Length=216, Percent_Identity=26.8518518518519, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320296, Length=184, Percent_Identity=24.4565217391304, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24643674, Length=218, Percent_Identity=32.1100917431193, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24666092, Length=231, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24648314, Length=224, Percent_Identity=29.9107142857143, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574150, Length=242, Percent_Identity=30.9917355371901, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI116007328, Length=244, Percent_Identity=31.9672131147541, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI221512771, Length=211, Percent_Identity=32.7014218009479, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI116007184, Length=230, Percent_Identity=30.8695652173913, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221500365, Length=230, Percent_Identity=30.8695652173913, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI85725262, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28573571, Length=244, Percent_Identity=30.7377049180328, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573573, Length=244, Percent_Identity=30.7377049180328, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24582014, Length=246, Percent_Identity=29.6747967479675, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24582012, Length=246, Percent_Identity=29.6747967479675, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24650853, Length=248, Percent_Identity=27.0161290322581, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650855, Length=248, Percent_Identity=27.0161290322581, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281362751, Length=248, Percent_Identity=27.4193548387097, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221500419, Length=213, Percent_Identity=27.2300469483568, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581191, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581189, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581193, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581195, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19920532, Length=210, Percent_Identity=27.1428571428571, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24580930, Length=210, Percent_Identity=27.1428571428571, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641342, Length=196, Percent_Identity=30.1020408163265, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 27676; Mature: 27676

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METAVRAENLHKVYPGGVHALRGLSFTVFDGEIYGLVGPNGSGKTTTLRILATLLRPTSG
CCCCHHHHCCCCCCCCHHHHHHCCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCC
KVLIYNIDVLSEPAKVRSLIAYLPEDAGVYRRLKGIEIIELFAKTRFKSSRDREAFIDEA
CEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHH
ARLSGLSWEELERPAGGYSKGMKRRLLLAITLALRPRLLILDEPTSGLDVMQSMRMRRMI
HHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHH
LRYNREHNITVLLSSHNMLEVEFLCNRVGIIYGGRLLAEGSPRELKEKFSAENLEQVFEK
HHHCCCCCEEEEEECCCEEEHHHHHHHHHHEECCEEEECCCHHHHHHHHCHHHHHHHHHH
ITGGVNA
HCCCCCC
>Mature Secondary Structure
METAVRAENLHKVYPGGVHALRGLSFTVFDGEIYGLVGPNGSGKTTTLRILATLLRPTSG
CCCCHHHHCCCCCCCCHHHHHHCCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCC
KVLIYNIDVLSEPAKVRSLIAYLPEDAGVYRRLKGIEIIELFAKTRFKSSRDREAFIDEA
CEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHH
ARLSGLSWEELERPAGGYSKGMKRRLLLAITLALRPRLLILDEPTSGLDVMQSMRMRRMI
HHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHH
LRYNREHNITVLLSSHNMLEVEFLCNRVGIIYGGRLLAEGSPRELKEKFSAENLEQVFEK
HHHCCCCCEEEEEECCCEEEHHHHHHHHHHEECCEEEECCCHHHHHHHHCHHHHHHHHHH
ITGGVNA
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9106203; 9274031; 9384377 [H]