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The map label for this gene is flpA [H]

Identifier: 124026934

GI number: 124026934

Start: 23736

End: 24446

Strand: Direct

Name: flpA [H]

Synonym: Hbut_0031

Alternate gene names: 124026934

Gene position: 23736-24446 (Clockwise)

Preceding gene: 124026933

Following gene: 124026935

Centisome position: 1.42

GC content: 50.91

Gene sequence:

>711_bases
ATGGTTGAAGTAGTTAATGTGTATGAGCATGAGAAGTATAAGGGTGTATACATCGTAGAGCTTGAGGATGGTTCTACGAG
ACTAGCAACAGTAAACCTAGCGCCGGGCCACAGGGTTTACGGCGAGAGGTTGTTCAAGTGGGAGGACCTTGAGCTGCGTG
AGTGGAATCCCTACCGTAGCAAGCTTGCTGCAGCATTACTCAAGGGTCTTGAGGAACTCCCGATAAGGCCTGGTCACAAG
ATACTCTACCTCGGTGCTGCAACCGGTACCACAGCGAGCCACGTCTCAGACATTGTTGGCAAGGAGGGGCTAGTATACGC
GCTTGATGTAGCACCGCGAGTAATGCGTGAACTGATAGCAGTGTGTGAAGTTAGACCCAACATGGTGCCCCTACTTGCCG
ATGCCAGGAAGCCCTACGAGTATCGCCACATAGTAGAGCTGGTAGACGGTATCTATGCAGACGTGGCGCAGCCGGATCAG
GCAGAGATTGTTGCAGACAACGCTGACTACTTCTTAAAGGAGGGTGGCTACCTTCTACTAGCTATCAAGGCTAGAAGCAT
AGATGTGACAAAGGAACCAAGCGAGGTATTCAAGAGAGAGATAGATGTGTTGAAGAGCAGGGGCTTCGAGATAGTAGACA
TGGTGCACCTAGAACCCTTCGACAGAGACCACGCAATGGTGTATGCAAGGTATAAGCCGCGCAAGCAGTAA

Upstream 100 bases:

>100_bases
CAGCACCCAGGCCAGCGAAGCCGGCAAGGAGGAAACGTGGCAAGCGCGGTAAGGGTAAAGGCAGGAAGTAGCCTACTCCA
TGTGATAGGGGGTGTAAGGT

Downstream 100 bases:

>100_bases
GGTAACTGTAGGCTAATCTATTTTTAATATAACCCATGTATCCTTTCTGACCACATACGAGCCGCTTTCCTAACACAGAA
CGGTGTAGCACGTTAGGGCT

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MVEVVNVYEHEKYKGVYIVELEDGSTRLATVNLAPGHRVYGERLFKWEDLELREWNPYRSKLAAALLKGLEELPIRPGHK
ILYLGAATGTTASHVSDIVGKEGLVYALDVAPRVMRELIAVCEVRPNMVPLLADARKPYEYRHIVELVDGIYADVAQPDQ
AEIVADNADYFLKEGGYLLLAIKARSIDVTKEPSEVFKREIDVLKSRGFEIVDMVHLEPFDRDHAMVYARYKPRKQ

Sequences:

>Translated_236_residues
MVEVVNVYEHEKYKGVYIVELEDGSTRLATVNLAPGHRVYGERLFKWEDLELREWNPYRSKLAAALLKGLEELPIRPGHK
ILYLGAATGTTASHVSDIVGKEGLVYALDVAPRVMRELIAVCEVRPNMVPLLADARKPYEYRHIVELVDGIYADVAQPDQ
AEIVADNADYFLKEGGYLLLAIKARSIDVTKEPSEVFKREIDVLKSRGFEIVDMVHLEPFDRDHAMVYARYKPRKQ
>Mature_236_residues
MVEVVNVYEHEKYKGVYIVELEDGSTRLATVNLAPGHRVYGERLFKWEDLELREWNPYRSKLAAALLKGLEELPIRPGHK
ILYLGAATGTTASHVSDIVGKEGLVYALDVAPRVMRELIAVCEVRPNMVPLLADARKPYEYRHIVELVDGIYADVAQPDQ
AEIVADNADYFLKEGGYLLLAIKARSIDVTKEPSEVFKREIDVLKSRGFEIVDMVHLEPFDRDHAMVYARYKPRKQ

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=229, Percent_Identity=46.2882096069869, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17563672, Length=233, Percent_Identity=50.2145922746781, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6320190, Length=236, Percent_Identity=46.1864406779661, Blast_Score=215, Evalue=5e-57,
Organism=Drosophila melanogaster, GI17647425, Length=229, Percent_Identity=48.0349344978166, Blast_Score=222, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24646406, Length=228, Percent_Identity=34.2105263157895, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 26867; Mature: 26867

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVVNVYEHEKYKGVYIVELEDGSTRLATVNLAPGHRVYGERLFKWEDLELREWNPYRS
CEEEEEEEECCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHEECCCCCCCCCCHHHH
KLAAALLKGLEELPIRPGHKILYLGAATGTTASHVSDIVGKEGLVYALDVAPRVMRELIA
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHH
VCEVRPNMVPLLADARKPYEYRHIVELVDGIYADVAQPDQAEIVADNADYFLKEGGYLLL
HHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCEEEE
AIKARSIDVTKEPSEVFKREIDVLKSRGFEIVDMVHLEPFDRDHAMVYARYKPRKQ
EEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MVEVVNVYEHEKYKGVYIVELEDGSTRLATVNLAPGHRVYGERLFKWEDLELREWNPYRS
CEEEEEEEECCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHEECCCCCCCCCCHHHH
KLAAALLKGLEELPIRPGHKILYLGAATGTTASHVSDIVGKEGLVYALDVAPRVMRELIA
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHH
VCEVRPNMVPLLADARKPYEYRHIVELVDGIYADVAQPDQAEIVADNADYFLKEGGYLLL
HHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCEEEE
AIKARSIDVTKEPSEVFKREIDVLKSRGFEIVDMVHLEPFDRDHAMVYARYKPRKQ
EEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA