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The map label for this gene is xapA [C]

Identifier: 124026925

GI number: 124026925

Start: 16746

End: 17570

Strand: Reverse

Name: xapA [C]

Synonym: Hbut_0022

Alternate gene names: 124026925

Gene position: 17570-16746 (Counterclockwise)

Preceding gene: 124026926

Following gene: 124026924

Centisome position: 1.05

GC content: 51.03

Gene sequence:

>825_bases
TTGCCCGACTTTCCCCCGAAACCATCCGTAAAAGCCGATATAGCCATAATAGGAGGTAGCGGCCTCTATGACCCCGGAGT
CCTCGAGAACGCCAAGGAGTACAAAATCTACACACCATATGGAGAGCCTAGCGACTACATAATTGTTGGAGAGCTTGGGG
GAAAGCGTGTAGCATTCCTACCAAGGCATGGCAGGGGACACAGAATTCCGCCACACAAGATAAACTATAGAGCGAACATT
TGGGCTCTCAAGATGCTTGGCGTAAAGTGGGTTATTGCCGTCTCTGCTGTAGGCTCCCTACGAGAAGACTACAAACCTGG
AGACATAGTTGTGCCAGACCAGTTTATAGACATGACTAAGAGCCGTGTATATACATTCTTCGACGAGGGCATAGTAGCCC
ACGTGAGTATGGCCGACCCGTTCTGCGAGCACCTACGCCAGGAAATAATTAGCACTGCGAGAGAGCTAGGCTACAGGGTT
CATCCCAGAGGTACATACATCTGTATTGAGGGGCCACGCTTCTCGACGAGAGCTGAAAGCAGAGTCTGGCGGGAGGTATT
CAAAGCAGACATTATAGGAATGACTCTGGTGCCCGAAGTAAACCTAGCTTGTGAGGCACAGCTATGCTATGCAACCATAG
CACTAGTCACCGATTATGACGTCTGGGCTGAGCGGCCAGTAACAGCTGAAGAGGTTGCTAGGGTTATGAAGGAGAACACT
GAGAAGGCCAAGAAGATACTCTACAAGCTAATACCCCGCCTGCCACCCGAACCCGACAAGGCGAGGTGCAGTTGCTGCAG
CTCACTAGAGACAGCACTCCTCTAA

Upstream 100 bases:

>100_bases
GTAAAACCCCGCTAACAAGACACAGAAGGATAGCAATTTTGCCTCACACGCTACACAGTAGTAGGTAGCTGGTTGTGTAG
GTGGGGGTGTAGCTTCTCCC

Downstream 100 bases:

>100_bases
CCCGGGAGAAGCTTAAACGCCTCGAAAAACAAGCCGAAGAACTAGCCAAGAGGATATTTTCCTTCTTAAACCAATCGTAT
AGCGAGCTCTACCTAACATA

Product: 5'-methylthioadenosine phosphorylase II

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFLPRHGRGHRIPPHKINYRANI
WALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTKSRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRV
HPRGTYICIEGPRFSTRAESRVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENT
EKAKKILYKLIPRLPPEPDKARCSCCSSLETALL

Sequences:

>Translated_274_residues
MPDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFLPRHGRGHRIPPHKINYRANI
WALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTKSRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRV
HPRGTYICIEGPRFSTRAESRVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENT
EKAKKILYKLIPRLPPEPDKARCSCCSSLETALL
>Mature_273_residues
PDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFLPRHGRGHRIPPHKINYRANIW
ALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTKSRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRVH
PRGTYICIEGPRFSTRAESRVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENTE
KAKKILYKLIPRLPPEPDKARCSCCSSLETALL

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=50.4032258064516, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI157168362, Length=274, Percent_Identity=27.7372262773723, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1788746, Length=232, Percent_Identity=26.2931034482759, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980569, Length=247, Percent_Identity=44.1295546558704, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323045, Length=263, Percent_Identity=39.1634980988593, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=43.956043956044, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI221459247, Length=278, Percent_Identity=38.8489208633094, Blast_Score=200, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30784; Mature: 30653

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFL
CCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCCEEEECCCCCCCCEEEEECCCCCEEEEE
PRHGRGHRIPPHKINYRANIWALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTK
CCCCCCCCCCCCCCCEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHH
SRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRVHPRGTYICIEGPRFSTRAES
HHEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCCCCHHHH
RVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENT
HHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
EKAKKILYKLIPRLPPEPDKARCSCCSSLETALL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFL
CCCCCCCCCCEEEEEEECCCCCCCCHHCCCCCEEEECCCCCCCCEEEEECCCCCEEEEE
PRHGRGHRIPPHKINYRANIWALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTK
CCCCCCCCCCCCCCCEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHH
SRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRVHPRGTYICIEGPRFSTRAES
HHEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCCCCHHHH
RVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENT
HHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
EKAKKILYKLIPRLPPEPDKARCSCCSSLETALL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]