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The map label for this gene is thrC [H]

Identifier: 124026905

GI number: 124026905

Start: 1863437

End: 1864543

Strand: Direct

Name: thrC [H]

Synonym: NATL1_22001

Alternate gene names: 124026905

Gene position: 1863437-1864543 (Clockwise)

Preceding gene: 124026904

Following gene: NA

Centisome position: 99.93

GC content: 35.77

Gene sequence:

>1107_bases
GTGTCATTTTCTAAGAAATTAAAACAACTTTTCACTTCTACCCCACCCAAAAACAATTGGGATGGACTTATAGAAACATA
CAAAACCTGGTTACCAGTAAGTAATAAGACACCCATCATTACTTTAAAAGAAGGCGCAACTCCTCTTATTGAAGTCAATT
CCATTTCTAATCGAATTGGAAATGGAGTAAAAGTATTTGTCAAATATGACGGTCTAAATCCGACTGGATCCTTCAAAGAC
AGAGGAATGACTATGGCGATAAGTAAAGCTAAAGAAGCTGGGTGTGAAGCTGTAATTTGCGCAAGCACAGGTAATACTTC
AGCCTCTGCAGCAGCTTATGCAAGCAAAGGAGGAATGAAATCCTTTGTTATTATTCCAGATGGATATGTAGCTCAAGGTA
AACTAGCTCAAGCTTTAGTTTACGGAGCTGAAGTATTAGCTATTAAAGGGAATTTTGATAAAGCACTAGATATTGTTAGA
GAACTATCTAATAAATATCCAATTACTTTAGTGAACTCGGTAAATCCTTACAGATTACAAGGACAAAAAACCGCAGCATT
TGAGATAATAGAAAATCTTGGAAATGCACCTGATTGGTTATGCATTCCAATGGGAAATGCTGGAAATATAAGTGCTTACT
GGATGGGATTTCAAGAATTTTTTCACGCTGGAAAATCAAAACATCTCCCAAGAATGATGGGTTTTCAAGCGAGTGGTTCT
GCGCCTTTAGTCGAAGGTAAAAGTATCAGTAACCCTGAGACAATTGCTACAGCAATAAGAATTGGTAATCCCGTTAATAG
AGAAAAAGCTCTTTTAGCAAAAGAATCAAGCAATGGTAGATTTTCTTCTGTATCAGATTCAGAAATAATCAACGCATATA
AAATTCTTGGTAGAGAAGAAGGCATTTTTTGTGAGCCTGCAAGTGCAGCTTCTGTGGCTGGTTTATTAAAAATCAAAGAA
GATGTCCCAAAAAATTCAACTATTGTTTGTGTTTTGACAGGGAATGGTCTAAAAGATCCTGATTGCGCAATAAAAAATAA
TGACTCAATGTTTCATACGGGAGTTGAACCAGAAATAAGTTCAATAACAAAAATAATGGGCTTTTAA

Upstream 100 bases:

>100_bases
CATTAAAAGAGTTAATCGAATTCTACGCAGATTCACCCTTTAAAAAGCTGAAAGATGGAAGGTCTAGCACTTAGATTGTT
TACAATTGATTAGCTAAGTA

Downstream 100 bases:

>100_bases
AAACATTCAAATATCCAAAAAAAAAACTGTCTGTTAATTTCGAAAGTTTTTGCTTCTGTTAACTGGGGAAAACCTATTAA
AACTCATCAATAATTAATCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSFSKKLKQLFTSTPPKNNWDGLIETYKTWLPVSNKTPIITLKEGATPLIEVNSISNRIGNGVKVFVKYDGLNPTGSFKD
RGMTMAISKAKEAGCEAVICASTGNTSASAAAYASKGGMKSFVIIPDGYVAQGKLAQALVYGAEVLAIKGNFDKALDIVR
ELSNKYPITLVNSVNPYRLQGQKTAAFEIIENLGNAPDWLCIPMGNAGNISAYWMGFQEFFHAGKSKHLPRMMGFQASGS
APLVEGKSISNPETIATAIRIGNPVNREKALLAKESSNGRFSSVSDSEIINAYKILGREEGIFCEPASAASVAGLLKIKE
DVPKNSTIVCVLTGNGLKDPDCAIKNNDSMFHTGVEPEISSITKIMGF

Sequences:

>Translated_368_residues
MSFSKKLKQLFTSTPPKNNWDGLIETYKTWLPVSNKTPIITLKEGATPLIEVNSISNRIGNGVKVFVKYDGLNPTGSFKD
RGMTMAISKAKEAGCEAVICASTGNTSASAAAYASKGGMKSFVIIPDGYVAQGKLAQALVYGAEVLAIKGNFDKALDIVR
ELSNKYPITLVNSVNPYRLQGQKTAAFEIIENLGNAPDWLCIPMGNAGNISAYWMGFQEFFHAGKSKHLPRMMGFQASGS
APLVEGKSISNPETIATAIRIGNPVNREKALLAKESSNGRFSSVSDSEIINAYKILGREEGIFCEPASAASVAGLLKIKE
DVPKNSTIVCVLTGNGLKDPDCAIKNNDSMFHTGVEPEISSITKIMGF
>Mature_367_residues
SFSKKLKQLFTSTPPKNNWDGLIETYKTWLPVSNKTPIITLKEGATPLIEVNSISNRIGNGVKVFVKYDGLNPTGSFKDR
GMTMAISKAKEAGCEAVICASTGNTSASAAAYASKGGMKSFVIIPDGYVAQGKLAQALVYGAEVLAIKGNFDKALDIVRE
LSNKYPITLVNSVNPYRLQGQKTAAFEIIENLGNAPDWLCIPMGNAGNISAYWMGFQEFFHAGKSKHLPRMMGFQASGSA
PLVEGKSISNPETIATAIRIGNPVNREKALLAKESSNGRFSSVSDSEIINAYKILGREEGIFCEPASAASVAGLLKIKED
VPKNSTIVCVLTGNGLKDPDCAIKNNDSMFHTGVEPEISSITKIMGF

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=26.9736842105263, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790207, Length=148, Percent_Identity=31.7567567567568, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508781, Length=313, Percent_Identity=24.2811501597444, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 39432; Mature: 39300

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSKKLKQLFTSTPPKNNWDGLIETYKTWLPVSNKTPIITLKEGATPLIEVNSISNRIG
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCHHHHCC
NGVKVFVKYDGLNPTGSFKDRGMTMAISKAKEAGCEAVICASTGNTSASAAAYASKGGMK
CCEEEEEEECCCCCCCCCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCE
SFVIIPDGYVAQGKLAQALVYGAEVLAIKGNFDKALDIVRELSNKYPITLVNSVNPYRLQ
EEEEECCCCCCCCHHHHHHHHCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEEC
GQKTAAFEIIENLGNAPDWLCIPMGNAGNISAYWMGFQEFFHAGKSKHLPRMMGFQASGS
CCCHHHHHHHHHHCCCCCEEEEECCCCCCEEHEEECHHHHHHCCCCCCCCHHHCCCCCCC
APLVEGKSISNPETIATAIRIGNPVNREKALLAKESSNGRFSSVSDSEIINAYKILGREE
CCEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
GIFCEPASAASVAGLLKIKEDVPKNSTIVCVLTGNGLKDPDCAIKNNDSMFHTGVEPEIS
CEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEECCCCEEECCCCCHHH
SITKIMGF
HHHHHHCC
>Mature Secondary Structure 
SFSKKLKQLFTSTPPKNNWDGLIETYKTWLPVSNKTPIITLKEGATPLIEVNSISNRIG
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCHHHHCC
NGVKVFVKYDGLNPTGSFKDRGMTMAISKAKEAGCEAVICASTGNTSASAAAYASKGGMK
CCEEEEEEECCCCCCCCCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCE
SFVIIPDGYVAQGKLAQALVYGAEVLAIKGNFDKALDIVRELSNKYPITLVNSVNPYRLQ
EEEEECCCCCCCCHHHHHHHHCEEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCEEEC
GQKTAAFEIIENLGNAPDWLCIPMGNAGNISAYWMGFQEFFHAGKSKHLPRMMGFQASGS
CCCHHHHHHHHHHCCCCCEEEEECCCCCCEEHEEECHHHHHHCCCCCCCCHHHCCCCCCC
APLVEGKSISNPETIATAIRIGNPVNREKALLAKESSNGRFSSVSDSEIINAYKILGREE
CCEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
GIFCEPASAASVAGLLKIKEDVPKNSTIVCVLTGNGLKDPDCAIKNNDSMFHTGVEPEIS
CEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEECCCCEEECCCCCHHH
SITKIMGF
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]