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The map label for this gene is tetA [H]

Identifier: 124026881

GI number: 124026881

Start: 1832634

End: 1833878

Strand: Direct

Name: tetA [H]

Synonym: NATL1_21761

Alternate gene names: 124026881

Gene position: 1832634-1833878 (Clockwise)

Preceding gene: 124026879

Following gene: 124026882

Centisome position: 98.28

GC content: 37.19

Gene sequence:

>1245_bases
TTGAGAAGGCTAAAAATTCCCACCCTTTTAGGAGCTTTCATCACACTTCTAGATGATCGATTAGGCGAAACCATTGTTTT
ACCTTTATTACCTTTTTTATTAGAACAATTCACGACAAGCGCGACGACTCTTGGTTTTTTAACTGGAACTTATGCGATAT
CTCAGTTTGCTGCAGCCCCACTAATTGGAGCTATGAGTGATCGTTTCGGTCGTAAGCCAATCATGATCACATGTGTATCT
GGTTCAGTAATAGGAATATGTCTATTTGCATTAACTGTAAGCCTAAATTGGGATAATTATTTACCTTTATGGGCCTCAAC
TTTACCTTTATCTTTACTATTTTTAGCCAGAATAATTGATGGTATAAGTGGTGGTACCGCAGCTACTGCTACTACAATAC
TTGCAGATATATCAACTCCGGAAAATCGCGCAAAAACCTTTGGATTAATTGGAGTAGCGTTTGGTTTAGGTTTTATTCTT
GGGCCAGGATTAGGAACAGCTCTTGCTAAATTTAGTGTTACTTTACCGGTATGGGTGGCCAGCGGATTTGCAATATTTAA
TCTTATTTTTGTAATTTGGTTTCTACCGGAAACACTGCCCAAAAACAAAAGAAATTTACTACCAAGAAAAAGAGATTTGA
ATCCAATTAGTCAGCTACTAGTTGTATTTAAAAACCCCTTAGCTAGAAGACTTTGCTTATCGTTCTTTGTTTTCTTTATG
GCATTTAATGGCTTTACAGCTGTTTTAGTCCTTTATTTAAAAGAAAAATTTGGATGGAGTCCTGAATTATGTAGTGCTGC
TTTTATTGTCGTTGGAGTTATTGCGATGATTGTTCAAGGAGGCCTAATTGGTCCTCTTGTAAAAAGATTTGGGGAGTCGA
GATTAACTTTTGCTGGTATTGGCTTTGTAATGACAGGATGCATTCTTTTAACGCTCGCCAATATAGACACTTCAATTCCT
CTTGTATTTTCTGGCGTCGCAATACTTGCAATGGGAACTGGACTAGTAACTCCTAGTTTAAGAGCACTAATTTCAAGAAG
ACTAAGTTCTATTGGTCAAGGAGCAGTATTGGGAAATCTGCAAGGTTTACAAAGTCTGGGAACTTTTCTTGGAGCAATAG
CAGCAGGACGGTCATATGATCTTTTGGGTCCAAGAAGTCCATTCTTTGGCACAATATTGCTTCTACTATTTGTTATGTTT
TTAATTTCAGGGAAAAGTCTTACCAAGAAAAAAGTAATCTCCTAG

Upstream 100 bases:

>100_bases
ATCAGAACTCTCACAAGGTCGCAAATATCGATTTAGACTGCTAAATGAAGCCAAGTTCTCTGACAGTATGAGAAGGTGAA
TAAATTATGAGCTATTTGCA

Downstream 100 bases:

>100_bases
ACTAATAGATGATCAAGATATTAAAGTAATAATTAGAAATTGAATAAATTGGTTATAGATATGACTAGTCCAAAAATCAA
TAATGAAACTTATATTAATC

Product: major facilitator superfamily multidrug-efflux transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MRRLKIPTLLGAFITLLDDRLGETIVLPLLPFLLEQFTTSATTLGFLTGTYAISQFAAAPLIGAMSDRFGRKPIMITCVS
GSVIGICLFALTVSLNWDNYLPLWASTLPLSLLFLARIIDGISGGTAATATTILADISTPENRAKTFGLIGVAFGLGFIL
GPGLGTALAKFSVTLPVWVASGFAIFNLIFVIWFLPETLPKNKRNLLPRKRDLNPISQLLVVFKNPLARRLCLSFFVFFM
AFNGFTAVLVLYLKEKFGWSPELCSAAFIVVGVIAMIVQGGLIGPLVKRFGESRLTFAGIGFVMTGCILLTLANIDTSIP
LVFSGVAILAMGTGLVTPSLRALISRRLSSIGQGAVLGNLQGLQSLGTFLGAIAAGRSYDLLGPRSPFFGTILLLLFVMF
LISGKSLTKKKVIS

Sequences:

>Translated_414_residues
MRRLKIPTLLGAFITLLDDRLGETIVLPLLPFLLEQFTTSATTLGFLTGTYAISQFAAAPLIGAMSDRFGRKPIMITCVS
GSVIGICLFALTVSLNWDNYLPLWASTLPLSLLFLARIIDGISGGTAATATTILADISTPENRAKTFGLIGVAFGLGFIL
GPGLGTALAKFSVTLPVWVASGFAIFNLIFVIWFLPETLPKNKRNLLPRKRDLNPISQLLVVFKNPLARRLCLSFFVFFM
AFNGFTAVLVLYLKEKFGWSPELCSAAFIVVGVIAMIVQGGLIGPLVKRFGESRLTFAGIGFVMTGCILLTLANIDTSIP
LVFSGVAILAMGTGLVTPSLRALISRRLSSIGQGAVLGNLQGLQSLGTFLGAIAAGRSYDLLGPRSPFFGTILLLLFVMF
LISGKSLTKKKVIS
>Mature_414_residues
MRRLKIPTLLGAFITLLDDRLGETIVLPLLPFLLEQFTTSATTLGFLTGTYAISQFAAAPLIGAMSDRFGRKPIMITCVS
GSVIGICLFALTVSLNWDNYLPLWASTLPLSLLFLARIIDGISGGTAATATTILADISTPENRAKTFGLIGVAFGLGFIL
GPGLGTALAKFSVTLPVWVASGFAIFNLIFVIWFLPETLPKNKRNLLPRKRDLNPISQLLVVFKNPLARRLCLSFFVFFM
AFNGFTAVLVLYLKEKFGWSPELCSAAFIVVGVIAMIVQGGLIGPLVKRFGESRLTFAGIGFVMTGCILLTLANIDTSIP
LVFSGVAILAMGTGLVTPSLRALISRRLSSIGQGAVLGNLQGLQSLGTFLGAIAAGRSYDLLGPRSPFFGTILLLLFVMF
LISGKSLTKKKVIS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=353, Percent_Identity=24.6458923512748, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI225703104, Length=372, Percent_Identity=26.6129032258064, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI225703102, Length=372, Percent_Identity=26.6129032258064, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI94721311, Length=351, Percent_Identity=24.5014245014245, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71996331, Length=358, Percent_Identity=25.6983240223464, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17551570, Length=361, Percent_Identity=24.6537396121884, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17738085, Length=443, Percent_Identity=27.313769751693, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21357569, Length=338, Percent_Identity=27.2189349112426, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI161080926, Length=360, Percent_Identity=26.9444444444444, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI161080924, Length=360, Percent_Identity=26.9444444444444, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24656463, Length=359, Percent_Identity=26.4623955431755, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24656468, Length=359, Percent_Identity=26.4623955431755, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI221513297, Length=351, Percent_Identity=25.3561253561254, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24667557, Length=192, Percent_Identity=28.125, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667561, Length=191, Percent_Identity=25.130890052356, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44309; Mature: 44309

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLKIPTLLGAFITLLDDRLGETIVLPLLPFLLEQFTTSATTLGFLTGTYAISQFAAAP
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGAMSDRFGRKPIMITCVSGSVIGICLFALTVSLNWDNYLPLWASTLPLSLLFLARIID
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
GISGGTAATATTILADISTPENRAKTFGLIGVAFGLGFILGPGLGTALAKFSVTLPVWVA
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SGFAIFNLIFVIWFLPETLPKNKRNLLPRKRDLNPISQLLVVFKNPLARRLCLSFFVFFM
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHH
AFNGFTAVLVLYLKEKFGWSPELCSAAFIVVGVIAMIVQGGLIGPLVKRFGESRLTFAGI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHH
GFVMTGCILLTLANIDTSIPLVFSGVAILAMGTGLVTPSLRALISRRLSSIGQGAVLGNL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
QGLQSLGTFLGAIAAGRSYDLLGPRSPFFGTILLLLFVMFLISGKSLTKKKVIS
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MRRLKIPTLLGAFITLLDDRLGETIVLPLLPFLLEQFTTSATTLGFLTGTYAISQFAAAP
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGAMSDRFGRKPIMITCVSGSVIGICLFALTVSLNWDNYLPLWASTLPLSLLFLARIID
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
GISGGTAATATTILADISTPENRAKTFGLIGVAFGLGFILGPGLGTALAKFSVTLPVWVA
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SGFAIFNLIFVIWFLPETLPKNKRNLLPRKRDLNPISQLLVVFKNPLARRLCLSFFVFFM
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHH
AFNGFTAVLVLYLKEKFGWSPELCSAAFIVVGVIAMIVQGGLIGPLVKRFGESRLTFAGI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHH
GFVMTGCILLTLANIDTSIPLVFSGVAILAMGTGLVTPSLRALISRRLSSIGQGAVLGNL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
QGLQSLGTFLGAIAAGRSYDLLGPRSPFFGTILLLLFVMFLISGKSLTKKKVIS
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]