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The map label for this gene is sam1 [H]

Identifier: 124026782

GI number: 124026782

Start: 1719910

End: 1721343

Strand: Reverse

Name: sam1 [H]

Synonym: NATL1_20771

Alternate gene names: 124026782

Gene position: 1721343-1719910 (Counterclockwise)

Preceding gene: 124026784

Following gene: 124026781

Centisome position: 92.31

GC content: 37.1

Gene sequence:

>1434_bases
ATGTTCGCAGCAACCAAGTCAAATCTCAACAGTATTGAGAATAATACTGATTACGTCGTTAACGATATAACGGAAGCAGA
ATTCGGGCGAAAAGAACTTTTGATAGCTGAAACAGAAATGCCTGGTTTAATGGCACTGAGAAAAAAATATGGATCCCAAA
AACCCTTAAAAGGGGCTTTCATAGCAGGTAGTCTCCACATGACTATTCAAACAGGAGTTCTTATTGAGACTCTCGTTGAA
CTTGGTGCAAAAGTTAGATGGGCTTCATGTAATATTTTTTCCACTCAGGATCATGCTGCTGCAGCTATTGCAAATTCAGG
AGTCCCAGTATTTGCCAAGAAGGGTGAGACTTTAGATGAATACTGGGAATATACGCATAAAATTTTTGAGTGGAGAGATG
GTGAATCTGCAAATATGATTCTTGACGATGGTGGTGATGCGACTGGATTGATTATTCTGGGGAGCAAAGCGGAAGAAGAT
ATTTCAGTTCTTAATAACCCTTCAAATGAAGAGGAAATTGCATTATTTGCTTCCATTAAGAAAAAACTTTCACAAGATCC
AACTTTTTATTCAAAAGCTAAATCTTTTATAAAAGGAATTACTGAGGAAACCACAACAGGTGTAGCGCGTCTTTACCAAA
TGGAAAAAAATGGAGAACTTGTTTTCCCAGCAATCAACGTAAACGATTCTGTGACTAAAAGTAAGTTTGATAATCTTTAT
GGTTGCCGAGAGTCCTTGGTGGATGGTATCAAAAGAGCTACAGATGTCATGGTGGCTGGCAAGGTAGCCCTTGTTATGGG
ATATGGAGATGTTGGAAAAGGTTCTGCGCAGTCTTTAAGGGGTTTAGGCGCGACAGTAATGATTGCTGAGATAGATCCAA
TATGTGCTCTTCAAGCCGCAATGGAGGGTTATAGAGTTGTGAGATTAAATGAAGTTGTGGAAGATGTAGATATTTTTGTT
ACTGCCACTGGAAATTTCCAAGTGATTCGTCATGAGCATTTGATTAGGATGAAGAATGAATCGATTGTTTGTAATATTGG
CCATTTTGATAATGAAATAGAGGTTTCCTCTTTAAAGTCTTATGAATGGGAAAATATTAAACCCCAAGTAGATCACATAA
CTTTACCAAGCGGTAACAAAATTATTCTTCTAGCAGAAGGGAGATTAGTTAATCTTGGATGTGCCACTGGCCATCCTAGT
TTTGTTATGAGTAATTCTTTTACTAATCAAGTATTAGCTCAAATTGAACTATTTAAATATGGCGTTAAATATTTGAACAA
AGTTTATGTCTTGCCCAAACATTTAGATGAAATGGTGGCTGTTCTTCATCTAGATAAGATTGGAGCAAAGTTAACTAAGT
TAACTCAAGAACAAGCTGAATATATTAATGTTCCAATCGAAGGCCCCTACAAGACAGAGCAATATCGTTATTGA

Upstream 100 bases:

>100_bases
GAGTCCAGCAGAAATTATTGGTTTGCTGAGCAAATGAATTAAAAACCTTGAATTGTTTTTCAGTATCTTTTTCCACTATC
TCCCATAGAGAGTTCAACTT

Downstream 100 bases:

>100_bases
TTTTATTTAAATAGTTCAAACTAAATGGAAATATCTGAATTTATTTCTTCTTTACCAGTATTTATAGGAAATGCAGTTGA
GACCAATCAGTGGATTGGTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MFAATKSNLNSIENNTDYVVNDITEAEFGRKELLIAETEMPGLMALRKKYGSQKPLKGAFIAGSLHMTIQTGVLIETLVE
LGAKVRWASCNIFSTQDHAAAAIANSGVPVFAKKGETLDEYWEYTHKIFEWRDGESANMILDDGGDATGLIILGSKAEED
ISVLNNPSNEEEIALFASIKKKLSQDPTFYSKAKSFIKGITEETTTGVARLYQMEKNGELVFPAINVNDSVTKSKFDNLY
GCRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLNEVVEDVDIFV
TATGNFQVIRHEHLIRMKNESIVCNIGHFDNEIEVSSLKSYEWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPS
FVMSNSFTNQVLAQIELFKYGVKYLNKVYVLPKHLDEMVAVLHLDKIGAKLTKLTQEQAEYINVPIEGPYKTEQYRY

Sequences:

>Translated_477_residues
MFAATKSNLNSIENNTDYVVNDITEAEFGRKELLIAETEMPGLMALRKKYGSQKPLKGAFIAGSLHMTIQTGVLIETLVE
LGAKVRWASCNIFSTQDHAAAAIANSGVPVFAKKGETLDEYWEYTHKIFEWRDGESANMILDDGGDATGLIILGSKAEED
ISVLNNPSNEEEIALFASIKKKLSQDPTFYSKAKSFIKGITEETTTGVARLYQMEKNGELVFPAINVNDSVTKSKFDNLY
GCRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLNEVVEDVDIFV
TATGNFQVIRHEHLIRMKNESIVCNIGHFDNEIEVSSLKSYEWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPS
FVMSNSFTNQVLAQIELFKYGVKYLNKVYVLPKHLDEMVAVLHLDKIGAKLTKLTQEQAEYINVPIEGPYKTEQYRY
>Mature_477_residues
MFAATKSNLNSIENNTDYVVNDITEAEFGRKELLIAETEMPGLMALRKKYGSQKPLKGAFIAGSLHMTIQTGVLIETLVE
LGAKVRWASCNIFSTQDHAAAAIANSGVPVFAKKGETLDEYWEYTHKIFEWRDGESANMILDDGGDATGLIILGSKAEED
ISVLNNPSNEEEIALFASIKKKLSQDPTFYSKAKSFIKGITEETTTGVARLYQMEKNGELVFPAINVNDSVTKSKFDNLY
GCRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAAMEGYRVVRLNEVVEDVDIFV
TATGNFQVIRHEHLIRMKNESIVCNIGHFDNEIEVSSLKSYEWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPS
FVMSNSFTNQVLAQIELFKYGVKYLNKVYVLPKHLDEMVAVLHLDKIGAKLTKLTQEQAEYINVPIEGPYKTEQYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.3073593073593, Blast_Score=510, Evalue=1e-144,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=59.3181818181818, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI195539337, Length=475, Percent_Identity=50.5263157894737, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI24308043, Length=475, Percent_Identity=50.9473684210526, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=50.6410256410256, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI195539349, Length=475, Percent_Identity=50.5263157894737, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI21361647, Length=475, Percent_Identity=49.8947368421053, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.2795698924731, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=57.5313807531381, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=60.6060606060606, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=469, Percent_Identity=50.7462686567164, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=50.8620689655172, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=50.755939524838, Blast_Score=450, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52726; Mature: 52726

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAATKSNLNSIENNTDYVVNDITEAEFGRKELLIAETEMPGLMALRKKYGSQKPLKGAF
CCCCCCCCHHHCCCCCCEEEECCHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEE
IAGSLHMTIQTGVLIETLVELGAKVRWASCNIFSTQDHAAAAIANSGVPVFAKKGETLDE
EEEEEEEEEECCHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHCCCCEEEECCCCCHHH
YWEYTHKIFEWRDGESANMILDDGGDATGLIILGSKAEEDISVLNNPSNEEEIALFASIK
HHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHH
KKLSQDPTFYSKAKSFIKGITEETTTGVARLYQMEKNGELVFPAINVNDSVTKSKFDNLY
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
GCRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAA
HHHHHHHHHHHHHHHHEEECEEEEEEECCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHH
MEGYRVVRLNEVVEDVDIFVTATGNFQVIRHEHLIRMKNESIVCNIGHFDNEIEVSSLKS
HCCCEEEEHHHHHCCEEEEEEECCCEEEEEEEEEEEECCCEEEEEECCCCCEEEHHHHCC
YEWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFKY
CCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHH
GVKYLNKVYVLPKHLDEMVAVLHLDKIGAKLTKLTQEQAEYINVPIEGPYKTEQYRY
HHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MFAATKSNLNSIENNTDYVVNDITEAEFGRKELLIAETEMPGLMALRKKYGSQKPLKGAF
CCCCCCCCHHHCCCCCCEEEECCHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEE
IAGSLHMTIQTGVLIETLVELGAKVRWASCNIFSTQDHAAAAIANSGVPVFAKKGETLDE
EEEEEEEEEECCHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHCCCCEEEECCCCCHHH
YWEYTHKIFEWRDGESANMILDDGGDATGLIILGSKAEEDISVLNNPSNEEEIALFASIK
HHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHH
KKLSQDPTFYSKAKSFIKGITEETTTGVARLYQMEKNGELVFPAINVNDSVTKSKFDNLY
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
GCRESLVDGIKRATDVMVAGKVALVMGYGDVGKGSAQSLRGLGATVMIAEIDPICALQAA
HHHHHHHHHHHHHHHHEEECEEEEEEECCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHH
MEGYRVVRLNEVVEDVDIFVTATGNFQVIRHEHLIRMKNESIVCNIGHFDNEIEVSSLKS
HCCCEEEEHHHHHCCEEEEEEECCCEEEEEEEEEEEECCCEEEEEECCCCCEEEHHHHCC
YEWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFKY
CCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHH
GVKYLNKVYVLPKHLDEMVAVLHLDKIGAKLTKLTQEQAEYINVPIEGPYKTEQYRY
HHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA