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The map label for this gene is trpE [H]

Identifier: 124026728

GI number: 124026728

Start: 1667649

End: 1669169

Strand: Reverse

Name: trpE [H]

Synonym: NATL1_20231

Alternate gene names: 124026728

Gene position: 1669169-1667649 (Counterclockwise)

Preceding gene: 124026729

Following gene: 124026727

Centisome position: 89.51

GC content: 38.13

Gene sequence:

>1521_bases
ATGCTTAATTTAGATAAGGAAGAATTTATTTTGTCAGCGTCCAGCGGGGCTAATTATATTCCGTTGGCAAAAAGTTGGCC
GGCAGATTTAGAAACTCCTCTTACTACCTGGCTTAAAGTTGGTAATGATGCTCCTTCAGGAGTATTGCTTGAATCAGTAG
AGGGTGGAGAAACTATCGGTAGGTGGAGTGTGGTTGCATCAGATCCCCTTTGGAAAGTAGTAGTAAGGGGCGATGAATTA
ACTAGATGCTGGAGGGATGGAAAACAAGAAAAGTTTCATGGAAATCCAGTGGAAATCCTCAGGAAAATGCTTGAGCCGTA
TAAATCTGTTTCTTTGCCTGGCTTGCCACAACTGGGACAACTTTTTGGCATGTGGGGATATGAACTAATTCAATGGATAG
AGCCCTCAGTGCCTACTTATGAATTATCAGATCAAGACTTACCTGATGGTATTTGGATGTTTATGGACAAAGTTCTGATT
TTTGATCAAGTCAAACGCCTAATAACAGCTGTTGCATATGGAAATTTAAGTGATGGAGTTTCTTCTCAAAAAGCTTATGA
AATTGCCTGTGAACAAATCAATGAACTGCAAGATTTAATGTCTTCTCCTTTAAAGCCAATAAAGTCTTTAAAGTGGAATC
AAAAATCGAATAGATCTCCTGATATGGCTGCTAATACCTCAAAAAGTGAATTTGAACATAGTGTTGAAGCGGCAAAAGAA
TTTATTAAACAAGGCGATGTTTTTCAGTTAGTTCTTAGTCAAAAATTGGAGTCGACTGTTACGCAAAAACCCTTTGAACT
ATATCGAAGCCTAAGGATGGTAAATCCCTCTCCATTTATGGCGTTTTTTGACTTTGGTGACTGGCAACTTATTGGTTCTA
GCCCGGAGGTAATGGTTAAGGCCCAAAAAACAGAAAAGGGTATTCAAACAAGTTTGAGACCAATTGCAGGTACACGTCCT
AGAGGTAAAAATGATTTGGAAGATGCAGCCTTAGAGAAAGATCTTTTAAAAGATCCCAAAGAACGAGCAGAACATGTGAT
GTTGGTAGATTTGGGTCGAAATGATTTAGGTCGTGTTTGTACCCCAGGTAGTGTTGTTGTGAAAGAATTAATGGTTATTG
AAAAATATTCGCATGTAATGCATATCGTCAGTGAGGTTGAAGGCACTTTAAAAAAAGAACAGGATGTTTGGGACTTATTA
ATTGCTTCTTTCCCAGCTGGGACTGTAAGTGGAGCCCCAAAAATAAGAGCAATGCAACTAATTAATCAATTAGAAAAACA
ACGTAGAGGGCCTTATTCAGGCGTTTATGGGTCTATAGATTTAAATGGCGCATTAAATACAGCTATTACTATTAGGACAA
TGATTGTACGTAAAAAAAATAAAAATGGTTTTACTGTTGAAGTGCAAGCAGGGGCAGGGGTTGTTGCAGATTCCATTTCT
TCTAATGAGTATCAAGAAACTTTAAATAAAGCCAAAGGGATGTTTACTGCTTTAGCTTGCTTAGACCCCCAAGATTTATG
A

Upstream 100 bases:

>100_bases
AGTTTGAAATTTAGCGGTAAAAAAACTTACGATGCATAAGTAATTCAATTTAAACTTGTGTTCCCTTTGAATATATATAT
TGGACTGCCATTATGCAGTC

Downstream 100 bases:

>100_bases
CCAACTTTATGCTTTTAAAGGGGTTTGAAGTGGAGCTTTTTACTGGCACATATGCTGGTAAAAATGTGGGTGTTGCATCT
GCTATTACTGAAGATTTATC

Product: anthranilate synthase component I/chorismate-binding protein

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLNLDKEEFILSASSGANYIPLAKSWPADLETPLTTWLKVGNDAPSGVLLESVEGGETIGRWSVVASDPLWKVVVRGDEL
TRCWRDGKQEKFHGNPVEILRKMLEPYKSVSLPGLPQLGQLFGMWGYELIQWIEPSVPTYELSDQDLPDGIWMFMDKVLI
FDQVKRLITAVAYGNLSDGVSSQKAYEIACEQINELQDLMSSPLKPIKSLKWNQKSNRSPDMAANTSKSEFEHSVEAAKE
FIKQGDVFQLVLSQKLESTVTQKPFELYRSLRMVNPSPFMAFFDFGDWQLIGSSPEVMVKAQKTEKGIQTSLRPIAGTRP
RGKNDLEDAALEKDLLKDPKERAEHVMLVDLGRNDLGRVCTPGSVVVKELMVIEKYSHVMHIVSEVEGTLKKEQDVWDLL
IASFPAGTVSGAPKIRAMQLINQLEKQRRGPYSGVYGSIDLNGALNTAITIRTMIVRKKNKNGFTVEVQAGAGVVADSIS
SNEYQETLNKAKGMFTALACLDPQDL

Sequences:

>Translated_506_residues
MLNLDKEEFILSASSGANYIPLAKSWPADLETPLTTWLKVGNDAPSGVLLESVEGGETIGRWSVVASDPLWKVVVRGDEL
TRCWRDGKQEKFHGNPVEILRKMLEPYKSVSLPGLPQLGQLFGMWGYELIQWIEPSVPTYELSDQDLPDGIWMFMDKVLI
FDQVKRLITAVAYGNLSDGVSSQKAYEIACEQINELQDLMSSPLKPIKSLKWNQKSNRSPDMAANTSKSEFEHSVEAAKE
FIKQGDVFQLVLSQKLESTVTQKPFELYRSLRMVNPSPFMAFFDFGDWQLIGSSPEVMVKAQKTEKGIQTSLRPIAGTRP
RGKNDLEDAALEKDLLKDPKERAEHVMLVDLGRNDLGRVCTPGSVVVKELMVIEKYSHVMHIVSEVEGTLKKEQDVWDLL
IASFPAGTVSGAPKIRAMQLINQLEKQRRGPYSGVYGSIDLNGALNTAITIRTMIVRKKNKNGFTVEVQAGAGVVADSIS
SNEYQETLNKAKGMFTALACLDPQDL
>Mature_506_residues
MLNLDKEEFILSASSGANYIPLAKSWPADLETPLTTWLKVGNDAPSGVLLESVEGGETIGRWSVVASDPLWKVVVRGDEL
TRCWRDGKQEKFHGNPVEILRKMLEPYKSVSLPGLPQLGQLFGMWGYELIQWIEPSVPTYELSDQDLPDGIWMFMDKVLI
FDQVKRLITAVAYGNLSDGVSSQKAYEIACEQINELQDLMSSPLKPIKSLKWNQKSNRSPDMAANTSKSEFEHSVEAAKE
FIKQGDVFQLVLSQKLESTVTQKPFELYRSLRMVNPSPFMAFFDFGDWQLIGSSPEVMVKAQKTEKGIQTSLRPIAGTRP
RGKNDLEDAALEKDLLKDPKERAEHVMLVDLGRNDLGRVCTPGSVVVKELMVIEKYSHVMHIVSEVEGTLKKEQDVWDLL
IASFPAGTVSGAPKIRAMQLINQLEKQRRGPYSGVYGSIDLNGALNTAITIRTMIVRKKNKNGFTVEVQAGAGVVADSIS
SNEYQETLNKAKGMFTALACLDPQDL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=386, Percent_Identity=36.5284974093264, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788114, Length=458, Percent_Identity=31.0043668122271, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI87082077, Length=275, Percent_Identity=26.1818181818182, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786809, Length=275, Percent_Identity=25.0909090909091, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=488, Percent_Identity=35.4508196721311, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6324361, Length=407, Percent_Identity=26.044226044226, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56329; Mature: 56329

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLDKEEFILSASSGANYIPLAKSWPADLETPLTTWLKVGNDAPSGVLLESVEGGETIG
CCCCCHHHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCC
RWSVVASDPLWKVVVRGDELTRCWRDGKQEKFHGNPVEILRKMLEPYKSVSLPGLPQLGQ
CEEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
LFGMWGYELIQWIEPSVPTYELSDQDLPDGIWMFMDKVLIFDQVKRLITAVAYGNLSDGV
HHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SSQKAYEIACEQINELQDLMSSPLKPIKSLKWNQKSNRSPDMAANTSKSEFEHSVEAAKE
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
FIKQGDVFQLVLSQKLESTVTQKPFELYRSLRMVNPSPFMAFFDFGDWQLIGSSPEVMVK
HHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEE
AQKTEKGIQTSLRPIAGTRPRGKNDLEDAALEKDLLKDPKERAEHVMLVDLGRNDLGRVC
EHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCEEEEEECCCCCCCCCC
TPGSVVVKELMVIEKYSHVMHIVSEVEGTLKKEQDVWDLLIASFPAGTVSGAPKIRAMQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
INQLEKQRRGPYSGVYGSIDLNGALNTAITIRTMIVRKKNKNGFTVEVQAGAGVVADSIS
HHHHHHHHCCCCCCCEECEECCCCCCHHHHHHHHEEEECCCCCEEEEEECCCCHHHHCCC
SNEYQETLNKAKGMFTALACLDPQDL
CHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLNLDKEEFILSASSGANYIPLAKSWPADLETPLTTWLKVGNDAPSGVLLESVEGGETIG
CCCCCHHHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCC
RWSVVASDPLWKVVVRGDELTRCWRDGKQEKFHGNPVEILRKMLEPYKSVSLPGLPQLGQ
CEEEEECCCCEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
LFGMWGYELIQWIEPSVPTYELSDQDLPDGIWMFMDKVLIFDQVKRLITAVAYGNLSDGV
HHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SSQKAYEIACEQINELQDLMSSPLKPIKSLKWNQKSNRSPDMAANTSKSEFEHSVEAAKE
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
FIKQGDVFQLVLSQKLESTVTQKPFELYRSLRMVNPSPFMAFFDFGDWQLIGSSPEVMVK
HHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEEE
AQKTEKGIQTSLRPIAGTRPRGKNDLEDAALEKDLLKDPKERAEHVMLVDLGRNDLGRVC
EHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCEEEEEECCCCCCCCCC
TPGSVVVKELMVIEKYSHVMHIVSEVEGTLKKEQDVWDLLIASFPAGTVSGAPKIRAMQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
INQLEKQRRGPYSGVYGSIDLNGALNTAITIRTMIVRKKNKNGFTVEVQAGAGVVADSIS
HHHHHHHHCCCCCCCEECEECCCCCCHHHHHHHHEEEECCCCCEEEEEECCCCHHHHCCC
SNEYQETLNKAKGMFTALACLDPQDL
CHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 3141423 [H]