Click here to switch to the map view.

The map label for this gene is ureC

Identifier: 124026631

GI number: 124026631

Start: 1584092

End: 1585801

Strand: Direct

Name: ureC

Synonym: NATL1_19261

Alternate gene names: 124026631

Gene position: 1584092-1585801 (Clockwise)

Preceding gene: 124026630

Following gene: 124026633

Centisome position: 84.95

GC content: 41.29

Gene sequence:

>1710_bases
ATGCCTTTCAAAATTTCTCGCCAAGCCTATGCAGAGACTTATGGTCCGACGAAAGGGGATCGCATTAGACTTGCAGATAC
GGACTTAATACTCGAAGTTGAACAGGATCATACTCACTATGGAGACGAAGTTAAATTTGGTGGGGGAAAAGTTATTCGTG
ATGGGATGGGACAATCACAACAAAGTAGAGACAATGGAGTAGTAGATACAGTTATCACAAATGCGCTAATTTTAGATTGG
TGGGGAATTGTTAAAGCTGATATTGGCATCAAAGACGGAAAAATCTCAGGTATTGGAAAAGCTGGAAATCCGGATACTCA
AGAAGGTGTCAACATTATTGTAGGCGCCAGTACAGAAGCAATCGCAGGAGAAGGAAGCATTATTACTGCAGGAGCTATAG
ATAGTCACATTCACTTTATCTGTCCACAACAAATAGAAACTGCTTTAGCTAGTGGGGTTACCACAATGCTCGGAGGAGGG
ACAGGCCCAGCAACAGGTACTAATGCAACGACATGTACACCTGGAGCATTTCACATCTCAAGGATGCTGCAATCTGCAGA
GGGATTTCCTGTTAATTTGGGATTCTTTGGAAAAGGCAATGCAACTAACAAAGCAGCATTAGAAGAACAAGTAAGAGCAG
GTGCTTGTGGGTTAAAACTGCATGAAGACTGGGGAACAACACCTGCCTGTATTGATTCCTGCCTAAGTGTTGCAGATCAA
CTAGACGTACAAGTTTGTATTCATACAGATACTTTAAATGAAGCTGGTTTTGTTGAAGATACAATTAAAGCAATAAAAGG
GAGAACAATTCATACCTTCCATACAGAAGGAGCTGGAGGTGGTCACGCCCCTGACATTATCAAAATTTGTGGAGAATCAA
ATGTGATTCCCAGCAGTACAAATCCAACTAGGCCTTTCACTCTAAATACTCTTGAAGAGCATTTAGATATGTTGATGGTT
TGTCATCATTTGGATCCCAAAATTCCAGAGGATGTTGCATTTGCTGAGTCAAGAATACGTCGTGAAACTATTGCCGCTGA
AGACATACTCCACGACTTAGGAGCCTTTTCTATTATTGCTAGTGACTCCCAGGCTATGGGTAGAGTTGGGGAAGTGATTA
GCCGAACTTTTCAAACTGCTCATAAAATGAAAGTTCAAAGAGGAGCCTTACCTGAGGATAATCAAAGGAATGATAATCAT
CGTCTGAAAAGATATATCTCAAAGGTCACTATTAATCCTGCGATAGCTCATGGAATAAGTGCTCATGTTGGTTCGGTAGA
GGTTGGAAAACTAGCAGACTTAGTACTTTGGAAACCAGGTTTTTTTGGAATTAAACCTGACTTAGTAGTCAAAGGAGGAT
GTATCGCATGGGCTCAAATGGGAGATGCAAATGCGTCGATTCCTACTCCACAACCAGTTCATGGTCGTCCAATGTTTTCT
TCCTTTGGAAAGGCGATAAGTCCTACATGTCTGACTTTCTTAAGCGAGAATGCAATAGACGCTGGTGTCCCTGAACGACT
CAAATTGGAACGCACTTGTGCTCCCGTTAAAGACACAAGAAAAATATCTAAACAATCAATGAAACTTAATGATGCAAGAC
CCAAAATCGAAGTAGACCCCCAAACATATGAAGTTTTTGCAAACGGAGAGCTTTTGACTTGTGAACCTGCTGAATCACTA
CCACTTGCGCAAAGATATCTATTACTTTAG

Upstream 100 bases:

>100_bases
GAGCCAGGTGACCAAAGAGAAGTTAATCTTGTTCCTTATGCTGGAGACCGTAAGATTTTTGGGTTCAACGGACTTATAAA
CAATTCACTTCAACAATAAA

Downstream 100 bases:

>100_bases
TTGATATTAAATTTCAAAAGATCTTAGGCTACGAGTGAATCTTCTTTATTAAAAGCCGTTACTCGGAGTCGTTGTTCTAA
ATTTGGTCCATATGACTCTA

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MPFKISRQAYAETYGPTKGDRIRLADTDLILEVEQDHTHYGDEVKFGGGKVIRDGMGQSQQSRDNGVVDTVITNALILDW
WGIVKADIGIKDGKISGIGKAGNPDTQEGVNIIVGASTEAIAGEGSIITAGAIDSHIHFICPQQIETALASGVTTMLGGG
TGPATGTNATTCTPGAFHISRMLQSAEGFPVNLGFFGKGNATNKAALEEQVRAGACGLKLHEDWGTTPACIDSCLSVADQ
LDVQVCIHTDTLNEAGFVEDTIKAIKGRTIHTFHTEGAGGGHAPDIIKICGESNVIPSSTNPTRPFTLNTLEEHLDMLMV
CHHLDPKIPEDVAFAESRIRRETIAAEDILHDLGAFSIIASDSQAMGRVGEVISRTFQTAHKMKVQRGALPEDNQRNDNH
RLKRYISKVTINPAIAHGISAHVGSVEVGKLADLVLWKPGFFGIKPDLVVKGGCIAWAQMGDANASIPTPQPVHGRPMFS
SFGKAISPTCLTFLSENAIDAGVPERLKLERTCAPVKDTRKISKQSMKLNDARPKIEVDPQTYEVFANGELLTCEPAESL
PLAQRYLLL

Sequences:

>Translated_569_residues
MPFKISRQAYAETYGPTKGDRIRLADTDLILEVEQDHTHYGDEVKFGGGKVIRDGMGQSQQSRDNGVVDTVITNALILDW
WGIVKADIGIKDGKISGIGKAGNPDTQEGVNIIVGASTEAIAGEGSIITAGAIDSHIHFICPQQIETALASGVTTMLGGG
TGPATGTNATTCTPGAFHISRMLQSAEGFPVNLGFFGKGNATNKAALEEQVRAGACGLKLHEDWGTTPACIDSCLSVADQ
LDVQVCIHTDTLNEAGFVEDTIKAIKGRTIHTFHTEGAGGGHAPDIIKICGESNVIPSSTNPTRPFTLNTLEEHLDMLMV
CHHLDPKIPEDVAFAESRIRRETIAAEDILHDLGAFSIIASDSQAMGRVGEVISRTFQTAHKMKVQRGALPEDNQRNDNH
RLKRYISKVTINPAIAHGISAHVGSVEVGKLADLVLWKPGFFGIKPDLVVKGGCIAWAQMGDANASIPTPQPVHGRPMFS
SFGKAISPTCLTFLSENAIDAGVPERLKLERTCAPVKDTRKISKQSMKLNDARPKIEVDPQTYEVFANGELLTCEPAESL
PLAQRYLLL
>Mature_568_residues
PFKISRQAYAETYGPTKGDRIRLADTDLILEVEQDHTHYGDEVKFGGGKVIRDGMGQSQQSRDNGVVDTVITNALILDWW
GIVKADIGIKDGKISGIGKAGNPDTQEGVNIIVGASTEAIAGEGSIITAGAIDSHIHFICPQQIETALASGVTTMLGGGT
GPATGTNATTCTPGAFHISRMLQSAEGFPVNLGFFGKGNATNKAALEEQVRAGACGLKLHEDWGTTPACIDSCLSVADQL
DVQVCIHTDTLNEAGFVEDTIKAIKGRTIHTFHTEGAGGGHAPDIIKICGESNVIPSSTNPTRPFTLNTLEEHLDMLMVC
HHLDPKIPEDVAFAESRIRRETIAAEDILHDLGAFSIIASDSQAMGRVGEVISRTFQTAHKMKVQRGALPEDNQRNDNHR
LKRYISKVTINPAIAHGISAHVGSVEVGKLADLVLWKPGFFGIKPDLVVKGGCIAWAQMGDANASIPTPQPVHGRPMFSS
FGKAISPTCLTFLSENAIDAGVPERLKLERTCAPVKDTRKISKQSMKLNDARPKIEVDPQTYEVFANGELLTCEPAESLP
LAQRYLLL

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_PROM1 (A2C4S2)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015746.1
- ProteinModelPortal:   A2C4S2
- SMR:   A2C4S2
- STRING:   A2C4S2
- GeneID:   4779668
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_19261
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   PMAR167555:NATL1_19261-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60977; Mature: 60846

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 322-322 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFKISRQAYAETYGPTKGDRIRLADTDLILEVEQDHTHYGDEVKFGGGKVIRDGMGQSQ
CCCCCCHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCCCEEEECCCEEECCCCCCCC
QSRDNGVVDTVITNALILDWWGIVKADIGIKDGKISGIGKAGNPDTQEGVNIIVGASTEA
HHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCE
IAGEGSIITAGAIDSHIHFICPQQIETALASGVTTMLGGGTGPATGTNATTCTPGAFHIS
ECCCCCEEEECCCCCCEEEECHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
RMLQSAEGFPVNLGFFGKGNATNKAALEEQVRAGACGLKLHEDWGTTPACIDSCLSVADQ
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHC
LDVQVCIHTDTLNEAGFVEDTIKAIKGRTIHTFHTEGAGGGHAPDIIKICGESNVIPSST
CCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCC
NPTRPFTLNTLEEHLDMLMVCHHLDPKIPEDVAFAESRIRRETIAAEDILHDLGAFSIIA
CCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
SDSQAMGRVGEVISRTFQTAHKMKVQRGALPEDNQRNDNHRLKRYISKVTINPAIAHGIS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCH
AHVGSVEVGKLADLVLWKPGFFGIKPDLVVKGGCIAWAQMGDANASIPTPQPVHGRPMFS
HCCCCEEHHHHHHEEEECCCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCCHH
SFGKAISPTCLTFLSENAIDAGVPERLKLERTCAPVKDTRKISKQSMKLNDARPKIEVDP
HHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECC
QTYEVFANGELLTCEPAESLPLAQRYLLL
CEEEEEECCCEEEECCCCCCCHHHHHHCC
>Mature Secondary Structure 
PFKISRQAYAETYGPTKGDRIRLADTDLILEVEQDHTHYGDEVKFGGGKVIRDGMGQSQ
CCCCCHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCCCEEEECCCEEECCCCCCCC
QSRDNGVVDTVITNALILDWWGIVKADIGIKDGKISGIGKAGNPDTQEGVNIIVGASTEA
HHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCE
IAGEGSIITAGAIDSHIHFICPQQIETALASGVTTMLGGGTGPATGTNATTCTPGAFHIS
ECCCCCEEEECCCCCCEEEECHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
RMLQSAEGFPVNLGFFGKGNATNKAALEEQVRAGACGLKLHEDWGTTPACIDSCLSVADQ
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHC
LDVQVCIHTDTLNEAGFVEDTIKAIKGRTIHTFHTEGAGGGHAPDIIKICGESNVIPSST
CCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCC
NPTRPFTLNTLEEHLDMLMVCHHLDPKIPEDVAFAESRIRRETIAAEDILHDLGAFSIIA
CCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
SDSQAMGRVGEVISRTFQTAHKMKVQRGALPEDNQRNDNHRLKRYISKVTINPAIAHGIS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCH
AHVGSVEVGKLADLVLWKPGFFGIKPDLVVKGGCIAWAQMGDANASIPTPQPVHGRPMFS
HCCCCEEHHHHHHEEEECCCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCCHH
SFGKAISPTCLTFLSENAIDAGVPERLKLERTCAPVKDTRKISKQSMKLNDARPKIEVDP
HHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECC
QTYEVFANGELLTCEPAESLPLAQRYLLL
CEEEEEECCCEEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA