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The map label for this gene is bioA [H]

Identifier: 124026577

GI number: 124026577

Start: 1531187

End: 1532512

Strand: Direct

Name: bioA [H]

Synonym: NATL1_18721

Alternate gene names: 124026577

Gene position: 1531187-1532512 (Clockwise)

Preceding gene: 124026576

Following gene: 124026579

Centisome position: 82.11

GC content: 38.84

Gene sequence:

>1326_bases
ATGAAACAAGAGGAAAAACTAAATTTGATGAATGAGAAAGAAAATTCAAATCAAACTATTCAGAATCCTCATATATGGCC
ACCATTCACTCAACTTACATCCTCTAAGCCTCAATTATTGGTTGAAAAAGCCAAAGGTGCCCTTTTACTTCCTAAAGACA
GAGCTCCAATAATCGATGGCATAAGTAGCTGGTGGGTCACCCTTCATGGTCATGCAAATGAATATATTGCTAAGGCTATC
GCAACACAAGCAGAGCAATTAGAACAAATTATCTTTGCAGATTTCACTCATCCTCAAGCTGAGCTATTAGCTAATCGACT
AAGTAAATTAACAGGCCTAGAAAAATTATTCTTTTCAGATAATGGCTCTACAGCAGTAGAAGTAGCTTTAAAAATGGCTC
GTCAATGGTGGAAAAATAAAGGGGATAATAGATCTCAAATCATTGCATTCGAAGGTGCCTACCATGGAGATACATTCGGA
GCTATGGCAGTAGGCGAACGCAATATATTTAGCGAGCCTTTTGATCAAATGCTATTTCCTGTTAGCAGAGTCCCTTGGCC
TGAAACATGGTGGGGGGATGAAGATTTTGAAAGACGAGAGAAGGAGGTTTTAGAAACTCTTGATCACCTCCTAAAGACAC
CAACTATTGCTGTAATTATTGAGCCATTAGTACAAGGGGCTGGAGGGATGCGGATGGTTCGTTCAGAATTTTTAGTAGAA
GTCGAAAAAAGAATTCGCCATGCAAATTCTTTACTTATCACAGATGAAGTATTAACTGGCTTTGGAAGGTGTGGAGAACT
ATTTGCTTTTCAAAGAGCCGGATTAAGGCCAGACCTTATATCACTCTCAAAAGGATTAACCGGTGGATTCCTTCCAATGG
GAGTGACTATGTCCAGTAAAAAGATTTCCGAAGGTTTCCTTGGGGAAGATCCCAAGCAAACCTTTTGGCACGGCCATAGT
TTCACAGCGAATCCATTAGGCTGTGCAGCTGCAAATGCTAGCTTAGATCTTTTAGAAAGATCCCCTCAAAAATATTTAGA
TTTTGAATCACGTCACCTACCACATCTACAAAAAATAGTTAAAGATCCAAGAATTGAATGTCCTAGAATTACAGGAACCA
TTGCTGCTTTTAATATTAAAGTGAAAGGCAACAAAGGGTATTTAAGTTCAGTTGGAAAAATCATGAAAGCGAGTGCATTG
AGTGTTGGTGTTTTCATTAGGCCATTAGGAGATGTAGTTTATCTAATGCCACCACTATGTATCACAGACCAAGAATTAGA
GAAATGCTATTTTGGAATCCAAGAGGGCTTAAATGCTCTATCCTAA

Upstream 100 bases:

>100_bases
GCATAAACAGCAATTAGATCAAAAGCTTAAAAGATACATTCAAAACTAAAATTTTATTTTTTTCTTAATCAAAAGATTAT
TTTGACTTCAATCAAGTTAA

Downstream 100 bases:

>100_bases
GATTTTTTCTTATAAAGACTCTAAGTACTTAGCTATATAATTAATTCTGAAAATTCAACCCTACATCAACCAACTTGGAG
TAAAATCCAAGTTTCCACCT

Product: putative diaminopelargonic acid synthase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKQEEKLNLMNEKENSNQTIQNPHIWPPFTQLTSSKPQLLVEKAKGALLLPKDRAPIIDGISSWWVTLHGHANEYIAKAI
ATQAEQLEQIIFADFTHPQAELLANRLSKLTGLEKLFFSDNGSTAVEVALKMARQWWKNKGDNRSQIIAFEGAYHGDTFG
AMAVGERNIFSEPFDQMLFPVSRVPWPETWWGDEDFERREKEVLETLDHLLKTPTIAVIIEPLVQGAGGMRMVRSEFLVE
VEKRIRHANSLLITDEVLTGFGRCGELFAFQRAGLRPDLISLSKGLTGGFLPMGVTMSSKKISEGFLGEDPKQTFWHGHS
FTANPLGCAAANASLDLLERSPQKYLDFESRHLPHLQKIVKDPRIECPRITGTIAAFNIKVKGNKGYLSSVGKIMKASAL
SVGVFIRPLGDVVYLMPPLCITDQELEKCYFGIQEGLNALS

Sequences:

>Translated_441_residues
MKQEEKLNLMNEKENSNQTIQNPHIWPPFTQLTSSKPQLLVEKAKGALLLPKDRAPIIDGISSWWVTLHGHANEYIAKAI
ATQAEQLEQIIFADFTHPQAELLANRLSKLTGLEKLFFSDNGSTAVEVALKMARQWWKNKGDNRSQIIAFEGAYHGDTFG
AMAVGERNIFSEPFDQMLFPVSRVPWPETWWGDEDFERREKEVLETLDHLLKTPTIAVIIEPLVQGAGGMRMVRSEFLVE
VEKRIRHANSLLITDEVLTGFGRCGELFAFQRAGLRPDLISLSKGLTGGFLPMGVTMSSKKISEGFLGEDPKQTFWHGHS
FTANPLGCAAANASLDLLERSPQKYLDFESRHLPHLQKIVKDPRIECPRITGTIAAFNIKVKGNKGYLSSVGKIMKASAL
SVGVFIRPLGDVVYLMPPLCITDQELEKCYFGIQEGLNALS
>Mature_441_residues
MKQEEKLNLMNEKENSNQTIQNPHIWPPFTQLTSSKPQLLVEKAKGALLLPKDRAPIIDGISSWWVTLHGHANEYIAKAI
ATQAEQLEQIIFADFTHPQAELLANRLSKLTGLEKLFFSDNGSTAVEVALKMARQWWKNKGDNRSQIIAFEGAYHGDTFG
AMAVGERNIFSEPFDQMLFPVSRVPWPETWWGDEDFERREKEVLETLDHLLKTPTIAVIIEPLVQGAGGMRMVRSEFLVE
VEKRIRHANSLLITDEVLTGFGRCGELFAFQRAGLRPDLISLSKGLTGGFLPMGVTMSSKKISEGFLGEDPKQTFWHGHS
FTANPLGCAAANASLDLLERSPQKYLDFESRHLPHLQKIVKDPRIECPRITGTIAAFNIKVKGNKGYLSSVGKIMKASAL
SVGVFIRPLGDVVYLMPPLCITDQELEKCYFGIQEGLNALS

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=403, Percent_Identity=24.8138957816377, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI13994255, Length=349, Percent_Identity=27.5071633237822, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI37574042, Length=333, Percent_Identity=26.4264264264264, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI226442705, Length=333, Percent_Identity=26.1261261261261, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226442709, Length=283, Percent_Identity=27.5618374558304, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=25.3086419753086, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI24119277, Length=314, Percent_Identity=24.5222929936306, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786991, Length=410, Percent_Identity=36.3414634146341, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI145693181, Length=323, Percent_Identity=30.6501547987616, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=27.4074074074074, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788044, Length=394, Percent_Identity=26.9035532994924, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789016, Length=376, Percent_Identity=29.2553191489362, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=25.5369928400955, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1786349, Length=308, Percent_Identity=26.2987012987013, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=394, Percent_Identity=24.3654822335025, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=443, Percent_Identity=23.9277652370203, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=228, Percent_Identity=28.0701754385965, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=452, Percent_Identity=30.9734513274336, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=28.4313725490196, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=25.531914893617, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=24.8743718592965, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356575, Length=464, Percent_Identity=24.5689655172414, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28574759, Length=296, Percent_Identity=24.6621621621622, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161085790, Length=296, Percent_Identity=24.6621621621622, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49288; Mature: 49288

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQEEKLNLMNEKENSNQTIQNPHIWPPFTQLTSSKPQLLVEKAKGALLLPKDRAPIIDG
CCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCEEECCCCCCHHHC
ISSWWVTLHGHANEYIAKAIATQAEQLEQIIFADFTHPQAELLANRLSKLTGLEKLFFSD
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECC
NGSTAVEVALKMARQWWKNKGDNRSQIIAFEGAYHGDTFGAMAVGERNIFSEPFDQMLFP
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHCCCCCHHHCCCHHHHHHH
VSRVPWPETWWGDEDFERREKEVLETLDHLLKTPTIAVIIEPLVQGAGGMRMVRSEFLVE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHH
VEKRIRHANSLLITDEVLTGFGRCGELFAFQRAGLRPDLISLSKGLTGGFLPMGVTMSSK
HHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCEEECCH
KISEGFLGEDPKQTFWHGHSFTANPLGCAAANASLDLLERSPQKYLDFESRHLPHLQKIV
HHHCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCHHHHHHCCHHHHHCCCCCCCHHHHHHH
KDPRIECPRITGTIAAFNIKVKGNKGYLSSVGKIMKASALSVGVFIRPLGDVVYLMPPLC
CCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ITDQELEKCYFGIQEGLNALS
CCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQEEKLNLMNEKENSNQTIQNPHIWPPFTQLTSSKPQLLVEKAKGALLLPKDRAPIIDG
CCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHCCCCEEECCCCCCHHHC
ISSWWVTLHGHANEYIAKAIATQAEQLEQIIFADFTHPQAELLANRLSKLTGLEKLFFSD
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEECC
NGSTAVEVALKMARQWWKNKGDNRSQIIAFEGAYHGDTFGAMAVGERNIFSEPFDQMLFP
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHCCCCCHHHCCCHHHHHHH
VSRVPWPETWWGDEDFERREKEVLETLDHLLKTPTIAVIIEPLVQGAGGMRMVRSEFLVE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHH
VEKRIRHANSLLITDEVLTGFGRCGELFAFQRAGLRPDLISLSKGLTGGFLPMGVTMSSK
HHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCEEECCH
KISEGFLGEDPKQTFWHGHSFTANPLGCAAANASLDLLERSPQKYLDFESRHLPHLQKIV
HHHCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCHHHHHHCCHHHHHCCCCCCCHHHHHHH
KDPRIECPRITGTIAAFNIKVKGNKGYLSSVGKIMKASALSVGVFIRPLGDVVYLMPPLC
CCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ITDQELEKCYFGIQEGLNALS
CCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]