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The map label for this gene is acoA [H]

Identifier: 124026413

GI number: 124026413

Start: 1393083

End: 1394177

Strand: Direct

Name: acoA [H]

Synonym: NATL1_17081

Alternate gene names: 124026413

Gene position: 1393083-1394177 (Clockwise)

Preceding gene: 124026407

Following gene: 124026416

Centisome position: 74.71

GC content: 41.55

Gene sequence:

>1095_bases
GTGAATATGAACGAAGTCATGTCTCACAACCAGGACAAAACAGGCCAAGACCCTATTCAGCACAGGGAACACGCCGACAG
GCTAAGCAATCTTGGCAACACCAAACCAGCTCAAATCAATAGAGAAATTGGTTTAAATCTTTTCAAAGATATGACTTTGG
GAAGACGATTTGAAGATAAATGCGCTGAAATGTATTACAGAGGGAAGATGTTTGGGTTTGTTCATCTTTACAACGGGCAA
GAAGCAATAAGTACAGGTGTTATTGGTGCGATGAAACGCAAACACGACTGGTTTTGCAGTACCTACAGAGATCATGTTCA
TGCTTTGAGTGCTGGAGTGCCTGCGAAAGAGGTGATGAGCGAGCTATTTGGGAAAGAGACAGGTTGCAGCAAAGGCAGAG
GTGGATCTATGCATCTGTTCTCTAAAGAACATCACCTACTTGGAGGTTATGCCTTTATTGGTGAAGGTATTCCAGTTGCC
CTTGGAGCAGCTTTCAGCAGTAAATACAAAAGAGAGGCTCTTAAAGAAAGTAGTGATTCTGTAACTGCAGCATTTTTTGG
AGATGGTACTTGCAATATTGGTCAGTTTTATGAATGTTTAAATATGGCCCAGCTATGGAAATTACCGATCATATTTGTAG
TCGAAAATAATAAATGGGCTATTGGGATGGCCCATGACAGAGCAACTAGTGAGACAGAAATATGGAGAAAAGCTTCAGCA
TTTGGCATGCACGGAGAAGAGATTGACGGTATGGACGTTTTAGCAGTAAGAGGGGCTGCCGAAAGGGCCCTAGAGCGGGC
AAGAGCTGGAGAAGGCCCCACTTTGATAGAATGCCTCACTTACAGATTCAGGGGGCATTCATTAGCTGACCCAGACGAGC
TTAGATCTGAAAAGGAAAAGGAATTCTGGGCTAAAAGAGATCCAATTAAAAAGTTAAAAAATGATTTAACTAGTTCTGGC
TTAGTCTCTGATGAAGAATTAAAAAATATTGAGAAAGAAATTGATCTAGAAGTTAACGATGCTGTTGAATTTGCTTTAAA
CGCCCCAGAGCCTGACCCTAGTGAGTTAACAAAATATATTTGGGCAGAAAACTAA

Upstream 100 bases:

>100_bases
TCCAATCGCTACTAGGTAATCAGAAAAAAGCTCTAGGCATCGTAAGGGGTTTTAACCATTTTGCATCCATTGACGCTTAA
AGTCTAAAAAGGATTGATAA

Downstream 100 bases:

>100_bases
AATTAGATAAAAAATCAAATTCCACTTGGAAGCTTTCTAGTGAGATTTCTCAATTTCCTTAAAGCTTTTAGCTCAACTTG
CCTTACCCTCTCGCGTGAAA

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MNMNEVMSHNQDKTGQDPIQHREHADRLSNLGNTKPAQINREIGLNLFKDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQ
EAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPAKEVMSELFGKETGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVA
LGAAFSSKYKREALKESSDSVTAAFFGDGTCNIGQFYECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSETEIWRKASA
FGMHGEEIDGMDVLAVRGAAERALERARAGEGPTLIECLTYRFRGHSLADPDELRSEKEKEFWAKRDPIKKLKNDLTSSG
LVSDEELKNIEKEIDLEVNDAVEFALNAPEPDPSELTKYIWAEN

Sequences:

>Translated_364_residues
MNMNEVMSHNQDKTGQDPIQHREHADRLSNLGNTKPAQINREIGLNLFKDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQ
EAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPAKEVMSELFGKETGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVA
LGAAFSSKYKREALKESSDSVTAAFFGDGTCNIGQFYECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSETEIWRKASA
FGMHGEEIDGMDVLAVRGAAERALERARAGEGPTLIECLTYRFRGHSLADPDELRSEKEKEFWAKRDPIKKLKNDLTSSG
LVSDEELKNIEKEIDLEVNDAVEFALNAPEPDPSELTKYIWAEN
>Mature_364_residues
MNMNEVMSHNQDKTGQDPIQHREHADRLSNLGNTKPAQINREIGLNLFKDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQ
EAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPAKEVMSELFGKETGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVA
LGAAFSSKYKREALKESSDSVTAAFFGDGTCNIGQFYECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSETEIWRKASA
FGMHGEEIDGMDVLAVRGAAERALERARAGEGPTLIECLTYRFRGHSLADPDELRSEKEKEFWAKRDPIKKLKNDLTSSG
LVSDEELKNIEKEIDLEVNDAVEFALNAPEPDPSELTKYIWAEN

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=328, Percent_Identity=36.890243902439, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI4505685, Length=328, Percent_Identity=38.109756097561, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI291084742, Length=328, Percent_Identity=38.109756097561, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI291084744, Length=335, Percent_Identity=37.3134328358209, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI291084757, Length=328, Percent_Identity=34.7560975609756, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI11386135, Length=341, Percent_Identity=29.0322580645161, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI258645172, Length=346, Percent_Identity=29.1907514450867, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=337, Percent_Identity=37.0919881305638, Blast_Score=220, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI32564172, Length=337, Percent_Identity=37.0919881305638, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI86563357, Length=343, Percent_Identity=27.1137026239067, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI86563355, Length=343, Percent_Identity=27.1137026239067, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321026, Length=310, Percent_Identity=37.741935483871, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24639744, Length=335, Percent_Identity=36.1194029850746, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28571106, Length=335, Percent_Identity=36.1194029850746, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24639740, Length=335, Percent_Identity=36.1194029850746, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24639748, Length=335, Percent_Identity=36.4179104477612, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24639746, Length=312, Percent_Identity=37.5, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI21355903, Length=308, Percent_Identity=25.974025974026, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40833; Mature: 40833

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMNEVMSHNQDKTGQDPIQHREHADRLSNLGNTKPAQINREIGLNLFKDMTLGRRFEDK
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
CAEMYYRGKMFGFVHLYNGQEAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPAKEVMS
HHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ELFGKETGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSKYKREALKESSDS
HHHCCCCCCCCCCCCCEEEECCCCHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
VTAAFFGDGTCNIGQFYECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSETEIWRKASA
EEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHH
FGMHGEEIDGMDVLAVRGAAERALERARAGEGPTLIECLTYRFRGHSLADPDELRSEKEK
CCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
EFWAKRDPIKKLKNDLTSSGLVSDEELKNIEKEIDLEVNDAVEFALNAPEPDPSELTKYI
HHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHEEECCCCCCHHHHHHHH
WAEN
HCCC
>Mature Secondary Structure
MNMNEVMSHNQDKTGQDPIQHREHADRLSNLGNTKPAQINREIGLNLFKDMTLGRRFEDK
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
CAEMYYRGKMFGFVHLYNGQEAISTGVIGAMKRKHDWFCSTYRDHVHALSAGVPAKEVMS
HHHHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ELFGKETGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSKYKREALKESSDS
HHHCCCCCCCCCCCCCEEEECCCCHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
VTAAFFGDGTCNIGQFYECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSETEIWRKASA
EEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHH
FGMHGEEIDGMDVLAVRGAAERALERARAGEGPTLIECLTYRFRGHSLADPDELRSEKEK
CCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
EFWAKRDPIKKLKNDLTSSGLVSDEELKNIEKEIDLEVNDAVEFALNAPEPDPSELTKYI
HHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHEEECCCCCCHHHHHHHH
WAEN
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]