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The map label for this gene is ribD [H]

Identifier: 124026389

GI number: 124026389

Start: 1372716

End: 1373768

Strand: Reverse

Name: ribD [H]

Synonym: NATL1_16841

Alternate gene names: 124026389

Gene position: 1373768-1372716 (Counterclockwise)

Preceding gene: 124026390

Following gene: 124026388

Centisome position: 73.67

GC content: 40.46

Gene sequence:

>1053_bases
ATGAGACGCTCAATCCAACTGGCTTTATTAGCAGAAGGTAGGACAAGCCCAAACCCCCTAGTAGGATCTGTTGTTTTGGA
TTCAAATGGAAGACTTGTTGGAGAGGGATTTCATACAGGCGCAGGGAATCCTCATGCTGAAATAGAAGCACTTGCTCAGG
CGGGAAAGAAGTCGCTGGATGGAACAATTGTTGTAACTTTAGAACCCTGTTGTCATCAAGGCTTAACACCTCCCTGCACA
GAAGCAATAATCAAAGCAGGTCTAAAGAAAGTTGTTGTTGGGATGGTCGATCCTGATCCAAGAGTTTCAGGTAATGGAAT
CTCAAGATTGAAAGACTCTGGACTTGAAGTAATCGAGGGTGTTTTGAGTCAAGAATGTGAATCAATAAATCGCGAATTTA
GTTTTCGAGTTCGTCATGGACGTCCTTGGGGAATTCTTAAATGGGCAATGAGCTTAGATGGGAAAATTGGCTTGCCAAAT
GGTTGTAGCAAGTGGATTACAGATATTCCTGCAAGGGATTCGGTTCATAGAATTCGATCTAAGTGCGATGCAGTAATAGT
TGGAGGAGGAACAGTTCGGGCCGATAATCCACTTTTAACTTCTAGGGGGAAATCAGATTTTGAACCGTTAAGGGTTGTTT
TTTCAAGAACTTTGAACTTGCCTCAATCTGCAAAACTTTGGGATACAAAAATCGCTAGAACATTAGTTGCTTATGGACCA
GAGGGTGATGAATCTTTCTTTTCTGATTTGCTAGATGGTCCAGAAAAATTGAGATTAAATTCGGATAATCCATCCGAATT
GCTTTCCTCACTTGCGAAAAAAGGCTGCAATAAAATTCTTTGGGAATGCGGTCCTCAACTTGCTACAAGTGCAATCGAAG
CAAATTGTGTTCAGGAATTAGTAGTTTTTGTAGCACCAAAACTCTTAGGAGGGATGTCTTCGATGAGTCCTTTGAACAAC
TTTGGATTTGAATCAATAAGTTCTTCCTATAAATTGCAACATTCTTTTTTAGATCGAAAAGGAGAAGACATCTGTTGGAG
ACTGATTTTTTAG

Upstream 100 bases:

>100_bases
ATGATTTACCAATCCCTCCCTACTTAGTAAGGGAATGGAGATCATTGGCTGAATAAAAATGATTAATTTGGCTGAGGATC
AAAAAATTTGGGTGCCATGG

Downstream 100 bases:

>100_bases
GGGGTTAATTTTTTAGAATTAGATATTCGTTCGGATCTCCCTCCAGTTAAACAAGACGATTTGGGATGAAAATTGTTTAA
CTTAGGTTTAATTAAATTTT

Product: putative diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRRSIQLALLAEGRTSPNPLVGSVVLDSNGRLVGEGFHTGAGNPHAEIEALAQAGKKSLDGTIVVTLEPCCHQGLTPPCT
EAIIKAGLKKVVVGMVDPDPRVSGNGISRLKDSGLEVIEGVLSQECESINREFSFRVRHGRPWGILKWAMSLDGKIGLPN
GCSKWITDIPARDSVHRIRSKCDAVIVGGGTVRADNPLLTSRGKSDFEPLRVVFSRTLNLPQSAKLWDTKIARTLVAYGP
EGDESFFSDLLDGPEKLRLNSDNPSELLSSLAKKGCNKILWECGPQLATSAIEANCVQELVVFVAPKLLGGMSSMSPLNN
FGFESISSSYKLQHSFLDRKGEDICWRLIF

Sequences:

>Translated_350_residues
MRRSIQLALLAEGRTSPNPLVGSVVLDSNGRLVGEGFHTGAGNPHAEIEALAQAGKKSLDGTIVVTLEPCCHQGLTPPCT
EAIIKAGLKKVVVGMVDPDPRVSGNGISRLKDSGLEVIEGVLSQECESINREFSFRVRHGRPWGILKWAMSLDGKIGLPN
GCSKWITDIPARDSVHRIRSKCDAVIVGGGTVRADNPLLTSRGKSDFEPLRVVFSRTLNLPQSAKLWDTKIARTLVAYGP
EGDESFFSDLLDGPEKLRLNSDNPSELLSSLAKKGCNKILWECGPQLATSAIEANCVQELVVFVAPKLLGGMSSMSPLNN
FGFESISSSYKLQHSFLDRKGEDICWRLIF
>Mature_350_residues
MRRSIQLALLAEGRTSPNPLVGSVVLDSNGRLVGEGFHTGAGNPHAEIEALAQAGKKSLDGTIVVTLEPCCHQGLTPPCT
EAIIKAGLKKVVVGMVDPDPRVSGNGISRLKDSGLEVIEGVLSQECESINREFSFRVRHGRPWGILKWAMSLDGKIGLPN
GCSKWITDIPARDSVHRIRSKCDAVIVGGGTVRADNPLLTSRGKSDFEPLRVVFSRTLNLPQSAKLWDTKIARTLVAYGP
EGDESFFSDLLDGPEKLRLNSDNPSELLSSLAKKGCNKILWECGPQLATSAIEANCVQELVVFVAPKLLGGMSSMSPLNN
FGFESISSSYKLQHSFLDRKGEDICWRLIF

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=366, Percent_Identity=35.792349726776, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI145693172, Length=152, Percent_Identity=34.8684210526316, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 37905; Mature: 37905

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSIQLALLAEGRTSPNPLVGSVVLDSNGRLVGEGFHTGAGNPHAEIEALAQAGKKSLD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCC
GTIVVTLEPCCHQGLTPPCTEAIIKAGLKKVVVGMVDPDPRVSGNGISRLKDSGLEVIEG
CEEEEEECHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHH
VLSQECESINREFSFRVRHGRPWGILKWAMSLDGKIGLPNGCSKWITDIPARDSVHRIRS
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHHHHHH
KCDAVIVGGGTVRADNPLLTSRGKSDFEPLRVVFSRTLNLPQSAKLWDTKIARTLVAYGP
HCCEEEECCCEEECCCCEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
EGDESFFSDLLDGPEKLRLNSDNPSELLSSLAKKGCNKILWECGPQLATSAIEANCVQEL
CCCHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VVFVAPKLLGGMSSMSPLNNFGFESISSSYKLQHSFLDRKGEDICWRLIF
HHHHHHHHHCCCHHCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MRRSIQLALLAEGRTSPNPLVGSVVLDSNGRLVGEGFHTGAGNPHAEIEALAQAGKKSLD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCC
GTIVVTLEPCCHQGLTPPCTEAIIKAGLKKVVVGMVDPDPRVSGNGISRLKDSGLEVIEG
CEEEEEECHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHH
VLSQECESINREFSFRVRHGRPWGILKWAMSLDGKIGLPNGCSKWITDIPARDSVHRIRS
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHHHHHH
KCDAVIVGGGTVRADNPLLTSRGKSDFEPLRVVFSRTLNLPQSAKLWDTKIARTLVAYGP
HCCEEEECCCEEECCCCEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
EGDESFFSDLLDGPEKLRLNSDNPSELLSSLAKKGCNKILWECGPQLATSAIEANCVQEL
CCCHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VVFVAPKLLGGMSSMSPLNNFGFESISSSYKLQHSFLDRKGEDICWRLIF
HHHHHHHHHCCCHHCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]