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The map label for this gene is acrA [H]

Identifier: 124026293

GI number: 124026293

Start: 1294157

End: 1295230

Strand: Direct

Name: acrA [H]

Synonym: NATL1_15871

Alternate gene names: 124026293

Gene position: 1294157-1295230 (Clockwise)

Preceding gene: 124026287

Following gene: 124026294

Centisome position: 69.4

GC content: 37.8

Gene sequence:

>1074_bases
ATGATTTGGAAAAACTTAAAAAAGAAAAAAGTTATAGGCCTTATTGCACTTTCGGCCTTAAGTGTTGGTGGAATTAGTTT
TAAACTTTCACAAGATAATGCATCGAATAAAGACATAACTGAATTTACAATTGCTGCTGAAAGCGGCAGTTTGCCTGGTT
TGATAACAGCAAGTGGTGAATTAAAAGCAAATAAAAGCGTAAATGTAAGCCCAAAAAGACAAGGAATACTTAACGAAATT
TTCGTGGAGGAAGGAGATCAGGTTAAGAAAGGTGATCTAATTGCGAAAATGGATTTTGGAGACTTGGAATTTAGAATTGA
AGAGATAAAAGCTAATTATGAGACTCAAAAAGCAAGCTTTAAAAGAAGGGAGATGCTTTTTAATGAAGGAGCCATAAGTG
CTGAAGAGTATGAAGAATATAAAAATAGATTTTTAAAAAGCAAAGCCAGATTCAAACAAATAGAAGTCGAAGAGAATGAG
ACAAGCATTAGAGCACCATTTAGAGGAGTAATAACCAGCAGATACGCAGTCCCAGGGGCATTCGTAACTCCTACGACCTC
TGCATCTTCCTCAAGAGAGGGTGGGGCTACAAGTTCATCAATCGTCAAGCTTTCCCAAGGTCTTGAAATAGTTGCGAAAG
TTCCTGAGAGTGATATTGGAAGAATCAAAACAGGTCAGGAAGCAAGTATCAGAGTAGATGCTTTTCCTGATAAGCGTTTT
AAAGCAGTTGTCTCCAAAATCTCTCCAAGTGCAATCAAGAACAACAACGTAACTTCCTTTGAAGTTACGTTGTTGTTGGA
GAATAGACCTCAAGATTTACGCCTTGGCATGACATCTGATATCAACTTTCAAACTGGAGCGACCAAAATCAGCACGCTTA
TTCCAACAGTAGCAATTGTCACAGAAGAAGGGAGAACTGGAGTTCTAATAGTCGGGAATAAGAATCAACCAGAGTTTAAA
AAAGTTGAATTAGGTACAAGCAGTGGCAGTAAGACTGCCATAATATCTGGGTTAGAACCTGGGGAGAAAGTTTTTATTGA
TCTTCCTTCTTGGGCAAAAAAAAGAGAGCGTTAA

Upstream 100 bases:

>100_bases
ACAGCGAAAATATTGTTATAAATCTCTTAAGGAAAGTTTTTAAGCTTTTTCTCTTCATCGTCCAAACTTCTAAAACTCTT
GAGTACTTGATTTTCACAAA

Downstream 100 bases:

>100_bases
TAGATTAATCACACTTCGACTGATTCATGACAGAAATAAAAAAGCCAACTTTATTATTGGTTGATGGCCATTCACTAGCC
TTTAGAAGTTTTTATGCTTT

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MIWKNLKKKKVIGLIALSALSVGGISFKLSQDNASNKDITEFTIAAESGSLPGLITASGELKANKSVNVSPKRQGILNEI
FVEEGDQVKKGDLIAKMDFGDLEFRIEEIKANYETQKASFKRREMLFNEGAISAEEYEEYKNRFLKSKARFKQIEVEENE
TSIRAPFRGVITSRYAVPGAFVTPTTSASSSREGGATSSSIVKLSQGLEIVAKVPESDIGRIKTGQEASIRVDAFPDKRF
KAVVSKISPSAIKNNNVTSFEVTLLLENRPQDLRLGMTSDINFQTGATKISTLIPTVAIVTEEGRTGVLIVGNKNQPEFK
KVELGTSSGSKTAIISGLEPGEKVFIDLPSWAKKRER

Sequences:

>Translated_357_residues
MIWKNLKKKKVIGLIALSALSVGGISFKLSQDNASNKDITEFTIAAESGSLPGLITASGELKANKSVNVSPKRQGILNEI
FVEEGDQVKKGDLIAKMDFGDLEFRIEEIKANYETQKASFKRREMLFNEGAISAEEYEEYKNRFLKSKARFKQIEVEENE
TSIRAPFRGVITSRYAVPGAFVTPTTSASSSREGGATSSSIVKLSQGLEIVAKVPESDIGRIKTGQEASIRVDAFPDKRF
KAVVSKISPSAIKNNNVTSFEVTLLLENRPQDLRLGMTSDINFQTGATKISTLIPTVAIVTEEGRTGVLIVGNKNQPEFK
KVELGTSSGSKTAIISGLEPGEKVFIDLPSWAKKRER
>Mature_357_residues
MIWKNLKKKKVIGLIALSALSVGGISFKLSQDNASNKDITEFTIAAESGSLPGLITASGELKANKSVNVSPKRQGILNEI
FVEEGDQVKKGDLIAKMDFGDLEFRIEEIKANYETQKASFKRREMLFNEGAISAEEYEEYKNRFLKSKARFKQIEVEENE
TSIRAPFRGVITSRYAVPGAFVTPTTSASSSREGGATSSSIVKLSQGLEIVAKVPESDIGRIKTGQEASIRVDAFPDKRF
KAVVSKISPSAIKNNNVTSFEVTLLLENRPQDLRLGMTSDINFQTGATKISTLIPTVAIVTEEGRTGVLIVGNKNQPEFK
KVELGTSSGSKTAIISGLEPGEKVFIDLPSWAKKRER

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=373, Percent_Identity=24.9329758713137, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39028; Mature: 39028

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWKNLKKKKVIGLIALSALSVGGISFKLSQDNASNKDITEFTIAAESGSLPGLITASGE
CCCCCCCHHHHHHHEEEHHHEECCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCC
LKANKSVNVSPKRQGILNEIFVEEGDQVKKGDLIAKMDFGDLEFRIEEIKANYETQKASF
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEHHCCCHHHHHHH
KRREMLFNEGAISAEEYEEYKNRFLKSKARFKQIEVEENETSIRAPFRGVITSRYAVPGA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEECCCHHHHHHHCEECCCC
FVTPTTSASSSREGGATSSSIVKLSQGLEIVAKVPESDIGRIKTGQEASIRVDAFPDKRF
EECCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCHHH
KAVVSKISPSAIKNNNVTSFEVTLLLENRPQDLRLGMTSDINFQTGATKISTLIPTVAIV
HHHHHHCCCCHHCCCCCEEEEEEEEEECCCCCEEECCCCCCCCCCCCHHHHHHHCEEEEE
TEEGRTGVLIVGNKNQPEFKKVELGTSSGSKTAIISGLEPGEKVFIDLPSWAKKRER
ECCCCEEEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEECCHHHHHCCC
>Mature Secondary Structure
MIWKNLKKKKVIGLIALSALSVGGISFKLSQDNASNKDITEFTIAAESGSLPGLITASGE
CCCCCCCHHHHHHHEEEHHHEECCEEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCC
LKANKSVNVSPKRQGILNEIFVEEGDQVKKGDLIAKMDFGDLEFRIEEIKANYETQKASF
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEHHCCCHHHHHHH
KRREMLFNEGAISAEEYEEYKNRFLKSKARFKQIEVEENETSIRAPFRGVITSRYAVPGA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEECCCHHHHHHHCEECCCC
FVTPTTSASSSREGGATSSSIVKLSQGLEIVAKVPESDIGRIKTGQEASIRVDAFPDKRF
EECCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCHHH
KAVVSKISPSAIKNNNVTSFEVTLLLENRPQDLRLGMTSDINFQTGATKISTLIPTVAIV
HHHHHHCCCCHHCCCCCEEEEEEEEEECCCCCEEECCCCCCCCCCCCHHHHHHHCEEEEE
TEEGRTGVLIVGNKNQPEFKKVELGTSSGSKTAIISGLEPGEKVFIDLPSWAKKRER
ECCCCEEEEEEECCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]