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The map label for this gene is zwf [H]

Identifier: 124026215

GI number: 124026215

Start: 1222696

End: 1224219

Strand: Direct

Name: zwf [H]

Synonym: NATL1_15091

Alternate gene names: 124026215

Gene position: 1222696-1224219 (Clockwise)

Preceding gene: 124026214

Following gene: 124026217

Centisome position: 65.57

GC content: 39.9

Gene sequence:

>1524_bases
ATGAGCATGCCAGTAACAAATCCATTGAGAATAGGGCTTCGCCAAGAGCGAGTAGTACCTCCTCAATGTCTGGTTATATT
TGGGGCCTCTGGAGATCTAACACACAGGAAACTTGTTCCTGCTCTATTTGAACTCTTTAAGCAAAGAAGATTACCAAGTG
AGTTTGCCGTTTTAGGCTGTGCGAGAAGGCCTTGGACTGATGAAATATTTAAAGAAAAAATGGAAGAAGCTCTTTCTTCT
CAAATAAAAGAAAGTCCAAAAGAGTGGGAATTATTTTCTCAAAATCTTTTTTATGAGCCTGTAGATCTGCAACAACCTGA
ACACCTAGTAAAACTTGGAGAAAGACTTGAAATAATTGACAAACTAAAAGCGACTCACGGTCATCGAACTTTTTACCTTT
CAGTATCTCCGAAGTTCTATGGAAGTGGATGCAGAGCTTTAGCTGCAGCAGGATTATTGAAAGATCCAAAACGAAGTAGG
GTCGTAATCGAAAAACCCTTTGGAAGAGATTTCAATAGCGCTCAGTCACTGAATTCTCTCGTTCAGGGGTGTGCCCAAGA
AAGTCAAATATTTCGAATAGATCATTATTTAGGTAAAGAAACAGTTCAAAATATTCTTGTTCTCCGATTTGCAAACACGA
TCTTTGAACCTATTTGGAATAGAAATTATATCTCGAGTGTTCAAATTACCAGTTCTGAAACAGTTGGAGTTGAAGATCGA
GCTGGATATTACGAATCTTCAGGCGCCTTAAGAGATATGGTTCAAAATCATCTAACTCAAATGCTTGCTCTAACAGCAAT
GGAACCACCTGGGCATTTTGATCCAGAAGCCATAAGAAATGAAAAAGCTAAAGTTCTTCAGGCAGTTAAGCTTGCGAATG
AAGAAAAGCCTTGGGAATGTTGCGTTAGAGGTCAATATTCAAAGGGAGGTAGCGATGAAGAACCACTCTTAGGTTATAGA
GATGAACCAGGTGTTAATCCAAACAGCACAACCGAAACATATGTAGCTATGAAGCTTTTCATAGATAATTGGAGATGGCA
GGGGGTCCCTTTTTATGTAAGGACCGGAAAACGTTTAGCTAAAAGGCTTAGTGAGGTTGTTCTCACATTTAGAGAAGCAC
CTGTTCACCTTTTTGATGCTGCAGGGGGGTGCCCAACTTCAAACCAATTAATTCTTAGAATTCAACCCAACGAAGGGGCT
GAATTTAGTTTTGAGGTTAAATCTCCAGGGTCTGGGATGAGAAGTAGACCTGTAAATATGGAGTTTTCCTATGATGAATC
CTTTGGAGAACCATCAGATGAAGGTTATGTGAGACTCCTTGCTGATGCAATGCTCGGAGATCCAACATTGTTTACTCGAA
GCGATGAAGTAGAGGCTGCTTGGCGTTTATATACTCCTCTACTTGAAAAGATTGAGGATTCTCCTTGGGAATTACCAATT
TATCCATATGAATCAAGAACATGGGGGCCTACTGAATCAGACTTACTTATTGGCAAAGATCAACTTCTATGGAGAAGACC
TTGA

Upstream 100 bases:

>100_bases
TATCAATTTTGTTTTTAGGCATCCGTCCACCGAAAATGGAGGAATGTATGGAAGCAACTTGAATTTAATATTTCTCATCT
GATTGGCAAGGAATTTATTA

Downstream 100 bases:

>100_bases
AAAAATTGAATCCAATTCTTTTATTTGAACCAAATTAGATGTCTCCTCAATTAACCCTACAAACACCCCTTCAGTTACCT
CCAACAGAAATTCCTACCTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSMPVTNPLRIGLRQERVVPPQCLVIFGASGDLTHRKLVPALFELFKQRRLPSEFAVLGCARRPWTDEIFKEKMEEALSS
QIKESPKEWELFSQNLFYEPVDLQQPEHLVKLGERLEIIDKLKATHGHRTFYLSVSPKFYGSGCRALAAAGLLKDPKRSR
VVIEKPFGRDFNSAQSLNSLVQGCAQESQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITSSETVGVEDR
AGYYESSGALRDMVQNHLTQMLALTAMEPPGHFDPEAIRNEKAKVLQAVKLANEEKPWECCVRGQYSKGGSDEEPLLGYR
DEPGVNPNSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGCPTSNQLILRIQPNEGA
EFSFEVKSPGSGMRSRPVNMEFSYDESFGEPSDEGYVRLLADAMLGDPTLFTRSDEVEAAWRLYTPLLEKIEDSPWELPI
YPYESRTWGPTESDLLIGKDQLLWRRP

Sequences:

>Translated_507_residues
MSMPVTNPLRIGLRQERVVPPQCLVIFGASGDLTHRKLVPALFELFKQRRLPSEFAVLGCARRPWTDEIFKEKMEEALSS
QIKESPKEWELFSQNLFYEPVDLQQPEHLVKLGERLEIIDKLKATHGHRTFYLSVSPKFYGSGCRALAAAGLLKDPKRSR
VVIEKPFGRDFNSAQSLNSLVQGCAQESQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITSSETVGVEDR
AGYYESSGALRDMVQNHLTQMLALTAMEPPGHFDPEAIRNEKAKVLQAVKLANEEKPWECCVRGQYSKGGSDEEPLLGYR
DEPGVNPNSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGCPTSNQLILRIQPNEGA
EFSFEVKSPGSGMRSRPVNMEFSYDESFGEPSDEGYVRLLADAMLGDPTLFTRSDEVEAAWRLYTPLLEKIEDSPWELPI
YPYESRTWGPTESDLLIGKDQLLWRRP
>Mature_506_residues
SMPVTNPLRIGLRQERVVPPQCLVIFGASGDLTHRKLVPALFELFKQRRLPSEFAVLGCARRPWTDEIFKEKMEEALSSQ
IKESPKEWELFSQNLFYEPVDLQQPEHLVKLGERLEIIDKLKATHGHRTFYLSVSPKFYGSGCRALAAAGLLKDPKRSRV
VIEKPFGRDFNSAQSLNSLVQGCAQESQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITSSETVGVEDRA
GYYESSGALRDMVQNHLTQMLALTAMEPPGHFDPEAIRNEKAKVLQAVKLANEEKPWECCVRGQYSKGGSDEEPLLGYRD
EPGVNPNSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGCPTSNQLILRIQPNEGAE
FSFEVKSPGSGMRSRPVNMEFSYDESFGEPSDEGYVRLLADAMLGDPTLFTRSDEVEAAWRLYTPLLEKIEDSPWELPIY
PYESRTWGPTESDLLIGKDQLLWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=36.5904365904366, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=36.5904365904366, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI52145310, Length=492, Percent_Identity=29.4715447154472, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=38.6503067484663, Blast_Score=349, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI17538218, Length=509, Percent_Identity=35.1669941060904, Blast_Score=302, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=35.6846473029046, Blast_Score=279, Evalue=9e-76,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=37.2384937238494, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=37.2384937238494, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI221513548, Length=470, Percent_Identity=29.5744680851064, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57690; Mature: 57559

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMPVTNPLRIGLRQERVVPPQCLVIFGASGDLTHRKLVPALFELFKQRRLPSEFAVLGC
CCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHC
ARRPWTDEIFKEKMEEALSSQIKESPKEWELFSQNLFYEPVDLQQPEHLVKLGERLEIID
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
KLKATHGHRTFYLSVSPKFYGSGCRALAAAGLLKDPKRSRVVIEKPFGRDFNSAQSLNSL
HHHHCCCCEEEEEEECCCHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHH
VQGCAQESQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITSSETVGVEDR
HHHHHHCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
AGYYESSGALRDMVQNHLTQMLALTAMEPPGHFDPEAIRNEKAKVLQAVKLANEEKPWEC
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
CVRGQYSKGGSDEEPLLGYRDEPGVNPNSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCEEECCHHHHH
KRLSEVVLTFREAPVHLFDAAGGCPTSNQLILRIQPNEGAEFSFEVKSPGSGMRSRPVNM
HHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCE
EFSYDESFGEPSDEGYVRLLADAMLGDPTLFTRSDEVEAAWRLYTPLLEKIEDSPWELPI
EECCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
YPYESRTWGPTESDLLIGKDQLLWRRP
ECCCCCCCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
SMPVTNPLRIGLRQERVVPPQCLVIFGASGDLTHRKLVPALFELFKQRRLPSEFAVLGC
CCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHC
ARRPWTDEIFKEKMEEALSSQIKESPKEWELFSQNLFYEPVDLQQPEHLVKLGERLEIID
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
KLKATHGHRTFYLSVSPKFYGSGCRALAAAGLLKDPKRSRVVIEKPFGRDFNSAQSLNSL
HHHHCCCCEEEEEEECCCHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHH
VQGCAQESQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITSSETVGVEDR
HHHHHHCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCC
AGYYESSGALRDMVQNHLTQMLALTAMEPPGHFDPEAIRNEKAKVLQAVKLANEEKPWEC
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
CVRGQYSKGGSDEEPLLGYRDEPGVNPNSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCEEECCHHHHH
KRLSEVVLTFREAPVHLFDAAGGCPTSNQLILRIQPNEGAEFSFEVKSPGSGMRSRPVNM
HHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCE
EFSYDESFGEPSDEGYVRLLADAMLGDPTLFTRSDEVEAAWRLYTPLLEKIEDSPWELPI
EECCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
YPYESRTWGPTESDLLIGKDQLLWRRP
ECCCCCCCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]