Click here to switch to the map view.

The map label for this gene is sasA [H]

Identifier: 124026213

GI number: 124026213

Start: 1219783

End: 1220928

Strand: Direct

Name: sasA [H]

Synonym: NATL1_15071

Alternate gene names: 124026213

Gene position: 1219783-1220928 (Clockwise)

Preceding gene: 124026209

Following gene: 124026214

Centisome position: 65.41

GC content: 38.66

Gene sequence:

>1146_bases
GTGGATAGTGCCGAAGCTAACGACAGACGGCAGTTAAAACTGTTGCTTGTGGCATCTCGCCACCATCTCTCAAGGAGTGA
TATTCGTTTGTCAATTGAATATTTAGAAAGAGAAGATTATGGATTTAATATCACTCTAGATTTTTCAGATCCCTCTGAAA
ACCCAGAATTACTTGAACTTTATAGACTAGTAGCTCTTCCTGCACTAATAAAATTAGAACCTTCGCCTAGACAAGTATTT
GCTGGGAGTTCAATTTTTGAACAAGTTAAAACATGGGTCCCAAGATGGCAACACGAAGGATTAAGTAACTCAATAGGAAT
AAGTCTTAGAGGAAAAACAATAGAATCTGATCAAACACAAAAAGAACTTTTACTAGAGGATGATCTACTAGTTCTGAGAC
AAGAAAATGAGACACTCACTAAAAAAATACACTCCCAAGAAAGCCTATTGAGAATGGTTGCTCATGAATTGAGAACTCCA
TTAACCGCCGCTGGATTAGCTCTCCAAAGCCAAAAGCTTGGTCAAATAAGCATGACTAAGTTTCAAGACGTCCTTAAGAG
AAGGCTTGAAGAAATTGAAATACTTTCTAAGGACTTATTAGAGGTTGGCAGTACTCGATGGGAAACTTTATTTAATCCTC
AAAAAGTTGATCTTGCAAGCATATCGGCTGAAGCAATTCTCGAGCTTGAAAAGCAATGGCTTAATCGCAAAATAAAAATA
AATACCGATATTCCAACTGATTTGCCATCCGTTTTTGCAGATCAAAGAAGAATGATGCAGGTTTTGTTAAACCTCATTGA
AAATGCTTTGAAATTTTCCGAGGACGAAGGTGAAATTTTTATAACAATGCTTCACAGAACAAATCAATGGGTTGAAGTAA
TTGTTCGAGATAATGGGCCTGGTATCCCTCAAGAAGAGCAACAAAGAATATTTGTTGATCGAGTGAGGCTTCCACAAACT
TCTCAAGAGACAATCGGCTTTGGCATTGGTCTTTCAGTTTGTAGAAGAATTGTTGAAGTTCATGGAGGTAAGATCTGGGT
GGTTTCTAAACCAACTGAAGGTGCATGTTTCTATTTCACCGTTCCTGTATGGCGTGGCCAAGATAAGGTTCAAGAAGCCT
TGACGAGTGGGAACGCGGGCCCGTAA

Upstream 100 bases:

>100_bases
AACTGAGAAAATTAAAAAGGTATCTCTTAATTATTAGCTAATTCCTAAAACGAGTCTCATTACCTTAAGGTATGCGTAAT
TATTTAGATTGCTCGACACT

Downstream 100 bases:

>100_bases
CTTTTATTTGTGATAACAATTACTTATTGAGTGATTTATCACAGCATCTGGCCCCATCGTCTAGAGGCCTAGGACACCTC
CCTTTCACGGAGGCGACAGG

Product: adaptive-response sensory kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDSAEANDRRQLKLLLVASRHHLSRSDIRLSIEYLEREDYGFNITLDFSDPSENPELLELYRLVALPALIKLEPSPRQVF
AGSSIFEQVKTWVPRWQHEGLSNSIGISLRGKTIESDQTQKELLLEDDLLVLRQENETLTKKIHSQESLLRMVAHELRTP
LTAAGLALQSQKLGQISMTKFQDVLKRRLEEIEILSKDLLEVGSTRWETLFNPQKVDLASISAEAILELEKQWLNRKIKI
NTDIPTDLPSVFADQRRMMQVLLNLIENALKFSEDEGEIFITMLHRTNQWVEVIVRDNGPGIPQEEQQRIFVDRVRLPQT
SQETIGFGIGLSVCRRIVEVHGGKIWVVSKPTEGACFYFTVPVWRGQDKVQEALTSGNAGP

Sequences:

>Translated_381_residues
MDSAEANDRRQLKLLLVASRHHLSRSDIRLSIEYLEREDYGFNITLDFSDPSENPELLELYRLVALPALIKLEPSPRQVF
AGSSIFEQVKTWVPRWQHEGLSNSIGISLRGKTIESDQTQKELLLEDDLLVLRQENETLTKKIHSQESLLRMVAHELRTP
LTAAGLALQSQKLGQISMTKFQDVLKRRLEEIEILSKDLLEVGSTRWETLFNPQKVDLASISAEAILELEKQWLNRKIKI
NTDIPTDLPSVFADQRRMMQVLLNLIENALKFSEDEGEIFITMLHRTNQWVEVIVRDNGPGIPQEEQQRIFVDRVRLPQT
SQETIGFGIGLSVCRRIVEVHGGKIWVVSKPTEGACFYFTVPVWRGQDKVQEALTSGNAGP
>Mature_381_residues
MDSAEANDRRQLKLLLVASRHHLSRSDIRLSIEYLEREDYGFNITLDFSDPSENPELLELYRLVALPALIKLEPSPRQVF
AGSSIFEQVKTWVPRWQHEGLSNSIGISLRGKTIESDQTQKELLLEDDLLVLRQENETLTKKIHSQESLLRMVAHELRTP
LTAAGLALQSQKLGQISMTKFQDVLKRRLEEIEILSKDLLEVGSTRWETLFNPQKVDLASISAEAILELEKQWLNRKIKI
NTDIPTDLPSVFADQRRMMQVLLNLIENALKFSEDEGEIFITMLHRTNQWVEVIVRDNGPGIPQEEQQRIFVDRVRLPQT
SQETIGFGIGLSVCRRIVEVHGGKIWVVSKPTEGACFYFTVPVWRGQDKVQEALTSGNAGP

Specific function: May be involved in signal transduction. Participates in the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with kaiC. Required for robustness of the circadian rhythm of gene expression an

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=31.6964285714286, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=27.3092369477912, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=29.8642533936652, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=31.5315315315315, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=27.3076923076923, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=245, Percent_Identity=29.7959183673469, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=26.4900662251656, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=29.7413793103448, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=29.2372881355932, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=27.6264591439689, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=29.5833333333333, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=196, Percent_Identity=29.0816326530612, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87082128, Length=221, Percent_Identity=24.8868778280543, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=21.8884120171674, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786783, Length=217, Percent_Identity=29.4930875576037, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011649
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF07689 KaiB [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43513; Mature: 43513

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSAEANDRRQLKLLLVASRHHLSRSDIRLSIEYLEREDYGFNITLDFSDPSENPELLEL
CCCCCCCCHHHEEEEEEEHHHCCCCCHHEEEEEEECCCCCCEEEEEECCCCCCCHHHHHH
YRLVALPALIKLEPSPRQVFAGSSIFEQVKTWVPRWQHEGLSNSIGISLRGKTIESDQTQ
HHHHHCCHHEEECCCCHHEECCHHHHHHHHHHCCCHHHCCCCCCCCEEEECCCCCCCCHH
KELLLEDDLLVLRQENETLTKKIHSQESLLRMVAHELRTPLTAAGLALQSQKLGQISMTK
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
FQDVLKRRLEEIEILSKDLLEVGSTRWETLFNPQKVDLASISAEAILELEKQWLNRKIKI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
NTDIPTDLPSVFADQRRMMQVLLNLIENALKFSEDEGEIFITMLHRTNQWVEVIVRDNGP
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCC
GIPQEEQQRIFVDRVRLPQTSQETIGFGIGLSVCRRIVEVHGGKIWVVSKPTEGACFYFT
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
VPVWRGQDKVQEALTSGNAGP
ECEECCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDSAEANDRRQLKLLLVASRHHLSRSDIRLSIEYLEREDYGFNITLDFSDPSENPELLEL
CCCCCCCCHHHEEEEEEEHHHCCCCCHHEEEEEEECCCCCCEEEEEECCCCCCCHHHHHH
YRLVALPALIKLEPSPRQVFAGSSIFEQVKTWVPRWQHEGLSNSIGISLRGKTIESDQTQ
HHHHHCCHHEEECCCCHHEECCHHHHHHHHHHCCCHHHCCCCCCCCEEEECCCCCCCCHH
KELLLEDDLLVLRQENETLTKKIHSQESLLRMVAHELRTPLTAAGLALQSQKLGQISMTK
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
FQDVLKRRLEEIEILSKDLLEVGSTRWETLFNPQKVDLASISAEAILELEKQWLNRKIKI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
NTDIPTDLPSVFADQRRMMQVLLNLIENALKFSEDEGEIFITMLHRTNQWVEVIVRDNGP
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCC
GIPQEEQQRIFVDRVRLPQTSQETIGFGIGLSVCRRIVEVHGGKIWVVSKPTEGACFYFT
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
VPVWRGQDKVQEALTSGNAGP
ECEECCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]