Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 124026204

GI number: 124026204

Start: 1210011

End: 1211657

Strand: Direct

Name: ubiB [C]

Synonym: NATL1_14981

Alternate gene names: 124026204

Gene position: 1210011-1211657 (Clockwise)

Preceding gene: 124026201

Following gene: 124026205

Centisome position: 64.89

GC content: 32.97

Gene sequence:

>1647_bases
ATGAAATACGATTTCCAAAGAGATTTAACTTGGTTGATTTCAAGACCATGGATATTGGTTCCTAGATTTATTCAGATAGT
TGGTGCAATATCACTTCTACTAGCAAGACTTATATTTCAAGGTTCAAGCACTGAAGACAACACACAAAAGAAATTAGCTA
AATTTCTACTTAAAACACTTATCGATCTGGGTCCCTGTTTTATAAAAGTAGGGCAAGCACTTTCAACCAGGCCAGATCTA
ATAAGAAAAGATTGGCTCGAAGAATTAACAAACCTACAAGATAATTTACCCTCATTTTCTCATGAAAAAGCACTTGAGAT
AATTGAAAATGAGCTAGGCAAACCAGCAAGTGAACTTTTTGAAGAGTTCCCATCTAAACCAATAGCCTCAGCAAGTCTTG
GGCAGGTTTATAAAGCAAAATTATTTGGCGATTATTGGGTAGCAGTAAAAGTTCAGAGGCCTAATCTGATTTTCAATATT
AGGAGAGATATCGTAATTATAAAAATACTTGGTGTTCTTAGTGCGCCAATACTTCCATTAAATCTTGGGTTCGGACTAGG
TGAAATAATAGATGAATTTGGAAGAAGTTTATTTGACGAAGTTGATTATAAAAAAGAAGCTGATAATGCAGAAAAATTTT
CTAACCTCTTCCACAATAATAATTCAGTAACTATACCGACAGTAGAAAGACATTTATCAACTATAAAAGTATTAACTACA
AGCTGGATTGATGGCACAAAACTAAAAGAAAGAAATGAATTAATTGAAAATAATTTAAATCCTTCAAAACTTATAAGAAC
TGGTGTTATCAGCGGCATACAACAATTATTGGAATTTGGATATTTTCATGCAGATCCTCATCCAGGAAATATGTTTGCAC
TGGAAGGTCATAATGGTGATTTAGGAAATATAGCCTATGTAGATTTCGGAATGATGGACTCAATTTCAGAGGTAGATAGA
TTAACTCTTACTGGTGCAATTGTTCACCTGATAAATAATGATTTTCATTCTGTTGCAAAAGATTTTCAAAAGCTAGGTTT
TCTAAGTAAAGAACAGGACCTTAAGCCTCTAATACCTGTATTAAAGGAAGTGCTTGGAAGTGCAATTGGCAAAGATGTTG
CAACTTTTAATTTCAAAGAAATTACCAACAAATTCTCCGAATTAATGTTTGATTATCCCTTTAGAGTCCCCGCAAGATTT
GCATTGATTATTAGAGCAGTAATCAGCCAAGAAGGACTTGCCATCCGATTAGATCCTGATTTTAAAATTATAGATTTAGC
ATATCCATATGTAGCCAAAAGATTACTCACTTCAGATACTAATGAAATGATAAATATATTATTAGACGTCATATTTGATC
AGAATGGACATTTAAGAGTTGAGCGAATAGAAAATTTATTTGATGTACTAGTCCAAGACTCGAGCACACCAGCTAAAGAA
CTAATACCAGTAGCAGGAGCAGGTTTAAAGCTTCTAACAAGCTCTAGAGGCTCATTAATAAGGAAAAATTTATTAATGAG
TATTATTAAAGACGAAAGGATCGATACTAAAGATATGAAGCAATTAATCAAATTAGTACGAAAAACCTTCAATCCTTTAA
AAATGGTTTCAGCTCTTACAAAACAAAACAACACACAAGTTGCGTAG

Upstream 100 bases:

>100_bases
GGAATAAAAGATTTACCTAAAATCAATGTAGTTAAATTAATCAGTAAGCAAATCAAAAGATCTTCTTAGATGTTTAGCTG
AAAGAACTTATGATGAATTC

Downstream 100 bases:

>100_bases
ATGATTTTAATAAAATATAATAAAAATTAAAAACATGTTAAATATCAATATTCAAAATATAATCACATTTATTGCAATCA
ATTTGGATGATCCAAATGTA

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKYDFQRDLTWLISRPWILVPRFIQIVGAISLLLARLIFQGSSTEDNTQKKLAKFLLKTLIDLGPCFIKVGQALSTRPDL
IRKDWLEELTNLQDNLPSFSHEKALEIIENELGKPASELFEEFPSKPIASASLGQVYKAKLFGDYWVAVKVQRPNLIFNI
RRDIVIIKILGVLSAPILPLNLGFGLGEIIDEFGRSLFDEVDYKKEADNAEKFSNLFHNNNSVTIPTVERHLSTIKVLTT
SWIDGTKLKERNELIENNLNPSKLIRTGVISGIQQLLEFGYFHADPHPGNMFALEGHNGDLGNIAYVDFGMMDSISEVDR
LTLTGAIVHLINNDFHSVAKDFQKLGFLSKEQDLKPLIPVLKEVLGSAIGKDVATFNFKEITNKFSELMFDYPFRVPARF
ALIIRAVISQEGLAIRLDPDFKIIDLAYPYVAKRLLTSDTNEMINILLDVIFDQNGHLRVERIENLFDVLVQDSSTPAKE
LIPVAGAGLKLLTSSRGSLIRKNLLMSIIKDERIDTKDMKQLIKLVRKTFNPLKMVSALTKQNNTQVA

Sequences:

>Translated_548_residues
MKYDFQRDLTWLISRPWILVPRFIQIVGAISLLLARLIFQGSSTEDNTQKKLAKFLLKTLIDLGPCFIKVGQALSTRPDL
IRKDWLEELTNLQDNLPSFSHEKALEIIENELGKPASELFEEFPSKPIASASLGQVYKAKLFGDYWVAVKVQRPNLIFNI
RRDIVIIKILGVLSAPILPLNLGFGLGEIIDEFGRSLFDEVDYKKEADNAEKFSNLFHNNNSVTIPTVERHLSTIKVLTT
SWIDGTKLKERNELIENNLNPSKLIRTGVISGIQQLLEFGYFHADPHPGNMFALEGHNGDLGNIAYVDFGMMDSISEVDR
LTLTGAIVHLINNDFHSVAKDFQKLGFLSKEQDLKPLIPVLKEVLGSAIGKDVATFNFKEITNKFSELMFDYPFRVPARF
ALIIRAVISQEGLAIRLDPDFKIIDLAYPYVAKRLLTSDTNEMINILLDVIFDQNGHLRVERIENLFDVLVQDSSTPAKE
LIPVAGAGLKLLTSSRGSLIRKNLLMSIIKDERIDTKDMKQLIKLVRKTFNPLKMVSALTKQNNTQVA
>Mature_548_residues
MKYDFQRDLTWLISRPWILVPRFIQIVGAISLLLARLIFQGSSTEDNTQKKLAKFLLKTLIDLGPCFIKVGQALSTRPDL
IRKDWLEELTNLQDNLPSFSHEKALEIIENELGKPASELFEEFPSKPIASASLGQVYKAKLFGDYWVAVKVQRPNLIFNI
RRDIVIIKILGVLSAPILPLNLGFGLGEIIDEFGRSLFDEVDYKKEADNAEKFSNLFHNNNSVTIPTVERHLSTIKVLTT
SWIDGTKLKERNELIENNLNPSKLIRTGVISGIQQLLEFGYFHADPHPGNMFALEGHNGDLGNIAYVDFGMMDSISEVDR
LTLTGAIVHLINNDFHSVAKDFQKLGFLSKEQDLKPLIPVLKEVLGSAIGKDVATFNFKEITNKFSELMFDYPFRVPARF
ALIIRAVISQEGLAIRLDPDFKIIDLAYPYVAKRLLTSDTNEMINILLDVIFDQNGHLRVERIENLFDVLVQDSSTPAKE
LIPVAGAGLKLLTSSRGSLIRKNLLMSIIKDERIDTKDMKQLIKLVRKTFNPLKMVSALTKQNNTQVA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=295, Percent_Identity=29.4915254237288, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI217035081, Length=294, Percent_Identity=27.891156462585, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI41393593, Length=277, Percent_Identity=27.7978339350181, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI34147522, Length=276, Percent_Identity=26.8115942028986, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI27363457, Length=290, Percent_Identity=25.5172413793103, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI32261307, Length=386, Percent_Identity=23.0569948186528, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI217416386, Length=226, Percent_Identity=25.2212389380531, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI2367309, Length=438, Percent_Identity=26.9406392694064, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17559152, Length=310, Percent_Identity=30.6451612903226, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=271, Percent_Identity=27.6752767527675, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323282, Length=260, Percent_Identity=28.8461538461538, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325148, Length=446, Percent_Identity=23.0941704035874, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=320, Percent_Identity=25, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24662575, Length=269, Percent_Identity=27.5092936802974, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI22024280, Length=305, Percent_Identity=24.9180327868852, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859849, Length=310, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61861; Mature: 61861

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDFQRDLTWLISRPWILVPRFIQIVGAISLLLARLIFQGSSTEDNTQKKLAKFLLKTL
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IDLGPCFIKVGQALSTRPDLIRKDWLEELTNLQDNLPSFSHEKALEIIENELGKPASELF
HHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
EEFPSKPIASASLGQVYKAKLFGDYWVAVKVQRPNLIFNIRRDIVIIKILGVLSAPILPL
HHCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCEEEEHHHHHHHHHHHHHHHCCCEEE
NLGFGLGEIIDEFGRSLFDEVDYKKEADNAEKFSNLFHNNNSVTIPTVERHLSTIKVLTT
ECCCCHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHH
SWIDGTKLKERNELIENNLNPSKLIRTGVISGIQQLLEFGYFHADPHPGNMFALEGHNGD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
LGNIAYVDFGMMDSISEVDRLTLTGAIVHLINNDFHSVAKDFQKLGFLSKEQDLKPLIPV
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHH
LKEVLGSAIGKDVATFNFKEITNKFSELMFDYPFRVPARFALIIRAVISQEGLAIRLDPD
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
FKIIDLAYPYVAKRLLTSDTNEMINILLDVIFDQNGHLRVERIENLFDVLVQDSSTPAKE
CEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHH
LIPVAGAGLKLLTSSRGSLIRKNLLMSIIKDERIDTKDMKQLIKLVRKTFNPLKMVSALT
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
KQNNTQVA
HCCCCCCC
>Mature Secondary Structure
MKYDFQRDLTWLISRPWILVPRFIQIVGAISLLLARLIFQGSSTEDNTQKKLAKFLLKTL
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IDLGPCFIKVGQALSTRPDLIRKDWLEELTNLQDNLPSFSHEKALEIIENELGKPASELF
HHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
EEFPSKPIASASLGQVYKAKLFGDYWVAVKVQRPNLIFNIRRDIVIIKILGVLSAPILPL
HHCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCEEEEHHHHHHHHHHHHHHHCCCEEE
NLGFGLGEIIDEFGRSLFDEVDYKKEADNAEKFSNLFHNNNSVTIPTVERHLSTIKVLTT
ECCCCHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHH
SWIDGTKLKERNELIENNLNPSKLIRTGVISGIQQLLEFGYFHADPHPGNMFALEGHNGD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
LGNIAYVDFGMMDSISEVDRLTLTGAIVHLINNDFHSVAKDFQKLGFLSKEQDLKPLIPV
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHH
LKEVLGSAIGKDVATFNFKEITNKFSELMFDYPFRVPARFALIIRAVISQEGLAIRLDPD
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
FKIIDLAYPYVAKRLLTSDTNEMINILLDVIFDQNGHLRVERIENLFDVLVQDSSTPAKE
CEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHH
LIPVAGAGLKLLTSSRGSLIRKNLLMSIIKDERIDTKDMKQLIKLVRKTFNPLKMVSALT
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
KQNNTQVA
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]