Click here to switch to the map view.

The map label for this gene is apt

Identifier: 124025764

GI number: 124025764

Start: 975052

End: 975570

Strand: Direct

Name: apt

Synonym: NATL1_10571

Alternate gene names: 124025764

Gene position: 975052-975570 (Clockwise)

Preceding gene: 124025759

Following gene: 124025769

Centisome position: 52.29

GC content: 31.6

Gene sequence:

>519_bases
ATGGATCACTTAAAGAAATACATTACAGAAATAAATGATTACCCGAAAAAGGGAATCGTCTTCAAAGACTTAAACCCAAT
ATATAAAGAGCCAAAGGCATGGAAAGAATTAATGTTTCCTCTTCAGAACCTGATATCTACTAAAAAACCTGATTATATTG
CTGGCATAGAATCAAGAGGATTTATTTCTGCATCTGCATTGGCATTTAAGCTTGAGATAGGTTTAATTACTATTAGAAAA
CCTAATAAATTACCTGGAGAAGTAATAGGTACTAATTATAAGCTTGAGTACGGTGAAGACAGATTAGAAATCCAGCAAAA
TATAATTGAAAAGGATAGTAAGATACTATTATTTGATGATTTACTAGCTACAGGAGGAACAGCAGGAGCAGCTGGTAAAT
TGATCAAAAAAGCAGGTGGTAATTTAATTGGATATGCTTTTCTTGTAGAGCTAACTGAACTTAAAGGGAGAGAAAATTTA
GATTCAAATTTATTGGTAGAAACCCTAATAAAGTATTAA

Upstream 100 bases:

>100_bases
AATTAGAAGTCTTCATAGAGTCAATAATGACAGGAGTTTGCTGATTTGCTAGCTTTAATGTTGGTTTTATAAAATCGCAC
ACCTCAAATATTTATAGTGC

Downstream 100 bases:

>100_bases
TTATTCTTTAGCCACAAAAGTATTATCTTTAGTTGAGACAAAGTAATTAAACCATAACTCCACATTACAATAGGAAGTGG
AGAATTTTCCAAACAAGATC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDHLKKYITEINDYPKKGIVFKDLNPIYKEPKAWKELMFPLQNLISTKKPDYIAGIESRGFISASALAFKLEIGLITIRK
PNKLPGEVIGTNYKLEYGEDRLEIQQNIIEKDSKILLFDDLLATGGTAGAAGKLIKKAGGNLIGYAFLVELTELKGRENL
DSNLLVETLIKY

Sequences:

>Translated_172_residues
MDHLKKYITEINDYPKKGIVFKDLNPIYKEPKAWKELMFPLQNLISTKKPDYIAGIESRGFISASALAFKLEIGLITIRK
PNKLPGEVIGTNYKLEYGEDRLEIQQNIIEKDSKILLFDDLLATGGTAGAAGKLIKKAGGNLIGYAFLVELTELKGRENL
DSNLLVETLIKY
>Mature_172_residues
MDHLKKYITEINDYPKKGIVFKDLNPIYKEPKAWKELMFPLQNLISTKKPDYIAGIESRGFISASALAFKLEIGLITIRK
PNKLPGEVIGTNYKLEYGEDRLEIQQNIIEKDSKILLFDDLLATGGTAGAAGKLIKKAGGNLIGYAFLVELTELKGRENL
DSNLLVETLIKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=160, Percent_Identity=41.25, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=40, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1786675, Length=161, Percent_Identity=40.3726708074534, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=43.9306358381503, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=165, Percent_Identity=40, Blast_Score=112, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=167, Percent_Identity=36.5269461077844, Blast_Score=99, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=41.3793103448276, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROM1 (A2C2A5)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014880.1
- ProteinModelPortal:   A2C2A5
- SMR:   A2C2A5
- STRING:   A2C2A5
- GeneID:   4781007
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_10571
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PMAR167555:NATL1_10571-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19275; Mature: 19275

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLKKYITEINDYPKKGIVFKDLNPIYKEPKAWKELMFPLQNLISTKKPDYIAGIESRG
CHHHHHHHHHHHCCCCCCEEECCCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
FISASALAFKLEIGLITIRKPNKLPGEVIGTNYKLEYGEDRLEIQQNIIEKDSKILLFDD
CEEHHHEEEEEEEEEEEEECCCCCCCCEECCCEEEECCCHHHHHHHHHHCCCCCEEEEHH
LLATGGTAGAAGKLIKKAGGNLIGYAFLVELTELKGRENLDSNLLVETLIKY
HHHCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDHLKKYITEINDYPKKGIVFKDLNPIYKEPKAWKELMFPLQNLISTKKPDYIAGIESRG
CHHHHHHHHHHHCCCCCCEEECCCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
FISASALAFKLEIGLITIRKPNKLPGEVIGTNYKLEYGEDRLEIQQNIIEKDSKILLFDD
CEEHHHEEEEEEEEEEEEECCCCCCCCEECCCEEEECCCHHHHHHHHHHCCCCCEEEEHH
LLATGGTAGAAGKLIKKAGGNLIGYAFLVELTELKGRENLDSNLLVETLIKY
HHHCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA