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The map label for this gene is engA

Identifier: 124025156

GI number: 124025156

Start: 405593

End: 406963

Strand: Direct

Name: engA

Synonym: NATL1_04431

Alternate gene names: 124025156

Gene position: 405593-406963 (Clockwise)

Preceding gene: 124025153

Following gene: 124025157

Centisome position: 21.75

GC content: 41.21

Gene sequence:

>1371_bases
TTGGCGCTACCAGTAGTCGCAATAATTGGACGCCCAAATGTTGGGAAATCTACATTGGTGAATCGCTTATGTCAGAGCAG
AGAAGCCATTGTTCATGATGAGCCGGGGGTAACGAGAGATCGAACTTATCAAGATGGATTCTGGAGGGATAGAGATTTTA
AAGTTGTAGATACTGGAGGGCTGGTTTTTGATGACGATAGTGAGTTCCTCCCTGAAATTAGAGAGCAAGCTAATCTTGCG
CTTGAGGAAGCCGTAGTTGCATTAGTAATTGTTGATGGCCAGGAGGGAATTACTACCGCTGATGAATCAATTGCTGAATT
TTTAAGGTCTCGTTCCTGCAAAACCCTCGTGGTGGTTAATAAATGTGAATCTCCCGAACAAGGTTTAGCAATGGCAGCTG
AATTTTGGAAGCTTGGTCTTGGTGAGCCCTATCCAATCTCTGCCATACATGGAGTAGGTACAGGCGATCTGCTTGATCAG
GTGGTTAATTTGTTTCCCTCTAAAGATTTAGATGAAGTTAGTGATTCTCCTGTTCAATTGGCAATTATTGGGAGACCAAA
TGTAGGTAAGTCCAGTCTTCTTAATTCTATTTGTGGAGAGACAAGGGCAATTGTTAGCTCTATTAGGGGTACAACTCGAG
ATACGATTGATACTCGAATTACTCATCAGGGTAAGGAATGGAAATTAGTTGATACGGCGGGAATACGTAGACGTAGAAGT
GTTAATTATGGCCCAGAATTTTTTGGTATTAATCGCAGTTTTAAGGCAATAGAAAGAAGTGATGTCTGTGTGTTGGTTAT
AGATGCTTTGGATGGCGTCACAGAACAAGATCAAAGGCTTGCAGGTAGAATTGAGCAGGAAGGAAGAGCTTGTTTGATAG
TCATTAATAAATGGGATGCTGTAGAAAAAGATAGTCACACAATGTCTGCAATGGAAAAAGACATTCGTTCAAAATTATAT
TTTCTCGATTGGGCCCAGATGATCTTTACATCAGCAGTTACGGGTCAAAGAGTAGAAGGTATTTTTGCATTAGCTACTTT
GGCCGTTGATCAGAGTAGAAGAAGGGTAACTACTTCAGTTGTTAATGAGGTGCTGACTGAGGCCTTAAAATGGAGAAGTC
CTCCTACAACAAGAGGGGGAAAACAAGGGCGTCTTTATTACGGTACTCAAGTAGCTATTAATCCTCCCAGTTTTACTCTG
TTCGTGAATGAACCTAAATTATTTGGTGAAACTTATCGAAGATATATTGAGAGACAAATTAGAGAGGGTCTTGGTTTTGA
AGGGACTCCTATAAAGTTATTTTGGAGAGGGAAGCAGCAACGCGATGTCGAAAAAGATATGGCACGCCAACAGAAAGGGG
TCCAAAATTAG

Upstream 100 bases:

>100_bases
TCATTTTGGAATCGAACTCTTTGCTCATACTTGTAGTATGAAGAATTAATCTTAATTTTGACCTATAAAGGGTCAATAAT
CTTATGAAAGGTAGAGAAAT

Downstream 100 bases:

>100_bases
TAATTATTTATGGATTGGCTAAAAAAGATTCCAATTGGTCAATATGTCTCTGGCAAATCTAGCTGGCTTCGTGGTATTGA
TCCTCGAATTAAACTCTCTT

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MALPVVAIIGRPNVGKSTLVNRLCQSREAIVHDEPGVTRDRTYQDGFWRDRDFKVVDTGGLVFDDDSEFLPEIREQANLA
LEEAVVALVIVDGQEGITTADESIAEFLRSRSCKTLVVVNKCESPEQGLAMAAEFWKLGLGEPYPISAIHGVGTGDLLDQ
VVNLFPSKDLDEVSDSPVQLAIIGRPNVGKSSLLNSICGETRAIVSSIRGTTRDTIDTRITHQGKEWKLVDTAGIRRRRS
VNYGPEFFGINRSFKAIERSDVCVLVIDALDGVTEQDQRLAGRIEQEGRACLIVINKWDAVEKDSHTMSAMEKDIRSKLY
FLDWAQMIFTSAVTGQRVEGIFALATLAVDQSRRRVTTSVVNEVLTEALKWRSPPTTRGGKQGRLYYGTQVAINPPSFTL
FVNEPKLFGETYRRYIERQIREGLGFEGTPIKLFWRGKQQRDVEKDMARQQKGVQN

Sequences:

>Translated_456_residues
MALPVVAIIGRPNVGKSTLVNRLCQSREAIVHDEPGVTRDRTYQDGFWRDRDFKVVDTGGLVFDDDSEFLPEIREQANLA
LEEAVVALVIVDGQEGITTADESIAEFLRSRSCKTLVVVNKCESPEQGLAMAAEFWKLGLGEPYPISAIHGVGTGDLLDQ
VVNLFPSKDLDEVSDSPVQLAIIGRPNVGKSSLLNSICGETRAIVSSIRGTTRDTIDTRITHQGKEWKLVDTAGIRRRRS
VNYGPEFFGINRSFKAIERSDVCVLVIDALDGVTEQDQRLAGRIEQEGRACLIVINKWDAVEKDSHTMSAMEKDIRSKLY
FLDWAQMIFTSAVTGQRVEGIFALATLAVDQSRRRVTTSVVNEVLTEALKWRSPPTTRGGKQGRLYYGTQVAINPPSFTL
FVNEPKLFGETYRRYIERQIREGLGFEGTPIKLFWRGKQQRDVEKDMARQQKGVQN
>Mature_455_residues
ALPVVAIIGRPNVGKSTLVNRLCQSREAIVHDEPGVTRDRTYQDGFWRDRDFKVVDTGGLVFDDDSEFLPEIREQANLAL
EEAVVALVIVDGQEGITTADESIAEFLRSRSCKTLVVVNKCESPEQGLAMAAEFWKLGLGEPYPISAIHGVGTGDLLDQV
VNLFPSKDLDEVSDSPVQLAIIGRPNVGKSSLLNSICGETRAIVSSIRGTTRDTIDTRITHQGKEWKLVDTAGIRRRRSV
NYGPEFFGINRSFKAIERSDVCVLVIDALDGVTEQDQRLAGRIEQEGRACLIVINKWDAVEKDSHTMSAMEKDIRSKLYF
LDWAQMIFTSAVTGQRVEGIFALATLAVDQSRRRVTTSVVNEVLTEALKWRSPPTTRGGKQGRLYYGTQVAINPPSFTLF
VNEPKLFGETYRRYIERQIREGLGFEGTPIKLFWRGKQQRDVEKDMARQQKGVQN

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=466, Percent_Identity=39.6995708154506, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI2367268, Length=91, Percent_Identity=40.6593406593407, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507259, Length=113, Percent_Identity=38.0530973451327, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=225, Percent_Identity=31.1111111111111, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_PROM1 (A2C0J7)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014272.1
- ProteinModelPortal:   A2C0J7
- SMR:   A2C0J7
- STRING:   A2C0J7
- GeneID:   4780821
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_04431
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   PMAR167555:NATL1_04431-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 50954; Mature: 50822

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPVVAIIGRPNVGKSTLVNRLCQSREAIVHDEPGVTRDRTYQDGFWRDRDFKVVDTGG
CCCCEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCC
LVFDDDSEFLPEIREQANLALEEAVVALVIVDGQEGITTADESIAEFLRSRSCKTLVVVN
EEECCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEE
KCESPEQGLAMAAEFWKLGLGEPYPISAIHGVGTGDLLDQVVNLFPSKDLDEVSDSPVQL
CCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHCCCCCHHHHCCCCEEE
AIIGRPNVGKSSLLNSICGETRAIVSSIRGTTRDTIDTRITHQGKEWKLVDTAGIRRRRS
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEHHCCHHHCC
VNYGPEFFGINRSFKAIERSDVCVLVIDALDGVTEQDQRLAGRIEQEGRACLIVINKWDA
CCCCCCEEECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCC
VEKDSHTMSAMEKDIRSKLYFLDWAQMIFTSAVTGQRVEGIFALATLAVDQSRRRVTTSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VNEVLTEALKWRSPPTTRGGKQGRLYYGTQVAINPPSFTLFVNEPKLFGETYRRYIERQI
HHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEECCCCEEEEECCCHHHHHHHHHHHHHHH
REGLGFEGTPIKLFWRGKQQRDVEKDMARQQKGVQN
HHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALPVVAIIGRPNVGKSTLVNRLCQSREAIVHDEPGVTRDRTYQDGFWRDRDFKVVDTGG
CCCEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCC
LVFDDDSEFLPEIREQANLALEEAVVALVIVDGQEGITTADESIAEFLRSRSCKTLVVVN
EEECCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEE
KCESPEQGLAMAAEFWKLGLGEPYPISAIHGVGTGDLLDQVVNLFPSKDLDEVSDSPVQL
CCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHCCCCCHHHHCCCCEEE
AIIGRPNVGKSSLLNSICGETRAIVSSIRGTTRDTIDTRITHQGKEWKLVDTAGIRRRRS
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEHHCCHHHCC
VNYGPEFFGINRSFKAIERSDVCVLVIDALDGVTEQDQRLAGRIEQEGRACLIVINKWDA
CCCCCCEEECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCC
VEKDSHTMSAMEKDIRSKLYFLDWAQMIFTSAVTGQRVEGIFALATLAVDQSRRRVTTSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VNEVLTEALKWRSPPTTRGGKQGRLYYGTQVAINPPSFTLFVNEPKLFGETYRRYIERQI
HHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEECCCCEEEEECCCHHHHHHHHHHHHHHH
REGLGFEGTPIKLFWRGKQQRDVEKDMARQQKGVQN
HHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA