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The map label for this gene is lytB

Identifier: 124025055

GI number: 124025055

Start: 317009

End: 318214

Strand: Direct

Name: lytB

Synonym: NATL1_03421

Alternate gene names: 124025055

Gene position: 317009-318214 (Clockwise)

Preceding gene: 124025054

Following gene: 124025056

Centisome position: 17.0

GC content: 36.24

Gene sequence:

>1206_bases
ATGGATACTCAAGCCTTTAAGCAAACTCTTCATAAATCGGATCGTTATAACCGAAGAGGATTTGGTTCAGCAAATAAGCG
AGCTCAAGCACTTGCTGAGGCTTATCAAAGTGGTTTAATTGGATCTATTAGAGAAAATGGAAATCTTTTAGAGCACGGAA
GATTAAAAGTTAAACTTGCAGAAGCTTTTGGATTTTGTTGGGGAGTAGAAAGATCAGTAGCAATGGCTTACGAGACTAGG
AAGCATTATCCAAATGAAAGAATATGGATCACTAATGAAATCATTCATAACCCCTCTGTGAATGATCATTTGAGGAAAAT
GAATGTTCTTTTTATTTCTGAGGAAAAAGGGGTTAAAGATTTTTCAGTAGTAAAAGATGGAGATGTAGTAATTCTTCCTG
CATTTGGAGCAACGGTTCAAGATATGAAGCTCTTACACGATAGAGGTTGTCATATTATTGATACCACTTGCCCATGGGTT
TCAAAAGTTTGGCATACAGTCGAAAAGCATAAAAAACATACATTCACATCAATTATTCATGGCAAATATAAACACGAAGA
AACTCTAGCGACTAGTTCTTTTGCAGGGACTTACCTAGTCCTATTTGACCTTGAAGAGGCGAATTATGTTTCTGATTATA
TTTTAGGCAAGGGAAATAGAGAAGATTTCTTAAAGCGTTTTTCAAAAGCTTCTTCAGCAGGGTTCGATCCCGATAAGGAT
TTGCAAAAAGTTGGAGTTGCTAATCAGACCACAATGTTAAAAAGCGAAACTGAGGAAATAGGACGATTGTTTGAGAAAAC
AATGTTGCAAAGATTTGGACCTGCTCAATTGAATGAACATTTTCTAGCTATTAATACCATTTGTGATGCTACTGAAGAAA
GACAAGGAGCAATGTTTTCGCTAGTTGATGAACCTCTTGATCTTATGGTTGTAATTGGTGGATTCAATTCTTCTAACACA
ACTCATCTTCAAGAAATCGCAATCAGTAGAGGGATTCGTTCATTTCATATTGATACTCCAGAGAGAATTGGAGAAGAGAC
TAATACCATTACTCATATGCCTCTAGAGGGAGGTGAATTGTTAACTGAGGAAAATTTTCTTCAAAACGGAAATATTAGTG
TAGGTATTACTTCGGGTGCTTCAACTCCCGACCGTGTAGTTGAAGATGTTATTCACAAGCTAATGAAAATAGGCGAAAAT
TTTTGA

Upstream 100 bases:

>100_bases
TACATTAAATCTAAAAAAGCCCAGAATATATCTGGGCTTTTTTATTGTGGTTTAATAGTGATGAGATTCCTATCAATTTG
TTTTTTACTATTTAATTGAA

Downstream 100 bases:

>100_bases
TAAGAAAAAAACGCAATTTTGCTCCAATCTCTCGTAGGATAGTTAATAGTTTTTAGTAGAAGATGACTCAAACAAACAAA
TCTAGTCTTAAAGATCCTGA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDTQAFKQTLHKSDRYNRRGFGSANKRAQALAEAYQSGLIGSIRENGNLLEHGRLKVKLAEAFGFCWGVERSVAMAYETR
KHYPNERIWITNEIIHNPSVNDHLRKMNVLFISEEKGVKDFSVVKDGDVVILPAFGATVQDMKLLHDRGCHIIDTTCPWV
SKVWHTVEKHKKHTFTSIIHGKYKHEETLATSSFAGTYLVLFDLEEANYVSDYILGKGNREDFLKRFSKASSAGFDPDKD
LQKVGVANQTTMLKSETEEIGRLFEKTMLQRFGPAQLNEHFLAINTICDATEERQGAMFSLVDEPLDLMVVIGGFNSSNT
THLQEIAISRGIRSFHIDTPERIGEETNTITHMPLEGGELLTEENFLQNGNISVGITSGASTPDRVVEDVIHKLMKIGEN
F

Sequences:

>Translated_401_residues
MDTQAFKQTLHKSDRYNRRGFGSANKRAQALAEAYQSGLIGSIRENGNLLEHGRLKVKLAEAFGFCWGVERSVAMAYETR
KHYPNERIWITNEIIHNPSVNDHLRKMNVLFISEEKGVKDFSVVKDGDVVILPAFGATVQDMKLLHDRGCHIIDTTCPWV
SKVWHTVEKHKKHTFTSIIHGKYKHEETLATSSFAGTYLVLFDLEEANYVSDYILGKGNREDFLKRFSKASSAGFDPDKD
LQKVGVANQTTMLKSETEEIGRLFEKTMLQRFGPAQLNEHFLAINTICDATEERQGAMFSLVDEPLDLMVVIGGFNSSNT
THLQEIAISRGIRSFHIDTPERIGEETNTITHMPLEGGELLTEENFLQNGNISVGITSGASTPDRVVEDVIHKLMKIGEN
F
>Mature_401_residues
MDTQAFKQTLHKSDRYNRRGFGSANKRAQALAEAYQSGLIGSIRENGNLLEHGRLKVKLAEAFGFCWGVERSVAMAYETR
KHYPNERIWITNEIIHNPSVNDHLRKMNVLFISEEKGVKDFSVVKDGDVVILPAFGATVQDMKLLHDRGCHIIDTTCPWV
SKVWHTVEKHKKHTFTSIIHGKYKHEETLATSSFAGTYLVLFDLEEANYVSDYILGKGNREDFLKRFSKASSAGFDPDKD
LQKVGVANQTTMLKSETEEIGRLFEKTMLQRFGPAQLNEHFLAINTICDATEERQGAMFSLVDEPLDLMVVIGGFNSSNT
THLQEIAISRGIRSFHIDTPERIGEETNTITHMPLEGGELLTEENFLQNGNISVGITSGASTPDRVVEDVIHKLMKIGEN
F

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family

Homologues:

Organism=Escherichia coli, GI1786212, Length=349, Percent_Identity=26.647564469914, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPH_PROM1 (A2C096)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014171.1
- STRING:   A2C096
- GeneID:   4780362
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_03421
- eggNOG:   COG0761
- HOGENOM:   HBG286221
- OMA:   HMQVARA
- ProtClustDB:   PRK13371
- BioCyc:   PMAR167555:NATL1_03421-MONOMER
- HAMAP:   MF_00191
- InterPro:   IPR003451
- TIGRFAMs:   TIGR00216

Pfam domain/function: PF02401 LYTB

EC number: =1.17.1.2

Molecular weight: Translated: 45134; Mature: 45134

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQAFKQTLHKSDRYNRRGFGSANKRAQALAEAYQSGLIGSIRENGNLLEHGRLKVKLA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCEEECCCEEEEHH
EAFGFCWGVERSVAMAYETRKHYPNERIWITNEIIHNPSVNDHLRKMNVLFISEEKGVKD
HHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHEEEEEEECCCCCCC
FSVVKDGDVVILPAFGATVQDMKLLHDRGCHIIDTTCPWVSKVWHTVEKHKKHTFTSIIH
EEEEECCCEEEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
GKYKHEETLATSSFAGTYLVLFDLEEANYVSDYILGKGNREDFLKRFSKASSAGFDPDKD
CCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHH
LQKVGVANQTTMLKSETEEIGRLFEKTMLQRFGPAQLNEHFLAINTICDATEERQGAMFS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEHHHHCCHHHHCCCHHH
LVDEPLDLMVVIGGFNSSNTTHLQEIAISRGIRSFHIDTPERIGEETNTITHMPLEGGEL
HHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEECCCHHHHCCCCCCEEECCCCCCCC
LTEENFLQNGNISVGITSGASTPDRVVEDVIHKLMKIGENF
CCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDTQAFKQTLHKSDRYNRRGFGSANKRAQALAEAYQSGLIGSIRENGNLLEHGRLKVKLA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCEEECCCEEEEHH
EAFGFCWGVERSVAMAYETRKHYPNERIWITNEIIHNPSVNDHLRKMNVLFISEEKGVKD
HHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHCCCCHHHHHHHEEEEEEECCCCCCC
FSVVKDGDVVILPAFGATVQDMKLLHDRGCHIIDTTCPWVSKVWHTVEKHKKHTFTSIIH
EEEEECCCEEEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
GKYKHEETLATSSFAGTYLVLFDLEEANYVSDYILGKGNREDFLKRFSKASSAGFDPDKD
CCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHH
LQKVGVANQTTMLKSETEEIGRLFEKTMLQRFGPAQLNEHFLAINTICDATEERQGAMFS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEHHHHCCHHHHCCCHHH
LVDEPLDLMVVIGGFNSSNTTHLQEIAISRGIRSFHIDTPERIGEETNTITHMPLEGGEL
HHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEECCCHHHHCCCCCCEEECCCCCCCC
LTEENFLQNGNISVGITSGASTPDRVVEDVIHKLMKIGENF
CCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA