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The map label for this gene is aspA

Identifier: 124025014

GI number: 124025014

Start: 279402

End: 280319

Strand: Direct

Name: aspA

Synonym: NATL1_03011

Alternate gene names: NA

Gene position: 279402-280319 (Clockwise)

Preceding gene: 124025010

Following gene: 124025016

Centisome position: 14.98

GC content: 34.64

Gene sequence:

>918_bases
ATGAAGCAGCTACAAGTACTGCTAGTGGCTGGTACGCATGGTAATGAAATAAATGGCATTTGGCTTTTTGATGAATGGAA
AAAATCATCGTTTTTAATAAATACTCACGGGATTAAAACCTTTCAGGTAATTGGAAACCCTGAGGCTAAAAAGGCTGGGA
AAAGATATATTCATCATGATTTGAATCGTAGTTTCAAAGAAGGATCATTCATCAAAATCAACCCTTTAAATTGTGAGAGA
ACTAGAGCAAGTGAGTTAGTAAATCTTTACGGTGAAGCTGGAGAAAACCCTTGTCAAATAGCATTAGATTTTCATACAAC
GACTGCCTCCATGGGGAGTTGCATAGTTGTTTATGGGAGAAGAGATGCAGATTTGGCTTTGGCTTCTTTGATTCAAAATC
AATTAGGTTTACCGGTATATCTCCACGAATCTGATCAAAAGCAAACAGGTTTTTTAGTTGAATCTTGGCCTTGTGGACTT
GTCGTAGAAATTGGCCCCATTGGACAAGGCCTATTGAATTCGAGAATTATTTCGCAAACAAAATTGATTCTCGAGACTTT
GATGGAACAAATTCATGAGGTTAAGAACTTAAATCTATTTTTTCCTAATAAGTTGATAATTCACAGACATATTAAAAGTA
TCGATTTCCCAAGAGATGAAGAGGGCAATATTGATGGATATGTGCATTCTTTAAGGCAATCAAAGGATTGGCAAGAATTA
AAGAAAAATGATGAATTGTTTTGTAAGTTGAATGGTGAAATAATTAGGTTTGAGGAAGATGAACCCTATATTCCTGTATT
TATAAATGAAGCAGCGTATGTGGAAAAAAATATCGCTATGAGTTTTACCAAAAGAGAATTATGGAATTTCAAAAAAGAAT
GGAAACAAGCACTCATTGATCTGATACATCAGAAGTAA

Upstream 100 bases:

>100_bases
CCATTCAAAACTCCATATGTCTCTCGCAGCTTTTACAAATATTGGTGGTATAGCCATGAATTTCTTTTAAGATTATTTTT
ATCTATGGGTTGATTGATTA

Downstream 100 bases:

>100_bases
GTTCTCTCGCTCCAATAAATAATTGCCCCTTGAGCTTCCAATTCATATTTTCTGTGACGAGCATCACTTAGAGGAACTCT
TTCTTCAAGCCTATGCCCAT

Product: aspartoacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKQLQVLLVAGTHGNEINGIWLFDEWKKSSFLINTHGIKTFQVIGNPEAKKAGKRYIHHDLNRSFKEGSFIKINPLNCER
TRASELVNLYGEAGENPCQIALDFHTTTASMGSCIVVYGRRDADLALASLIQNQLGLPVYLHESDQKQTGFLVESWPCGL
VVEIGPIGQGLLNSRIISQTKLILETLMEQIHEVKNLNLFFPNKLIIHRHIKSIDFPRDEEGNIDGYVHSLRQSKDWQEL
KKNDELFCKLNGEIIRFEEDEPYIPVFINEAAYVEKNIAMSFTKRELWNFKKEWKQALIDLIHQK

Sequences:

>Translated_305_residues
MKQLQVLLVAGTHGNEINGIWLFDEWKKSSFLINTHGIKTFQVIGNPEAKKAGKRYIHHDLNRSFKEGSFIKINPLNCER
TRASELVNLYGEAGENPCQIALDFHTTTASMGSCIVVYGRRDADLALASLIQNQLGLPVYLHESDQKQTGFLVESWPCGL
VVEIGPIGQGLLNSRIISQTKLILETLMEQIHEVKNLNLFFPNKLIIHRHIKSIDFPRDEEGNIDGYVHSLRQSKDWQEL
KKNDELFCKLNGEIIRFEEDEPYIPVFINEAAYVEKNIAMSFTKRELWNFKKEWKQALIDLIHQK
>Mature_305_residues
MKQLQVLLVAGTHGNEINGIWLFDEWKKSSFLINTHGIKTFQVIGNPEAKKAGKRYIHHDLNRSFKEGSFIKINPLNCER
TRASELVNLYGEAGENPCQIALDFHTTTASMGSCIVVYGRRDADLALASLIQNQLGLPVYLHESDQKQTGFLVESWPCGL
VVEIGPIGQGLLNSRIISQTKLILETLMEQIHEVKNLNLFFPNKLIIHRHIKSIDFPRDEEGNIDGYVHSLRQSKDWQEL
KKNDELFCKLNGEIIRFEEDEPYIPVFINEAAYVEKNIAMSFTKRELWNFKKEWKQALIDLIHQK

Specific function: Unknown

COG id: COG2988

COG function: function code E; Succinylglutamate desuccinylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AspA/AstE family. Aspartoacylase subfamily

Homologues:

Organism=Homo sapiens, GI18087825, Length=303, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4557335, Length=296, Percent_Identity=33.1081081081081, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI189339202, Length=296, Percent_Identity=33.1081081081081, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ASPA_PROM1 (A2C055)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014130.1
- ProteinModelPortal:   A2C055
- SMR:   A2C055
- STRING:   A2C055
- GeneID:   4780189
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_03011
- eggNOG:   COG2988
- HOGENOM:   HBG635125
- OMA:   DFLIQMF
- ProtClustDB:   PRK02259
- BioCyc:   PMAR167555:NATL1_03011-MONOMER
- HAMAP:   MF_00704
- InterPro:   IPR016708
- InterPro:   IPR007036
- PIRSF:   PIRSF018001

Pfam domain/function: PF04952 AstE_AspA

EC number: =3.5.1.15

Molecular weight: Translated: 35059; Mature: 35059

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 163-163 BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLQVLLVAGTHGNEINGIWLFDEWKKSSFLINTHGIKTFQVIGNPEAKKAGKRYIHHD
CCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHH
LNRSFKEGSFIKINPLNCERTRASELVNLYGEAGENPCQIALDFHTTTASMGSCIVVYGR
HCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCEEEEECC
RDADLALASLIQNQLGLPVYLHESDQKQTGFLVESWPCGLVVEIGPIGQGLLNSRIISQT
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHH
KLILETLMEQIHEVKNLNLFFPNKLIIHRHIKSIDFPRDEEGNIDGYVHSLRQSKDWQEL
HHHHHHHHHHHHHHHCCEEECCCEEEEEHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHH
KKNDELFCKLNGEIIRFEEDEPYIPVFINEAAYVEKNIAMSFTKRELWNFKKEWKQALID
HCCCCEEEEECCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIHQK
HHHCC
>Mature Secondary Structure
MKQLQVLLVAGTHGNEINGIWLFDEWKKSSFLINTHGIKTFQVIGNPEAKKAGKRYIHHD
CCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHH
LNRSFKEGSFIKINPLNCERTRASELVNLYGEAGENPCQIALDFHTTTASMGSCIVVYGR
HCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCEEEEECC
RDADLALASLIQNQLGLPVYLHESDQKQTGFLVESWPCGLVVEIGPIGQGLLNSRIISQT
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHH
KLILETLMEQIHEVKNLNLFFPNKLIIHRHIKSIDFPRDEEGNIDGYVHSLRQSKDWQEL
HHHHHHHHHHHHHHHCCEEECCCEEEEEHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHH
KKNDELFCKLNGEIIRFEEDEPYIPVFINEAAYVEKNIAMSFTKRELWNFKKEWKQALID
HCCCCEEEEECCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIHQK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA