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The map label for this gene is ubiB [C]

Identifier: 124024998

GI number: 124024998

Start: 264676

End: 266301

Strand: Reverse

Name: ubiB [C]

Synonym: NATL1_02851

Alternate gene names: 124024998

Gene position: 266301-264676 (Counterclockwise)

Preceding gene: 124024999

Following gene: 124024996

Centisome position: 14.28

GC content: 33.76

Gene sequence:

>1626_bases
ATGATATTATTAGGTTTACTCTTCTATTTATGGTTTGATTCTAAAAAATGGACTTATTTAAAAGGATATACCACTAAAAA
AAGAGAAAAAAGAACTATTTCAAGAGCAAAATGGATTACAAAAGAATTAATTAATTTAGGATCAGCATTTATAAAATTAG
GCCAACTTTTATCTGCTAGAGCTGATGTTATTCCATCTTCTTGGGTAAATGAGCTTACCTCTCTACAAGACAGAGTTCCA
CCTTTTGCATTTGAAAAAGTCGATGAAATTCTAAGGAAACAACTTGGAAATTTATACAATAAAATCATAAGTATTGATAA
AAATCCAATTGGCTCAGCTTCACTTGCTCAAGTTCATAAGGCTAGATTAAATAATGACAAAAATGTCATTTTTAAAGTAC
AAAGACCAGATATAGAAAAGTTTTTCAGGCTTGACTTAGATGTGATGAATCAAGTTGCAAAAGTAGTGCAAAGAATAAAG
TCTTTAAGTAGAGGTAATGACTGGATAGGTATTGCAAAGGAGTCTAGGAGAGTATTACTCAGAGAGCTAGATTTTCGAAT
TGAAGCTCAATATGCTGCAAGATTTAAACAACAATTTATAGATGATTCAGATATTTTAATACCAAGTGTATTTTGGGATT
TAAGCACTAGTAAAGTTTTATGCTTGGAGTATTTACCAGGAATTAAGATCAATGACATTAAATCTCTAAAAAGTAATGAT
ATTGATACTTCTTCAATCGCAAAGATTGGAGCTACAAGTTATTTAAAGCAATTAGTTAATTACGGTTTTTTTCACGCTGA
TCCTCATCCTGGTAACTTAGCTGTTTCTAAGAGTGGTTCTCTCATTTACTATGATTTTGGGATGATGGGTTTTGTCTCTG
AGCGTATTAGAGGCAGGCTCAATTCAATGATAAAAGCGGCAGCGTTGAGAGACGTTAGTGGACTGGTCAAAGAACTTCAA
ATTGCTGGACTAATAGAAGACGATATTGAAATAGGTCCAGTTAGAAGATTAATAAGAATAATGTTAAATGAAGCCCTAAC
TCCTCCTTTTGATTCTCAAATCATAGAAAAGCTCTCTGGGGATATATCCGAACTGGCTTATGGCAAACCCTTTAGAATAC
CAATTGAGTTGATTTTTGTTTTTAGAGCATTATCTACTTTTGAAGGAGTTGGAAGATATTTAGACCCAGAATTTAACTTA
ATAGCAATAGCAAAACCCTTCCTTCTCCCTCTCATGACTTCAAAGAATCCAGACTCTAATGATCTATTTAATGAATTAGG
AAGACAAGTTACTGAAATAGGAAGTAAAGCAGTTGGGTTGCCAAAACGCTTAGATGAAAATCTAGAAAGACTTGAACAAG
GGGACCTGCAACTTCAAGTACGAATGGGTGAATCAGACAGACAACTGAGAAGAATGATTAATGCACAACAAACGCTAGGT
AATTCCGTTCTCCTTGGCTCACTTGCAATATCGTCAGCTTTATTAGCCTCAAATAGCAAACCACATTTATTTTTCATACC
ATTAATTCCAGGGTTTCCAATAGCCCTAAATTGGATCACATTACAATTCAAAATGAGAAACGAAAATCGACTTGATAATT
TTCAAGGAAGACGAGGCTCTCGCTAG

Upstream 100 bases:

>100_bases
TCAGATCAAAGGTTATCGATATTAATAAAGATATTGAGGGGAAAAATTGATATTTTTAGCTAATCAACTTCAAAGACTTG
TTAGAGCCTTTAGGATTTGG

Downstream 100 bases:

>100_bases
TTTATTGAAATCACCCTTTCAAGCTTCCTCTTGGTCCCAAACCAACAAGCCCAGCATATGTTGCTTGACTTCCTAACTCA
TCCTCAATACGCAGTAGTTG

Product: putative kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MILLGLLFYLWFDSKKWTYLKGYTTKKREKRTISRAKWITKELINLGSAFIKLGQLLSARADVIPSSWVNELTSLQDRVP
PFAFEKVDEILRKQLGNLYNKIISIDKNPIGSASLAQVHKARLNNDKNVIFKVQRPDIEKFFRLDLDVMNQVAKVVQRIK
SLSRGNDWIGIAKESRRVLLRELDFRIEAQYAARFKQQFIDDSDILIPSVFWDLSTSKVLCLEYLPGIKINDIKSLKSND
IDTSSIAKIGATSYLKQLVNYGFFHADPHPGNLAVSKSGSLIYYDFGMMGFVSERIRGRLNSMIKAAALRDVSGLVKELQ
IAGLIEDDIEIGPVRRLIRIMLNEALTPPFDSQIIEKLSGDISELAYGKPFRIPIELIFVFRALSTFEGVGRYLDPEFNL
IAIAKPFLLPLMTSKNPDSNDLFNELGRQVTEIGSKAVGLPKRLDENLERLEQGDLQLQVRMGESDRQLRRMINAQQTLG
NSVLLGSLAISSALLASNSKPHLFFIPLIPGFPIALNWITLQFKMRNENRLDNFQGRRGSR

Sequences:

>Translated_541_residues
MILLGLLFYLWFDSKKWTYLKGYTTKKREKRTISRAKWITKELINLGSAFIKLGQLLSARADVIPSSWVNELTSLQDRVP
PFAFEKVDEILRKQLGNLYNKIISIDKNPIGSASLAQVHKARLNNDKNVIFKVQRPDIEKFFRLDLDVMNQVAKVVQRIK
SLSRGNDWIGIAKESRRVLLRELDFRIEAQYAARFKQQFIDDSDILIPSVFWDLSTSKVLCLEYLPGIKINDIKSLKSND
IDTSSIAKIGATSYLKQLVNYGFFHADPHPGNLAVSKSGSLIYYDFGMMGFVSERIRGRLNSMIKAAALRDVSGLVKELQ
IAGLIEDDIEIGPVRRLIRIMLNEALTPPFDSQIIEKLSGDISELAYGKPFRIPIELIFVFRALSTFEGVGRYLDPEFNL
IAIAKPFLLPLMTSKNPDSNDLFNELGRQVTEIGSKAVGLPKRLDENLERLEQGDLQLQVRMGESDRQLRRMINAQQTLG
NSVLLGSLAISSALLASNSKPHLFFIPLIPGFPIALNWITLQFKMRNENRLDNFQGRRGSR
>Mature_541_residues
MILLGLLFYLWFDSKKWTYLKGYTTKKREKRTISRAKWITKELINLGSAFIKLGQLLSARADVIPSSWVNELTSLQDRVP
PFAFEKVDEILRKQLGNLYNKIISIDKNPIGSASLAQVHKARLNNDKNVIFKVQRPDIEKFFRLDLDVMNQVAKVVQRIK
SLSRGNDWIGIAKESRRVLLRELDFRIEAQYAARFKQQFIDDSDILIPSVFWDLSTSKVLCLEYLPGIKINDIKSLKSND
IDTSSIAKIGATSYLKQLVNYGFFHADPHPGNLAVSKSGSLIYYDFGMMGFVSERIRGRLNSMIKAAALRDVSGLVKELQ
IAGLIEDDIEIGPVRRLIRIMLNEALTPPFDSQIIEKLSGDISELAYGKPFRIPIELIFVFRALSTFEGVGRYLDPEFNL
IAIAKPFLLPLMTSKNPDSNDLFNELGRQVTEIGSKAVGLPKRLDENLERLEQGDLQLQVRMGESDRQLRRMINAQQTLG
NSVLLGSLAISSALLASNSKPHLFFIPLIPGFPIALNWITLQFKMRNENRLDNFQGRRGSR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=31.1355311355311, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI40254938, Length=276, Percent_Identity=29.7101449275362, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI217035081, Length=252, Percent_Identity=30.1587301587302, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI27363457, Length=288, Percent_Identity=27.0833333333333, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI217416386, Length=225, Percent_Identity=28.4444444444444, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI34147522, Length=329, Percent_Identity=24.9240121580547, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=466, Percent_Identity=28.1115879828326, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17559152, Length=261, Percent_Identity=32.183908045977, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=261, Percent_Identity=26.0536398467433, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=307, Percent_Identity=28.0130293159609, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6325148, Length=291, Percent_Identity=26.1168384879725, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=349, Percent_Identity=23.2091690544413, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24662575, Length=385, Percent_Identity=29.0909090909091, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI22024280, Length=280, Percent_Identity=31.4285714285714, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI18859849, Length=307, Percent_Identity=25.0814332247557, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61422; Mature: 61422

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLGLLFYLWFDSKKWTYLKGYTTKKREKRTISRAKWITKELINLGSAFIKLGQLLSAR
CHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVIPSSWVNELTSLQDRVPPFAFEKVDEILRKQLGNLYNKIISIDKNPIGSASLAQVHK
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ARLNNDKNVIFKVQRPDIEKFFRLDLDVMNQVAKVVQRIKSLSRGNDWIGIAKESRRVLL
HHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHH
RELDFRIEAQYAARFKQQFIDDSDILIPSVFWDLSTSKVLCLEYLPGIKINDIKSLKSND
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHCCCCEECCHHHHCCCC
IDTSSIAKIGATSYLKQLVNYGFFHADPHPGNLAVSKSGSLIYYDFGMMGFVSERIRGRL
CCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHH
NSMIKAAALRDVSGLVKELQIAGLIEDDIEIGPVRRLIRIMLNEALTPPFDSQIIEKLSG
HHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
DISELAYGKPFRIPIELIFVFRALSTFEGVGRYLDPEFNLIAIAKPFLLPLMTSKNPDSN
CHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHCCCCCCCH
DLFNELGRQVTEIGSKAVGLPKRLDENLERLEQGDLQLQVRMGESDRQLRRMINAQQTLG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHC
NSVLLGSLAISSALLASNSKPHLFFIPLIPGFPIALNWITLQFKMRNENRLDNFQGRRGS
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCC
R
C
>Mature Secondary Structure
MILLGLLFYLWFDSKKWTYLKGYTTKKREKRTISRAKWITKELINLGSAFIKLGQLLSAR
CHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVIPSSWVNELTSLQDRVPPFAFEKVDEILRKQLGNLYNKIISIDKNPIGSASLAQVHK
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ARLNNDKNVIFKVQRPDIEKFFRLDLDVMNQVAKVVQRIKSLSRGNDWIGIAKESRRVLL
HHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHH
RELDFRIEAQYAARFKQQFIDDSDILIPSVFWDLSTSKVLCLEYLPGIKINDIKSLKSND
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHCCCCEECCHHHHCCCC
IDTSSIAKIGATSYLKQLVNYGFFHADPHPGNLAVSKSGSLIYYDFGMMGFVSERIRGRL
CCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHH
NSMIKAAALRDVSGLVKELQIAGLIEDDIEIGPVRRLIRIMLNEALTPPFDSQIIEKLSG
HHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
DISELAYGKPFRIPIELIFVFRALSTFEGVGRYLDPEFNLIAIAKPFLLPLMTSKNPDSN
CHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHCCCCCCCH
DLFNELGRQVTEIGSKAVGLPKRLDENLERLEQGDLQLQVRMGESDRQLRRMINAQQTLG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHC
NSVLLGSLAISSALLASNSKPHLFFIPLIPGFPIALNWITLQFKMRNENRLDNFQGRRGS
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]