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The map label for this gene is nadC [H]

Identifier: 124024976

GI number: 124024976

Start: 241515

End: 242378

Strand: Reverse

Name: nadC [H]

Synonym: NATL1_02631

Alternate gene names: 124024976

Gene position: 242378-241515 (Counterclockwise)

Preceding gene: 124024977

Following gene: 124024975

Centisome position: 13.0

GC content: 38.54

Gene sequence:

>864_bases
GTGGATCTTCGCTCACCCAAGCTACATAAAATATTAGACACATGGATTGAGGAAGATCTTGGCGACGGAGATCTCACAAG
ATTTGTCCTCAGCGACAGAAGTGCATCAGCGCATTGGGTTGCGAAAGAGGATGGGACTTTTTGTGGTGGAGATCTGGTCA
AACTTATATTTAGAAAAATTGATCCTAAAGTTGATATTCAACTTCTCATAGAGGATGGTCAGAAGTTTGAAAAGAATCAA
AGACTACTAGAATTAAAAGGGTCTTCCTCTTCCTTAGTAGCAGGAGAGCGAGTAAGTCTGAATGTGGCCATGCATCTTTC
TGGTATTGCTACATCGACAGCTCTATTGGTAACTAAACTATCAGGATCCAAGGTGAAATTAGCAGACACCCGTAAAACAA
CTCCAGGGATGAGAGTATTCGAAAAATATGCCTTTCATTGTGGTGGCGGCATTAATCATAGACTTGGATTAGATGATGCT
GCCATGTTAAAAGAAAATCATATTGAATGGTCGCAAGGGATTAGCGAGAGTATCAAAATCTTAAAAAATACTATTCCATG
GACAAAAAAAATAATAGTCGAAGCAGAAACACCCTCCCAAGCGAAAGAAGCTGTAGAAGCAGGCGCTGATGGAGTTTTAC
TTGACGAAATGTCTGTTCAAGCTATAGAGAAATTAGTTCCCGAATTACGTCAACTTTCAAAAAATAGTAAGTCCAAATAC
GTCTCCCAAAATATTGTTATTGAAGTTTCTGGAATCAATCCAAATAATGTATCAGACTATATTTTGACAGGTATTGATCT
AATCTCAACTAGTGCGCCAATCACTAAAAGCAAATGGATAGATTTCAGTATGCGCTTTGACTAA

Upstream 100 bases:

>100_bases
TTTTTAAGATAAAGATAAGTAGATGAAATTAAAAAATAGAAGAAGATATTTTTTATAATGGTTTTAAGATTGGTATAGTA
ATAAATGTATTAGTTGTATT

Downstream 100 bases:

>100_bases
AAAATGAATAAACAGTTTTCTAACAACTTCTAAAAATCCTAAAAGTAACTACTTAACCATAAACATCATGCTTGAAATAT
CCGCCAGATTAGAAGAAGCA

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MDLRSPKLHKILDTWIEEDLGDGDLTRFVLSDRSASAHWVAKEDGTFCGGDLVKLIFRKIDPKVDIQLLIEDGQKFEKNQ
RLLELKGSSSSLVAGERVSLNVAMHLSGIATSTALLVTKLSGSKVKLADTRKTTPGMRVFEKYAFHCGGGINHRLGLDDA
AMLKENHIEWSQGISESIKILKNTIPWTKKIIVEAETPSQAKEAVEAGADGVLLDEMSVQAIEKLVPELRQLSKNSKSKY
VSQNIVIEVSGINPNNVSDYILTGIDLISTSAPITKSKWIDFSMRFD

Sequences:

>Translated_287_residues
MDLRSPKLHKILDTWIEEDLGDGDLTRFVLSDRSASAHWVAKEDGTFCGGDLVKLIFRKIDPKVDIQLLIEDGQKFEKNQ
RLLELKGSSSSLVAGERVSLNVAMHLSGIATSTALLVTKLSGSKVKLADTRKTTPGMRVFEKYAFHCGGGINHRLGLDDA
AMLKENHIEWSQGISESIKILKNTIPWTKKIIVEAETPSQAKEAVEAGADGVLLDEMSVQAIEKLVPELRQLSKNSKSKY
VSQNIVIEVSGINPNNVSDYILTGIDLISTSAPITKSKWIDFSMRFD
>Mature_287_residues
MDLRSPKLHKILDTWIEEDLGDGDLTRFVLSDRSASAHWVAKEDGTFCGGDLVKLIFRKIDPKVDIQLLIEDGQKFEKNQ
RLLELKGSSSSLVAGERVSLNVAMHLSGIATSTALLVTKLSGSKVKLADTRKTTPGMRVFEKYAFHCGGGINHRLGLDDA
AMLKENHIEWSQGISESIKILKNTIPWTKKIIVEAETPSQAKEAVEAGADGVLLDEMSVQAIEKLVPELRQLSKNSKSKY
VSQNIVIEVSGINPNNVSDYILTGIDLISTSAPITKSKWIDFSMRFD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=282, Percent_Identity=29.7872340425532, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=36.2007168458781, Blast_Score=145, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=283, Percent_Identity=30.0353356890459, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31664; Mature: 31664

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRSPKLHKILDTWIEEDLGDGDLTRFVLSDRSASAHWVAKEDGTFCGGDLVKLIFRKI
CCCCCCHHHHHHHHHHHHCCCCCHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHC
DPKVDIQLLIEDGQKFEKNQRLLELKGSSSSLVAGERVSLNVAMHLSGIATSTALLVTKL
CCCCEEEEEEECCCHHHCCCEEEEECCCCCCEEECCEEEEEEEEEECCHHHHHEEEEEEC
SGSKVKLADTRKTTPGMRVFEKYAFHCGGGINHRLGLDDAAMLKENHIEWSQGISESIKI
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHCHHHHHHH
LKNTIPWTKKIIVEAETPSQAKEAVEAGADGVLLDEMSVQAIEKLVPELRQLSKNSKSKY
HHHCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHE
VSQNIVIEVSGINPNNVSDYILTGIDLISTSAPITKSKWIDFSMRFD
ECCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MDLRSPKLHKILDTWIEEDLGDGDLTRFVLSDRSASAHWVAKEDGTFCGGDLVKLIFRKI
CCCCCCHHHHHHHHHHHHCCCCCHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHC
DPKVDIQLLIEDGQKFEKNQRLLELKGSSSSLVAGERVSLNVAMHLSGIATSTALLVTKL
CCCCEEEEEEECCCHHHCCCEEEEECCCCCCEEECCEEEEEEEEEECCHHHHHEEEEEEC
SGSKVKLADTRKTTPGMRVFEKYAFHCGGGINHRLGLDDAAMLKENHIEWSQGISESIKI
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHCHHHHHHH
LKNTIPWTKKIIVEAETPSQAKEAVEAGADGVLLDEMSVQAIEKLVPELRQLSKNSKSKY
HHHCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHE
VSQNIVIEVSGINPNNVSDYILTGIDLISTSAPITKSKWIDFSMRFD
ECCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]