Click here to switch to the map view.

The map label for this gene is ndhD

Identifier: 124024935

GI number: 124024935

Start: 207250

End: 208866

Strand: Direct

Name: ndhD

Synonym: NATL1_02221

Alternate gene names: 124024935

Gene position: 207250-208866 (Clockwise)

Preceding gene: 124024934

Following gene: 124024936

Centisome position: 11.11

GC content: 38.16

Gene sequence:

>1617_bases
ATGCTAATTCCTGAGCCAATTCAAGCCGATTTTCCTTGGTTAAGTTTATCCATATTGTTTCCCATAGTTGGAGCATTGAT
TGTTCCTTTTATTCCAGATAAAGGTGAGGGAAAAGAAGTTCGATGGTATGCACTCATAATTTCTTTAATTACTTTTCTAA
TTACTGTCGCTGCTTACTTCAAAGGTTTTGATCCAAGTCTAGAAGGCTTGCAATTATATGAAAAAGTTAGTTGGCTTCCT
GATCTTGGGTTGACTTGGTCTGTTGGTGCAGATGGACTATCAATGCCATTGATATTGCTTACAAGCTTTATAACTTCTCT
TGCCGTTTTGGCGGCATGGCCAGTTAGCTATAAACCAAAATTATTTTTCTTTTTAATTCTCGCCATGGATGGCGGCCAGA
TAGCTGTCTTTGCAGTTCAAGATATGTTGCTTTTCTTCCTGGCTTGGGAATTGGAATTGTTCCCCGTTTATTTATTCCTT
GCAATCTGGGGCGGAAAGAAGAGGCAATATGCGGCGACCAAATTTATTATTTATACAGCAGGAAGCTCGTTATTTATTCT
CCTTGCTGGTCTTGCGATGGGTTTCTTTCAAGGAGGAGGGGTGCCAGATTTCGGTTATACCCATTTAGCTCAGCAAAATT
TTGGGAGGGGTTTTCAACTGCTTTGTTATTCAGGTTTGTTAATAGCATTTGGGGTCAAACTTCCTATTGTTCCCCTACAT
ACTTGGTTGCCTGATGCACATGGAGAGGCTACTGCTCCAGTACATATGCTCTTGGCAGGAATCTTGTTAAAGATGGGAGG
ATATGCTCTCCTTAGATTTAATGCACAATTACTGCCAGATGCTCATGCTCAATTTGCTCCATTGTTAATTGTATTGGGAG
TGGTAAATATTATTTATGCAGCTTTAACCTCTTTTGCTCAAAGAAATTTAAAAAGGAAAATTGCCTACAGCTCAATAAGT
CATATGGGTTTTGTTTTAATAGGCATTGGAAGCTTTAGCTCTTTAGGTACTAGTGGTGCAATGTTGCAAATGGTAAGCCA
CGGTTTAATAGGAGCAAGCTTGTTTTTCCTTGTTGGTGCAACTTACGACAGAACTCATACCCTTCAATTAGATGAGATGG
GTGGTATTGGTCAAAATATGAGGATTATGTTTGCGTTATGGACTGCATGCGCTTTCGCTTCTCTTGCTTTGCCTGGGATG
AGTGGATTTATCTCGGAATTAATGGTTTTTGTTGGGTTTGTAACTGATGAAGTTTATACTCTTCCATTTAGGATTGTTGT
TGCTTCGTTGGCAGCAATTGGAGTCATTTTGACACCTATATATTTATTATCGATGCTCAGAGAAATCTTCTTCGGAAAAG
AGAATGCAAAGTTAATATCTAAAGCAAAGTTAGTAGATGCTGAACCTAGAGAAATCTATATTATTGCTTGTTTATTAGTT
CCCATTATTGGAATTGGTTTGTATCCAAAAATTATGACTGATACTTATATTTCATCAATTGATGGATTGGTTAAGAGAGA
TTTGTTAGCCGTTGAGAGAATTAGAAGTGATCGGGCAACAATTATGAGCAATACAAGCTTATCAATTGGGACTATTGAGG
CTCCTCTTTTAGATTGA

Upstream 100 bases:

>100_bases
TTTAGAGGGTGCCAATAATTTCATAATTTCTAAACTCAAAATGTGTAATTAATTTCGAGTCTTGGAATTTGCTCTCAATA
CAAGTTTGAATCTAGGGACA

Downstream 100 bases:

>100_bases
AAATTATTTCATCTGGCATTACATCCAATATAGAGATAACTTGCATTTAGATTAATAGTGCTCATTGCCAGTTGATTTTT
TAACTCAATCTGCAGATTCT

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4; NDH-1, chain 4

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MLIPEPIQADFPWLSLSILFPIVGALIVPFIPDKGEGKEVRWYALIISLITFLITVAAYFKGFDPSLEGLQLYEKVSWLP
DLGLTWSVGADGLSMPLILLTSFITSLAVLAAWPVSYKPKLFFFLILAMDGGQIAVFAVQDMLLFFLAWELELFPVYLFL
AIWGGKKRQYAATKFIIYTAGSSLFILLAGLAMGFFQGGGVPDFGYTHLAQQNFGRGFQLLCYSGLLIAFGVKLPIVPLH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPDAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSIS
HMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTHTLQLDEMGGIGQNMRIMFALWTACAFASLALPGM
SGFISELMVFVGFVTDEVYTLPFRIVVASLAAIGVILTPIYLLSMLREIFFGKENAKLISKAKLVDAEPREIYIIACLLV
PIIGIGLYPKIMTDTYISSIDGLVKRDLLAVERIRSDRATIMSNTSLSIGTIEAPLLD

Sequences:

>Translated_538_residues
MLIPEPIQADFPWLSLSILFPIVGALIVPFIPDKGEGKEVRWYALIISLITFLITVAAYFKGFDPSLEGLQLYEKVSWLP
DLGLTWSVGADGLSMPLILLTSFITSLAVLAAWPVSYKPKLFFFLILAMDGGQIAVFAVQDMLLFFLAWELELFPVYLFL
AIWGGKKRQYAATKFIIYTAGSSLFILLAGLAMGFFQGGGVPDFGYTHLAQQNFGRGFQLLCYSGLLIAFGVKLPIVPLH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPDAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSIS
HMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTHTLQLDEMGGIGQNMRIMFALWTACAFASLALPGM
SGFISELMVFVGFVTDEVYTLPFRIVVASLAAIGVILTPIYLLSMLREIFFGKENAKLISKAKLVDAEPREIYIIACLLV
PIIGIGLYPKIMTDTYISSIDGLVKRDLLAVERIRSDRATIMSNTSLSIGTIEAPLLD
>Mature_538_residues
MLIPEPIQADFPWLSLSILFPIVGALIVPFIPDKGEGKEVRWYALIISLITFLITVAAYFKGFDPSLEGLQLYEKVSWLP
DLGLTWSVGADGLSMPLILLTSFITSLAVLAAWPVSYKPKLFFFLILAMDGGQIAVFAVQDMLLFFLAWELELFPVYLFL
AIWGGKKRQYAATKFIIYTAGSSLFILLAGLAMGFFQGGGVPDFGYTHLAQQNFGRGFQLLCYSGLLIAFGVKLPIVPLH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPDAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSIS
HMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTHTLQLDEMGGIGQNMRIMFALWTACAFASLALPGM
SGFISELMVFVGFVTDEVYTLPFRIVVASLAAIGVILTPIYLLSMLREIFFGKENAKLISKAKLVDAEPREIYIIACLLV
PIIGIGLYPKIMTDTYISSIDGLVKRDLLAVERIRSDRATIMSNTSLSIGTIEAPLLD

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=388, Percent_Identity=30.1546391752577, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1788613, Length=517, Percent_Identity=38.1044487427466, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788831, Length=190, Percent_Identity=34.2105263157895, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788827, Length=252, Percent_Identity=29.7619047619048, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788614, Length=462, Percent_Identity=24.025974025974, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693160, Length=222, Percent_Identity=31.0810810810811, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI2367154, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788829, Length=424, Percent_Identity=24.7641509433962, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C_PROM1 (A2BZX6)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014051.1
- STRING:   A2BZX6
- GeneID:   4779479
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_02221
- eggNOG:   COG1008
- HOGENOM:   HBG643593
- OMA:   TSFAQRN
- ProtClustDB:   PRK02546
- BioCyc:   PMAR167555:NATL1_02221-MONOMER
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: 1.6.5.3

Molecular weight: Translated: 58756; Mature: 58756

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f2bb358)-; HASH(0x1eaf4d58)-; HASH(0x1f16fdd0)-; HASH(0x1f188eb8)-; HASH(0xec20404)-; HASH(0x1f188c54)-; HASH(0x1f181c34)-; HASH(0x1f18ab44)-; HASH(0x1f12a46c)-; HASH(0x1eb1d980)-; HASH(0x1f1900c4)-; HASH(0x1f188cfc)-; HASH(0x1f18c728)-; HASH(0x1f18389c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIPEPIQADFPWLSLSILFPIVGALIVPFIPDKGEGKEVRWYALIISLITFLITVAAYF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KGFDPSLEGLQLYEKVSWLPDLGLTWSVGADGLSMPLILLTSFITSLAVLAAWPVSYKPK
CCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LFFFLILAMDGGQIAVFAVQDMLLFFLAWELELFPVYLFLAIWGGKKRQYAATKFIIYTA
EEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHEEEEEEEC
GSSLFILLAGLAMGFFQGGGVPDFGYTHLAQQNFGRGFQLLCYSGLLIAFGVKLPIVPLH
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEHH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPDAHAQFAPLLIVLGVVNIIYA
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHH
ALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGA
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHCC
TYDRTHTLQLDEMGGIGQNMRIMFALWTACAFASLALPGMSGFISELMVFVGFVTDEVYT
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LPFRIVVASLAAIGVILTPIYLLSMLREIFFGKENAKLISKAKLVDAEPREIYIIACLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEHHHHHH
PIIGIGLYPKIMTDTYISSIDGLVKRDLLAVERIRSDRATIMSNTSLSIGTIEAPLLD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCEEEEECCCCCCH
>Mature Secondary Structure
MLIPEPIQADFPWLSLSILFPIVGALIVPFIPDKGEGKEVRWYALIISLITFLITVAAYF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KGFDPSLEGLQLYEKVSWLPDLGLTWSVGADGLSMPLILLTSFITSLAVLAAWPVSYKPK
CCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
LFFFLILAMDGGQIAVFAVQDMLLFFLAWELELFPVYLFLAIWGGKKRQYAATKFIIYTA
EEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHEEEEEEEC
GSSLFILLAGLAMGFFQGGGVPDFGYTHLAQQNFGRGFQLLCYSGLLIAFGVKLPIVPLH
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEHH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPDAHAQFAPLLIVLGVVNIIYA
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHH
ALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGA
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHCC
TYDRTHTLQLDEMGGIGQNMRIMFALWTACAFASLALPGMSGFISELMVFVGFVTDEVYT
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LPFRIVVASLAAIGVILTPIYLLSMLREIFFGKENAKLISKAKLVDAEPREIYIIACLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEHHHHHH
PIIGIGLYPKIMTDTYISSIDGLVKRDLLAVERIRSDRATIMSNTSLSIGTIEAPLLD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCEEEEECCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA