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The map label for this gene is hhoA [H]

Identifier: 124024871

GI number: 124024871

Start: 154034

End: 155212

Strand: Reverse

Name: hhoA [H]

Synonym: NATL1_01581

Alternate gene names: 124024871

Gene position: 155212-154034 (Counterclockwise)

Preceding gene: 124024877

Following gene: 124024869

Centisome position: 8.32

GC content: 34.01

Gene sequence:

>1179_bases
ATGCATGGATTAGATGACAACAGACTATTAATAGGATCCCTAAAGTTACGTCAAAAAAAATATTTTAAAATTTTTGTTTT
AGTTGTTCTTATTTTTTTTAACTTCCGATATGAAACTCCTCTTCATTCAAGTGAAGCTTCACTGTTATCCCAAGAAAATC
ACAATAAGCAATCTTTCGTATCAAAAGCATTAAATATTAGTGGGGATGCAGTGGTCACAATTGAAACACAACGTCAGGTT
TTATCTTCAAGTGAAGGTGTATTTCCTCCTGGGATCTTAAATGATCGATATTTTGAACGATTCTTTGGTCTAAGAGGCCT
GCAAGTTCCACGATCTCGAATTGAAAAAGGCCAAGGAAGTGGAGTGATTTTTTCTAAAGAAGGTCTGGTCTTGACTAATG
CTCATGTAATAGAAAAAACTGATCAATTAATAGTGGGTTTATCAGATGGAAGAAGAGTGCTTGGAAATGTTGTTGGAGAA
GATTCTTTAACAGATCTTGCAGTTATAAAACTCCAAGCAAAAGGTCCTTGGCCAACTGCCCAATTAGGAAACTCCGATAA
TTTAAAAGTTGGTGATTGGGCAATTGCAGTTGGAAATCCTTTTGGACTTGAAAATACGGTTACTCTTGGAATCATTAGTA
ATCTCAATAGAGATGTTGCTCAATTAGGTATATCCGACAAAAGAATAGATCTCATTCAAACTGATGCAGCTATTAATCCA
GGTAATTCTGGAGGACCATTATTAAATTCTGTTGGAGAAGTGATTGGTATTAATACTCTTGTTCGCTCAGGACCAGGAGC
AGGATTAGGTTTCGCAATTCCAATAAATAGAGCTAGAAAAATCGCCAAAGATTTAATCACCAGCGGGAGAGCCAAGCATC
CCATGATCGGAGTAACACTTTCAAGCAATATCAAACAAAAAAGTAATTTTCTTTCCCAAACAGAAGATGGAGCGATAATT
AAATATTTAATGCCAAATGGTCCGGCCGAAAAAGGTGGATTAAAAGTAAATGATCTAATAATTTCAATCAACAATGAAAA
AATTTCAACTCCAGCAGATGTGGTAAAAAAAATTAATAAAAATAATTTACAATCAGCATTAAAAATTAAAATACTTAGAG
GGAATATAGAGTCTATAAAAATCATCAAACCAGTTGATGTTTATGATCTTCAAGTATAA

Upstream 100 bases:

>100_bases
ATTTAGTAAAAATCTACGGTAGTTAAAATGGTGGGCATTTCAATTTTTAAATTAGCTATGATTAGTTTTGATAATAATAA
CTAATCCCTTTCTGAAGATT

Downstream 100 bases:

>100_bases
TCAAAAAACATTTCTATCATAATTATTTTTGTTTAGTTTTCTTCTTCCTACGCTGTTTTTCTCGATTAGCCAACCTTTTT
CTTTCCCTTTCAGCTAATTG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MHGLDDNRLLIGSLKLRQKKYFKIFVLVVLIFFNFRYETPLHSSEASLLSQENHNKQSFVSKALNISGDAVVTIETQRQV
LSSSEGVFPPGILNDRYFERFFGLRGLQVPRSRIEKGQGSGVIFSKEGLVLTNAHVIEKTDQLIVGLSDGRRVLGNVVGE
DSLTDLAVIKLQAKGPWPTAQLGNSDNLKVGDWAIAVGNPFGLENTVTLGIISNLNRDVAQLGISDKRIDLIQTDAAINP
GNSGGPLLNSVGEVIGINTLVRSGPGAGLGFAIPINRARKIAKDLITSGRAKHPMIGVTLSSNIKQKSNFLSQTEDGAII
KYLMPNGPAEKGGLKVNDLIISINNEKISTPADVVKKINKNNLQSALKIKILRGNIESIKIIKPVDVYDLQV

Sequences:

>Translated_392_residues
MHGLDDNRLLIGSLKLRQKKYFKIFVLVVLIFFNFRYETPLHSSEASLLSQENHNKQSFVSKALNISGDAVVTIETQRQV
LSSSEGVFPPGILNDRYFERFFGLRGLQVPRSRIEKGQGSGVIFSKEGLVLTNAHVIEKTDQLIVGLSDGRRVLGNVVGE
DSLTDLAVIKLQAKGPWPTAQLGNSDNLKVGDWAIAVGNPFGLENTVTLGIISNLNRDVAQLGISDKRIDLIQTDAAINP
GNSGGPLLNSVGEVIGINTLVRSGPGAGLGFAIPINRARKIAKDLITSGRAKHPMIGVTLSSNIKQKSNFLSQTEDGAII
KYLMPNGPAEKGGLKVNDLIISINNEKISTPADVVKKINKNNLQSALKIKILRGNIESIKIIKPVDVYDLQV
>Mature_392_residues
MHGLDDNRLLIGSLKLRQKKYFKIFVLVVLIFFNFRYETPLHSSEASLLSQENHNKQSFVSKALNISGDAVVTIETQRQV
LSSSEGVFPPGILNDRYFERFFGLRGLQVPRSRIEKGQGSGVIFSKEGLVLTNAHVIEKTDQLIVGLSDGRRVLGNVVGE
DSLTDLAVIKLQAKGPWPTAQLGNSDNLKVGDWAIAVGNPFGLENTVTLGIISNLNRDVAQLGISDKRIDLIQTDAAINP
GNSGGPLLNSVGEVIGINTLVRSGPGAGLGFAIPINRARKIAKDLITSGRAKHPMIGVTLSSNIKQKSNFLSQTEDGAII
KYLMPNGPAEKGGLKVNDLIISINNEKISTPADVVKKINKNNLQSALKIKILRGNIESIKIIKPVDVYDLQV

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=296, Percent_Identity=37.8378378378378, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI22129776, Length=310, Percent_Identity=34.1935483870968, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI24308541, Length=273, Percent_Identity=35.8974358974359, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI7019477, Length=270, Percent_Identity=35.9259259259259, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1789629, Length=282, Percent_Identity=38.6524822695035, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789630, Length=263, Percent_Identity=39.9239543726236, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786356, Length=262, Percent_Identity=38.9312977099237, Blast_Score=160, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646839, Length=347, Percent_Identity=33.4293948126801, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42498; Mature: 42498

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGLDDNRLLIGSLKLRQKKYFKIFVLVVLIFFNFRYETPLHSSEASLLSQENHNKQSFV
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHH
SKALNISGDAVVTIETQRQVLSSSEGVFPPGILNDRYFERFFGLRGLQVPRSRIEKGQGS
HHHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCC
GVIFSKEGLVLTNAHVIEKTDQLIVGLSDGRRVLGNVVGEDSLTDLAVIKLQAKGPWPTA
EEEEECCCEEEECCHHEECCCEEEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCH
QLGNSDNLKVGDWAIAVGNPFGLENTVTLGIISNLNRDVAQLGISDKRIDLIQTDAAINP
HCCCCCCEEECCEEEEECCCCCCCCEEEEEEHHHCCHHHHHHCCCCCEEEEEEECCCCCC
GNSGGPLLNSVGEVIGINTLVRSGPGAGLGFAIPINRARKIAKDLITSGRAKHPMIGVTL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEE
SSNIKQKSNFLSQTEDGAIIKYLMPNGPAEKGGLKVNDLIISINNEKISTPADVVKKINK
CCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHCC
NNLQSALKIKILRGNIESIKIIKPVDVYDLQV
CCCCCEEEEEEEECCCCEEEEECCCCEEEECC
>Mature Secondary Structure
MHGLDDNRLLIGSLKLRQKKYFKIFVLVVLIFFNFRYETPLHSSEASLLSQENHNKQSFV
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHH
SKALNISGDAVVTIETQRQVLSSSEGVFPPGILNDRYFERFFGLRGLQVPRSRIEKGQGS
HHHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCC
GVIFSKEGLVLTNAHVIEKTDQLIVGLSDGRRVLGNVVGEDSLTDLAVIKLQAKGPWPTA
EEEEECCCEEEECCHHEECCCEEEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCH
QLGNSDNLKVGDWAIAVGNPFGLENTVTLGIISNLNRDVAQLGISDKRIDLIQTDAAINP
HCCCCCCEEECCEEEEECCCCCCCCEEEEEEHHHCCHHHHHHCCCCCEEEEEEECCCCCC
GNSGGPLLNSVGEVIGINTLVRSGPGAGLGFAIPINRARKIAKDLITSGRAKHPMIGVTL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEE
SSNIKQKSNFLSQTEDGAIIKYLMPNGPAEKGGLKVNDLIISINNEKISTPADVVKKINK
CCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHCC
NNLQSALKIKILRGNIESIKIIKPVDVYDLQV
CCCCCEEEEEEEECCCCEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]