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The map label for this gene is pgm [H]

Identifier: 124024854

GI number: 124024854

Start: 137922

End: 139571

Strand: Direct

Name: pgm [H]

Synonym: NATL1_01411

Alternate gene names: 124024854

Gene position: 137922-139571 (Clockwise)

Preceding gene: 124024853

Following gene: 124024855

Centisome position: 7.4

GC content: 37.7

Gene sequence:

>1650_bases
GTGTTTTCTACAGAATTTACCCAACTTACAGTTCAGTTAAACTCACCTTTTACTGATCAAAAACCAGGTACTTCTGGATT
AAGAAAAAGTACTTTGCAGTTCGAAGAGACACATTACCTAGAGAGTTTTATTGAATCAATCTTGTGTTCCCTGCCAGGGG
TGCGAGGAGGTGTTTTGGTTGTGGGAGGTGATGGTAGATATGGCAACAAAAGAGCAATTGACATTATTATTCGGATGGCA
GCTGCACATGGAATTCAAAAAGTCATAACAACTGTAGATGGGATTTTATCGACCCCTGCAGCTTCGAATTTGATTCGAAT
TAATAAAGCAATAGGTGGAATTATTTTATCTGCTAGTCATAACCCAGGTGGACTGGAAGGTGATTTTGGAGTCAAGCTAA
ATGGCTCAAATGGTGGACCTGCCTCAGAATCTTTAACTGATGAAATTTATAATTACTCCAAGAATCTTAAAGAATATAAG
ATCATAAAATGTCAATCAAATAATTCTTTTTCACTCGGCAAATATAAATTAGCTTCAATGATTGTCGAGATTATTGATGG
AATAGACGATTACTTAGATTTAATGAAAAAAATATTTGATTTTGATTTGATTAGTTCCTATATCAACAATGATTTTCCGA
TCGTTTTTGATGCATTAAATGCTGTTACAGGTCCATATGCAAAGCGTCTTTTTGTGGATCATTTAGGAGCTACTGCAGAA
ACAGTAAGAAATGGAATACCTTTGGAAGATTTTGGAGGTCTTCATCCTGATCCAAATTTGACTTATGCTAAAGATCTTGC
TGATTTGCTTTTAAAAGGCAATCTATTTTCCTTCGGAGCAGCTTGTGATGGGGATGGGGATAGAAATATGATTTTAGGAC
GTGGTTGCTTTGTAAATCCTAGTGATAGCCTTGCAATCTTGGCTGCTAATTACGATTGTGTACCAGGCTATGCCAAAGGT
TTATCGGGTGTGGCTCGTTCCATGCCTACGAGCTCAGCGGTGGATGTTGTGGCAAAACATTTAGGGATAAATTGCTTTGA
AACACCTACTGGCTGGAAATTCTTTGGCAATCTCTTGGACGCTAATCAAATCACTCTGTGTGGAGAGGAGAGCTTTGGTA
CTGGAAGTGATCATGTAAGAGAGAAAGATGGATTGTGGGCTGTTCTTTTTTGGTTGCAGATACTTGCGTCAAAGAAAAAG
TCTGTTTCTGAGATAATGAAAAATCATTGGCTATTTTTTGGTCGCCATTACTATTCTCGACATGATTATGAATCTATTCC
ATCTGAAGTTGCAAATTCTCTTTATTCAAGATTGAGCAATATGCTTCCCACTTTGATAGGTGAATCTTTTGCTCGAAGGA
CGATTGAAAATGCTGATGATTTTAGCTACACAGATCCAGTTGATGGTTCAATTACGCTTAATCAAGGTTTAAGAATTTTA
TTAGATGATGGTAGTCGAGTGTTAGTGAGACTTTCGGGTACGGGTACTCAAGGAGCTACTTTGAGAGTTTATTTTGAAAG
CTTTGTTCCAAGGGATGGTGATATCACTCAAGACCCTCAGTTAGCTTTGGATCCCTTAATTAAAAGTATTGATTCTCTAG
CTGAGATTTCAAAACGAACTGGGATGTCCGCTCCTACAGTTATTACGTAG

Upstream 100 bases:

>100_bases
TATCGCAATGCTTCGTACTTCTGAAATGCCTCACTGACTTTAATGTGTTGCCATTTCATTTTCGATTCATTTTCATATCA
TTAACTAATTTATTTTCAAA

Downstream 100 bases:

>100_bases
ATCAAAAATCTTCAATTTGAAATCATCAAAACAACTTTATAAGTTTTTTTTTGCTTTTAGAGTATCAAAAATGTTTATTT
ATTAGCTTTGTCCAAAGATC

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MFSTEFTQLTVQLNSPFTDQKPGTSGLRKSTLQFEETHYLESFIESILCSLPGVRGGVLVVGGDGRYGNKRAIDIIIRMA
AAHGIQKVITTVDGILSTPAASNLIRINKAIGGIILSASHNPGGLEGDFGVKLNGSNGGPASESLTDEIYNYSKNLKEYK
IIKCQSNNSFSLGKYKLASMIVEIIDGIDDYLDLMKKIFDFDLISSYINNDFPIVFDALNAVTGPYAKRLFVDHLGATAE
TVRNGIPLEDFGGLHPDPNLTYAKDLADLLLKGNLFSFGAACDGDGDRNMILGRGCFVNPSDSLAILAANYDCVPGYAKG
LSGVARSMPTSSAVDVVAKHLGINCFETPTGWKFFGNLLDANQITLCGEESFGTGSDHVREKDGLWAVLFWLQILASKKK
SVSEIMKNHWLFFGRHYYSRHDYESIPSEVANSLYSRLSNMLPTLIGESFARRTIENADDFSYTDPVDGSITLNQGLRIL
LDDGSRVLVRLSGTGTQGATLRVYFESFVPRDGDITQDPQLALDPLIKSIDSLAEISKRTGMSAPTVIT

Sequences:

>Translated_549_residues
MFSTEFTQLTVQLNSPFTDQKPGTSGLRKSTLQFEETHYLESFIESILCSLPGVRGGVLVVGGDGRYGNKRAIDIIIRMA
AAHGIQKVITTVDGILSTPAASNLIRINKAIGGIILSASHNPGGLEGDFGVKLNGSNGGPASESLTDEIYNYSKNLKEYK
IIKCQSNNSFSLGKYKLASMIVEIIDGIDDYLDLMKKIFDFDLISSYINNDFPIVFDALNAVTGPYAKRLFVDHLGATAE
TVRNGIPLEDFGGLHPDPNLTYAKDLADLLLKGNLFSFGAACDGDGDRNMILGRGCFVNPSDSLAILAANYDCVPGYAKG
LSGVARSMPTSSAVDVVAKHLGINCFETPTGWKFFGNLLDANQITLCGEESFGTGSDHVREKDGLWAVLFWLQILASKKK
SVSEIMKNHWLFFGRHYYSRHDYESIPSEVANSLYSRLSNMLPTLIGESFARRTIENADDFSYTDPVDGSITLNQGLRIL
LDDGSRVLVRLSGTGTQGATLRVYFESFVPRDGDITQDPQLALDPLIKSIDSLAEISKRTGMSAPTVIT
>Mature_549_residues
MFSTEFTQLTVQLNSPFTDQKPGTSGLRKSTLQFEETHYLESFIESILCSLPGVRGGVLVVGGDGRYGNKRAIDIIIRMA
AAHGIQKVITTVDGILSTPAASNLIRINKAIGGIILSASHNPGGLEGDFGVKLNGSNGGPASESLTDEIYNYSKNLKEYK
IIKCQSNNSFSLGKYKLASMIVEIIDGIDDYLDLMKKIFDFDLISSYINNDFPIVFDALNAVTGPYAKRLFVDHLGATAE
TVRNGIPLEDFGGLHPDPNLTYAKDLADLLLKGNLFSFGAACDGDGDRNMILGRGCFVNPSDSLAILAANYDCVPGYAKG
LSGVARSMPTSSAVDVVAKHLGINCFETPTGWKFFGNLLDANQITLCGEESFGTGSDHVREKDGLWAVLFWLQILASKKK
SVSEIMKNHWLFFGRHYYSRHDYESIPSEVANSLYSRLSNMLPTLIGESFARRTIENADDFSYTDPVDGSITLNQGLRIL
LDDGSRVLVRLSGTGTQGATLRVYFESFVPRDGDITQDPQLALDPLIKSIDSLAEISKRTGMSAPTVIT

Specific function: This enzyme participates in both the breakdown and synthesis of glucose. Required for the synthesis of capsular polysaccharide and normal lipopolysaccharide [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=554, Percent_Identity=52.7075812274368, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI21361621, Length=560, Percent_Identity=51.0714285714286, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI133922562, Length=561, Percent_Identity=48.6631016042781, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI290463104, Length=366, Percent_Identity=52.4590163934426, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI239743670, Length=115, Percent_Identity=46.9565217391304, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI239741729, Length=114, Percent_Identity=49.1228070175439, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1786904, Length=524, Percent_Identity=25.5725190839695, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17535441, Length=559, Percent_Identity=47.5849731663685, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6323752, Length=568, Percent_Identity=46.6549295774648, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322722, Length=560, Percent_Identity=47.6785714285714, Blast_Score=478, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17864244, Length=564, Percent_Identity=46.8085106382979, Blast_Score=529, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59731; Mature: 59731

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSTEFTQLTVQLNSPFTDQKPGTSGLRKSTLQFEETHYLESFIESILCSLPGVRGGVLV
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VGGDGRYGNKRAIDIIIRMAAAHGIQKVITTVDGILSTPAASNLIRINKAIGGIILSASH
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHHHCCEEEEECC
NPGGLEGDFGVKLNGSNGGPASESLTDEIYNYSKNLKEYKIIKCQSNNSFSLGKYKLASM
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHH
IVEIIDGIDDYLDLMKKIFDFDLISSYINNDFPIVFDALNAVTGPYAKRLFVDHLGATAE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHH
TVRNGIPLEDFGGLHPDPNLTYAKDLADLLLKGNLFSFGAACDGDGDRNMILGRGCFVNP
HHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECC
SDSLAILAANYDCVPGYAKGLSGVARSMPTSSAVDVVAKHLGINCFETPTGWKFFGNLLD
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHCC
ANQITLCGEESFGTGSDHVREKDGLWAVLFWLQILASKKKSVSEIMKNHWLFFGRHYYSR
CCEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHCC
HDYESIPSEVANSLYSRLSNMLPTLIGESFARRTIENADDFSYTDPVDGSITLNQGLRIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCEEE
LDDGSRVLVRLSGTGTQGATLRVYFESFVPRDGDITQDPQLALDPLIKSIDSLAEISKRT
EECCCEEEEEEECCCCCCCEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GMSAPTVIT
CCCCCCCCC
>Mature Secondary Structure
MFSTEFTQLTVQLNSPFTDQKPGTSGLRKSTLQFEETHYLESFIESILCSLPGVRGGVLV
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VGGDGRYGNKRAIDIIIRMAAAHGIQKVITTVDGILSTPAASNLIRINKAIGGIILSASH
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHHHCCEEEEECC
NPGGLEGDFGVKLNGSNGGPASESLTDEIYNYSKNLKEYKIIKCQSNNSFSLGKYKLASM
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHH
IVEIIDGIDDYLDLMKKIFDFDLISSYINNDFPIVFDALNAVTGPYAKRLFVDHLGATAE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHH
TVRNGIPLEDFGGLHPDPNLTYAKDLADLLLKGNLFSFGAACDGDGDRNMILGRGCFVNP
HHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECC
SDSLAILAANYDCVPGYAKGLSGVARSMPTSSAVDVVAKHLGINCFETPTGWKFFGNLLD
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHCC
ANQITLCGEESFGTGSDHVREKDGLWAVLFWLQILASKKKSVSEIMKNHWLFFGRHYYSR
CCEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHCC
HDYESIPSEVANSLYSRLSNMLPTLIGESFARRTIENADDFSYTDPVDGSITLNQGLRIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCEEE
LDDGSRVLVRLSGTGTQGATLRVYFESFVPRDGDITQDPQLALDPLIKSIDSLAEISKRT
EECCCEEEEEEECCCCCCCEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GMSAPTVIT
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7959036; 2307661 [H]