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The map label for this gene is csd [H]

Identifier: 124024847

GI number: 124024847

Start: 130693

End: 131943

Strand: Reverse

Name: csd [H]

Synonym: NATL1_01341

Alternate gene names: 124024847

Gene position: 131943-130693 (Counterclockwise)

Preceding gene: 124024848

Following gene: 124024845

Centisome position: 7.08

GC content: 33.09

Gene sequence:

>1251_bases
GTGAACAATTTAGTAAAAAATATTGCTGAAAAAAGTAGAAATGATTTCCCATTATTTAATAGAGATATTAATAAAAATTT
AATATATTTAGATCATGCAGCGACTAGTCAAAAGCCTAAACAAGTTATAGATTCTCTAAAAAAATACTATAGCTTTCAAA
ATGCCAACGTTCATAGAGGTGCCCATCAGCTAAGTGCAATCGCAACAGAAAAATTTGAAAATTCTAGAAAGTTAACAGCA
AATTTTATAAATAGTAAGAATGAAAAAGAGATTATTTTTACTAGAAATGCTACTGAAGCTATAAACCTCGTAGCTTATAC
ATGGGGCAATTATGAACTTCAGGAAAACGACGAAATCTTAATAAGTTTAATGGAGCATCACAGTAATATAGTCCCCTGGC
AACTAATAGCCAAAGCAAAAAAGTGCAAGCTAATTTATATCAATATTGATAAAAATGGAGAATTAGATTTTGATGATTTT
AGAAAAAAATTGAGTGATAAAACTAAAATAGTCAGCCTTGTTCACGTAAGTAATACACTCGGTTGTTGTAATCCTATCGA
GGAAATTTCATCCCTTGCACACCAAAAAGGTAGCTTAGTTCTTTTAGATGCTTGCCAAAGTCTTGCTCATAAGCAGGTAG
ATATTAAAAAACTTGGTATTGATTTTCTGGCAGGATCTTCTCATAAACTTTGCGGGCCTACTGGAATAGGTTTTTTATGG
GGTAGAGAAGAAATTTTAAAAAAAATTCCTCCTTTCCTTGGTGGAGGAGAGATGATTAACGAAGTTTTTAAGGACAACAG
CACGTGGGCAGAGTTACCGCATAAATTCGAAGCAGGTACTCCAGCTATTGGGGAAGCCATTGGTATGGGAACTGCACTTA
AGTATTTACAGTCAATTGGATTAAACGAAATCCATAATTACGAAAAAGAATTAACAAAATATCTTTTCGAAAAATTAGAG
GAAATAGATGATTTAAAAATTCTTGGTCCTAGCCCTTTCATTCAGCCTGATAGAGGGCCTTTAGCAACCTTTTATATTAA
AGGTGTTCACTCCAATGATGTTGCTGAGTTACTTGATAACAGCAATATTTACATAAGGAGTGGTCATCATTGCTGCCAAC
CACTTCATCGCTTCTATGGCATAAAAAGCACAGCTAGAGCAAGCTTGAGCTTTACATCTACTCCATCTGAAATTGATTAT
CTTGCTGAAGAACTAAAATCAGTAATTTCTTTTTTAAAGAAAAATTCTTAA

Upstream 100 bases:

>100_bases
CTTTATTATTACAAGGATATTATGATGAAGTGATTTCACACTTTCCTAAAAGTGCTGGCAAATGGAACTTTATTGAAAAA
TTAATACAAGACATAAAAAA

Downstream 100 bases:

>100_bases
ATATTTAGATATTGTCTAAAAAAAGCCTCTGTTTTGTTTAATACATCAACTTTGATTTTACCGTCTTTAAATCCATGACC
TTCGTTCTCAAATAAATTGA

Product: putative cysteine desulfurase or selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNNLVKNIAEKSRNDFPLFNRDINKNLIYLDHAATSQKPKQVIDSLKKYYSFQNANVHRGAHQLSAIATEKFENSRKLTA
NFINSKNEKEIIFTRNATEAINLVAYTWGNYELQENDEILISLMEHHSNIVPWQLIAKAKKCKLIYINIDKNGELDFDDF
RKKLSDKTKIVSLVHVSNTLGCCNPIEEISSLAHQKGSLVLLDACQSLAHKQVDIKKLGIDFLAGSSHKLCGPTGIGFLW
GREEILKKIPPFLGGGEMINEVFKDNSTWAELPHKFEAGTPAIGEAIGMGTALKYLQSIGLNEIHNYEKELTKYLFEKLE
EIDDLKILGPSPFIQPDRGPLATFYIKGVHSNDVAELLDNSNIYIRSGHHCCQPLHRFYGIKSTARASLSFTSTPSEIDY
LAEELKSVISFLKKNS

Sequences:

>Translated_416_residues
MNNLVKNIAEKSRNDFPLFNRDINKNLIYLDHAATSQKPKQVIDSLKKYYSFQNANVHRGAHQLSAIATEKFENSRKLTA
NFINSKNEKEIIFTRNATEAINLVAYTWGNYELQENDEILISLMEHHSNIVPWQLIAKAKKCKLIYINIDKNGELDFDDF
RKKLSDKTKIVSLVHVSNTLGCCNPIEEISSLAHQKGSLVLLDACQSLAHKQVDIKKLGIDFLAGSSHKLCGPTGIGFLW
GREEILKKIPPFLGGGEMINEVFKDNSTWAELPHKFEAGTPAIGEAIGMGTALKYLQSIGLNEIHNYEKELTKYLFEKLE
EIDDLKILGPSPFIQPDRGPLATFYIKGVHSNDVAELLDNSNIYIRSGHHCCQPLHRFYGIKSTARASLSFTSTPSEIDY
LAEELKSVISFLKKNS
>Mature_416_residues
MNNLVKNIAEKSRNDFPLFNRDINKNLIYLDHAATSQKPKQVIDSLKKYYSFQNANVHRGAHQLSAIATEKFENSRKLTA
NFINSKNEKEIIFTRNATEAINLVAYTWGNYELQENDEILISLMEHHSNIVPWQLIAKAKKCKLIYINIDKNGELDFDDF
RKKLSDKTKIVSLVHVSNTLGCCNPIEEISSLAHQKGSLVLLDACQSLAHKQVDIKKLGIDFLAGSSHKLCGPTGIGFLW
GREEILKKIPPFLGGGEMINEVFKDNSTWAELPHKFEAGTPAIGEAIGMGTALKYLQSIGLNEIHNYEKELTKYLFEKLE
EIDDLKILGPSPFIQPDRGPLATFYIKGVHSNDVAELLDNSNIYIRSGHHCCQPLHRFYGIKSTARASLSFTSTPSEIDY
LAEELKSVISFLKKNS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=401, Percent_Identity=21.6957605985037, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156713448, Length=435, Percent_Identity=23.9080459770115, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787970, Length=405, Percent_Identity=43.4567901234568, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1789175, Length=400, Percent_Identity=34.75, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI48994898, Length=399, Percent_Identity=23.5588972431078, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=295, Percent_Identity=27.4576271186441, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193211090, Length=397, Percent_Identity=25.4408060453401, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=400, Percent_Identity=25.5, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129463, Length=421, Percent_Identity=22.8028503562945, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46868; Mature: 46868

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLVKNIAEKSRNDFPLFNRDINKNLIYLDHAATSQKPKQVIDSLKKYYSFQNANVHRG
CCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHH
AHQLSAIATEKFENSRKLTANFINSKNEKEIIFTRNATEAINLVAYTWGNYELQENDEIL
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCHHHEEEEEEECCCEEECCCHHHH
ISLMEHHSNIVPWQLIAKAKKCKLIYINIDKNGELDFDDFRKKLSDKTKIVSLVHVSNTL
HHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCHHHHEEEEECCCCC
GCCNPIEEISSLAHQKGSLVLLDACQSLAHKQVDIKKLGIDFLAGSSHKLCGPTGIGFLW
CCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHCHHHCCCCCCCCCCCCCCCHHC
GREEILKKIPPFLGGGEMINEVFKDNSTWAELPHKFEAGTPAIGEAIGMGTALKYLQSIG
CHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
LNEIHNYEKELTKYLFEKLEEIDDLKILGPSPFIQPDRGPLATFYIKGVHSNDVAELLDN
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHCC
SNIYIRSGHHCCQPLHRFYGIKSTARASLSFTSTPSEIDYLAEELKSVISFLKKNS
CCEEEECCHHHHHHHHHHHCCCHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNLVKNIAEKSRNDFPLFNRDINKNLIYLDHAATSQKPKQVIDSLKKYYSFQNANVHRG
CCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHH
AHQLSAIATEKFENSRKLTANFINSKNEKEIIFTRNATEAINLVAYTWGNYELQENDEIL
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCCHHHEEEEEEECCCEEECCCHHHH
ISLMEHHSNIVPWQLIAKAKKCKLIYINIDKNGELDFDDFRKKLSDKTKIVSLVHVSNTL
HHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCHHHHEEEEECCCCC
GCCNPIEEISSLAHQKGSLVLLDACQSLAHKQVDIKKLGIDFLAGSSHKLCGPTGIGFLW
CCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHCHHHCCCCCCCCCCCCCCCHHC
GREEILKKIPPFLGGGEMINEVFKDNSTWAELPHKFEAGTPAIGEAIGMGTALKYLQSIG
CHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
LNEIHNYEKELTKYLFEKLEEIDDLKILGPSPFIQPDRGPLATFYIKGVHSNDVAELLDN
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHCC
SNIYIRSGHHCCQPLHRFYGIKSTARASLSFTSTPSEIDYLAEELKSVISFLKKNS
CCEEEECCHHHHHHHHHHHCCCHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]