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The map label for this gene is accC [H]

Identifier: 124024837

GI number: 124024837

Start: 121949

End: 123292

Strand: Direct

Name: accC [H]

Synonym: NATL1_01241

Alternate gene names: 124024837

Gene position: 121949-123292 (Clockwise)

Preceding gene: 124024835

Following gene: 124024839

Centisome position: 6.54

GC content: 41.0

Gene sequence:

>1344_bases
ATGCCCATAGGCAAACTGCTCATAGCTAATCGTGGCGAAATAGCTTTAAGAATTCTCCGAAGCTGTCGTGAGATGGGGAT
AGCTACGGTTGCTGTTTACAGTACTGTTGATAAAAATGCATTACATGTTCAATTAGCTGATGAAGCTGTATGCGTTGGAG
ATTCACCTAGCAGTAAAAGTTATCTAAATGTTCCAAACATACTTGCTGCAGCAACATCAAGAGGAGTAGATGCTATTCAT
CCTGGTTATGGATTTTTAGCTGAGAATGATCGATTTGCAGAGATTTGCGGTGACCACGGTCTTATTTTTGTAGGCCCATC
TCCTCATGCAATTCGTTCCATGGGTGATAAGTCGACAGCTAAATCGACTATGCAAAAGGTTGGAGTGCCTACCGTCCCTG
GAAGTGAAGGTTTGCTAGATAGTGTTTCAGATGCATCAAAGCTTGCCTCTGGAATGGGTTATCCAGTAATGATTAAAGCA
ACTGCAGGCGGCGGCGGAAGAGGTATGCGTTTAGTTACTCATTCAGATGAATTGGAGAACCTTTTTAAAGCTGCTCAGGG
GGAAGCAGAGGCTGCATTTGGCAATCCTGGACTATATATGGAGAAATTTATTGATCGCCCAAGGCATGTGGAGGTTCAGA
TTCTTGCTGATCGATTTGGTAATGTTGTTCATCTTGGAGAAAGAGATTGCTCGATTCAAAGACGGCATCAGAAATTGTTA
GAGGAATCGCCAAGTCCAGCTTTAGATGATCACCTAAGAATAAGAATGGGAGAAGCAGCAGTTGCAGCAGCAAAAAGCAT
CAACTATGAAGGCGCTGGAACGGTGGAATTTCTTCTTGATCGGCACGGAAGTTTTTATTTTATGGAAATGAATACTCGAA
TACAGGTGGAACATCCTGTTACTGAGTTAGTTACTGGTATGGATTTAATTTCAGAACAATTACGTATTGCGGGAGGAGAA
AAATTACAATTTGCTCAAGCAGAGATCAAGCTTGAGGGACATGCAATTGAATGTAGAATTAACGCAGAAGATCCAAGTCA
CAACTTTCGACCTTCCCCAGGAAAAATCACAGGTTGGTTGCCTCCTGGTGGACCGGGCGTCAGGGTGGATAGCCATGTTT
ACACTGGATACGATATTCCTCCTTTTTATGATTCCTTAATAGGAAAATTAATTGTTTGGGGGAAGAATCGAGAAGCTGCA
CTAAAAAGGATGGAAAGAGCTTTAAGTGAATGTGCAGTCACAGGAATTACTACTACTATTGATTTTCATTTGAAATTACT
TAAAAGAAAAGAATTTATAGAAGGCGATGTTCATACAAAATTTGTTGAAAAAGAAATGTTGTAA

Upstream 100 bases:

>100_bases
ACCCTGATCATAATGCTTAACCTATTAAGCTTCTACTTAATGGGTTTCAATCTTGGGCACCAATCCTGATACGATCCCGC
TGAGGACTTAATAATTTTGA

Downstream 100 bases:

>100_bases
ATAGCTATGAAGATCAGAATATAATTTGAGTTAATAATCCTTGTTGTCCAAGAAATAATTCGCGAAAGAGACTTAAGAGA
CCTACCCAAATAATTGGAGT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MPIGKLLIANRGEIALRILRSCREMGIATVAVYSTVDKNALHVQLADEAVCVGDSPSSKSYLNVPNILAAATSRGVDAIH
PGYGFLAENDRFAEICGDHGLIFVGPSPHAIRSMGDKSTAKSTMQKVGVPTVPGSEGLLDSVSDASKLASGMGYPVMIKA
TAGGGGRGMRLVTHSDELENLFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
EESPSPALDDHLRIRMGEAAVAAAKSINYEGAGTVEFLLDRHGSFYFMEMNTRIQVEHPVTELVTGMDLISEQLRIAGGE
KLQFAQAEIKLEGHAIECRINAEDPSHNFRPSPGKITGWLPPGGPGVRVDSHVYTGYDIPPFYDSLIGKLIVWGKNREAA
LKRMERALSECAVTGITTTIDFHLKLLKRKEFIEGDVHTKFVEKEML

Sequences:

>Translated_447_residues
MPIGKLLIANRGEIALRILRSCREMGIATVAVYSTVDKNALHVQLADEAVCVGDSPSSKSYLNVPNILAAATSRGVDAIH
PGYGFLAENDRFAEICGDHGLIFVGPSPHAIRSMGDKSTAKSTMQKVGVPTVPGSEGLLDSVSDASKLASGMGYPVMIKA
TAGGGGRGMRLVTHSDELENLFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
EESPSPALDDHLRIRMGEAAVAAAKSINYEGAGTVEFLLDRHGSFYFMEMNTRIQVEHPVTELVTGMDLISEQLRIAGGE
KLQFAQAEIKLEGHAIECRINAEDPSHNFRPSPGKITGWLPPGGPGVRVDSHVYTGYDIPPFYDSLIGKLIVWGKNREAA
LKRMERALSECAVTGITTTIDFHLKLLKRKEFIEGDVHTKFVEKEML
>Mature_446_residues
PIGKLLIANRGEIALRILRSCREMGIATVAVYSTVDKNALHVQLADEAVCVGDSPSSKSYLNVPNILAAATSRGVDAIHP
GYGFLAENDRFAEICGDHGLIFVGPSPHAIRSMGDKSTAKSTMQKVGVPTVPGSEGLLDSVSDASKLASGMGYPVMIKAT
AGGGGRGMRLVTHSDELENLFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLLE
ESPSPALDDHLRIRMGEAAVAAAKSINYEGAGTVEFLLDRHGSFYFMEMNTRIQVEHPVTELVTGMDLISEQLRIAGGEK
LQFAQAEIKLEGHAIECRINAEDPSHNFRPSPGKITGWLPPGGPGVRVDSHVYTGYDIPPFYDSLIGKLIVWGKNREAAL
KRMERALSECAVTGITTTIDFHLKLLKRKEFIEGDVHTKFVEKEML

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=50.7936507936508, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=49.5454545454545, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=49.5454545454545, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=49.5454545454545, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=47.0982142857143, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=47.0982142857143, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=47.0982142857143, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI38679971, Length=512, Percent_Identity=34.375, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI38679974, Length=512, Percent_Identity=34.375, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI38679960, Length=512, Percent_Identity=34.375, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI38679977, Length=512, Percent_Identity=34.375, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI38679967, Length=512, Percent_Identity=34.375, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=32.6771653543307, Blast_Score=259, Evalue=5e-69,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=54.8314606741573, Blast_Score=487, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71987519, Length=450, Percent_Identity=47.7777777777778, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=46.8181818181818, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=43.8478747203579, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=31.237721021611, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=31.237721021611, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=30.4703476482618, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=43.5665914221219, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.5190156599553, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.0892857142857, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.9457364341085, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=32.3275862068966, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=48.0984340044743, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=46.875, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=47.5490196078431, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=32.4055666003976, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=32.4055666003976, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=32.4055666003976, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=32.4055666003976, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48682; Mature: 48551

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGKLLIANRGEIALRILRSCREMGIATVAVYSTVDKNALHVQLADEAVCVGDSPSSKS
CCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCEEEECCCCCCCC
YLNVPNILAAATSRGVDAIHPGYGFLAENDRFAEICGDHGLIFVGPSPHAIRSMGDKSTA
EECCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHHCCCCCEEEECCCCHHHHHCCCHHHH
KSTMQKVGVPTVPGSEGLLDSVSDASKLASGMGYPVMIKATAGGGGRGMRLVTHSDELEN
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCHHHHH
LFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
HHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEHHCCCEEEECCCCCHHHHHHHHHH
EESPSPALDDHLRIRMGEAAVAAAKSINYEGAGTVEFLLDRHGSFYFMEMNTRIQVEHPV
HCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCEEEEECCH
TELVTGMDLISEQLRIAGGEKLQFAQAEIKLEGHAIECRINAEDPSHNFRPSPGKITGWL
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECEEEEEEEECCCCCCCCCCCCCCEEEEC
PPGGPGVRVDSHVYTGYDIPPFYDSLIGKLIVWGKNREAALKRMERALSECAVTGITTTI
CCCCCCCEECCEEEECCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCEEEH
DFHLKLLKRKEFIEGDVHTKFVEKEML
HHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
PIGKLLIANRGEIALRILRSCREMGIATVAVYSTVDKNALHVQLADEAVCVGDSPSSKS
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCEEEECCCCCCCC
YLNVPNILAAATSRGVDAIHPGYGFLAENDRFAEICGDHGLIFVGPSPHAIRSMGDKSTA
EECCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHHCCCCCEEEECCCCHHHHHCCCHHHH
KSTMQKVGVPTVPGSEGLLDSVSDASKLASGMGYPVMIKATAGGGGRGMRLVTHSDELEN
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCHHHHH
LFKAAQGEAEAAFGNPGLYMEKFIDRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
HHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEHHCCCEEEECCCCCHHHHHHHHHH
EESPSPALDDHLRIRMGEAAVAAAKSINYEGAGTVEFLLDRHGSFYFMEMNTRIQVEHPV
HCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCEEEEECCH
TELVTGMDLISEQLRIAGGEKLQFAQAEIKLEGHAIECRINAEDPSHNFRPSPGKITGWL
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECEEEEEEEECCCCCCCCCCCCCCEEEEC
PPGGPGVRVDSHVYTGYDIPPFYDSLIGKLIVWGKNREAALKRMERALSECAVTGITTTI
CCCCCCCEECCEEEECCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCEEEH
DFHLKLLKRKEFIEGDVHTKFVEKEML
HHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]