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The map label for this gene is ppiA [H]

Identifier: 124024815

GI number: 124024815

Start: 100202

End: 101989

Strand: Direct

Name: ppiA [H]

Synonym: NATL1_01021

Alternate gene names: 124024815

Gene position: 100202-101989 (Clockwise)

Preceding gene: 124024812

Following gene: 124024816

Centisome position: 5.37

GC content: 33.61

Gene sequence:

>1788_bases
ATGACCGCGCCACTAATACAAGGTGCCTCTGGTATGGAGGGAGAAAAATTAACTTATGCTTCTACTAATGAAAATAATAA
GGAAATATATACTTTTACTGCTAACGAGCCAGTTACTTGGTCCATAAGTGGCGGAGAGAAACACCTCTTTTCGATTGATC
AAGATACTGGAAAATTAAGTTTTAAAGATGTTCCTGATTATGAAACGATCAAGAGCTTAAATGGAACAACTGTAGAATTT
CATACTAACTTTTCAACGGCCAGTGTCGGTTCAAAGTTTTTTGTAGAGGTTTATAACGATCAAAATCAAACTAATAAAAC
TACACCTATTACAACAAATAACTTTATTGAATATGTAAGTGACGGTTCATACGATAATACTTTAATTCATAGATTAGTTT
CTGATTTTGTTATTCAGGGTGGTGGATACACATGGCCATCTTTAGCATCTAATGAAAGTGGTGGCTATCCATTAACAGTC
AAATCGAAAGGTGAAATAATTAATGAACCTATTAATTCAAATCTAATGGGTACTATTGCAATGGCAAAAGTTTCTGGTCA
GCCAAATAGTGCGACATCTGAGTGGTTTATAAATTTATCCGATAATATTAATCTTGATTCTCAAAATGAGGGGTTTAGTG
TCTTTGGTCATCTATTAGGAGATAGTATTAATAATCCACTTTTATTAAATAACCAAACAAAGTATAATGTAAATTTTTCT
GATGTTGGGCTGAATATACCCGAGTTACCTTTAATTAACTTACAGGGAAATGTTATAAATATTGCGAATTATTTTGCGAT
TCATAAAGTTTCTACAATTAGCCAACGTCCTAGTGAAATTGAGAATGTATTTAATGTAATCGTGACTGCTAATGATTCAC
TTGGAAATCAATCAAATCAATATGTAGTCGTTAATGTTAAAGATATCCAAGGAGAGGTTCTTGATGGCATAGATGGACCA
GATGTTCTCAAGGGAGGCTTGGGAAATGATACTTTTAAAGGGAATGGTGGAAACGATACGATTGATGGAGGCAGTGATTT
TGATATAGCTACTTACTCAGGTAATTTTTCTGATTACACTTTTACCATCGCTAATAAAGTTGTTACCATTAGCGATAACC
GTTTATCGGAAAATGATGGAATAGATACATTGTCTAATATCGAGAAACTTACTTTTGTTGATAAAAATGCTTTAATCACC
AGTAAAGAAATTAAAGCAATTGATGTCTTAGGATTTCAAGCAGAAAAAGTTTATTCAGGCAAAAGTGATTCTTATAAATT
TTATGATTTAGGAGGTAATAACTATGGTGTTGGGACTTCTACTGGTATTGATCAGTTGACTGGTGAATCTATTCTCAAAT
TTGATGATAAAAACATGAATTTAAAGCATGACATCAAAGCAACATTTGATCAAGTAACGGGTTTAGATACAGATTCTGGA
AAAATGTTCCGACTATACAACGCCTCATTTAAACGTCTACCTGATCCAGATGGATTACGATATTGGATCAGTAATTTTAG
TTCTGGTAAAGATGATGAAAGAGCAGTGGCTTCATCATTTTTAGCCTCTGCAGAATTCAAGGAGCGTTATGGGGAAGACG
TCTCCAATGAAAGCTATGTGAACACTCTTTATATCAATGTTTTAGGTAGAGATTACGACCAGGCTGGTTATAATTACTGG
TTAGGTAATCTGAATAATGGTGTTGAGACCAAGTATGAATTGCTATTGGGGTTTTCTGAATCAGTGGAAAACAAAGGACT
TTTTTCTGAGATGACTGGTTTCTATTAA

Upstream 100 bases:

>100_bases
TCAGTACCTAAAACGTTTTTTTGCGACATGAATTGTTTTCTCTATACAGCTATAATATGGCTTTAAATAATTGTTTATCA
AATATTAAAGGATAAAAAAT

Downstream 100 bases:

>100_bases
TGCTACGATTGAAAAAATTTAAAGTTACATTCATCATCTAAAGTAAAAACATCTTCTCATTTTTTACTTAAACAACCAAA
ACAGTTGCGAAGAGATAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MTAPLIQGASGMEGEKLTYASTNENNKEIYTFTANEPVTWSISGGEKHLFSIDQDTGKLSFKDVPDYETIKSLNGTTVEF
HTNFSTASVGSKFFVEVYNDQNQTNKTTPITTNNFIEYVSDGSYDNTLIHRLVSDFVIQGGGYTWPSLASNESGGYPLTV
KSKGEIINEPINSNLMGTIAMAKVSGQPNSATSEWFINLSDNINLDSQNEGFSVFGHLLGDSINNPLLLNNQTKYNVNFS
DVGLNIPELPLINLQGNVINIANYFAIHKVSTISQRPSEIENVFNVIVTANDSLGNQSNQYVVVNVKDIQGEVLDGIDGP
DVLKGGLGNDTFKGNGGNDTIDGGSDFDIATYSGNFSDYTFTIANKVVTISDNRLSENDGIDTLSNIEKLTFVDKNALIT
SKEIKAIDVLGFQAEKVYSGKSDSYKFYDLGGNNYGVGTSTGIDQLTGESILKFDDKNMNLKHDIKATFDQVTGLDTDSG
KMFRLYNASFKRLPDPDGLRYWISNFSSGKDDERAVASSFLASAEFKERYGEDVSNESYVNTLYINVLGRDYDQAGYNYW
LGNLNNGVETKYELLLGFSESVENKGLFSEMTGFY

Sequences:

>Translated_595_residues
MTAPLIQGASGMEGEKLTYASTNENNKEIYTFTANEPVTWSISGGEKHLFSIDQDTGKLSFKDVPDYETIKSLNGTTVEF
HTNFSTASVGSKFFVEVYNDQNQTNKTTPITTNNFIEYVSDGSYDNTLIHRLVSDFVIQGGGYTWPSLASNESGGYPLTV
KSKGEIINEPINSNLMGTIAMAKVSGQPNSATSEWFINLSDNINLDSQNEGFSVFGHLLGDSINNPLLLNNQTKYNVNFS
DVGLNIPELPLINLQGNVINIANYFAIHKVSTISQRPSEIENVFNVIVTANDSLGNQSNQYVVVNVKDIQGEVLDGIDGP
DVLKGGLGNDTFKGNGGNDTIDGGSDFDIATYSGNFSDYTFTIANKVVTISDNRLSENDGIDTLSNIEKLTFVDKNALIT
SKEIKAIDVLGFQAEKVYSGKSDSYKFYDLGGNNYGVGTSTGIDQLTGESILKFDDKNMNLKHDIKATFDQVTGLDTDSG
KMFRLYNASFKRLPDPDGLRYWISNFSSGKDDERAVASSFLASAEFKERYGEDVSNESYVNTLYINVLGRDYDQAGYNYW
LGNLNNGVETKYELLLGFSESVENKGLFSEMTGFY
>Mature_594_residues
TAPLIQGASGMEGEKLTYASTNENNKEIYTFTANEPVTWSISGGEKHLFSIDQDTGKLSFKDVPDYETIKSLNGTTVEFH
TNFSTASVGSKFFVEVYNDQNQTNKTTPITTNNFIEYVSDGSYDNTLIHRLVSDFVIQGGGYTWPSLASNESGGYPLTVK
SKGEIINEPINSNLMGTIAMAKVSGQPNSATSEWFINLSDNINLDSQNEGFSVFGHLLGDSINNPLLLNNQTKYNVNFSD
VGLNIPELPLINLQGNVINIANYFAIHKVSTISQRPSEIENVFNVIVTANDSLGNQSNQYVVVNVKDIQGEVLDGIDGPD
VLKGGLGNDTFKGNGGNDTIDGGSDFDIATYSGNFSDYTFTIANKVVTISDNRLSENDGIDTLSNIEKLTFVDKNALITS
KEIKAIDVLGFQAEKVYSGKSDSYKFYDLGGNNYGVGTSTGIDQLTGESILKFDDKNMNLKHDIKATFDQVTGLDTDSGK
MFRLYNASFKRLPDPDGLRYWISNFSSGKDDERAVASSFLASAEFKERYGEDVSNESYVNTLYINVLGRDYDQAGYNYWL
GNLNNGVETKYELLLGFSESVENKGLFSEMTGFY

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=33.9393939393939, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786736, Length=149, Percent_Identity=32.8859060402685, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 65356; Mature: 65224

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00626 RCC1_2 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLIQGASGMEGEKLTYASTNENNKEIYTFTANEPVTWSISGGEKHLFSIDQDTGKLS
CCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECCCCEEEEEECCCCCCEE
FKDVPDYETIKSLNGTTVEFHTNFSTASVGSKFFVEVYNDQNQTNKTTPITTNNFIEYVS
ECCCCCHHHHHHCCCCEEEEEECCCCHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHC
DGSYDNTLIHRLVSDFVIQGGGYTWPSLASNESGGYPLTVKSKGEIINEPINSNLMGTIA
CCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCEEEEE
MAKVSGQPNSATSEWFINLSDNINLDSQNEGFSVFGHLLGDSINNPLLLNNQTKYNVNFS
EEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCCEEEEEEHH
DVGLNIPELPLINLQGNVINIANYFAIHKVSTISQRPSEIENVFNVIVTANDSLGNQSNQ
HCCCCCCCCEEEECCCCEEEEEHHEEHHHHHHHHCCHHHHHHHEEEEEEECCCCCCCCCC
YVVVNVKDIQGEVLDGIDGPDVLKGGLGNDTFKGNGGNDTIDGGSDFDIATYSGNFSDYT
EEEEEEEECCCHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEE
FTIANKVVTISDNRLSENDGIDTLSNIEKLTFVDKNALITSKEIKAIDVLGFQAEKVYSG
EEEECEEEEEECCCCCCCCCCCHHHCCCEEEEECCCCEEECCCCEEEEEECCCHHHHCCC
KSDSYKFYDLGGNNYGVGTSTGIDQLTGESILKFDDKNMNLKHDIKATFDQVTGLDTDSG
CCCCEEEEEECCCCCCCCCCCCHHHHCCCCEEEECCCCCCEEHHHHHHHHHHCCCCCCCC
KMFRLYNASFKRLPDPDGLRYWISNFSSGKDDERAVASSFLASAEFKERYGEDVSNESYV
CEEEEECCHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
NTLYINVLGRDYDQAGYNYWLGNLNNGVETKYELLLGFSESVENKGLFSEMTGFY
EEEEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEEECHHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
TAPLIQGASGMEGEKLTYASTNENNKEIYTFTANEPVTWSISGGEKHLFSIDQDTGKLS
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECCCCEEEEEECCCCCCEE
FKDVPDYETIKSLNGTTVEFHTNFSTASVGSKFFVEVYNDQNQTNKTTPITTNNFIEYVS
ECCCCCHHHHHHCCCCEEEEEECCCCHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHC
DGSYDNTLIHRLVSDFVIQGGGYTWPSLASNESGGYPLTVKSKGEIINEPINSNLMGTIA
CCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCEEEEE
MAKVSGQPNSATSEWFINLSDNINLDSQNEGFSVFGHLLGDSINNPLLLNNQTKYNVNFS
EEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCCEEEEEEHH
DVGLNIPELPLINLQGNVINIANYFAIHKVSTISQRPSEIENVFNVIVTANDSLGNQSNQ
HCCCCCCCCEEEECCCCEEEEEHHEEHHHHHHHHCCHHHHHHHEEEEEEECCCCCCCCCC
YVVVNVKDIQGEVLDGIDGPDVLKGGLGNDTFKGNGGNDTIDGGSDFDIATYSGNFSDYT
EEEEEEEECCCHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEE
FTIANKVVTISDNRLSENDGIDTLSNIEKLTFVDKNALITSKEIKAIDVLGFQAEKVYSG
EEEECEEEEEECCCCCCCCCCCHHHCCCEEEEECCCCEEECCCCEEEEEECCCHHHHCCC
KSDSYKFYDLGGNNYGVGTSTGIDQLTGESILKFDDKNMNLKHDIKATFDQVTGLDTDSG
CCCCEEEEEECCCCCCCCCCCCHHHHCCCCEEEECCCCCCEEHHHHHHHHHHCCCCCCCC
KMFRLYNASFKRLPDPDGLRYWISNFSSGKDDERAVASSFLASAEFKERYGEDVSNESYV
CEEEEECCHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
NTLYINVLGRDYDQAGYNYWLGNLNNGVETKYELLLGFSESVENKGLFSEMTGFY
EEEEEEEECCCCCCCCCEEEECCCCCCCCEEEEEEEECHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]