Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 124024773

GI number: 124024773

Start: 66510

End: 66965

Strand: Direct

Name: ndk

Synonym: NATL1_00601

Alternate gene names: 124024773

Gene position: 66510-66965 (Clockwise)

Preceding gene: 124024771

Following gene: 124024775

Centisome position: 3.57

GC content: 38.82

Gene sequence:

>456_bases
ATGACTTTGGAAAGAACCTTTGTTGCTATCAAGCCAGATGGTGTGCAAAGAGGTTTAATCGCTGAAATACTTGGACGATT
TGAAACTAAAGGATTCAAATTAGTTGGCTTAAAGCAACTAACACCAAGCAAAGAACTTGCTGAAAAACACTATGGTGTTC
ATAAAGACCGTCCTTTCTTTTCAGGTTTAGTTGATTTCATCACTAGTGGACCTGTTGTAGCGATGGTTTGGGAAGGTGAA
GGTGTTATTGCAAGTGCTAGAAAATTGATTGGAGCAACAAAGCCTCTTGAGGCAGAACCTGGAACTATTAGAGGTGATTT
GGCTGTGAATATTGGTCGTAATGTCATTCATGGTTCTGATGGTTCTGATACGGCAGTTTTTGAAATTAACTTATGGTTCC
AAGAAAATGAGCTTGTTGATTGGAATCCATCAGATCAAGCATGGAGAGTTGAATAA

Upstream 100 bases:

>100_bases
AATACAATTAAATCTAAGAACAGTTTTATTAAGTGTCATGTTTTACTTGCCAAGAGGGCAGTTTTAGGAAGACTATGGCT
TCATATTATTAAATATCGCA

Downstream 100 bases:

>100_bases
TTTATTCAACGTCAAAATCTTTTTGTGAGCAGTTTTTAAAATCTGTCCCATCTGAAATGGGACAACAAACTATCTTCCTC
ATTACTTAAAGGAGTTGAGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MTLERTFVAIKPDGVQRGLIAEILGRFETKGFKLVGLKQLTPSKELAEKHYGVHKDRPFFSGLVDFITSGPVVAMVWEGE
GVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGSDTAVFEINLWFQENELVDWNPSDQAWRVE

Sequences:

>Translated_151_residues
MTLERTFVAIKPDGVQRGLIAEILGRFETKGFKLVGLKQLTPSKELAEKHYGVHKDRPFFSGLVDFITSGPVVAMVWEGE
GVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGSDTAVFEINLWFQENELVDWNPSDQAWRVE
>Mature_150_residues
TLERTFVAIKPDGVQRGLIAEILGRFETKGFKLVGLKQLTPSKELAEKHYGVHKDRPFFSGLVDFITSGPVVAMVWEGEG
VIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGSDTAVFEINLWFQENELVDWNPSDQAWRVE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=150, Percent_Identity=56.6666666666667, Blast_Score=185, Evalue=1e-47,
Organism=Homo sapiens, GI4557797, Length=150, Percent_Identity=56.6666666666667, Blast_Score=184, Evalue=2e-47,
Organism=Homo sapiens, GI66392203, Length=150, Percent_Identity=56, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI66392227, Length=150, Percent_Identity=56, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI66392205, Length=150, Percent_Identity=56, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI4505409, Length=150, Percent_Identity=56, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI66392192, Length=150, Percent_Identity=56, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=54.7297297297297, Blast_Score=174, Evalue=3e-44,
Organism=Homo sapiens, GI4826862, Length=145, Percent_Identity=51.7241379310345, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI5031951, Length=143, Percent_Identity=32.8671328671329, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=5e-13,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=46.0431654676259, Blast_Score=128, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=53.0201342281879, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17507605, Length=91, Percent_Identity=43.956043956044, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=54.0540540540541, Blast_Score=180, Evalue=7e-47,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=57.4324324324324, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=31.6176470588235, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PROM1 (A2BZG4)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001013889.1
- ProteinModelPortal:   A2BZG4
- SMR:   A2BZG4
- STRING:   A2BZG4
- GeneID:   4780165
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_00601
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   PMAR167555:NATL1_00601-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16646; Mature: 16515

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLERTFVAIKPDGVQRGLIAEILGRFETKGFKLVGLKQLTPSKELAEKHYGVHKDRPFF
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCHH
SGLVDFITSGPVVAMVWEGEGVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEECEEEEECCCEEEECCC
GSDTAVFEINLWFQENELVDWNPSDQAWRVE
CCCEEEEEEEEEEECCCEECCCCCCCCEECC
>Mature Secondary Structure 
TLERTFVAIKPDGVQRGLIAEILGRFETKGFKLVGLKQLTPSKELAEKHYGVHKDRPFF
CCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCHH
SGLVDFITSGPVVAMVWEGEGVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEECEEEEECCCEEEECCC
GSDTAVFEINLWFQENELVDWNPSDQAWRVE
CCCEEEEEEEEEEECCCEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA