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The map label for this gene is speA [H]

Identifier: 124024772

GI number: 124024772

Start: 64424

End: 66367

Strand: Reverse

Name: speA [H]

Synonym: NATL1_00591

Alternate gene names: 124024772

Gene position: 66367-64424 (Counterclockwise)

Preceding gene: 124024774

Following gene: 124024770

Centisome position: 3.56

GC content: 34.57

Gene sequence:

>1944_bases
ATGGCTGTGAAAAATACTAATCAATCTCTTTCTTGGACTATCCAAAATAGCTCAGAGCTCTATGGGATTGATCGATGGGG
CAAGGGTTATTTCACTATCAATGAAAAAGGGAATATTAGTATTTGTCCTAACGGTTCCAAAAACAAATCTCATGATTTGA
TAGAACTATTAGATGAACTCGAAAGTCGAAAACTAAAATTTCCTCTGTTAATAAGATTTGACGATATTCTAGAAGACTGC
TTAAAAAACTTACATAAAGCTTTTGAAAAAGCGATTAATGACTATCAATATGAAGGAAAATACCAAGGTGTATTTCCAAT
AAAATGTAATCAACAGCGTCACGTAGTTGAAGAATTAATCACCTGTGGTTCCAAATGGAATTTTGGCTTAGAAGCTGGAA
GCAAACCAGAGTTACTAATTGGTTTATCAATCCTAGAAAATCCTAAAGCCTTACTCATATGTAATGGCTATAAAGATCAA
CGTTATATTGAAACAGCTATTTTAGCACGTCAGCTTGGACGTCAACCTATAGTAGTTATAGAACAAGCAAATGATGTTGA
GCTTATAATCAAATCTAGTGATTTACTTGGAGCGTCTCCACTCATAGGAATACGAGCCAAGCTATCGAGTCAAAGCAGTG
GAAGATGGAGTAGCTCGATTGGTGACAAGTCAAAATTTGGACTTTCAATTCCAGAAATTTTAAAAACAATCAAAAGGTTA
AAAGAAGCAAATCTTCTCAATGAATTAAAGCTTTTACATTTTCATCTAGGGAGTCAAATTAACGATATAGGTGTTTTAAA
AGATGCCTTACAAGAAGCAGGACAAATTTATGCCGAATTAATTAATCTTGGGGCACCTATGGGATACTTAGATGTTGGAG
GTGGCTTAGGAATTGATTACGATGGAAGTCAAACCGCCTCAATAGCATCTACTAACTATTCACTTCAAAATTATGCAAAT
GATGTAGTAGCAACAATTAAAGAATGTTGTGAATCAAAAAAGATACCACTACCCACTTTAATTACAGAGAGTGGAAGAGC
TATTGCTAGTCACTTTTCGATTTTAATCTTCAATATTCTAGGTAAAAATTCGTTACCTTCTGACATTCCTAAAGAAAGCG
AAAAAGAATGTCTCTCTGTCAGAAATTTACGTGACACATTAGTCCATATAAATTCTCTAGAACTTAAGCAAGAAGAAGAT
TTAGCCAAACTACAAGAAGCATGGAATGATTCTCTTAAATTCAAAGCAGATGCACTTGCGGCTTTTCGACTCGGTTATAT
AGATTTAGTTGAACGAGCAAAAGCTGAGCAGTTGACATGGGCCTGTGCAAAAACAATAGTTAATCAGTTACCAAAAAACA
TACTTCTACCTAAAGAACTAAAGAAATTAAGTGAAAGCTTAGCCGTTACGTATTACGCAAATCTTTCCGTATTTAGATCA
GCTCCAGACACATGGGCCATTGATCAAGTCTTTCCAATTATGCCAATCCATCGGCTTCGCAAAGAACCGAAAAAACTTGG
TCACTTTGCAGATTTAACATGTGATTCAGATGGAAAGCTTGATCAATTTATTGATAATGGAAAAATTAAAAATTTGCTCC
CTCTTCATGAATTTAATCAAGACGAAAAATATCTAATTGGTCTTTTCTTGGGTGGCGCCTATCAAGAAGTAATGGGAAAT
CTACATAATTTATTTGGAAGTACTAATGCAGTCCATATAAGATTTACAGAAAATGGGAACTATAAAGTTGAGCATGTCAT
TCGTGGAAATACAAAATCAAATGTTCTTGAATATTTAGAACATGATCCAGAAATATTATTAGAACGATTACGAAAATCAA
GCGAATTAGCTATTCAAGGCGGGCATCTAAAAATCCATGATGCACAAAAACTAATAGAGCATGTAGAAGCAAGCCTCCGT
CAAAGTACTTACCTACAGAGCTAA

Upstream 100 bases:

>100_bases
CCCTCTTGGCAAGTAAAACATGACACTTAATAAAACTGTTCTTAGATTTAATTGTATTAATCGTGAATGATCAAAACTTG
GCAACTTTGTTATCGCATAA

Downstream 100 bases:

>100_bases
ATTAAGATAATTGTTGAGTCAAATTCTCATTAGCTTTTTCTAAAGCTAGATCCAACGATTGAGGTTGACTACCACCAGCT
TGGGCGAGGTTTGGACGACC

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MAVKNTNQSLSWTIQNSSELYGIDRWGKGYFTINEKGNISICPNGSKNKSHDLIELLDELESRKLKFPLLIRFDDILEDC
LKNLHKAFEKAINDYQYEGKYQGVFPIKCNQQRHVVEELITCGSKWNFGLEAGSKPELLIGLSILENPKALLICNGYKDQ
RYIETAILARQLGRQPIVVIEQANDVELIIKSSDLLGASPLIGIRAKLSSQSSGRWSSSIGDKSKFGLSIPEILKTIKRL
KEANLLNELKLLHFHLGSQINDIGVLKDALQEAGQIYAELINLGAPMGYLDVGGGLGIDYDGSQTASIASTNYSLQNYAN
DVVATIKECCESKKIPLPTLITESGRAIASHFSILIFNILGKNSLPSDIPKESEKECLSVRNLRDTLVHINSLELKQEED
LAKLQEAWNDSLKFKADALAAFRLGYIDLVERAKAEQLTWACAKTIVNQLPKNILLPKELKKLSESLAVTYYANLSVFRS
APDTWAIDQVFPIMPIHRLRKEPKKLGHFADLTCDSDGKLDQFIDNGKIKNLLPLHEFNQDEKYLIGLFLGGAYQEVMGN
LHNLFGSTNAVHIRFTENGNYKVEHVIRGNTKSNVLEYLEHDPEILLERLRKSSELAIQGGHLKIHDAQKLIEHVEASLR
QSTYLQS

Sequences:

>Translated_647_residues
MAVKNTNQSLSWTIQNSSELYGIDRWGKGYFTINEKGNISICPNGSKNKSHDLIELLDELESRKLKFPLLIRFDDILEDC
LKNLHKAFEKAINDYQYEGKYQGVFPIKCNQQRHVVEELITCGSKWNFGLEAGSKPELLIGLSILENPKALLICNGYKDQ
RYIETAILARQLGRQPIVVIEQANDVELIIKSSDLLGASPLIGIRAKLSSQSSGRWSSSIGDKSKFGLSIPEILKTIKRL
KEANLLNELKLLHFHLGSQINDIGVLKDALQEAGQIYAELINLGAPMGYLDVGGGLGIDYDGSQTASIASTNYSLQNYAN
DVVATIKECCESKKIPLPTLITESGRAIASHFSILIFNILGKNSLPSDIPKESEKECLSVRNLRDTLVHINSLELKQEED
LAKLQEAWNDSLKFKADALAAFRLGYIDLVERAKAEQLTWACAKTIVNQLPKNILLPKELKKLSESLAVTYYANLSVFRS
APDTWAIDQVFPIMPIHRLRKEPKKLGHFADLTCDSDGKLDQFIDNGKIKNLLPLHEFNQDEKYLIGLFLGGAYQEVMGN
LHNLFGSTNAVHIRFTENGNYKVEHVIRGNTKSNVLEYLEHDPEILLERLRKSSELAIQGGHLKIHDAQKLIEHVEASLR
QSTYLQS
>Mature_646_residues
AVKNTNQSLSWTIQNSSELYGIDRWGKGYFTINEKGNISICPNGSKNKSHDLIELLDELESRKLKFPLLIRFDDILEDCL
KNLHKAFEKAINDYQYEGKYQGVFPIKCNQQRHVVEELITCGSKWNFGLEAGSKPELLIGLSILENPKALLICNGYKDQR
YIETAILARQLGRQPIVVIEQANDVELIIKSSDLLGASPLIGIRAKLSSQSSGRWSSSIGDKSKFGLSIPEILKTIKRLK
EANLLNELKLLHFHLGSQINDIGVLKDALQEAGQIYAELINLGAPMGYLDVGGGLGIDYDGSQTASIASTNYSLQNYAND
VVATIKECCESKKIPLPTLITESGRAIASHFSILIFNILGKNSLPSDIPKESEKECLSVRNLRDTLVHINSLELKQEEDL
AKLQEAWNDSLKFKADALAAFRLGYIDLVERAKAEQLTWACAKTIVNQLPKNILLPKELKKLSESLAVTYYANLSVFRSA
PDTWAIDQVFPIMPIHRLRKEPKKLGHFADLTCDSDGKLDQFIDNGKIKNLLPLHEFNQDEKYLIGLFLGGAYQEVMGNL
HNLFGSTNAVHIRFTENGNYKVEHVIRGNTKSNVLEYLEHDPEILLERLRKSSELAIQGGHLKIHDAQKLIEHVEASLRQ
STYLQS

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=651, Percent_Identity=36.5591397849462, Blast_Score=452, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 72507; Mature: 72376

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKNTNQSLSWTIQNSSELYGIDRWGKGYFTINEKGNISICPNGSKNKSHDLIELLDEL
CCCCCCCCCEEEEECCCCCEEEEECCCCEEEEECCCCCEEECCCCCCCCCHHHHHHHHHH
ESRKLKFPLLIRFDDILEDCLKNLHKAFEKAINDYQYEGKYQGVFPIKCNQQRHVVEELI
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCEEEEECCCHHHHHHHHH
TCGSKWNFGLEAGSKPELLIGLSILENPKALLICNGYKDQRYIETAILARQLGRQPIVVI
HCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEE
EQANDVELIIKSSDLLGASPLIGIRAKLSSQSSGRWSSSIGDKSKFGLSIPEILKTIKRL
ECCCCEEEEEECCCCCCCCCCEEHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KEANLLNELKLLHFHLGSQINDIGVLKDALQEAGQIYAELINLGAPMGYLDVGGGLGIDY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
DGSQTASIASTNYSLQNYANDVVATIKECCESKKIPLPTLITESGRAIASHFSILIFNIL
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
GKNSLPSDIPKESEKECLSVRNLRDTLVHINSLELKQEEDLAKLQEAWNDSLKFKADALA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEHHHHHH
AFRLGYIDLVERAKAEQLTWACAKTIVNQLPKNILLPKELKKLSESLAVTYYANLSVFRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHHEEEEEECCHHEEC
APDTWAIDQVFPIMPIHRLRKEPKKLGHFADLTCDSDGKLDQFIDNGKIKNLLPLHEFNQ
CCCCCCHHHHHCCCCHHHHHHCHHHCCCEEEEEECCCCCHHHHHCCCCCCCCCCHHHCCC
DEKYLIGLFLGGAYQEVMGNLHNLFGSTNAVHIRFTENGNYKVEHVIRGNTKSNVLEYLE
CCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHH
HDPEILLERLRKSSELAIQGGHLKIHDAQKLIEHVEASLRQSTYLQS
CCHHHHHHHHHCCCCEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVKNTNQSLSWTIQNSSELYGIDRWGKGYFTINEKGNISICPNGSKNKSHDLIELLDEL
CCCCCCCCEEEEECCCCCEEEEECCCCEEEEECCCCCEEECCCCCCCCCHHHHHHHHHH
ESRKLKFPLLIRFDDILEDCLKNLHKAFEKAINDYQYEGKYQGVFPIKCNQQRHVVEELI
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCEEEEECCCHHHHHHHHH
TCGSKWNFGLEAGSKPELLIGLSILENPKALLICNGYKDQRYIETAILARQLGRQPIVVI
HCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEE
EQANDVELIIKSSDLLGASPLIGIRAKLSSQSSGRWSSSIGDKSKFGLSIPEILKTIKRL
ECCCCEEEEEECCCCCCCCCCEEHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KEANLLNELKLLHFHLGSQINDIGVLKDALQEAGQIYAELINLGAPMGYLDVGGGLGIDY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
DGSQTASIASTNYSLQNYANDVVATIKECCESKKIPLPTLITESGRAIASHFSILIFNIL
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
GKNSLPSDIPKESEKECLSVRNLRDTLVHINSLELKQEEDLAKLQEAWNDSLKFKADALA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEHHHHHH
AFRLGYIDLVERAKAEQLTWACAKTIVNQLPKNILLPKELKKLSESLAVTYYANLSVFRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHHEEEEEECCHHEEC
APDTWAIDQVFPIMPIHRLRKEPKKLGHFADLTCDSDGKLDQFIDNGKIKNLLPLHEFNQ
CCCCCCHHHHHCCCCHHHHHHCHHHCCCEEEEEECCCCCHHHHHCCCCCCCCCCHHHCCC
DEKYLIGLFLGGAYQEVMGNLHNLFGSTNAVHIRFTENGNYKVEHVIRGNTKSNVLEYLE
CCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHH
HDPEILLERLRKSSELAIQGGHLKIHDAQKLIEHVEASLRQSTYLQS
CCHHHHHHHHHCCCCEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]