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The map label for this gene is argH

Identifier: 124024724

GI number: 124024724

Start: 14783

End: 16174

Strand: Direct

Name: argH

Synonym: NATL1_00111

Alternate gene names: 124024724

Gene position: 14783-16174 (Clockwise)

Preceding gene: 124024723

Following gene: 124024725

Centisome position: 0.79

GC content: 35.06

Gene sequence:

>1392_bases
GTGGAAAAAGCATTGAGCAAAACTTGGAGTGACAGATTTGATAAAGGACTTAATCCTTTTATAGAAAAATTTAATGCTTC
AATCGAGTTTGATATTTGTTTATTAGAGGAAGATTTGGATGGATCAATTGCCCATGCACGTATGCTTGGAATTCAAGGGA
TTATTACCAAGGAAGAGGCGCTTAGATTAGAGAATGGTCTTCAACAGATTCGAAAAGAGGCTTCTGATGGCTTATTTCAG
CCTGTCATTGCAGATGAAGATGTGCATTTTGCAGTAGAAAAAAAATTAATAGACTTGATAGGCCCAGTAGGGAAAAAACT
ACATACTGGTCGTAGTCGTAATGATCAAGTTGGAACAGATCTGAGATTATGGCTAAGAAAACGTATTGATGAAATTGATA
TGGATTTGGTACGTCTTCAGAAATCTCTTTTTTTATTAGCAGAGGAAAATCTGTATACGCTTATTCCTGGTTATACGCAT
TTACAAAGAGCCCAACCTTTGTCTCTGGCGCATCACTTGTTGGCATATATTGAGATGGCACAAAGAGATAGAAATAGATT
AAAAGATGTAAGAAAACGAGTGAATATTTCTCCACTAGGAGCAGCTGCTTTAGCTGGCACATCGATTTCTATAAGCAGAA
AGATTACTTCTTCAGAATTACACTTTCAAGGTATTTATTCTAATAGTTTAGATGCTGTAAGTGATAGAGACTTTGTCGTA
GAATTTTTAGGAGCTTCATCGTTAATTATGGCTCATTTAAGTAGATTATCTGAAGAAGTAATTTTGTGGGCATCTGAAGA
ATTTGCCTTTATTCAATTAACCGACCGATGTGCTACTGGAAGTAGTCTTATGCCTCAAAAAAAGAATCCTGATGTACCTG
AACTTGTTCGAGGCAAGTCAGGAAGAGTATTTGGACATTTACAAGCTATGCTGACTATGATTAAGGGATTACCTTTAGCT
TACAACAAAGATTTTCAAGAAGACAAAGAAGCTATCTTTGATAGTGTTAAAACAGTTAAGAATTCTTTGATTGCCATATC
AATTTTGTTTGAAGAGGGTTTAATTTTTAGAAAAGAAAGACTTAATCAAGCTGTTTCCTCAGATTTTTCAAATGCGACTG
ATGTCGCTGATTATTTAGTGGCTAAGGACATACCTTTCCGAGAGGCTTATCAATTAGTTGGGCGAATTGTAAAAACTTCC
TTGGAGGAGGGGATTTTATTAAAAGATTTTCCTTTAGAAAGATGGAAAACATTTCATAAATTTTTTGAAAAAGATATTTA
TGAAAAGCTTTTGCCTTCGAGTGTAGTTGAGTCTCGTTTGAGTGCTGGTGGAACTGGATTTGAGAGAGTTCAAGAACAGC
TTCTTTCTTGGCGAGAAAAATTATTTAATTAA

Upstream 100 bases:

>100_bases
ATCAATGGTGGTTTTAAAAGTCAAAGAATCAACGGTTCCTGAATTAAATTAGTAATCGCCTGACAATTGCTAAGACTCTT
GCTTTATTTGTATTAGTTAT

Downstream 100 bases:

>100_bases
AAAAATTCTTTTAGATCTATTTTAGGGCTTTCGGTATTAAAGTGTTTAGTGATAACTCATTTTAGAGTTATTAATTTTGG
CTATTTATAGCCTATTAGTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MEKALSKTWSDRFDKGLNPFIEKFNASIEFDICLLEEDLDGSIAHARMLGIQGIITKEEALRLENGLQQIRKEASDGLFQ
PVIADEDVHFAVEKKLIDLIGPVGKKLHTGRSRNDQVGTDLRLWLRKRIDEIDMDLVRLQKSLFLLAEENLYTLIPGYTH
LQRAQPLSLAHHLLAYIEMAQRDRNRLKDVRKRVNISPLGAAALAGTSISISRKITSSELHFQGIYSNSLDAVSDRDFVV
EFLGASSLIMAHLSRLSEEVILWASEEFAFIQLTDRCATGSSLMPQKKNPDVPELVRGKSGRVFGHLQAMLTMIKGLPLA
YNKDFQEDKEAIFDSVKTVKNSLIAISILFEEGLIFRKERLNQAVSSDFSNATDVADYLVAKDIPFREAYQLVGRIVKTS
LEEGILLKDFPLERWKTFHKFFEKDIYEKLLPSSVVESRLSAGGTGFERVQEQLLSWREKLFN

Sequences:

>Translated_463_residues
MEKALSKTWSDRFDKGLNPFIEKFNASIEFDICLLEEDLDGSIAHARMLGIQGIITKEEALRLENGLQQIRKEASDGLFQ
PVIADEDVHFAVEKKLIDLIGPVGKKLHTGRSRNDQVGTDLRLWLRKRIDEIDMDLVRLQKSLFLLAEENLYTLIPGYTH
LQRAQPLSLAHHLLAYIEMAQRDRNRLKDVRKRVNISPLGAAALAGTSISISRKITSSELHFQGIYSNSLDAVSDRDFVV
EFLGASSLIMAHLSRLSEEVILWASEEFAFIQLTDRCATGSSLMPQKKNPDVPELVRGKSGRVFGHLQAMLTMIKGLPLA
YNKDFQEDKEAIFDSVKTVKNSLIAISILFEEGLIFRKERLNQAVSSDFSNATDVADYLVAKDIPFREAYQLVGRIVKTS
LEEGILLKDFPLERWKTFHKFFEKDIYEKLLPSSVVESRLSAGGTGFERVQEQLLSWREKLFN
>Mature_463_residues
MEKALSKTWSDRFDKGLNPFIEKFNASIEFDICLLEEDLDGSIAHARMLGIQGIITKEEALRLENGLQQIRKEASDGLFQ
PVIADEDVHFAVEKKLIDLIGPVGKKLHTGRSRNDQVGTDLRLWLRKRIDEIDMDLVRLQKSLFLLAEENLYTLIPGYTH
LQRAQPLSLAHHLLAYIEMAQRDRNRLKDVRKRVNISPLGAAALAGTSISISRKITSSELHFQGIYSNSLDAVSDRDFVV
EFLGASSLIMAHLSRLSEEVILWASEEFAFIQLTDRCATGSSLMPQKKNPDVPELVRGKSGRVFGHLQAMLTMIKGLPLA
YNKDFQEDKEAIFDSVKTVKNSLIAISILFEEGLIFRKERLNQAVSSDFSNATDVADYLVAKDIPFREAYQLVGRIVKTS
LEEGILLKDFPLERWKTFHKFFEKDIYEKLLPSSVVESRLSAGGTGFERVQEQLLSWREKLFN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=43.6123348017621, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=43.6123348017621, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=41.4096916299559, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=40.9691629955947, Blast_Score=336, Evalue=3e-92,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=44.7427293064877, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=465, Percent_Identity=41.7204301075269, Blast_Score=340, Evalue=3e-94,
Organism=Drosophila melanogaster, GI221473854, Length=454, Percent_Identity=39.647577092511, Blast_Score=331, Evalue=8e-91,
Organism=Drosophila melanogaster, GI78706858, Length=454, Percent_Identity=39.647577092511, Blast_Score=331, Evalue=8e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PROM1 (A2BZB5)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001013840.1
- ProteinModelPortal:   A2BZB5
- SMR:   A2BZB5
- STRING:   A2BZB5
- GeneID:   4781267
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_00111
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   PMAR167555:NATL1_00111-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52529; Mature: 52529

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKALSKTWSDRFDKGLNPFIEKFNASIEFDICLLEEDLDGSIAHARMLGIQGIITKEEA
CCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHH
LRLENGLQQIRKEASDGLFQPVIADEDVHFAVEKKLIDLIGPVGKKLHTGRSRNDQVGTD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LRLWLRKRIDEIDMDLVRLQKSLFLLAEENLYTLIPGYTHLQRAQPLSLAHHLLAYIEMA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHH
QRDRNRLKDVRKRVNISPLGAAALAGTSISISRKITSSELHFQGIYSNSLDAVSDRDFVV
HHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHH
EFLGASSLIMAHLSRLSEEVILWASEEFAFIQLTDRCATGSSLMPQKKNPDVPELVRGKS
HHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCC
GRVFGHLQAMLTMIKGLPLAYNKDFQEDKEAIFDSVKTVKNSLIAISILFEEGLIFRKER
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEHHCCHHHHHHH
LNQAVSSDFSNATDVADYLVAKDIPFREAYQLVGRIVKTSLEEGILLKDFPLERWKTFHK
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
FFEKDIYEKLLPSSVVESRLSAGGTGFERVQEQLLSWREKLFN
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKALSKTWSDRFDKGLNPFIEKFNASIEFDICLLEEDLDGSIAHARMLGIQGIITKEEA
CCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHH
LRLENGLQQIRKEASDGLFQPVIADEDVHFAVEKKLIDLIGPVGKKLHTGRSRNDQVGTD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LRLWLRKRIDEIDMDLVRLQKSLFLLAEENLYTLIPGYTHLQRAQPLSLAHHLLAYIEMA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHH
QRDRNRLKDVRKRVNISPLGAAALAGTSISISRKITSSELHFQGIYSNSLDAVSDRDFVV
HHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHH
EFLGASSLIMAHLSRLSEEVILWASEEFAFIQLTDRCATGSSLMPQKKNPDVPELVRGKS
HHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCC
GRVFGHLQAMLTMIKGLPLAYNKDFQEDKEAIFDSVKTVKNSLIAISILFEEGLIFRKER
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEHHCCHHHHHHH
LNQAVSSDFSNATDVADYLVAKDIPFREAYQLVGRIVKTSLEEGILLKDFPLERWKTFHK
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
FFEKDIYEKLLPSSVVESRLSAGGTGFERVQEQLLSWREKLFN
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA