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The map label for this gene is argG

Identifier: 124024697

GI number: 124024697

Start: 2664683

End: 2665888

Strand: Reverse

Name: argG

Synonym: P9303_30091

Alternate gene names: 124024697

Gene position: 2665888-2664683 (Counterclockwise)

Preceding gene: 124024698

Following gene: 124024692

Centisome position: 99.37

GC content: 51.82

Gene sequence:

>1206_bases
ATGGGGCGTGCGAAGAAGGTGGTGCTTGCTTATTCCGGTGGTGTTGATACCAGCGTTTGCATCCCATATCTCAAGCATGA
ATGGGGGGTAGACGAGGTGATCACCTTTGCTGCCGATTTAGGTCAGGGCGATGAGCTTGATCCCATCCGCCTTAAGGCTC
TTGATGCTGGTGCTAGTCAGTCTCTGGTGGGAGATTTGATAGAGCCTTTTGTAGAAGAGTTTGCTTTGCCGGCGATTCGT
GCCAATGCTCTTTATGAAGGTCGTTATCCACTGTCTACGGCTTTAGCTCGCCCCCTGATTGCTCGTCGGTTGGTAGAGGT
TGCCAGGGAGGTCGGTGCCGATGCGGTTGCTCATGGCTGTACCGGTAAAGGCAACGATCAGGTGCGTTTTGATTTGGCTA
TTGCAGCACTAGCACCTGATCTCAAGGTGCTAACTCCCGCTCGGGAATGGAGCATGAGCAGAGAGGAGGCGATCGCCTAT
GGCGAACGTTGTGGGATCCCTGCCCCCGTGAGTAAGAAATCGCCTTATTCGATTGATCTGAATCTGTTGGGTCGAAGTAT
TGAAGCGGGTCCTCTTGAAGATCCGATGGTGGCTCCGCCCGAGGAGGTCTTTGCCATGACCTCCTCGATTGACGCTGCAC
CCTCTCAGGCTCAGGACATTGAGATCAGATTTGAAGCTGGTAATCCTGTGGCTATTGATGGGGTGCGACTTGATTCGGTG
GGTTTGATCAAGGAGGCGAATCGTCTTGCTGGACGGCATGGTTTCGGTCGCCTTGACATCATTGAGAATCGGGTGGTTGG
TATCAAGAGTCGGGAGATTTATGAAACTCCAGGGTTACTTTTATTGATTCGTGCTCATCAGGAATTGGAGAGTTTGACAC
TTGCTGCGGATGTGTTGCGCATGAAGCGTCAATTGGAGATGCAATGGGCTGAGCTGGTCTATCAGGGTCTTTGGTTTTCC
CCTTTGAAGGATGCTCTGGATGGATTCATGGATCGCACTCAGATTTATGTGAATGGCTTGGTGCGGATTCGTCTCCATAA
AGGCAATGCCATGGTGATTGGCCGGAGCTCTGACACCAACAGCTTGTATATATCTGAGATGGCTACCTATGGCAGCGAGG
ACAACTTTGACCACAGGGCTGCTGAAGGATTTATCTACATCTGGGGACTTCCAAGTCGCCTTTGGGCAGCAGCTCGGCGA
GGCTAA

Upstream 100 bases:

>100_bases
TCGGTATTTGGGTCATGCGGGAGGGATTTCCTACGGTTGATTCCGGGTCTTTGGTCAACGGGAAGGGAGAATCTTTGAAT
TGTGATTCGGAGTCCAGTTG

Downstream 100 bases:

>100_bases
GTTGTGATCTTTTGATTAGTTTTCTTGTGGAGATTGTCCTCTGCCTCCAAGCCATCTTGTGCGAAGCAGGGAAGGCACTT
TTAATGTGTGAGGCTCCTCA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVDEVITFAADLGQGDELDPIRLKALDAGASQSLVGDLIEPFVEEFALPAIR
ANALYEGRYPLSTALARPLIARRLVEVAREVGADAVAHGCTGKGNDQVRFDLAIAALAPDLKVLTPAREWSMSREEAIAY
GERCGIPAPVSKKSPYSIDLNLLGRSIEAGPLEDPMVAPPEEVFAMTSSIDAAPSQAQDIEIRFEAGNPVAIDGVRLDSV
GLIKEANRLAGRHGFGRLDIIENRVVGIKSREIYETPGLLLLIRAHQELESLTLAADVLRMKRQLEMQWAELVYQGLWFS
PLKDALDGFMDRTQIYVNGLVRIRLHKGNAMVIGRSSDTNSLYISEMATYGSEDNFDHRAAEGFIYIWGLPSRLWAAARR
G

Sequences:

>Translated_401_residues
MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVDEVITFAADLGQGDELDPIRLKALDAGASQSLVGDLIEPFVEEFALPAIR
ANALYEGRYPLSTALARPLIARRLVEVAREVGADAVAHGCTGKGNDQVRFDLAIAALAPDLKVLTPAREWSMSREEAIAY
GERCGIPAPVSKKSPYSIDLNLLGRSIEAGPLEDPMVAPPEEVFAMTSSIDAAPSQAQDIEIRFEAGNPVAIDGVRLDSV
GLIKEANRLAGRHGFGRLDIIENRVVGIKSREIYETPGLLLLIRAHQELESLTLAADVLRMKRQLEMQWAELVYQGLWFS
PLKDALDGFMDRTQIYVNGLVRIRLHKGNAMVIGRSSDTNSLYISEMATYGSEDNFDHRAAEGFIYIWGLPSRLWAAARR
G
>Mature_400_residues
GRAKKVVLAYSGGVDTSVCIPYLKHEWGVDEVITFAADLGQGDELDPIRLKALDAGASQSLVGDLIEPFVEEFALPAIRA
NALYEGRYPLSTALARPLIARRLVEVAREVGADAVAHGCTGKGNDQVRFDLAIAALAPDLKVLTPAREWSMSREEAIAYG
ERCGIPAPVSKKSPYSIDLNLLGRSIEAGPLEDPMVAPPEEVFAMTSSIDAAPSQAQDIEIRFEAGNPVAIDGVRLDSVG
LIKEANRLAGRHGFGRLDIIENRVVGIKSREIYETPGLLLLIRAHQELESLTLAADVLRMKRQLEMQWAELVYQGLWFSP
LKDALDGFMDRTQIYVNGLVRIRLHKGNAMVIGRSSDTNSLYISEMATYGSEDNFDHRAAEGFIYIWGLPSRLWAAARRG

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=403, Percent_Identity=41.9354838709677, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI16950633, Length=403, Percent_Identity=41.9354838709677, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1789563, Length=384, Percent_Identity=30.46875, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324514, Length=410, Percent_Identity=38.0487804878049, Blast_Score=270, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21358151, Length=399, Percent_Identity=39.3483709273183, Blast_Score=266, Evalue=2e-71,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_PROM3 (A2CE29)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001019004.1
- ProteinModelPortal:   A2CE29
- SMR:   A2CE29
- STRING:   A2CE29
- GeneID:   4776345
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_30091
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 43914; Mature: 43783

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 38-38 BINDING 89-89 BINDING 119-119 BINDING 121-121 BINDING 125-125 BINDING 125-125 BINDING 126-126 BINDING 129-129 BINDING 177-177 BINDING 186-186 BINDING 262-262 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRAKKVVLAYSGGVDTSVCIPYLKHEWGVDEVITFAADLGQGDELDPIRLKALDAGASQ
CCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCH
SLVGDLIEPFVEEFALPAIRANALYEGRYPLSTALARPLIARRLVEVAREVGADAVAHGC
HHHHHHHHHHHHHHCCCHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
TGKGNDQVRFDLAIAALAPDLKVLTPAREWSMSREEAIAYGERCGIPAPVSKKSPYSIDL
CCCCCCEEEEEEEEEHHCCCCEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEH
NLLGRSIEAGPLEDPMVAPPEEVFAMTSSIDAAPSQAQDIEIRFEAGNPVAIDGVRLDSV
EEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEECEEECCC
GLIKEANRLAGRHGFGRLDIIENRVVGIKSREIYETPGLLLLIRAHQELESLTLAADVLR
HHHHHHHHHHCCCCCCCEEEECCCEEECCCCEEECCCCEEEEEECHHHHHHHHHHHHHHH
MKRQLEMQWAELVYQGLWFSPLKDALDGFMDRTQIYVNGLVRIRLHKGNAMVIGRSSDTN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEEEEEEECCCEEEEECCCCCC
SLYISEMATYGSEDNFDHRAAEGFIYIWGLPSRLWAAARRG
CEEEEHHHHCCCCCCCCCHHHCCEEEEEECHHHHHHHHCCC
>Mature Secondary Structure 
GRAKKVVLAYSGGVDTSVCIPYLKHEWGVDEVITFAADLGQGDELDPIRLKALDAGASQ
CCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCH
SLVGDLIEPFVEEFALPAIRANALYEGRYPLSTALARPLIARRLVEVAREVGADAVAHGC
HHHHHHHHHHHHHHCCCHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
TGKGNDQVRFDLAIAALAPDLKVLTPAREWSMSREEAIAYGERCGIPAPVSKKSPYSIDL
CCCCCCEEEEEEEEEHHCCCCEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEH
NLLGRSIEAGPLEDPMVAPPEEVFAMTSSIDAAPSQAQDIEIRFEAGNPVAIDGVRLDSV
EEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEECEEECCC
GLIKEANRLAGRHGFGRLDIIENRVVGIKSREIYETPGLLLLIRAHQELESLTLAADVLR
HHHHHHHHHHCCCCCCCEEEECCCEEECCCCEEECCCCEEEEEECHHHHHHHHHHHHHHH
MKRQLEMQWAELVYQGLWFSPLKDALDGFMDRTQIYVNGLVRIRLHKGNAMVIGRSSDTN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEEEEEEECCCEEEEECCCCCC
SLYISEMATYGSEDNFDHRAAEGFIYIWGLPSRLWAAARRG
CEEEEHHHHCCCCCCCCCHHHCCEEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA