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The map label for this gene is cysG [H]

Identifier: 124024670

GI number: 124024670

Start: 2634670

End: 2635455

Strand: Reverse

Name: cysG [H]

Synonym: P9303_29821

Alternate gene names: 124024670

Gene position: 2635455-2634670 (Counterclockwise)

Preceding gene: 124024671

Following gene: 124024665

Centisome position: 98.24

GC content: 52.29

Gene sequence:

>786_bases
ATGAGCTGCTTGGACTTTGGCACTGTGTATTTGGTGGGTGCAGGCCCTGGTGATCCTGATTTGCTCACACTGAAGGCTTA
TCGTCTGCTTCGCCAATGCGGAGCCTTGGTTCACGATGCTCTGGTGCCTAAGGAAGTACTCGAGTTAGTGCCCGAGTCTT
GTGAACGGCATTTTGTTGGTAAACGTCGAGAACGTCATTGGGTTCCACAGTCCAAGACAAATGAGTTGCTTGTTGAATTG
GCTCAGCGTCATTCCTGTGTAGTACGCCTAAAAGGTGGTGATCCTTTTCTGTTTGGGCGGGGTGGTGAGGAGGCCGCCCA
TTTGCAGAGTCATGGGGTATCGGTGGAGGTGGTCCCTGGGATTACAGCGGGGATGGCTGCGCCGGCCTATGTGGGTATTC
CTCTGACCCATCGTTGTGGTGGTAGTTCTGTCACCTTTGTGACAGGTCACGAGAAGATCGACAAACAGCGCCCTTCTGTG
AATTGGAAGGATCTTGCTAGCGCAAGTGACAGCCTGGTGATTTATATGGGTTTGCATAACCTTGCTTATATAGTCGAAGA
GTTGATTGCCGGTGGACTTGATCCAGCTACGTCTGCAGCAATCATTCAACAGGGCACTGTCGTAGGTCAGCGCTACCTCA
AAGCTCCCTTGGAACAGTTGGCTCAAAGGGTGCAGAGCGAAGGGTTTGCAGCTCCGTCGATTGTGATTGTGGGTGCAGTA
GTTGATGAACAGGTGGCAGCGTGTGCTCCTCAGCCGGCTGAGGTTTTGATGCCGATCAAGTCTTGA

Upstream 100 bases:

>100_bases
TCCAGATTACGGAGACGCTGCGCGCTTCTGGGGTGATGACTTCCCTACTTGAGATTGAGTTATTGCGATTGGGTCTGATT
GATTTGCTGGCTGCATTGCC

Downstream 100 bases:

>100_bases
TCTATTCCTTAGCTACCTAAAGGTAGATGTTGAACTTAGCGTTTAGATTAGGAGATATCGCTGGGCCATTGGTAGTTCTT
CTGCGGGGTCGCAGGTGAGT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSCLDFGTVYLVGAGPGDPDLLTLKAYRLLRQCGALVHDALVPKEVLELVPESCERHFVGKRRERHWVPQSKTNELLVEL
AQRHSCVVRLKGGDPFLFGRGGEEAAHLQSHGVSVEVVPGITAGMAAPAYVGIPLTHRCGGSSVTFVTGHEKIDKQRPSV
NWKDLASASDSLVIYMGLHNLAYIVEELIAGGLDPATSAAIIQQGTVVGQRYLKAPLEQLAQRVQSEGFAAPSIVIVGAV
VDEQVAACAPQPAEVLMPIKS

Sequences:

>Translated_261_residues
MSCLDFGTVYLVGAGPGDPDLLTLKAYRLLRQCGALVHDALVPKEVLELVPESCERHFVGKRRERHWVPQSKTNELLVEL
AQRHSCVVRLKGGDPFLFGRGGEEAAHLQSHGVSVEVVPGITAGMAAPAYVGIPLTHRCGGSSVTFVTGHEKIDKQRPSV
NWKDLASASDSLVIYMGLHNLAYIVEELIAGGLDPATSAAIIQQGTVVGQRYLKAPLEQLAQRVQSEGFAAPSIVIVGAV
VDEQVAACAPQPAEVLMPIKS
>Mature_260_residues
SCLDFGTVYLVGAGPGDPDLLTLKAYRLLRQCGALVHDALVPKEVLELVPESCERHFVGKRRERHWVPQSKTNELLVELA
QRHSCVVRLKGGDPFLFGRGGEEAAHLQSHGVSVEVVPGITAGMAAPAYVGIPLTHRCGGSSVTFVTGHEKIDKQRPSVN
WKDLASASDSLVIYMGLHNLAYIVEELIAGGLDPATSAAIIQQGTVVGQRYLKAPLEQLAQRVQSEGFAAPSIVIVGAVV
DEQVAACAPQPAEVLMPIKS

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=235, Percent_Identity=45.9574468085106, Blast_Score=198, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322922, Length=240, Percent_Identity=30.8333333333333, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27886; Mature: 27755

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCLDFGTVYLVGAGPGDPDLLTLKAYRLLRQCGALVHDALVPKEVLELVPESCERHFVG
CCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KRRERHWVPQSKTNELLVELAQRHSCVVRLKGGDPFLFGRGGEEAAHLQSHGVSVEVVPG
CHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEECCCCHHHHHHHCCCEEEECCC
ITAGMAAPAYVGIPLTHRCGGSSVTFVTGHEKIDKQRPSVNWKDLASASDSLVIYMGLHN
CHHHHCCCEEECCCCEECCCCCEEEEEECHHHHHHCCCCCCHHHHHCCCCCEEEEECHHH
LAYIVEELIAGGLDPATSAAIIQQGTVVGQRYLKAPLEQLAQRVQSEGFAAPSIVIVGAV
HHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHH
VDEQVAACAPQPAEVLMPIKS
HHHHHHHCCCCCHHHEEECCC
>Mature Secondary Structure 
SCLDFGTVYLVGAGPGDPDLLTLKAYRLLRQCGALVHDALVPKEVLELVPESCERHFVG
CCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KRRERHWVPQSKTNELLVELAQRHSCVVRLKGGDPFLFGRGGEEAAHLQSHGVSVEVVPG
CHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEECCCCHHHHHHHCCCEEEECCC
ITAGMAAPAYVGIPLTHRCGGSSVTFVTGHEKIDKQRPSVNWKDLASASDSLVIYMGLHN
CHHHHCCCEEECCCCEECCCCCEEEEEECHHHHHHCCCCCCHHHHHCCCCCEEEEECHHH
LAYIVEELIAGGLDPATSAAIIQQGTVVGQRYLKAPLEQLAQRVQSEGFAAPSIVIVGAV
HHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHH
VDEQVAACAPQPAEVLMPIKS
HHHHHHHCCCCCHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]