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The map label for this gene is nadC [H]

Identifier: 124024441

GI number: 124024441

Start: 2424267

End: 2425160

Strand: Reverse

Name: nadC [H]

Synonym: P9303_27531

Alternate gene names: 124024441

Gene position: 2425160-2424267 (Counterclockwise)

Preceding gene: 124024442

Following gene: 124024440

Centisome position: 90.4

GC content: 57.61

Gene sequence:

>894_bases
ATGTTTCCCATGTCAGTCTCTTCACCTTCGCTGACCCTGACTCCAGAACTGCGCAGCAGGCTTGAGAGCTGGTTGGCAGA
AGATCTCGGTCGTGGTGATCTCACCGCTCCTGCTTTGCGTGGTTGTCATGGTCGTGCGTGTTGGCGAGCGAAAGCCGATG
GTCTGTTTTGTGGAGGAGTGTTCGTTGAGCCATTGCTGCATGCGCTTGATCCAAAGGCCAGGGTGCAGCTTCTGGTCATT
GAAGGGGCTTCAGTTTCAGTTGGCCAAGACTTGCTGCGGCTTGAGGGGCAGGCCTCAGCGTTGGCGGCTGTTGAGCGCAC
AGCACTGAATTTGGCGATGCGATTGTCTGGCGTGGCAACCGCAACTGCCGCGCTCGTGGATCAGTTGCGTGGGTCGTCTG
TGCGCTTGGCTGACACCCGTAAGACCACTCCTGGGCTACGTGTGTTGGAGAAGTACGCCGTTCGCTGTGGGGGGGGAGTG
AATCACCGTTGTGGTTTGGATGATGCCGCCATGCTGAAGGAGAACCATTTGGCTTGGGCTGGCGGCATGGCTGCAGCTGT
CGCCGCTGTTCGCACAAGCGCACCATGGCCAGCTCAAGTGATCGTTGAAGCTGAAACTGCCGACCAGGCTGATGAGGCGA
TTCGGGCTGGAGCGAATGGTGTGCTGTTGGATGAATTTTCCCCTACTCAGTTGCAAGATTTGGTGCCGCGCTTGCGTCTC
TTGGCAGAGCAAAGATCTGAAGGGTCTGTGGTTCTGGAGGCGTCTGGTGTTGACCCTGGCCAGTTGCATGCCTACGCGGC
AACAGGGATTGACTTGATCTCGACGAGTGCTCCAGTGACGCGCAGCCCCTGGCTTGATATCAGCATGCGGTTTGAATCAA
CGAGGCCTGCCTAA

Upstream 100 bases:

>100_bases
TAAGTGAAAATAGAAACGCACTAGTGTGAATCAATAGTGGCAAAATGCTTTGTTCTGCCTAGCCAATCACGCTTCGAAAG
ATTGTATTTTTGTTTGCAAG

Downstream 100 bases:

>100_bases
GTTGCGCGAGGTTGTTCTGTTTTAAGCCAATCTTGCTAGCCAACCCAACGACTGCCTCACGCTCTGCTTTGCAAGCCAGT
TTTCAAAGCAGTATGAGCTG

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MFPMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGVFVEPLLHALDPKARVQLLVI
EGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVATATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGV
NHRCGLDDAAMLKENHLAWAGGMAAAVAAVRTSAPWPAQVIVEAETADQADEAIRAGANGVLLDEFSPTQLQDLVPRLRL
LAEQRSEGSVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTRPA

Sequences:

>Translated_297_residues
MFPMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGVFVEPLLHALDPKARVQLLVI
EGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVATATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGV
NHRCGLDDAAMLKENHLAWAGGMAAAVAAVRTSAPWPAQVIVEAETADQADEAIRAGANGVLLDEFSPTQLQDLVPRLRL
LAEQRSEGSVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTRPA
>Mature_297_residues
MFPMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGVFVEPLLHALDPKARVQLLVI
EGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVATATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGV
NHRCGLDDAAMLKENHLAWAGGMAAAVAAVRTSAPWPAQVIVEAETADQADEAIRAGANGVLLDEFSPTQLQDLVPRLRL
LAEQRSEGSVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTRPA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=292, Percent_Identity=34.5890410958904, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786299, Length=275, Percent_Identity=39.6363636363636, Blast_Score=157, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=297, Percent_Identity=30.976430976431, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31363; Mature: 31363

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGV
CCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEECCCCEEECHH
FVEPLLHALDPKARVQLLVIEGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVAT
HHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGVNHRCGLDDAAMLKENHLAWA
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEH
GGMAAAVAAVRTSAPWPAQVIVEAETADQADEAIRAGANGVLLDEFSPTQLQDLVPRLRL
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
LAEQRSEGSVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTRPA
HHHCCCCCCEEEEECCCCCHHEEEEHHCCCHHCCCCCCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MFPMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGV
CCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEECCCCEEECHH
FVEPLLHALDPKARVQLLVIEGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVAT
HHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGVNHRCGLDDAAMLKENHLAWA
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEH
GGMAAAVAAVRTSAPWPAQVIVEAETADQADEAIRAGANGVLLDEFSPTQLQDLVPRLRL
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
LAEQRSEGSVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTRPA
HHHCCCCCCEEEEECCCCCHHEEEEHHCCCHHCCCCCCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]