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The map label for this gene is cvrA [H]

Identifier: 124024315

GI number: 124024315

Start: 2317638

End: 2318987

Strand: Reverse

Name: cvrA [H]

Synonym: P9303_26271

Alternate gene names: 124024315

Gene position: 2318987-2317638 (Counterclockwise)

Preceding gene: 124024317

Following gene: 124024314

Centisome position: 86.44

GC content: 54.74

Gene sequence:

>1350_bases
GTGGCCTTTGCTGGTGCAGATGTTTCGGCCATGAGGTGGCTTTATCTAAGACTCAGGCTAGAACCTCCTCAGGATCACCA
ACATTCTGATTTGGGTCATTCACTCGCCCTCTATTTTTTGGCCTTCGGAGCTCTGTTGCTTGTAGCCGTGCTTCTCGATG
ACCTGGCGGCTCGCGTGAGGGTTCCGGGGATCCTGATGGTGCTGATTCTTGGTTTGTTGGTTGACAACCATTTGAATGTG
TCTGCGGATGCTGCTGATGCGCTCCCTCCCTTGCTTTCTTTGGTCCACGCAGACCAAATCACGCAGGCAGCCCTTGTTTT
AGTGCTTTTCTTTGGGGGGCTCACGACGAATTGGGCAGAGATGCGCTCTGTGATCCCATCGGCGCTAAGGCTGGCAACTT
TTGGTGCTTTATTCACAGCTCTCCTGATCACCTTGGCGATGCTTGGATTGGGCGTGGCCGAAGGGAGTGTCGGTTGGGTG
GTGTTGTTCCCGCAGGCTTTGTTCGTGGGTGCGATGTTGTCCAGCACGGATGCATCTGCGACCTTTGCTCTCTTGCGGCC
TCTTGCTGGACGATTGCCCAAGCCTGTTTTGGACCTGATTGAGACGGAGTCGGGTTTCAACGACCCTGTTGCTGTGGTTT
TGGCAGGGGTGGCAATGGCTTTAGCAGGTGGGGAGGGTGTTGCTCCGGCTGCTTTGGTGACGGTGGTGTTACGTCAGTTT
CTGTTGGGCATCTTGCTTGGCTTTCTCGGGGGCAGTCTCACCACTCAGGTGCTTGGTAGTCGTAGGTCCCTGAATACCAA
TTCAATGTTGCCAGTTGTGAGTCTTGCTTTGTTGATGGTGCTTGCAGGTGGAACCACCTTGATGGGTGGCAGTGCCTTGC
TGGCTGCTTATGTGGCGGGGCTTGTGCTCGGCAATGGTTCAAGCACCGATCAGTTGGTGCTTGCGGAGGCCCATGCCAGC
TTTGCAAAAATGGCTGAACTGCTTTTGTTCCTTTGTATGGGGCTTGTGGTTTCCCCTGAGGACGTTGTTCGAGCAGCTGG
CGAAGCATTCCTGCTGTTTCTCTTAATGCAGGTGGTGCGTTGGTTGATTGTTCACTCTTTGCTCTTACGCAGTTCATTTT
CGGTAGGGCAGCGGACGTTTGTGTGCTGCGCTGGCCTGCGTGGTGCGGTCCCTATTGCTTTGGCGATTCAGGTCTGGGCT
TCGTCGTCGGTGAGTTGGGGAAAAGCCATGCCTCCCCTTGCCCTGGCGGTGGTTTTGTTCGGATTGTTGTTCCAGGGGTT
TGCTTTAGTGCCTATTGCAAATCGCCTTGGGCTAGCTAGTCCAGTGGAGGCTCCGCTCTCAGCCCCTTAG

Upstream 100 bases:

>100_bases
AATGTAGTCGGGAGGAGAGGGATCACTGGCCGCGGCTTCAGTGCTGCTGCTAAAGGCGTGCCTATTGACCCGAACAAGGG
CTCCTTTCTTGAGGGCTGCC

Downstream 100 bases:

>100_bases
TCTCGCGGCCAATGCCGTCAGTTCTTTCATGCGCCTTCTACTTGTTGGTTGCACAGGTTTTGTCGGCCGTGAGCTGGTCC
CCCAGTTGTTAGCAGCCAAG

Product: Na+/H+ antiporter, CPA1 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAFAGADVSAMRWLYLRLRLEPPQDHQHSDLGHSLALYFLAFGALLLVAVLLDDLAARVRVPGILMVLILGLLVDNHLNV
SADAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAEMRSVIPSALRLATFGALFTALLITLAMLGLGVAEGSVGWV
VLFPQALFVGAMLSSTDASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVVLRQF
LLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAGLVLGNGSSTDQLVLAEAHAS
FAKMAELLLFLCMGLVVSPEDVVRAAGEAFLLFLLMQVVRWLIVHSLLLRSSFSVGQRTFVCCAGLRGAVPIALAIQVWA
SSSVSWGKAMPPLALAVVLFGLLFQGFALVPIANRLGLASPVEAPLSAP

Sequences:

>Translated_449_residues
MAFAGADVSAMRWLYLRLRLEPPQDHQHSDLGHSLALYFLAFGALLLVAVLLDDLAARVRVPGILMVLILGLLVDNHLNV
SADAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAEMRSVIPSALRLATFGALFTALLITLAMLGLGVAEGSVGWV
VLFPQALFVGAMLSSTDASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVVLRQF
LLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAGLVLGNGSSTDQLVLAEAHAS
FAKMAELLLFLCMGLVVSPEDVVRAAGEAFLLFLLMQVVRWLIVHSLLLRSSFSVGQRTFVCCAGLRGAVPIALAIQVWA
SSSVSWGKAMPPLALAVVLFGLLFQGFALVPIANRLGLASPVEAPLSAP
>Mature_448_residues
AFAGADVSAMRWLYLRLRLEPPQDHQHSDLGHSLALYFLAFGALLLVAVLLDDLAARVRVPGILMVLILGLLVDNHLNVS
ADAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAEMRSVIPSALRLATFGALFTALLITLAMLGLGVAEGSVGWVV
LFPQALFVGAMLSSTDASATFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVVLRQFL
LGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAGLVLGNGSSTDQLVLAEAHASF
AKMAELLLFLCMGLVVSPEDVVRAAGEAFLLFLLMQVVRWLIVHSLLLRSSFSVGQRTFVCCAGLRGAVPIALAIQVWAS
SSVSWGKAMPPLALAVVLFGLLFQGFALVPIANRLGLASPVEAPLSAP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=359, Percent_Identity=31.1977715877437, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 46720; Mature: 46589

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFAGADVSAMRWLYLRLRLEPPQDHQHSDLGHSLALYFLAFGALLLVAVLLDDLAARVR
CCCCCCCHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VPGILMVLILGLLVDNHLNVSADAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAE
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
MRSVIPSALRLATFGALFTALLITLAMLGLGVAEGSVGWVVLFPQALFVGAMLSSTDASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCHHH
TFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVVLRQF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAG
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHH
LVLGNGSSTDQLVLAEAHASFAKMAELLLFLCMGLVVSPEDVVRAAGEAFLLFLLMQVVR
HHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WLIVHSLLLRSSFSVGQRTFVCCAGLRGAVPIALAIQVWASSSVSWGKAMPPLALAVVLF
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
GLLFQGFALVPIANRLGLASPVEAPLSAP
HHHHCCHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AFAGADVSAMRWLYLRLRLEPPQDHQHSDLGHSLALYFLAFGALLLVAVLLDDLAARVR
CCCCCCHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VPGILMVLILGLLVDNHLNVSADAADALPPLLSLVHADQITQAALVLVLFFGGLTTNWAE
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
MRSVIPSALRLATFGALFTALLITLAMLGLGVAEGSVGWVVLFPQALFVGAMLSSTDASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCHHH
TFALLRPLAGRLPKPVLDLIETESGFNDPVAVVLAGVAMALAGGEGVAPAALVTVVLRQF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LLGILLGFLGGSLTTQVLGSRRSLNTNSMLPVVSLALLMVLAGGTTLMGGSALLAAYVAG
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHH
LVLGNGSSTDQLVLAEAHASFAKMAELLLFLCMGLVVSPEDVVRAAGEAFLLFLLMQVVR
HHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WLIVHSLLLRSSFSVGQRTFVCCAGLRGAVPIALAIQVWASSSVSWGKAMPPLALAVVLF
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
GLLFQGFALVPIANRLGLASPVEAPLSAP
HHHHCCHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]