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The map label for this gene is mtnP [H]

Identifier: 124024222

GI number: 124024222

Start: 2226226

End: 2227140

Strand: Reverse

Name: mtnP [H]

Synonym: P9303_25331

Alternate gene names: 124024222

Gene position: 2227140-2226226 (Counterclockwise)

Preceding gene: 124024224

Following gene: 124024215

Centisome position: 83.02

GC content: 50.16

Gene sequence:

>915_bases
TTGAATCGCCTCACAACTTCTCCTCTCGAAGGCGCTCGTTTGGGAGTTTTGGGAGGAAGTGGTCTCTATGCCATCGAAGG
CCTTGAGAACATTCAAGAATTGGAGATTGATACTCCCTTTGGAAAGCCTTCGGATGCTTTTCGACTCGGCAACCTTGACG
GTATGGAGGTGGTGTTTCTTGCTCGCCATGGACGTAATCACACTTTTTTACCTACGGAAGTTCCCTATCGAGCGAATATT
TGGGCGATGCGTTCGCTTGGTGTGCGTTGGATCCTTTCACCTTCAGCAGTTGGTTCATTGCAGGAACAGGTGCGCCCCTT
AGACATGGTGGTACCTGATCAATTCATTGATCGGACTCATCAGCGACCACTGACTTTTTTTGGAGATGGGGCGGTGGCTC
ATGTGGCAATGGCTGATCCTTTTTGCCTCACGCTTTCTCGCTTATTAGCGGATGTTGGCGAAAGCCTGATGCCGGATGGA
CGCCAATTGCATCGTAGTGGTACCTATCTGGCGATGGAAGGTCCGGCCTTCTCCACGCGAGCCGAATCGAAGCTTTATAG
GAGTTGGGGCTGCATGGTGATCGGAATGACCAATCACACTGAGGCTCGCCTGGCTCGGGAAGCAGAGATTGCCTATGCTT
CTTTATCAATGGTTACTGATTACGATTGTTGGCATGGTCACCATGACAGCGTGACTGTAGAGATGGTGCTTGCAAATCTG
AGGGCCAATGCACAGTTGGCGACAAAGATCGTTCGTGCAACAGCCAAAATGGTTGCAGATATTCGTCCAGTCAGCACTGC
TCACAATGCTTTGGAAGATGCTTTGCTAACCGCAAAAAAACATGTAACTGACTCAACCCGCCGTAAACTTGACCTCTTTA
CAAGGCCTTACTGGGGCGAGTTTGGCGGTAGTTGA

Upstream 100 bases:

>100_bases
TGATACTTCGGCTATCAGTTGTTTGTATGAAGCCTTTGAAGACTATAAGTATTGATCGAGTTATTGACGGGCTATGCTAT
TTAAAGCTGAAAGACGTTAA

Downstream 100 bases:

>100_bases
TGGTCTATTTTTTGTTTTTTAGAAGATCTAACTCTGCATGTAAATCCCCACCTTGCTAGGTAGGGTTTACACACAGAATC
TTGACTCTAAATTAAGCTGA

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNRLTTSPLEGARLGVLGGSGLYAIEGLENIQELEIDTPFGKPSDAFRLGNLDGMEVVFLARHGRNHTFLPTEVPYRANI
WAMRSLGVRWILSPSAVGSLQEQVRPLDMVVPDQFIDRTHQRPLTFFGDGAVAHVAMADPFCLTLSRLLADVGESLMPDG
RQLHRSGTYLAMEGPAFSTRAESKLYRSWGCMVIGMTNHTEARLAREAEIAYASLSMVTDYDCWHGHHDSVTVEMVLANL
RANAQLATKIVRATAKMVADIRPVSTAHNALEDALLTAKKHVTDSTRRKLDLFTRPYWGEFGGS

Sequences:

>Translated_304_residues
MNRLTTSPLEGARLGVLGGSGLYAIEGLENIQELEIDTPFGKPSDAFRLGNLDGMEVVFLARHGRNHTFLPTEVPYRANI
WAMRSLGVRWILSPSAVGSLQEQVRPLDMVVPDQFIDRTHQRPLTFFGDGAVAHVAMADPFCLTLSRLLADVGESLMPDG
RQLHRSGTYLAMEGPAFSTRAESKLYRSWGCMVIGMTNHTEARLAREAEIAYASLSMVTDYDCWHGHHDSVTVEMVLANL
RANAQLATKIVRATAKMVADIRPVSTAHNALEDALLTAKKHVTDSTRRKLDLFTRPYWGEFGGS
>Mature_304_residues
MNRLTTSPLEGARLGVLGGSGLYAIEGLENIQELEIDTPFGKPSDAFRLGNLDGMEVVFLARHGRNHTFLPTEVPYRANI
WAMRSLGVRWILSPSAVGSLQEQVRPLDMVVPDQFIDRTHQRPLTFFGDGAVAHVAMADPFCLTLSRLLADVGESLMPDG
RQLHRSGTYLAMEGPAFSTRAESKLYRSWGCMVIGMTNHTEARLAREAEIAYASLSMVTDYDCWHGHHDSVTVEMVLANL
RANAQLATKIVRATAKMVADIRPVSTAHNALEDALLTAKKHVTDSTRRKLDLFTRPYWGEFGGS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=265, Percent_Identity=44.1509433962264, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71980569, Length=254, Percent_Identity=40.9448818897638, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323045, Length=303, Percent_Identity=37.953795379538, Blast_Score=192, Evalue=8e-50,
Organism=Drosophila melanogaster, GI20130079, Length=282, Percent_Identity=37.9432624113475, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI221459247, Length=256, Percent_Identity=38.28125, Blast_Score=170, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 33595; Mature: 33595

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLTTSPLEGARLGVLGGSGLYAIEGLENIQELEIDTPFGKPSDAFRLGNLDGMEVVFL
CCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHEECCCCCCCCCCCEEECCCCCCEEEEE
ARHGRNHTFLPTEVPYRANIWAMRSLGVRWILSPSAVGSLQEQVRPLDMVVPDQFIDRTH
EECCCCCCCCCCCCCCCCCCEEHHHCCEEEEECCHHHHHHHHHCCCHHEECCHHHHHHHC
QRPLTFFGDGAVAHVAMADPFCLTLSRLLADVGESLMPDGRQLHRSGTYLAMEGPAFSTR
CCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCHH
AESKLYRSWGCMVIGMTNHTEARLAREAEIAYASLSMVTDYDCWHGHHDSVTVEMVLANL
HHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEHHHHHHHH
RANAQLATKIVRATAKMVADIRPVSTAHNALEDALLTAKKHVTDSTRRKLDLFTRPYWGE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
FGGS
CCCC
>Mature Secondary Structure
MNRLTTSPLEGARLGVLGGSGLYAIEGLENIQELEIDTPFGKPSDAFRLGNLDGMEVVFL
CCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHEECCCCCCCCCCCEEECCCCCCEEEEE
ARHGRNHTFLPTEVPYRANIWAMRSLGVRWILSPSAVGSLQEQVRPLDMVVPDQFIDRTH
EECCCCCCCCCCCCCCCCCCEEHHHCCEEEEECCHHHHHHHHHCCCHHEECCHHHHHHHC
QRPLTFFGDGAVAHVAMADPFCLTLSRLLADVGESLMPDGRQLHRSGTYLAMEGPAFSTR
CCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCHH
AESKLYRSWGCMVIGMTNHTEARLAREAEIAYASLSMVTDYDCWHGHHDSVTVEMVLANL
HHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEHHHHHHHH
RANAQLATKIVRATAKMVADIRPVSTAHNALEDALLTAKKHVTDSTRRKLDLFTRPYWGE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
FGGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA