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The map label for this gene is pth

Identifier: 124024149

GI number: 124024149

Start: 2160377

End: 2160997

Strand: Reverse

Name: pth

Synonym: P9303_24601

Alternate gene names: 124024149

Gene position: 2160997-2160377 (Counterclockwise)

Preceding gene: 124024150

Following gene: 124024148

Centisome position: 80.55

GC content: 53.46

Gene sequence:

>621_bases
ATGAGGCCGGGTCGTTTACGTTTATTGGTAGGCCTAGGTAATCCAGGCTCAAAGTATGTCGGTACCCGTCACAACATCGG
CTTCATGGCCCTCGATAAGTTGGCTGGGCAGAAGTCAGTCAGTTTCAGGCCGCAAACAAAGTTCCATGGACTGATGGCGG
AAGTGGGGGTTGGCTCAGAGAGGGTTCGATTGCTGATGCCTCAGACTTATATGAATGAAAGCGGTAGGGCGATTCGTGCA
GCCATCGATTGGTTTGGCTTGGAGGTTGATCAGTTGCTGGTGCTAGTAGATGACATGGATTTGCCTTTGGGTCGACTGCG
GCTTCGCGCCCAGGGAAGTGCAGGAGGTCACAATGGTTTGCGCAGCGCGATTCAACATCTGGGGACTCAGGATTTTTGTC
GTCTGAGGATCGGGATCGGTGCTCCAGGTTGTACCTCTGAGGAACGAAGAGCTCGAACCGTCTCGCATGTGCTCGGGGTG
TTTAGTCGGCAGGAGAGCCTCCTAGTCGATCAAGTGCTTGATGAGGTGCTGATCGGTTTGGATCTGATTCAGTGCCTTGG
GTTGGAACGGGCAGGTAATCGTCTCAATGCTTTTCAACCGGAGGGTTGTTCTGCCTGCTGA

Upstream 100 bases:

>100_bases
ATCGAACAGGCTGCGACGGAAGAGTTCAAGCAGCAAGACACCAATGCAATAAGTGAAACCCCTCAGGAGGCTAAAAACCC
TCCCGCCGGCTGAGAGTGGT

Downstream 100 bases:

>100_bases
TGAGTCATTTGCCTGTCACCACGGCTCGCCTCTGTGTACACCGGCAAAGCTTTGCCGACCAACGCTTGGATGGGGAGGTC
TCCGCTGGGGGGTTTCAGTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAGQKSVSFRPQTKFHGLMAEVGVGSERVRLLMPQTYMNESGRAIRA
AIDWFGLEVDQLLVLVDDMDLPLGRLRLRAQGSAGGHNGLRSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGV
FSRQESLLVDQVLDEVLIGLDLIQCLGLERAGNRLNAFQPEGCSAC

Sequences:

>Translated_206_residues
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAGQKSVSFRPQTKFHGLMAEVGVGSERVRLLMPQTYMNESGRAIRA
AIDWFGLEVDQLLVLVDDMDLPLGRLRLRAQGSAGGHNGLRSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGV
FSRQESLLVDQVLDEVLIGLDLIQCLGLERAGNRLNAFQPEGCSAC
>Mature_206_residues
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAGQKSVSFRPQTKFHGLMAEVGVGSERVRLLMPQTYMNESGRAIRA
AIDWFGLEVDQLLVLVDDMDLPLGRLRLRAQGSAGGHNGLRSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGV
FSRQESLLVDQVLDEVLIGLDLIQCLGLERAGNRLNAFQPEGCSAC

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=181, Percent_Identity=38.121546961326, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1787455, Length=195, Percent_Identity=41.5384615384615, Blast_Score=131, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321983, Length=171, Percent_Identity=33.9181286549708, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PROM3 (A2CCI1)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018456.1
- ProteinModelPortal:   A2CCI1
- SMR:   A2CCI1
- STRING:   A2CCI1
- GeneID:   4775966
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_24601
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22475; Mature: 22475

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAGQKSVSFRPQTKFHGLMAEVGVGSE
CCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
RVRLLMPQTYMNESGRAIRAAIDWFGLEVDQLLVLVDDMDLPLGRLRLRAQGSAGGHNGL
CEEEECCHHHHCCCCCEEHHHHHHHCCCHHHEEEEECCCCCCHHHEEEEECCCCCCHHHH
RSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGVFSRQESLLVDQVLDEVLIGL
HHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIQCLGLERAGNRLNAFQPEGCSAC
HHHHHHCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPGRLRLLVGLGNPGSKYVGTRHNIGFMALDKLAGQKSVSFRPQTKFHGLMAEVGVGSE
CCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
RVRLLMPQTYMNESGRAIRAAIDWFGLEVDQLLVLVDDMDLPLGRLRLRAQGSAGGHNGL
CEEEECCHHHHCCCCCEEHHHHHHHCCCHHHEEEEECCCCCCHHHEEEEECCCCCCHHHH
RSAIQHLGTQDFCRLRIGIGAPGCTSEERRARTVSHVLGVFSRQESLLVDQVLDEVLIGL
HHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIQCLGLERAGNRLNAFQPEGCSAC
HHHHHHCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA