Click here to switch to the map view.

The map label for this gene is dfp [H]

Identifier: 124024078

GI number: 124024078

Start: 2104045

End: 2105331

Strand: Reverse

Name: dfp [H]

Synonym: P9303_23871

Alternate gene names: 124024078

Gene position: 2105331-2104045 (Counterclockwise)

Preceding gene: 124024079

Following gene: 124024076

Centisome position: 78.48

GC content: 56.49

Gene sequence:

>1287_bases
ATGAAGATTGAGGCGGCACGCCCTCTGATGGGTCGCCGTCTGCTTGTTGCAGTCACTGGCAGTATCGCGGCTGTTAAAAC
ACCATTGCTGGTGAGTGCTCTCATCAAGGCCGGCGCTGAGGTGCGCTGTCTTGTGACGCCTAGTGCTGCTCGTCTAGTCA
GCCCTGTTGCTCTGGCCAGTCTTAGTAGGCATCGCTGCTACCAGGATGAGGATCAATGGAATTCGAGTGAACCTCGTCCT
TTACATGTGGCCCTGGCTGAATGGGCTGAGCTTGTCATTGTCGCTCCTTTAAGTGCAACGAGTCTTGCCCGCTGGACGCA
GGGGCTTGCAGATGGGCTGCTGGCAAGTTTGTTGCTGGCTTGTGAACGGCCGGTGCTTGCAGCGGCAGCAATGAACACTG
CCATGTGGTCCAATCCTGCCGTGAGGAGGAACTGGCAAGAGTTGCAGACTGATCCACGCGTGCTGCCATTGGCTCCTGAA
TCTGGGCTGCTGGCCTGTGATCGGATCGGGGATGGCCGCATGGCCGATCCGAAGTTGATTGAGCTGGCTGTGGTGAGTGG
GCTTTTGCAGGCTGATGAGACAGGCAGGCTGCAACGCGATTGGCAAGGGCGAAGGTTGTTGGTGACCGCTGGATCGACAG
TGGAGGTTTTGGATCCAGCCAGGCTGTTGATCAATCGCAGCAGCGGCCGTATGGGGGTGTTGCTGGCGCAGGCAGCTCGG
CTACGCGGTGCCCAGGTGGATTTGGTACATGGTCCTTTGAAACTACCTGTTGCTTGGTTGGAGGGGTTGGCGGCCTATCC
AGTGGCAAGCGCAGATGAGATGCAGAACATGCTGGCGCAGCTGCAGTCCAAAGCAGATGCAGTGGCAATGGCGGCGGCGG
TTGCGGACGTCCGTCGGGTTAACCCTGCTCAGACTGAGAAACTTTCGAAGGATTGCTTGCTTCAGTCTTTTTCTCAGGGC
TGGGAGCAAGTCCCTGACCTTCTAGCTGAGCTTGTTCTCAGGCGACCAGCTGGTCAGGTTCTGCTTGGTTTTGCTGCTCT
AACTGGTAATGAAGCTCAGATTCAGCAGCTTGGTGAGGAAAAGCGTCTTCGCAAAGGCTGTGATCTGCTGATGGCGAATC
CGATTGATCGCCCTGGTCAGGGTTTTGAGGAGGATTGCAATGGTGGTTGGTTGCTTGCTGCCGGTGGCAGCGTCCGTTCT
TTACCTGTTACGTCCAAGCTGGCTTTGGCGCATCAGTTGCTTGATGCCATTTTGGAGGTTCAGGTCGTGATTTCGACGCC
ATCTTGA

Upstream 100 bases:

>100_bases
TTTGCCGGGTTGGGCGATTGGCATCTATTGAGGGCTTTGGCGATTCATCGCCCTGAGCTGACAGCTCCATACGTGCATCT
GATCGATCAGGAACCCTTCG

Downstream 100 bases:

>100_bases
CCCAGTAGATCGATGAAAGTGCGCAGTTGCAGCCTTGGGATATATGCCCAGCCTCCGCTTTTCTCCATGGTCTGAAGCAG
GGTGCAAAGGTCTTGACGGT

Product: p-pantothenate cysteine ligase and p-pantothenenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALASLSRHRCYQDEDQWNSSEPRP
LHVALAEWAELVIVAPLSATSLARWTQGLADGLLASLLLACERPVLAAAAMNTAMWSNPAVRRNWQELQTDPRVLPLAPE
SGLLACDRIGDGRMADPKLIELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
LRGAQVDLVHGPLKLPVAWLEGLAAYPVASADEMQNMLAQLQSKADAVAMAAAVADVRRVNPAQTEKLSKDCLLQSFSQG
WEQVPDLLAELVLRRPAGQVLLGFAALTGNEAQIQQLGEEKRLRKGCDLLMANPIDRPGQGFEEDCNGGWLLAAGGSVRS
LPVTSKLALAHQLLDAILEVQVVISTPS

Sequences:

>Translated_428_residues
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALASLSRHRCYQDEDQWNSSEPRP
LHVALAEWAELVIVAPLSATSLARWTQGLADGLLASLLLACERPVLAAAAMNTAMWSNPAVRRNWQELQTDPRVLPLAPE
SGLLACDRIGDGRMADPKLIELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
LRGAQVDLVHGPLKLPVAWLEGLAAYPVASADEMQNMLAQLQSKADAVAMAAAVADVRRVNPAQTEKLSKDCLLQSFSQG
WEQVPDLLAELVLRRPAGQVLLGFAALTGNEAQIQQLGEEKRLRKGCDLLMANPIDRPGQGFEEDCNGGWLLAAGGSVRS
LPVTSKLALAHQLLDAILEVQVVISTPS
>Mature_428_residues
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALASLSRHRCYQDEDQWNSSEPRP
LHVALAEWAELVIVAPLSATSLARWTQGLADGLLASLLLACERPVLAAAAMNTAMWSNPAVRRNWQELQTDPRVLPLAPE
SGLLACDRIGDGRMADPKLIELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
LRGAQVDLVHGPLKLPVAWLEGLAAYPVASADEMQNMLAQLQSKADAVAMAAAVADVRRVNPAQTEKLSKDCLLQSFSQG
WEQVPDLLAELVLRRPAGQVLLGFAALTGNEAQIQQLGEEKRLRKGCDLLMANPIDRPGQGFEEDCNGGWLLAAGGSVRS
LPVTSKLALAHQLLDAILEVQVVISTPS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=195, Percent_Identity=37.9487179487179, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI87082301, Length=416, Percent_Identity=34.6153846153846, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17560194, Length=196, Percent_Identity=31.6326530612245, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=180, Percent_Identity=32.2222222222222, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 45792; Mature: 45792

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALAS
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LSRHRCYQDEDQWNSSEPRPLHVALAEWAELVIVAPLSATSLARWTQGLADGLLASLLLA
HHHHCCCCCCCCCCCCCCCEEEEEHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
CERPVLAAAAMNTAMWSNPAVRRNWQELQTDPRVLPLAPESGLLACDRIGDGRMADPKLI
HCCCHHHHHHHHHHHCCCCHHHCCHHHHCCCCCEEEECCCCCCEEEECCCCCCCCCHHHH
ELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
HHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEECCCHHHHEEECCCCCCHHHHHHHHH
LRGAQVDLVHGPLKLPVAWLEGLAAYPVASADEMQNMLAQLQSKADAVAMAAAVADVRRV
HCCCEEEEEECCHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPAQTEKLSKDCLLQSFSQGWEQVPDLLAELVLRRPAGQVLLGFAALTGNEAQIQQLGEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHHCCCHHHHHHHHHH
KRLRKGCDLLMANPIDRPGQGFEEDCNGGWLLAAGGSVRSLPVTSKLALAHQLLDAILEV
HHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEE
QVVISTPS
EEEEECCC
>Mature Secondary Structure
MKIEAARPLMGRRLLVAVTGSIAAVKTPLLVSALIKAGAEVRCLVTPSAARLVSPVALAS
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LSRHRCYQDEDQWNSSEPRPLHVALAEWAELVIVAPLSATSLARWTQGLADGLLASLLLA
HHHHCCCCCCCCCCCCCCCEEEEEHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
CERPVLAAAAMNTAMWSNPAVRRNWQELQTDPRVLPLAPESGLLACDRIGDGRMADPKLI
HCCCHHHHHHHHHHHCCCCHHHCCHHHHCCCCCEEEECCCCCCEEEECCCCCCCCCHHHH
ELAVVSGLLQADETGRLQRDWQGRRLLVTAGSTVEVLDPARLLINRSSGRMGVLLAQAAR
HHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEECCCHHHHEEECCCCCCHHHHHHHHH
LRGAQVDLVHGPLKLPVAWLEGLAAYPVASADEMQNMLAQLQSKADAVAMAAAVADVRRV
HCCCEEEEEECCHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPAQTEKLSKDCLLQSFSQGWEQVPDLLAELVLRRPAGQVLLGFAALTGNEAQIQQLGEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHHCCCHHHHHHHHHH
KRLRKGCDLLMANPIDRPGQGFEEDCNGGWLLAAGGSVRSLPVTSKLALAHQLLDAILEV
HHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEE
QVVISTPS
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]