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The map label for this gene is met3 [H]

Identifier: 124024075

GI number: 124024075

Start: 2101472

End: 2102644

Strand: Reverse

Name: met3 [H]

Synonym: P9303_23841

Alternate gene names: 124024075

Gene position: 2102644-2101472 (Counterclockwise)

Preceding gene: 124024076

Following gene: 124024074

Centisome position: 78.38

GC content: 54.56

Gene sequence:

>1173_bases
ATGATTGCCAGTCCCTCTGCATCTGCCCAGTCTCCCGGCGTGATCGCGCCCTATGGAGGGACACTGGTGGATTTGATGGT
GGCTACTGATCAGCAGGAAGCTGTCAAGGCCAGTGCCAACCATGTGTTGGAGTGCTCAGATCGCAATGCTTGCGATCTGG
AGTTGCTTGTCGGTGGAGGCTTTTCGCCTGAGCGGGGCTTTATGCATCAGGGTGATTACGACGCTGTTGTTGCAGGCCAT
CGCACTCTTTCCGGCTATCTTTTCGGCCTGCCAATCGTGATGGATACCGATCGAGAGGATGTAGCGATCGGTGATCGGGT
GTTGCTGAGTTACAAGGGTCAGGATTTGGCAGTTCTTCAAGTCGAGGACAAATGGGAGCCCGACAAGGTGGTGGAAGCCA
AAGGTTGCTATGGCACTACCTCTCTAGAACATCCCGCTGTGCGCATGATTGCCACTGAACGCAAGCGCTTTTATCTCGGG
GGCACCTTGCAGGGTTTGGAGTTGCCTAAGCGTATTTTTCCTTGCAAGAGCCCTGCTCAGGTTCGGGCGGAACTTCCTGC
CGGGGAGGACGTTGTTGCCTTTCAGTGTCGCAATCCCATTCATCGCGCTCACTACGAGTTGTTTACGCGAGCCTTGCATG
CCAGCAATGTGAGCGAGAACGCTGTTGTGTTAGTGCATCCAACCTGTGGACCAACTCAGCAGGATGATATCCCTGGTGGC
GTACGTTTTCAGACCTATGAGCGGTTGGCTGCTGAGGTAGATAATCCCCGCATTCGCTGGGCCTATCTTCCCTATGCCAT
GCATATGGCAGGTCCGCGCGAAGCCCTGCAACACATGATTATTCGCCGCAATTATGGATGTACCCATTTCATCATCGGTC
GTGACATGGCCGGATGTAAGTCCTCCCTTAGCGGCGATGACTTCTATGGCCCTTACGACGCGCAGAACTTTGCACAGGAA
TGTGCAGGAGAGCTGGCAATGGAAACGGTCCCCTCGTTGAATCTTGTTTTCACTGAAGAGGAGGGCTACGTCACTGCCGA
GCATGCTGAGGCTCGTGGATTACATGTCAAGAAGCTCAGCGGTACGCAGTTCCGCAAGATGTTGAGAAGTGGCGAGGAGA
TCCCTGAGTGGTTCGCCTTCCGTAGCGTGGTTGAGGTGCTGAGAGCCACGTGA

Upstream 100 bases:

>100_bases
CCTATGGGCCCCTTTTTTTTGACCATGCTTTAGTTGCGCCTGGTCTTAGCTGAGCAAAACCATCCGTCTGGGAGAATCTC
CCGGCATCCCCAGGCTTGTC

Downstream 100 bases:

>100_bases
TTCCCTGAGCCCGAATAACATTCATTCATTACAGGCAGGAGAATCTTGGATAAACGCTGGCGCAACGTAGGTCTTTACGT
TCTTCTGGTGGTCGTGGTTG

Product: ATP-sulfurylase

Products: NA

Alternate protein names: Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MIASPSASAQSPGVIAPYGGTLVDLMVATDQQEAVKASANHVLECSDRNACDLELLVGGGFSPERGFMHQGDYDAVVAGH
RTLSGYLFGLPIVMDTDREDVAIGDRVLLSYKGQDLAVLQVEDKWEPDKVVEAKGCYGTTSLEHPAVRMIATERKRFYLG
GTLQGLELPKRIFPCKSPAQVRAELPAGEDVVAFQCRNPIHRAHYELFTRALHASNVSENAVVLVHPTCGPTQQDDIPGG
VRFQTYERLAAEVDNPRIRWAYLPYAMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSLSGDDFYGPYDAQNFAQE
CAGELAMETVPSLNLVFTEEEGYVTAEHAEARGLHVKKLSGTQFRKMLRSGEEIPEWFAFRSVVEVLRAT

Sequences:

>Translated_390_residues
MIASPSASAQSPGVIAPYGGTLVDLMVATDQQEAVKASANHVLECSDRNACDLELLVGGGFSPERGFMHQGDYDAVVAGH
RTLSGYLFGLPIVMDTDREDVAIGDRVLLSYKGQDLAVLQVEDKWEPDKVVEAKGCYGTTSLEHPAVRMIATERKRFYLG
GTLQGLELPKRIFPCKSPAQVRAELPAGEDVVAFQCRNPIHRAHYELFTRALHASNVSENAVVLVHPTCGPTQQDDIPGG
VRFQTYERLAAEVDNPRIRWAYLPYAMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSLSGDDFYGPYDAQNFAQE
CAGELAMETVPSLNLVFTEEEGYVTAEHAEARGLHVKKLSGTQFRKMLRSGEEIPEWFAFRSVVEVLRAT
>Mature_390_residues
MIASPSASAQSPGVIAPYGGTLVDLMVATDQQEAVKASANHVLECSDRNACDLELLVGGGFSPERGFMHQGDYDAVVAGH
RTLSGYLFGLPIVMDTDREDVAIGDRVLLSYKGQDLAVLQVEDKWEPDKVVEAKGCYGTTSLEHPAVRMIATERKRFYLG
GTLQGLELPKRIFPCKSPAQVRAELPAGEDVVAFQCRNPIHRAHYELFTRALHASNVSENAVVLVHPTCGPTQQDDIPGG
VRFQTYERLAAEVDNPRIRWAYLPYAMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSLSGDDFYGPYDAQNFAQE
CAGELAMETVPSLNLVFTEEEGYVTAEHAEARGLHVKKLSGTQFRKMLRSGEEIPEWFAFRSVVEVLRAT

Specific function: Unknown

COG id: COG2046

COG function: function code P; ATP sulfurylase (sulfate adenylyltransferase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI46094058, Length=348, Percent_Identity=28.735632183908, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI62912492, Length=403, Percent_Identity=27.2952853598015, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI34447231, Length=398, Percent_Identity=27.3869346733668, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17542422, Length=314, Percent_Identity=30.2547770700637, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322469, Length=390, Percent_Identity=37.9487179487179, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI116007838, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667044, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667032, Length=370, Percent_Identity=25.9459459459459, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667028, Length=370, Percent_Identity=25.9459459459459, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667036, Length=370, Percent_Identity=25.9459459459459, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667040, Length=370, Percent_Identity=25.9459459459459, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR015947
- InterPro:   IPR014729
- InterPro:   IPR020792
- InterPro:   IPR002650 [H]

Pfam domain/function: PF01583 APS_kinase; PF01747 ATP-sulfurylase [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 43007; Mature: 43007

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASPSASAQSPGVIAPYGGTLVDLMVATDQQEAVKASANHVLECSDRNACDLELLVGGG
CCCCCCCCCCCCCEEECCCCCEEEEEEECCHHHHHHHHCCCEEEECCCCCCEEEEEECCC
FSPERGFMHQGDYDAVVAGHRTLSGYLFGLPIVMDTDREDVAIGDRVLLSYKGQDLAVLQ
CCCCCCCCCCCCCCEEEECCCEECCEEEECCEEEECCCCCCCCCCEEEEEECCCCEEEEE
VEDKWEPDKVVEAKGCYGTTSLEHPAVRMIATERKRFYLGGTLQGLELPKRIFPCKSPAQ
ECCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCEEEECCEECCCCCHHHHCCCCCHHH
VRAELPAGEDVVAFQCRNPIHRAHYELFTRALHASNVSENAVVLVHPTCGPTQQDDIPGG
HEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
VRFQTYERLAAEVDNPRIRWAYLPYAMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCK
CCHHHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHH
SSLSGDDFYGPYDAQNFAQECAGELAMETVPSLNLVFTEEEGYVTAEHAEARGLHVKKLS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCEEEECC
GTQFRKMLRSGEEIPEWFAFRSVVEVLRAT
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIASPSASAQSPGVIAPYGGTLVDLMVATDQQEAVKASANHVLECSDRNACDLELLVGGG
CCCCCCCCCCCCCEEECCCCCEEEEEEECCHHHHHHHHCCCEEEECCCCCCEEEEEECCC
FSPERGFMHQGDYDAVVAGHRTLSGYLFGLPIVMDTDREDVAIGDRVLLSYKGQDLAVLQ
CCCCCCCCCCCCCCEEEECCCEECCEEEECCEEEECCCCCCCCCCEEEEEECCCCEEEEE
VEDKWEPDKVVEAKGCYGTTSLEHPAVRMIATERKRFYLGGTLQGLELPKRIFPCKSPAQ
ECCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCEEEECCEECCCCCHHHHCCCCCHHH
VRAELPAGEDVVAFQCRNPIHRAHYELFTRALHASNVSENAVVLVHPTCGPTQQDDIPGG
HEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
VRFQTYERLAAEVDNPRIRWAYLPYAMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCK
CCHHHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHH
SSLSGDDFYGPYDAQNFAQECAGELAMETVPSLNLVFTEEEGYVTAEHAEARGLHVKKLS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCEEEECC
GTQFRKMLRSGEEIPEWFAFRSVVEVLRAT
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]