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The map label for this gene is ubiE [H]

Identifier: 124023756

GI number: 124023756

Start: 1815841

End: 1816542

Strand: Reverse

Name: ubiE [H]

Synonym: P9303_20621

Alternate gene names: 124023756

Gene position: 1816542-1815841 (Counterclockwise)

Preceding gene: 124023757

Following gene: 124023755

Centisome position: 67.71

GC content: 60.4

Gene sequence:

>702_bases
ATGAGGCCTGGTGACCCCCAGGCGGTGGAGCAGTTGTTTGATGCGGTCGCTCCTAATTACGACCGGCTTAACGACTTGTT
GAGTCTTGGCTTGCACCGCATCTGGAAACGCCAGTTGTTGGCATGGTTGTCTCCGCTTCCAGGTGAACATTGGCTTGACC
TTTGCTGCGGTACTGGTGATCTGGCACTGGCATTGGCCCGCAGGTTGCGACCTGGAGGGTCTGTGTTGGGGCTAGATGCG
GCTGCGGCACCTCTTGCCGTGGCAAGGCGCCGCGCCGCGGCTGAGCCCTGGTTGCCCCTCTCCTGGTTGCAGGGAGACGC
TCTGGATACTGGCTTGCCTTCCCATCGTTTTGACGGTGCTGTGATGGCTTACGGCCTGCGCAATTTGGCGGATCCAGGCG
CTGGGTTAATAGAGCTTCGACGCCTTTTGCGGCCTGGTGCTCGGGCAGGAATCCTTGATTTCAATCGCATGGGCGAGGGG
TCCTTGGCAGCACGTTTTCAGCGGTTTTATCTGCGAAGGTTGGTGGTGCCGGTGGCTGCCCAGGTGGGTTTGCGCGAGCA
TTACGCCTATTTGGAGGCCAGTTTGCAGCAGTTCCCAAAGGGAGAGGTTCAGGAGCGACTGGCTCGGGACGCGGGATTTG
CCACAGCGAGCCATCGGCCTCTGGCTGCGGGACAGATGGGCGCCTTGCTGCTTACCGCTTGA

Upstream 100 bases:

>100_bases
TTCTGTTGGCGAGAGTGCTTTTGGATGTGTTGCTGATCGATCACCCTTGGGCGCAGCAGTTGCTCCAAGCAGTGTTCACG
CCCCTGGATGGAATCTTCTG

Downstream 100 bases:

>100_bases
TGAGCTGATCGAGCAAAAAGACTCTTGCGAAAAGACGGATCGATGACTTATGAAGAAAACATTAAGACGCAGTTCGCTGT
GGCCTTCCCTCTCCCTTCTC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRPGDPQAVEQLFDAVAPNYDRLNDLLSLGLHRIWKRQLLAWLSPLPGEHWLDLCCGTGDLALALARRLRPGGSVLGLDA
AAAPLAVARRRAAAEPWLPLSWLQGDALDTGLPSHRFDGAVMAYGLRNLADPGAGLIELRRLLRPGARAGILDFNRMGEG
SLAARFQRFYLRRLVVPVAAQVGLREHYAYLEASLQQFPKGEVQERLARDAGFATASHRPLAAGQMGALLLTA

Sequences:

>Translated_233_residues
MRPGDPQAVEQLFDAVAPNYDRLNDLLSLGLHRIWKRQLLAWLSPLPGEHWLDLCCGTGDLALALARRLRPGGSVLGLDA
AAAPLAVARRRAAAEPWLPLSWLQGDALDTGLPSHRFDGAVMAYGLRNLADPGAGLIELRRLLRPGARAGILDFNRMGEG
SLAARFQRFYLRRLVVPVAAQVGLREHYAYLEASLQQFPKGEVQERLARDAGFATASHRPLAAGQMGALLLTA
>Mature_233_residues
MRPGDPQAVEQLFDAVAPNYDRLNDLLSLGLHRIWKRQLLAWLSPLPGEHWLDLCCGTGDLALALARRLRPGGSVLGLDA
AAAPLAVARRRAAAEPWLPLSWLQGDALDTGLPSHRFDGAVMAYGLRNLADPGAGLIELRRLLRPGARAGILDFNRMGEG
SLAARFQRFYLRRLVVPVAAQVGLREHYAYLEASLQQFPKGEVQERLARDAGFATASHRPLAAGQMGALLLTA

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=252, Percent_Identity=32.5396825396825, Blast_Score=120, Evalue=9e-28,
Organism=Escherichia coli, GI48994983, Length=217, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17557039, Length=223, Percent_Identity=30.0448430493274, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323526, Length=246, Percent_Identity=25.609756097561, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641702, Length=235, Percent_Identity=29.7872340425532, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 25353; Mature: 25353

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGDPQAVEQLFDAVAPNYDRLNDLLSLGLHRIWKRQLLAWLSPLPGEHWLDLCCGTGD
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCH
LALALARRLRPGGSVLGLDAAAAPLAVARRRAAAEPWLPLSWLQGDALDTGLPSHRFDGA
HHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCH
VMAYGLRNLADPGAGLIELRRLLRPGARAGILDFNRMGEGSLAARFQRFYLRRLVVPVAA
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHH
QVGLREHYAYLEASLQQFPKGEVQERLARDAGFATASHRPLAAGQMGALLLTA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MRPGDPQAVEQLFDAVAPNYDRLNDLLSLGLHRIWKRQLLAWLSPLPGEHWLDLCCGTGD
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCH
LALALARRLRPGGSVLGLDAAAAPLAVARRRAAAEPWLPLSWLQGDALDTGLPSHRFDGA
HHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCH
VMAYGLRNLADPGAGLIELRRLLRPGARAGILDFNRMGEGSLAARFQRFYLRRLVVPVAA
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHH
QVGLREHYAYLEASLQQFPKGEVQERLARDAGFATASHRPLAAGQMGALLLTA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA