Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 124023703

GI number: 124023703

Start: 1760486

End: 1761088

Strand: Direct

Name: clpP [H]

Synonym: P9303_20031

Alternate gene names: 124023703

Gene position: 1760486-1761088 (Clockwise)

Preceding gene: 124023702

Following gene: 124023704

Centisome position: 65.62

GC content: 53.73

Gene sequence:

>603_bases
ATGCCGATCGGTACCCCAAGCGTTCCCTACCGTCTTCCCGGCAGCCAGATGGAGCGCTGGGTCGACATCTATACCCGCCT
GGGGGTGGAAAGGATCCTGTTCCTTGGCCAAGAAGTCAGTGATGGTGTTGCCAACAGCTTGGTAGCCCAGATGCTCTACC
TCGATTCGGAAGACAGCACAAAACCGATCTATCTGTACATCAACTCCCCAGGTGGATCAGTCACTGCTGGCCTGGCGATC
TACGACACGATGAAATACGTCAAAAGTGATGTCGTAACAATCTGCGTTGGCTTGGCAGCTTCGATGGGCGCCTTCCTTCT
CACTGCAGGAACCAAAGGGAAAAGACTCGCCCTGCCCCACAGCCGAATCATGATCCACCAACCGCTAGGTGGAACCAACC
AACGACAAGCCAGCGATATCGAAATCGAAGCGCGTGAAATCCTGCGCATCAAAGACATGCTCAACCACTCCATGGCAGAG
CTGACAGGTCAGACCTTTGAAAAAATCGAAAAAGACACCGACCGCGACTACTTCTTAAGTGCAGCCGAGGCCAAAGACTA
TGGCCTTATCGATCGTGTGATTGCCCACCCGAACGAAGCCTGA

Upstream 100 bases:

>100_bases
CTGAACTGATCGATCCACTGCAACCCTGGACTCAACCCTTCCAGGCTCTTTCTCAGATCATTCCTAATCCAGTTCTGATT
TCCTCCTTTCTTTTTTCACC

Downstream 100 bases:

>100_bases
AAGTCCTGCCAACCGAAGCCAAAAACCAAGCCGCCATAACAATCAGGCATGCAGAACTTCACTGATTGGTTTAAGCCCTA
CCTGCTTTCGGATCAAAACG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MPIGTPSVPYRLPGSQMERWVDIYTRLGVERILFLGQEVSDGVANSLVAQMLYLDSEDSTKPIYLYINSPGGSVTAGLAI
YDTMKYVKSDVVTICVGLAASMGAFLLTAGTKGKRLALPHSRIMIHQPLGGTNQRQASDIEIEAREILRIKDMLNHSMAE
LTGQTFEKIEKDTDRDYFLSAAEAKDYGLIDRVIAHPNEA

Sequences:

>Translated_200_residues
MPIGTPSVPYRLPGSQMERWVDIYTRLGVERILFLGQEVSDGVANSLVAQMLYLDSEDSTKPIYLYINSPGGSVTAGLAI
YDTMKYVKSDVVTICVGLAASMGAFLLTAGTKGKRLALPHSRIMIHQPLGGTNQRQASDIEIEAREILRIKDMLNHSMAE
LTGQTFEKIEKDTDRDYFLSAAEAKDYGLIDRVIAHPNEA
>Mature_199_residues
PIGTPSVPYRLPGSQMERWVDIYTRLGVERILFLGQEVSDGVANSLVAQMLYLDSEDSTKPIYLYINSPGGSVTAGLAIY
DTMKYVKSDVVTICVGLAASMGAFLLTAGTKGKRLALPHSRIMIHQPLGGTNQRQASDIEIEAREILRIKDMLNHSMAEL
TGQTFEKIEKDTDRDYFLSAAEAKDYGLIDRVIAHPNEA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=182, Percent_Identity=51.6483516483517, Blast_Score=194, Evalue=5e-50,
Organism=Escherichia coli, GI1786641, Length=184, Percent_Identity=62.5, Blast_Score=238, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17538017, Length=179, Percent_Identity=53.6312849162011, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI20129427, Length=182, Percent_Identity=52.1978021978022, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22039; Mature: 21907

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGTPSVPYRLPGSQMERWVDIYTRLGVERILFLGQEVSDGVANSLVAQMLYLDSEDST
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
KPIYLYINSPGGSVTAGLAIYDTMKYVKSDVVTICVGLAASMGAFLLTAGTKGKRLALPH
CCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEECCC
SRIMIHQPLGGTNQRQASDIEIEAREILRIKDMLNHSMAELTGQTFEKIEKDTDRDYFLS
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEE
AAEAKDYGLIDRVIAHPNEA
CCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
PIGTPSVPYRLPGSQMERWVDIYTRLGVERILFLGQEVSDGVANSLVAQMLYLDSEDST
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
KPIYLYINSPGGSVTAGLAIYDTMKYVKSDVVTICVGLAASMGAFLLTAGTKGKRLALPH
CCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEECCC
SRIMIHQPLGGTNQRQASDIEIEAREILRIKDMLNHSMAELTGQTFEKIEKDTDRDYFLS
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEE
AAEAKDYGLIDRVIAHPNEA
CCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA