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The map label for this gene is hemN [C]

Identifier: 124023699

GI number: 124023699

Start: 1757163

End: 1758473

Strand: Reverse

Name: hemN [C]

Synonym: P9303_19991

Alternate gene names: 124023699

Gene position: 1758473-1757163 (Counterclockwise)

Preceding gene: 124023708

Following gene: 124023696

Centisome position: 65.55

GC content: 56.45

Gene sequence:

>1311_bases
ATGAGAGAAGGTCTTGCTGTGTTGCCACCTCGCAGTGCCTATCTGCACATTCCTTTCTGCCATCGGCGTTGCTTTTATTG
CGATTTCGCTGTCGTGCCGCTTGGCGATCATGCCAATGGGGCTAAGGGCTCAGGTAGCGCCTCGATTCAGTCTTATCTGC
AGCTATTGCAACGGGAGATTGCGCTTGTCAAGCCTGGGCCAACGCTGGCCACGGTGTACATCGGTGGCGGAACACCATCT
CTGCTCAGCTCAGCTCAGATTGGGGCTCTGTTGGATCAGCTACGGCAACGGTTTGGCGTTCAGCTTGGTGCAGAAATCAC
ACTGGAAATGGATCCAGCTAGTTTCGATCAGGCTTACCTAGCGGCCGTATTAGCGGCTGGTGTCAACAGGGTGAGCTTGG
GGGGGCAGAGTTTCGATGATGCAGTGCTCGAGACGCTTGGGCGCCGTCATCGTCGCCACCATTTACTGGAGGCGTGCGGA
TGGTTGCATCAGGCTCATCAGTGCGGAGAGCTGAAAAGTTGGAGTTTGGATCTCATCCAGAACCTGCCAGGACAGGAGTT
GGTGGCTTGGAAGCAACAGCTTGTTGAGGCCATTGATACTGGTTCACCTCATCTTTCGATCTACGATTTATCTGTTGAAC
CAGGCACGGTATTTGCTTGGCGTCAGCGGCGGGGGGAGTTGGATTTGCCCGATGATGATTTAGCAGCTGAGCAGATGCAG
ACCACCAGTGTCTTGCTTCGTCAGGCAGGATTTGGCCGCTATGAAATCTCCAATTACGCCTTGCCAGGGCACGCCTCGCG
CCACAACCGCGTGTATTGGAGTGGGGCAGGGTGGTGGGCGTTTGGTCAGGGTGCGACCAGTGCGCCCTGGGGCGAGAGGC
TGGCTCGTCCGCGCACAAGGGATGGTTACTGCAACTGGATTGAGGTTCAGGAGGTAGAAGGACTGGATTCCTCTCTCGTT
GCGGCTCAGGCAAGACCCTTACCTCTGGATGAACAGTTGTTGGTGGGTTTGCGTTGTCGTGAGGGAGTTGATCTTGAGGC
CCTCAGTAGGGCTTGGGGCTGGACTCATGAGCAGTGCAACGCTCTATTGCCGTCGTTGCAGGTGCGCTGGCAGGCGGCGT
TGGATCGGGGCTGGTTAGAGCTGCATGGACGACGTTGGCAGCTCAGTGATCCCGAGGGGATGGCCATCAGCAATCAGGTT
CTGGTTGAGATGTTGTTGTGGTGGCAGTCTCTGCCTGCTGATGCAGTTGCTTCACCCAACCTTGAAGGGCTTCTACGCAC
AGCTGGCGACCTTGGATCAATGGCGGACTGA

Upstream 100 bases:

>100_bases
CATGGGGTCAGATCGTGTCTGCTCGCTCCGGATGCAGGCAGCATGCACCATCCTCTGGAGCTTGGCCCGGGCAGATGTCC
GCACCTTTGCGGATTGATTG

Downstream 100 bases:

>100_bases
AGGGGGGTTGGCTGGGAGTTAGTCCCAACAGGTCAGCGGTGACCCTTACCTGTCCATCGCAATCTTCGCCAGCGCCGATA
CCGATCACGGGGATGGTGAG

Product: oxygen-independent coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MREGLAVLPPRSAYLHIPFCHRRCFYCDFAVVPLGDHANGAKGSGSASIQSYLQLLQREIALVKPGPTLATVYIGGGTPS
LLSSAQIGALLDQLRQRFGVQLGAEITLEMDPASFDQAYLAAVLAAGVNRVSLGGQSFDDAVLETLGRRHRRHHLLEACG
WLHQAHQCGELKSWSLDLIQNLPGQELVAWKQQLVEAIDTGSPHLSIYDLSVEPGTVFAWRQRRGELDLPDDDLAAEQMQ
TTSVLLRQAGFGRYEISNYALPGHASRHNRVYWSGAGWWAFGQGATSAPWGERLARPRTRDGYCNWIEVQEVEGLDSSLV
AAQARPLPLDEQLLVGLRCREGVDLEALSRAWGWTHEQCNALLPSLQVRWQAALDRGWLELHGRRWQLSDPEGMAISNQV
LVEMLLWWQSLPADAVASPNLEGLLRTAGDLGSMAD

Sequences:

>Translated_436_residues
MREGLAVLPPRSAYLHIPFCHRRCFYCDFAVVPLGDHANGAKGSGSASIQSYLQLLQREIALVKPGPTLATVYIGGGTPS
LLSSAQIGALLDQLRQRFGVQLGAEITLEMDPASFDQAYLAAVLAAGVNRVSLGGQSFDDAVLETLGRRHRRHHLLEACG
WLHQAHQCGELKSWSLDLIQNLPGQELVAWKQQLVEAIDTGSPHLSIYDLSVEPGTVFAWRQRRGELDLPDDDLAAEQMQ
TTSVLLRQAGFGRYEISNYALPGHASRHNRVYWSGAGWWAFGQGATSAPWGERLARPRTRDGYCNWIEVQEVEGLDSSLV
AAQARPLPLDEQLLVGLRCREGVDLEALSRAWGWTHEQCNALLPSLQVRWQAALDRGWLELHGRRWQLSDPEGMAISNQV
LVEMLLWWQSLPADAVASPNLEGLLRTAGDLGSMAD
>Mature_436_residues
MREGLAVLPPRSAYLHIPFCHRRCFYCDFAVVPLGDHANGAKGSGSASIQSYLQLLQREIALVKPGPTLATVYIGGGTPS
LLSSAQIGALLDQLRQRFGVQLGAEITLEMDPASFDQAYLAAVLAAGVNRVSLGGQSFDDAVLETLGRRHRRHHLLEACG
WLHQAHQCGELKSWSLDLIQNLPGQELVAWKQQLVEAIDTGSPHLSIYDLSVEPGTVFAWRQRRGELDLPDDDLAAEQMQ
TTSVLLRQAGFGRYEISNYALPGHASRHNRVYWSGAGWWAFGQGATSAPWGERLARPRTRDGYCNWIEVQEVEGLDSSLV
AAQARPLPLDEQLLVGLRCREGVDLEALSRAWGWTHEQCNALLPSLQVRWQAALDRGWLELHGRRWQLSDPEGMAISNQV
LVEMLLWWQSLPADAVASPNLEGLLRTAGDLGSMAD

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=277, Percent_Identity=37.5451263537906, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789325, Length=299, Percent_Identity=37.7926421404682, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082341, Length=256, Percent_Identity=29.6875, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 48089; Mature: 48089

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREGLAVLPPRSAYLHIPFCHRRCFYCDFAVVPLGDHANGAKGSGSASIQSYLQLLQREI
CCCCCEECCCCCCEEECCHHHCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALVKPGPTLATVYIGGGTPSLLSSAQIGALLDQLRQRFGVQLGAEITLEMDPASFDQAYL
EEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEECCCCHHHHHH
AAVLAAGVNRVSLGGQSFDDAVLETLGRRHRRHHLLEACGWLHQAHQCGELKSWSLDLIQ
HHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
NLPGQELVAWKQQLVEAIDTGSPHLSIYDLSVEPGTVFAWRQRRGELDLPDDDLAAEQMQ
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEHHHHCCCCCCCCCCHHHHHHHH
TTSVLLRQAGFGRYEISNYALPGHASRHNRVYWSGAGWWAFGQGATSAPWGERLARPRTR
HHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHCCCCCC
DGYCNWIEVQEVEGLDSSLVAAQARPLPLDEQLLVGLRCREGVDLEALSRAWGWTHEQCN
CCCCCEEEEHHHCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHH
ALLPSLQVRWQAALDRGWLELHGRRWQLSDPEGMAISNQVLVEMLLWWQSLPADAVASPN
HHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHCCCCCHHCCCC
LEGLLRTAGDLGSMAD
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MREGLAVLPPRSAYLHIPFCHRRCFYCDFAVVPLGDHANGAKGSGSASIQSYLQLLQREI
CCCCCEECCCCCCEEECCHHHCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALVKPGPTLATVYIGGGTPSLLSSAQIGALLDQLRQRFGVQLGAEITLEMDPASFDQAYL
EEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEECCCCHHHHHH
AAVLAAGVNRVSLGGQSFDDAVLETLGRRHRRHHLLEACGWLHQAHQCGELKSWSLDLIQ
HHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
NLPGQELVAWKQQLVEAIDTGSPHLSIYDLSVEPGTVFAWRQRRGELDLPDDDLAAEQMQ
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEHHHHCCCCCCCCCCHHHHHHHH
TTSVLLRQAGFGRYEISNYALPGHASRHNRVYWSGAGWWAFGQGATSAPWGERLARPRTR
HHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHCCCCCC
DGYCNWIEVQEVEGLDSSLVAAQARPLPLDEQLLVGLRCREGVDLEALSRAWGWTHEQCN
CCCCCEEEEHHHCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHH
ALLPSLQVRWQAALDRGWLELHGRRWQLSDPEGMAISNQVLVEMLLWWQSLPADAVASPN
HHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHCCCCCHHCCCC
LEGLLRTAGDLGSMAD
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]