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The map label for this gene is argD [H]

Identifier: 124023684

GI number: 124023684

Start: 1744203

End: 1745459

Strand: Direct

Name: argD [H]

Synonym: P9303_19841

Alternate gene names: 124023684

Gene position: 1744203-1745459 (Clockwise)

Preceding gene: 124023683

Following gene: 124023685

Centisome position: 65.02

GC content: 55.85

Gene sequence:

>1257_bases
TTGGTAGACGCACTGGATTCAAAATCCAGCGCCTTCGGGCATGTGGGTTCAAGTCCCACCGCTCCCACTGCTGTGATGGG
CACCTACAAACGTTTTCCCGTCACTCTCTTACGCGGGAAAGGATGCTGGTTATGGGATGACCATGGTCATCAATACCTTG
ACGCTGTTGCCGGTATCGCGACCTGCGCCCTCGGTCACAGTGACCGGGCCCTGCGTCGCTCTCTTGGCCAGCAGCTGAAA
CAACTTCAGCATGTTTCCAATCTGTATCGGATTCCTGAACAAGAGGCTCTTGCCCATTGGTTAGTAGAAAACAGCTGCGC
AGACAGCGTGTTCTTCTGCAATTCCGGTGCAGAAGCCAACGAAGCCGCCATCAAGCTGGCTCGCAAACACGGTCATCGCC
GTCGCGGCATTGATCGGCCAATCATTCTCACCGCCAATTCCAGTTTCCACGGCCGCACACTTGCCGCCATAAGTGCCACA
GGTCAGCCCAACTACCACAAAGGTTTCGAACCCATGGTTGAGGGCTTTGAATTTTTCCCGTTCAATGACCTCCAAGCCTT
TGAGCAACAGCTAAATCGCCTCGAAGCTCAGGGGCCCTCTGTTGCCGCCGTGCTAATCGAACCACTGCAAGGTGAGGGTG
GCGTAAATCCAGGCGAAGCAAGCTTCTTCCGGCGCCTTAGAGAACTCTGTAGCCAGCATCAGATCCTGCTGATCTTTGAT
GAAGTTCAGGTCGGGATGGGCCGTTGTGGTCACTGGTGGGGGTATCAGCAGCTTGGGGTCGAACCAGATGCCTTCACCTT
GGCCAAAGGACTCGGGGGAGGCCATGCCATCGGAGCGTTGCTTGTCAAACAGCACGCTGATCTTTTCGAACCAGGTGACC
ACGCCAGTACTTTTGGCGGCAATCCCTTTGCCTGCAAGGCAGCTCTCACAGTTGCCAAGGAGATCGAACGACGGGGTTTG
ATCGCAAAGGTCCAGCAACGAGGCGCCCAGCTTCGTGAAGGCCTCACTGACCTAGTGCAACGTTTCCCGAGGCAACTCAA
AGGGGTAAGAGGCTGGGGGCTACTGCAGGGATTGGTGCTCCAAGACGAAAGCACATTCACAGCACCAAATATCGCCCAAG
CCGCCCTTGAAGAAAAGCTACTGGTGATAGCAGCAGGCCCAAAGGTTGTGCGGATGGTGCCGCCGCTGATCATCAAACCA
AGCGAAATCCGCCAACTGCTCCAACGTCTGGAAGCCACCCTGGCGCACTTCCGCTAA

Upstream 100 bases:

>100_bases
GGATTGAAACCAAATTGAATGCATCTGGAGCCCATATCCTTCGGCATCAGCCCTCAGGATGACCCTGGCATAACATCACC
TCCAAGGGAGCGTGGCGGAA

Downstream 100 bases:

>100_bases
GTGGCCAAACCCACAAGTCCAAGCAAGGAAGATTTAAGCGATCTGATTCCTCGTTTTGATCAGCGGGGGATGGATCTTGG
CCTTGAGCGCATGCAACAAG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWLWDDHGHQYLDAVAGIATCALGHSDRALRRSLGQQLK
QLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEANEAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISAT
GQPNYHKGFEPMVEGFEFFPFNDLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEASFFRRLRELCSQHQILLIFD
EVQVGMGRCGHWWGYQQLGVEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGGNPFACKAALTVAKEIERRGL
IAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVLQDESTFTAPNIAQAALEEKLLVIAAGPKVVRMVPPLIIKP
SEIRQLLQRLEATLAHFR

Sequences:

>Translated_418_residues
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWLWDDHGHQYLDAVAGIATCALGHSDRALRRSLGQQLK
QLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEANEAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISAT
GQPNYHKGFEPMVEGFEFFPFNDLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEASFFRRLRELCSQHQILLIFD
EVQVGMGRCGHWWGYQQLGVEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGGNPFACKAALTVAKEIERRGL
IAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVLQDESTFTAPNIAQAALEEKLLVIAAGPKVVRMVPPLIIKP
SEIRQLLQRLEATLAHFR
>Mature_418_residues
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWLWDDHGHQYLDAVAGIATCALGHSDRALRRSLGQQLK
QLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEANEAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISAT
GQPNYHKGFEPMVEGFEFFPFNDLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEASFFRRLRELCSQHQILLIFD
EVQVGMGRCGHWWGYQQLGVEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGGNPFACKAALTVAKEIERRGL
IAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVLQDESTFTAPNIAQAALEEKLLVIAAGPKVVRMVPPLIIKP
SEIRQLLQRLEATLAHFR

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=34.010152284264, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI284507298, Length=308, Percent_Identity=36.6883116883117, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=26.491646778043, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI13994255, Length=381, Percent_Identity=29.6587926509186, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=25.8215962441315, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=26.6666666666667, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI226442709, Length=338, Percent_Identity=27.810650887574, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI188536080, Length=446, Percent_Identity=24.4394618834081, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI38679950, Length=446, Percent_Identity=24.4394618834081, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI38679946, Length=446, Percent_Identity=24.4394618834081, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=41.1764705882353, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1789759, Length=383, Percent_Identity=38.9033942558747, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=33.59375, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789016, Length=399, Percent_Identity=31.5789473684211, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=30.75, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786349, Length=368, Percent_Identity=26.6304347826087, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=395, Percent_Identity=30.379746835443, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25144274, Length=280, Percent_Identity=31.0714285714286, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32564660, Length=443, Percent_Identity=27.765237020316, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=26.9503546099291, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=447, Percent_Identity=25.0559284116331, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=31.6770186335404, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=36.0493827160494, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6323470, Length=391, Percent_Identity=31.9693094629156, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6321456, Length=361, Percent_Identity=24.0997229916898, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=484, Percent_Identity=22.5206611570248, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=392, Percent_Identity=31.1224489795918, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=27.7647058823529, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=28.5024154589372, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28574759, Length=418, Percent_Identity=27.511961722488, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281366494, Length=434, Percent_Identity=26.4976958525346, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667139, Length=434, Percent_Identity=26.4976958525346, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667143, Length=434, Percent_Identity=26.4976958525346, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 45762; Mature: 45762

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWLWDDHGHQYLDAVAGIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCCEEEEECCCCEEECCCCHHHHHHHHHHH
TCALGHSDRALRRSLGQQLKQLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEAN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCHH
EAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISATGQPNYHKGFEPMVEGFEFFP
HHHHHHHHHHCHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCC
FNDLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEASFFRRLRELCSQHQILLIFD
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
EVQVGMGRCGHWWGYQQLGVEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGG
CHHHCCCCCCCCCCHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPFACKAALTVAKEIERRGLIAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEE
QDESTFTAPNIAQAALEEKLLVIAAGPKVVRMVPPLIIKPSEIRQLLQRLEATLAHFR
ECCCCCCCCHHHHHHHHCCEEEEECCCHHHHHCCCCEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDALDSKSSAFGHVGSSPTAPTAVMGTYKRFPVTLLRGKGCWLWDDHGHQYLDAVAGIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCCEEEEECCCCEEECCCCHHHHHHHHHHH
TCALGHSDRALRRSLGQQLKQLQHVSNLYRIPEQEALAHWLVENSCADSVFFCNSGAEAN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCHH
EAAIKLARKHGHRRRGIDRPIILTANSSFHGRTLAAISATGQPNYHKGFEPMVEGFEFFP
HHHHHHHHHHCHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCC
FNDLQAFEQQLNRLEAQGPSVAAVLIEPLQGEGGVNPGEASFFRRLRELCSQHQILLIFD
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
EVQVGMGRCGHWWGYQQLGVEPDAFTLAKGLGGGHAIGALLVKQHADLFEPGDHASTFGG
CHHHCCCCCCCCCCHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
NPFACKAALTVAKEIERRGLIAKVQQRGAQLREGLTDLVQRFPRQLKGVRGWGLLQGLVL
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEE
QDESTFTAPNIAQAALEEKLLVIAAGPKVVRMVPPLIIKPSEIRQLLQRLEATLAHFR
ECCCCCCCCHHHHHHHHCCEEEEECCCHHHHHCCCCEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]