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The map label for this gene is acoA [H]

Identifier: 124023659

GI number: 124023659

Start: 1723691

End: 1724782

Strand: Direct

Name: acoA [H]

Synonym: P9303_19591

Alternate gene names: 124023659

Gene position: 1723691-1724782 (Clockwise)

Preceding gene: 124023648

Following gene: 124023662

Centisome position: 64.25

GC content: 54.4

Gene sequence:

>1092_bases
ATGAGCCAGAAAACCTCCGTGAGCTCAGGCCAAACCACGGCAAAACCCCTGGCAGCAGGCCGCCATGGCGAGAGAATCTC
CACGCTAATCAGCTCCAAACGCGCCAAGGTTGATCGTCAGATCGGCCTAGAACTCTTCCGAGACATGACCCTTGGGCGAC
GCTTCGAGGACAAATGTGCCGAGATGTACTACCGGGGAAAAATGTTTGGCTTCGTTCACCTCTACAACGGCCAAGAAGCC
GTTAGCACAGGTGTGATCGGTGCAATGAAACGCCAGCACGATTGGTTTTGCAGTACCTATCGCGATCACGTTCATGCTCT
TAGCGCCGGTGTACCCGCCCGCGAAGTAATGAGTGAGCTCTTCGGCAAGGAAACCGGCTGTAGCAAAGGTCGTGGGGGCT
CCATGCACCTCTTTTCGCAAGAGCATCACCTCCTAGGAGGATTTGCCTTCATCGGCGAAGGGATTCCCATCGCCCTGGGG
GCAGCCTTCACCAGTCGCTATAAGCGGGATGCCCTGGGTGATGCCAGCAGCAATGCTGTAACAGCAGCTTTTTTCGGTGA
CGGCACCTGCAACAACGGCCAATTCTTTGAGTGCCTCAACATGGCGCAGCTTTGGCAACTGCCGATCCTGTTCGTTGTCG
AGAACAACAAATGGGCCATTGGCATGGCCCATGAGCGAGCCACCAGTGAACCGGAAATCTGGCAAAAAGCTGCTGCCTTC
GGAATGGCTGGCGAAGAGGTTGACGGCATGGATGTTCTCGCCGTAAGAGCTGCCACTCAGAGAGCAATAAAAAGAGCCAG
GGCTGGTGAAGGTCCCACCCTGCTGGAGTGCCTCACCTATCGATTCCGTGGCCATTCTCTTGCTGATCCAGATGAACTAC
GCGCCGAAGAGGAAAAGCAATTCTGGGCAAAACGAGATCCCCTAAAGGCTCTTGAGAAGGATCTCACCTCTGAATCTTTG
GTGCGTGCTGATGAACTACGCGCTATTGAAAAAGAGATCGATGCAGAAGTAAATGACTGCGTGGAGTTTGCCCTTGCCGC
AGCCGAACCAAATGCCAACGAACTCACTCGCTACATCTGGGCTGAAGATTGA

Upstream 100 bases:

>100_bases
TGCGCAGCGATTGGCATAAAACTCTAGACATTGGAAGGGATTTTGCCCATTGCTAATCAACGGACCATTACAGTCGTCAC
TCGAATGACGGTCGTCTGTC

Downstream 100 bases:

>100_bases
CAGCCCTCTTGATCACTAATTACTGGAAGCAAGCAGAGACAACAAGATAAGTAAGGCAGTTTCAGATCCCGTTGGGCACC
CTACGCGTGAGGTTACGCAG

Product: pyruvate dehydrogenase E1 subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSQKTSVSSGQTTAKPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEA
VSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSELFGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALG
AAFTSRYKRDALGDASSNAVTAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQFWAKRDPLKALEKDLTSESL
VRADELRAIEKEIDAEVNDCVEFALAAAEPNANELTRYIWAED

Sequences:

>Translated_363_residues
MSQKTSVSSGQTTAKPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEA
VSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSELFGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALG
AAFTSRYKRDALGDASSNAVTAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQFWAKRDPLKALEKDLTSESL
VRADELRAIEKEIDAEVNDCVEFALAAAEPNANELTRYIWAED
>Mature_362_residues
SQKTSVSSGQTTAKPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAV
STGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSELFGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALGA
AFTSRYKRDALGDASSNAVTAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAFG
MAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQFWAKRDPLKALEKDLTSESLV
RADELRAIEKEIDAEVNDCVEFALAAAEPNANELTRYIWAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=36.1702127659575, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=36.1702127659575, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=36.1702127659575, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=35.4166666666667, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=33.434650455927, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI11386135, Length=344, Percent_Identity=27.0348837209302, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI258645172, Length=344, Percent_Identity=27.0348837209302, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17536047, Length=312, Percent_Identity=37.1794871794872, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32564172, Length=310, Percent_Identity=37.4193548387097, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI86563355, Length=343, Percent_Identity=26.2390670553936, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI86563357, Length=343, Percent_Identity=26.2390670553936, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=36.1022364217252, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24639748, Length=331, Percent_Identity=37.1601208459215, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24639744, Length=331, Percent_Identity=35.6495468277946, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI28571106, Length=331, Percent_Identity=35.6495468277946, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24639740, Length=331, Percent_Identity=35.6495468277946, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=36.741214057508, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21355903, Length=334, Percent_Identity=22.1556886227545, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40171; Mature: 40040

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKTSVSSGQTTAKPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCA
CCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EMYYRGKMFGFVHLYNGQEAVSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSEL
HHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALGAAFTSRYKRDALGDASSNAV
HCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCE
TAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
EEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECHHCCCCCHHHHHHHHHH
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FWAKRDPLKALEKDLTSESLVRADELRAIEKEIDAEVNDCVEFALAAAEPNANELTRYIW
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHC
AED
CCC
>Mature Secondary Structure 
SQKTSVSSGQTTAKPLAAGRHGERISTLISSKRAKVDRQIGLELFRDMTLGRRFEDKCA
CCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EMYYRGKMFGFVHLYNGQEAVSTGVIGAMKRQHDWFCSTYRDHVHALSAGVPAREVMSEL
HHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FGKETGCSKGRGGSMHLFSQEHHLLGGFAFIGEGIPIALGAAFTSRYKRDALGDASSNAV
HCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCE
TAAFFGDGTCNNGQFFECLNMAQLWQLPILFVVENNKWAIGMAHERATSEPEIWQKAAAF
EEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECHHCCCCCHHHHHHHHHH
GMAGEEVDGMDVLAVRAATQRAIKRARAGEGPTLLECLTYRFRGHSLADPDELRAEEEKQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FWAKRDPLKALEKDLTSESLVRADELRAIEKEIDAEVNDCVEFALAAAEPNANELTRYIW
HHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHC
AED
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]