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The map label for this gene is hemE

Identifier: 124023536

GI number: 124023536

Start: 1594488

End: 1595546

Strand: Reverse

Name: hemE

Synonym: P9303_18361

Alternate gene names: 124023536

Gene position: 1595546-1594488 (Counterclockwise)

Preceding gene: 124023537

Following gene: 124023535

Centisome position: 59.48

GC content: 54.58

Gene sequence:

>1059_bases
ATGAGCGACTCCCAGCCCTTATTGCTCCGCGCTGCGCGTGGTGAGTCGGTCGAGCGGACCCCTGTGTGGATGATGCGCCA
GGCGGGACGCTACATGAAGGTTTACAGGGATCTCCGGGACCGTTACCCCAGTTTTCGAGAGCGTTCTGAAAATCCTGATC
TCTCTTACCAGATCTCGATGCAGCCCTTTGAAGCATTCCAGCCTGATGGGGTGATTTTGTTCTCAGACATCCTCACTCCC
TTGCCTGGCATGGGTATCGATTTCGACATCGTTGAAAGCAAGGGCCCCCTCATCCAAAAGCCGATTCGCAGCCTCAGCCA
AATTGAGGCTCTTCAGCCATTGGAGCCAAACGCAACCATGCCTTTTGTTGGCGAGGTGCTCGGACGCCTGCGCGAGAGCG
TTGGTAATAGGGCTGCTGTGTTGGGTTTTGTGGGGGCTCCCTGGACCCTTGCTGCCTATGTGGTTGAGGGCAAAAGCAGC
AAGAATTACGCCGTGATCAAGGCGATGGCTTTCCAGCAGCCAGATCTTCTGCATCGTTTGCTCAACCATTTCGCTGAATC
GATTGCAACTTATTTGCGTTATCAAATCGATTCCGGCGCCCAGGTCGTGCAGATGTTTGATTCCTGGGCCGGTCAGCTCA
GCCCGGCCGACTACGACACCTTTGCAGCGCCTTATCAAAAAAGAGTCGTAGACCTGGTGAAATCCACTCATCCCGACACT
CCAATGATTCTCTACATCTCCGGCAGCGCTGGAGTGTTGGAACGAATGGGGCGCACAGGCGTCGATATCATCTCTCTTGA
CTGGACTGTTGATATGGCCGATGGCTGCGCTCGACTTCCCGAGCACTTAGGTGTGCAAGGCAATGTTGACCCTGGCCTGT
TGTTTGGAACACCAGAAGCGATTCGAGAGCGAATTGTCGATGCGGTTCGTAAGGCTCGAGGTCGCCGGCACATCCTCAAC
CTCGGCCATGGCATCCTGCCTGGAACACCTGAGGACAATGCCAAGGTGTTTTTCGAAACTGGCAAGAATGTTGACAATCT
GATCGGATCTGCCGCTTGA

Upstream 100 bases:

>100_bases
AAGCCAATGAACATGTGACGAAGCTGCGTTCTCAACATCACTGATGGCCTTAACAACAACGGCCTTCAGGTAGGTTTTCT
GACTGATCCTGACCCTTGTA

Downstream 100 bases:

>100_bases
CTCCTGCCCGGATCCTGATCACAGGAGCCAGCGGCTGTGTTGGGCAGTACACAGCCGCCTGGCTACTTGAAAACTCCGAT
GCCGAGTTACTGCTCTGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISMQPFEAFQPDGVILFSDILTP
LPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATMPFVGEVLGRLRESVGNRAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQQPDLLHRLLNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEAIRERIVDAVRKARGRRHILN
LGHGILPGTPEDNAKVFFETGKNVDNLIGSAA

Sequences:

>Translated_352_residues
MSDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISMQPFEAFQPDGVILFSDILTP
LPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATMPFVGEVLGRLRESVGNRAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQQPDLLHRLLNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEAIRERIVDAVRKARGRRHILN
LGHGILPGTPEDNAKVFFETGKNVDNLIGSAA
>Mature_351_residues
SDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISMQPFEAFQPDGVILFSDILTPL
PGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATMPFVGEVLGRLRESVGNRAAVLGFVGAPWTLAAYVVEGKSSK
NYAVIKAMAFQQPDLLHRLLNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDTP
MILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEAIRERIVDAVRKARGRRHILNL
GHGILPGTPEDNAKVFFETGKNVDNLIGSAA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=347, Percent_Identity=32.8530259365994, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI2367337, Length=334, Percent_Identity=37.7245508982036, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=350, Percent_Identity=31.1428571428571, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI19921920, Length=351, Percent_Identity=35.6125356125356, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI221330099, Length=337, Percent_Identity=36.2017804154303, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PROM3 (A2CAR8)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017843.1
- ProteinModelPortal:   A2CAR8
- SMR:   A2CAR8
- STRING:   A2CAR8
- GeneID:   4776134
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_18361
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38974; Mature: 38843

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 153-153 BINDING 208-208 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISM
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEEC
QPFEAFQPDGVILFSDILTPLPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATM
CHHHHCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PFVGEVLGRLRESVGNRAAVLGFVGAPWTLAAYVVEGKSSKNYAVIKAMAFQQPDLLHRL
CHHHHHHHHHHHHHCCCEEEEEECCCCHHEEEEEEECCCCCCEEEEEEHHCCCHHHHHHH
LNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCC
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEA
CEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCHHH
IRERIVDAVRKARGRRHILNLGHGILPGTPEDNAKVFFETGKNVDNLIGSAA
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHCCCC
>Mature Secondary Structure 
SDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISM
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEEC
QPFEAFQPDGVILFSDILTPLPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATM
CHHHHCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PFVGEVLGRLRESVGNRAAVLGFVGAPWTLAAYVVEGKSSKNYAVIKAMAFQQPDLLHRL
CHHHHHHHHHHHHHCCCEEEEEECCCCHHEEEEEEECCCCCCEEEEEEHHCCCHHHHHHH
LNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCC
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEA
CEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCHHH
IRERIVDAVRKARGRRHILNLGHGILPGTPEDNAKVFFETGKNVDNLIGSAA
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA